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Search Results: 1 - 10 of 248788 matches for " Daniel C. Malone "
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Predictors of hospitalization and institutionalization in Medicaid patient populations with Alzheimer’s Disease  [PDF]
Adrienne M. Gilligan, Daniel C. Malone, Terri L. Warholak, Edward P. Armstrong
Advances in Alzheimer's Disease (AAD) , 2013, DOI: 10.4236/aad.2013.23011
Abstract: Objectives: Determine predictors of hospitalization and institutionalization in Medicaid populations with Alzheimer’s Disease (AD). Methods: Data were obtained from the Centers for Medicareand Medicaid Services (CMS). Individuals enrolled in Florida,New Jersey, and New York Medicaid programs on January 1, 2004, remained in that program for 1 year and exposed to an AD medication were included. AD diagnosis was based on the ICD-9-CM code 331.0. Outcomes of interest were hospitalization and institutionalization. Multivariate logistic regression models were used to test for the association between outcomes of interest and demographics, resource utilization factors, and type of AD pharmacotherapy exposure. Results: A total of 65,442 individuals qualified for the study. Age was positively and significantly associated with hospitalization (p < 0.001) and institutionalization (p < 0.001). Exposure tomemantine was significantly associated with less chance of hospitalization (OR = 0.88; 99% CI: 0.77 - 0.99). Non-Hispanic Blacks were significantly (p < 0.001) more likely to be hospitalized than Non-Hispanic Whites (OR = 1.60; 99% CI: 1.41 - 1.81). Compared to Non-Hispanic Whites, Non-Hispanic Blacks (OR = 0.73; 99% CI: 0.60 - 0.88), Hispanics (OR = 0.36; 99% CI: 0.27 - 0.47), and Non-Hispanic Others (OR = 0.42; 99% CI: 0.21 - 0.82) were significantly less likely to be institutionalized. Individuals prescribed donepezil (OR = 1.29, 99% CI, 1.08 - 1.54) and galantamine (OR = 1.46, 99% CI: 1.19 - 1.79) were significantly more likely to have an institutionalization claim (p < 0.001 for both medications). Residents of New York were significantly morelikely to be hospitalized than Florida residents (OR = 1.30; 99% CI: 1.17 - 1.44), where as New Jersey residents were significantly less likely to be hospitalized (OR = 0.75; 99% CI: 0.66 - 0.85). Finally, compared toFloridaresidents, residents of New Jerseywere significantly more likely to be institutionalized (OR = 4.61; 99% CI: 3.98 - 5.33). Conclusion: Demographics, state of residence and pharmacotherapy exposure weresignificant predictors of health care service utilization. Further pharmacoeconomic studies in AD medication therapy are warranted.
YfiBNR Mediates Cyclic di-GMP Dependent Small Colony Variant Formation and Persistence in Pseudomonas aeruginosa
Jacob G. Malone ,Tina Jaeger,Christian Spangler,Daniel Ritz,Anne Spang,Cécile Arrieumerlou,Volkhard Kaever,Regine Landmann,Urs Jenal
PLOS Pathogens , 2010, DOI: 10.1371/journal.ppat.1000804
Abstract: During long-term cystic fibrosis lung infections, Pseudomonas aeruginosa undergoes genetic adaptation resulting in progressively increased persistence and the generation of adaptive colony morphotypes. This includes small colony variants (SCVs), auto-aggregative, hyper-adherent cells whose appearance correlates with poor lung function and persistence of infection. The SCV morphotype is strongly linked to elevated levels of cyclic-di-GMP, a ubiquitous bacterial second messenger that regulates the transition between motile and sessile, cooperative lifestyles. A genetic screen in PA01 for SCV-related loci identified the yfiBNR operon, encoding a tripartite signaling module that regulates c-di-GMP levels in P. aeruginosa. Subsequent analysis determined that YfiN is a membrane-integral diguanylate cyclase whose activity is tightly controlled by YfiR, a small periplasmic protein, and the OmpA/Pal-like outer-membrane lipoprotein YfiB. Exopolysaccharide synthesis was identified as the principal downstream target for YfiBNR, with increased production of Pel and Psl exopolysaccharides responsible for many characteristic SCV behaviors. An yfi-dependent SCV was isolated from the sputum of a CF patient. Consequently, the effect of the SCV morphology on persistence of infection was analyzed in vitro and in vivo using the YfiN-mediated SCV as a representative strain. The SCV strain exhibited strong, exopolysaccharide-dependent resistance to nematode scavenging and macrophage phagocytosis. Furthermore, the SCV strain effectively persisted over many weeks in mouse infection models, despite exhibiting a marked fitness disadvantage in vitro. Exposure to sub-inhibitory concentrations of antibiotics significantly decreased both the number of suppressors arising, and the relative fitness disadvantage of the SCV mutant in vitro, suggesting that the SCV persistence phenotype may play a more important role during antimicrobial chemotherapy. This study establishes YfiBNR as an important player in P. aeruginosa persistence, and implicates a central role for c-di-GMP, and by extension the SCV phenotype in chronic infections.
Role of Multiple High-Capacity Irrigation Wells on a Surficial Sand and Gravel Aquifer  [PDF]
Logan C. Seipel, Eric W. Peterson, David H. Malone, Jason F. Thomason
Journal of Geoscience and Environment Protection (GEP) , 2016, DOI: 10.4236/gep.2016.45005
Abstract: Within McHenry County, IL, the fastest growing county in Illinois, groundwater is used for 100% of the water needs. Concerns over water resources have prompted the investigation of the surficial sand and gravel aquifers of the county. While the eastern portion of the county is urbanizing, the western portion remains devoted to agriculture. High-capacity irrigation wells screened within the surficial sand and gravel aquifer are used for crop production. To assess the impacts of the irrigation wells on the aquifer, a groundwater flow model was developed to examine five different scenarios reflecting drought conditions and increased pumping. Results show that the surficial sand and gravel aquifer is capable of meeting current water demands even if recharge is decreased 20% and pumping is increased 20%. The additional loss of discharge and increases in pumping result in head differences throughout the aquifer.
Investigating γH2AX as a Biomarker of Radiosensitivity Using Flow Cytometry Methods
Lindsay A. Beaton,Leonora Marro,Shawn Malone,Sara Samiee,Scott Grimes,Kyle Malone,Ruth C. Wilkins
ISRN Radiology , 2013, DOI: 10.5402/2013/704659
Abstract: Background and Purpose. This project examined the in vitro??γH2AX response in lymphocytes of prostate cancer patients who had a radiosensitive response after receiving radiotherapy. The goal of this project was to determine whether the γH2AX response, as measured by flow cytometry, could be used as a marker of individual patient radiosensitivity. Materials and Methods. Patients were selected from a randomized clinical trial evaluating the optimal timing of Dose Escalated Radiation and short-course Androgen Deprivation Therapy. Of 438 patients, 3% developed Grade 3 late radiation proctitis and were considered to be radiosensitive. Blood was drawn from 10 of these patients along with 20 matched samples from patients with Grade 0 proctitis. Dose response curves up to 10?Gy along with time response curves after 2?Gy (0–24?h) were generated for each sample. The γH2AX response in lymphocytes and lymphocyte subsets was analyzed by flow cytometry. Results. There were no significant differences between the radiosensitive and control samples for either the dose course or the time course. Conclusions. Although γH2AX response has previously been demonstrated to be an indicator of individual patient radiosensitivity, flow cytometry lacks the sensitivity necessary to distinguish any differences between samples from control and radiosensitive patients. 1. Introduction The severity of late normal tissue toxicity is a limiting factor during the administration of radiotherapy [1]. It has become clear that interpatient variability in the incidence of late normal tissue toxicity could be partially due to individual patient sensitivity to radiation [2] and the prediction of a patient’s radiosensitivity would facilitate improved patient treatment [3]. The induction and repair of chromosomal damage in irradiated lymphocytes are thought to be promising predictors of individual patient sensitivity to ionizing radiation [4]. Since DNA double-strand breaks (DSBs) are considered to be the critical lesion for DNA damage, the lack of repair, or misrepair, can have severe repercussions. As such, it is important to be able to quantitate the induction and disappearance of DSBs. Rogakou et al. in 1999 [5] showed that H2AX (an electrophoretic isoform of the histone H2A) is phosphorylated (γH2AX) at the sites of DSBs, and Sedelnikova et al. in 2003 [4] demonstrated that γH2AX foci corresponded one to one with DSBs. These results mean that the number of DSBs induced can be measured by counting the number of γH2AX foci [4]. Furthermore, by staining γH2AX with a fluorochrome-labelled
Stress tensor computations at Mount St. Helens (1995-1998)
C. Musumeci,S. D. Malone,E. Giampiccolo,S. Gresta
Annals of Geophysics , 2000, DOI: 10.4401/ag-3681
Abstract: Fault plane solutions of 459 events occurring between 1995 and 1998 at Mount St. Helens (State of Washington, Northwest U.S.A.) were considered in order to infer the state of stress beneath the volcano. These events occurred in two distinct depth zones. The shallower zone is between 2 and 5.5 km, with shocks clustering in a tight cylindrical distribution about 1 km in radius directly beneath the crater. The deeper events are spread over a larger volume from 5.5 to 10 km depth and surround an aseismic zone below and slightly west of the lava dome. Faulting is characterized by a mixture of strike-slip, reverse and normal faults with maximum compression axes which do not cluster around a single direction. In the deep zone, between 5.5 and 10 km, P axes define a wheel-spoke pattern pointing radially away from the center of the aseismic zone. The 459 fault plane solutions were inverted for stress tensor parameters using the algorithm of Gephart and Forsyth. The inversion of the whole data set revealed that faulting was not produced by a uniform stress distribution. The subdivision of the zone into smaller volumes significantly reduced misfit and confidence areas of the solutions, whereas temporal subdivision of the sample did not lead to significant improvements in terms of stress uniformity. We suggest that the inhomogeneous stress field is consistent with a varying pressure source originating from the inferred crustal magma chamber and a thin conduit extending above it.
Discussion forum rubrics: Using rubrics to enhance and increase project management students' participation in online discussions
Margaret Ruth Lee,Deborah S Carstens,Linda C Malone
Journal of Project, Program & Portfolio Management , 2012,
Abstract: This paper examines the impact of using a discussion forum grading rubric to encourage and enhance discussions (posts) in an online introduction to project management course. The study consists of 53 Master of Business Administration (MBA) students enrolled in three sections of the course from October 2010 to May 2011. A control group of 20 students was compared to two experimental groups of 16 and 17 students respectively. The two experimental groups were given the specific grading rubric and instructions designed to encourage online conversation; the control group was not. The results indicate that there was a statistical difference in average postings per student between the two experimental groups and the control group but no statistical difference between the two experimental groups. The results suggest that the use of a rubric specifically designed to engage the student and expand the student's learning experience can increase online classroom participation and, as a consequence, enhance the educational experience for the online project management student and strengthen the university's MBA program.
Diabetic Cardiovascular Risk and Carnitine Deficiency
—Carnitine Deficiency in Clinical Diabetes Mellitus

John I. Malone, Michael A. Malone, Anthony D. Morrison
Journal of Diabetes Mellitus (JDM) , 2014, DOI: 10.4236/jdm.2014.43029

Background: Type 1 diabetes mellitus increases the risk of coronary heart disease. The Pittsburgh IDDM morbidity and mortality study reported greater than 10 fold coronary heart disease mortality compared with US national data [1]. Adults with diabetes have heart disease death rates 2 to 4 times higher than adults without diabetes [2]. Diabetic cardiomyopathy explains much of this survival difference and carnitine deficiency is a cause of cardiomyopathy. Research Design and Methods: Adult subjects (40) with type 1 diabetes mellitus were seen for a routine annual visit having no clinical complaints. Fasting serum samples were collected for annual chemistries and the measurement of carnitine. Results: The mean total (40.8 ± 8.8) [40 - 80 nmol/ml] and free (32.9 ± 7.9) [30 - 60 nmol/ml] carnitine levels for this group included 43% low total and 28% low free carnitine. The mean esterified/free (E/F) carnitine ratio (0.25 ± 0.09) for this group was elevated indicating carnitine insufficiency. Conclusions: Fatty acids are the primary energy source for diabetic heart muscle, and carnitine is essential for intracellular fatty acid transport and ATP production. Therefore, mild carnitine deficiency can compromise fatty acid energy production in a failing heart. Carnitine deficiency in subjects at high risk for cardiovascular failure is a possible unrecognized reason for the 4 fold increased death rate in patients with type 1 diabetes. Supplementation with oral carnitine could reduce that increased risk of heart failure, in patients with type 1 diabetes. Intravenous carnitine may be life saving when managing acute cardiac failure in patients with diabetes mellitus. Normal carnitine levels in patients with type

Variabilidade genética interespecífica em formigas cortadeiras do gênero Acromyrmex que ocorrem no Estado do Rio Grande do Sul
Grutzmacher, Douglas Daniel;Loeck, Alci Enimar;Oliveira, Ant?nio Costa;Zimmer, Paulo Dejalma;Malone, Gaspar;
Ciência Rural , 2007, DOI: 10.1590/S0103-84782007000400001
Abstract: at present, a few number of taxonomists work on identification of leaf cutting ants. morphological-based methods do not always produce a reliable identification, due to the strong polymorphism observed even in the same colony. this fact leads to hypothesize that, besides those variations, others may also occur related to geographic distribution of the ants. six acromyrmex species were sampled at four locations in the state of rio grande do sul and analyzed by rapd and aflp. fifty ubc primers, originated from the university of british columbia, were evaluated to select a set of primers that could be useful for species identification and genetic variability studies. only 13 primers, which amplified fragments of all species, were selected. although the selected primers produced fragments that allowed various ways for identification of a. heyeri, a. ambiguus, a. crassispinus, a. striatus, a. laticeps and a. aspersus, only ubc 354, ubc348 and ubc356 primers allowed a reliable identification showing the most visible fragments. results by dendogram and morphological-based identification, showed that a. striatus and a. laticeps are less related to the other species. however a. ambiguus e a. crassispinus are the most genetically related ants in the state of rio grande do sul. the results indicate that a reliable identification of acromyrmex can be carried out by rapd and aflp, yet allowing verification of genetic distance between species.
Mutations in the Hedgehog Pathway Genes SMO and PTCH1 in Human Gastric Tumors
Xi-De Wang, Hector Inzunza, Han Chang, Zhenhao Qi, Beihong Hu, Daniel Malone, John Cogswell
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0054415
Abstract: The causal role of the hedgehog pathway in cancer has been best documented in basal cell carcinoma of the skin. To assess potential DNA alterations of the hedgehog pathway in gastric cancer, we sequenced SMO and PTCH1 genes in a set of 39 gastric tumors. Tumors were classified by histology based on the Lauren classification and Sanger sequencing was performed to obtain full length coding sequences. Genomic instability was evident in these tumors as a number of silent or missense mutations were found. In addition to those that are potential germline polymorphisms, we found three SMO missense mutations, and one PTCH1 frameshift mutation that are novel and have not been documented in basal cell carcinoma. Mutations were found in both intestinal and diffuse type gastric tumors as well as in tumors that exhibit both intestinal and diffuse features. mRNA expression of hedgehog pathway genes was also examined and their levels do not indicate unequivocal higher pathway activity in tumors with mutations than those without. In summary, SMO and/or PTCH1 mutations are present at low frequency in different histologic subtypes of gastric tumors and these do not appear to be driver mutations.
Periodic Bifurcations in Descendant Trees of Finite p-Groups  [PDF]
Daniel C. Mayer
Advances in Pure Mathematics (APM) , 2015, DOI: 10.4236/apm.2015.54020
Abstract: Theoretical background and an implementation of the p-group generation algorithm by Newman and O’Brien are used to provide computational evidence of a new type of periodically repeating patterns in pruned descendant trees of finite p-groups.
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