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Search Results: 1 - 10 of 28150 matches for " Danian Zhu "
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Upregulation of Protein Phosphatase 2A and NR3A-Pleiotropic Effect of Simvastatin on Ischemic Stroke Rats
Minxia Zhu, Jin Wang, Min Liu, Dongshu Du, Chunmei Xia, Linlin Shen, Danian Zhu
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0051552
Abstract: Ca2+ influxes are regulated by the functional state of N-methyl-D-aspartate receptors (NMDARs). Dephosphorylation of NMDARs subunits decreases Ca2+ influxes. NR3, a novel subunit of NMDARs, also decreases Ca2+ influxes by forming new NMDARs with NR1 and NR2. It is meaningful to uncover whether protein phosphatase 2A (PP2A) and NR3A play a role in the protective effect of Simvastatin on ischemic stroke. In the present study, the Sprague-Dawley rats were pretreated with Simvastatin for 7 days before middle cerebral artery occlusion was performed to mimic ischemic stroke. The results showed that Simvastatin decreased brain ischemic infarct area significantly while increasing the expression levels of PP2A and NR3A, thus dephosphorylating the serine sites of NR1 (ser896 and ser897) along with increased enzymatic activities of PP2A. The protein levels of NR3A decreased as the enzymatic activities of PP2A were inhibited by okadaic acid. The results indicated that Simvastatin could protect the cerebrum from ischemic injury through a signaling mechanism involving elevated levels of PP2A and NR3A, and that PP2A might involve in the regulatory mechanism of NR3A expression.
QTL analysis of rice low temperature germinability
Sheng Teng,Dali Zeng,Qian Qian,Yasufumi Kunihifo,Danian Huang,Lihuang Zhu
Chinese Science Bulletin , 2001, DOI: 10.1007/BF02900554
Abstract: A double haploid population, derived from anther culture of F1 hybrid between a typicalindica and ajaponica (ZYQ8/JX17), has been used to investigate the low temperature germinability (LTG) at 15°C. The low temperature germinability of two parents was significantly different. In 6–11 d, the germination percentage of ZYQ8 was higher than that of JX17. In 12–16 d, the germination percentage of JX17 was higher than that of ZYQ8. The quantitative trait loci (QTLs) of every day for low temperature germinability have been mapped based on a molecular linkage map constructed from this population. In 8–11 d, qLTG-9 was identified in C397B-RZ617B on chromosome 9, the additive effect was positive, showing that the allele from JX17 could increase low temperature germinability. In 12–16 d, qLTG-4 was mapped between RG908 and CT563 on chromosome 4, the additive effect was negative, showing that the allele from ZYQ8 could increase low temperature germinability. These two QTLs were detected at different stages, showing the complexity of the mechanism of low temperature germinability.
The Effect of Orexin-A on Cardiac Dysfunction Mediated by NADPH Oxidase-Derived Superoxide Anion in Ventrolateral Medulla
Jun Chen, Chunmei Xia, Jin Wang, Meiyan Jiang, Huanhuan Zhang, Chengrong Zhang, Minxia Zhu, Linlin Shen, Danian Zhu
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0069840
Abstract: Hypocretin/orexin-producing neurons, located in the perifornical region of the lateral hypothalamus area (LHA) and projecting to the brain sites of rostral ventrolateral medulla (RVLM), involve in the increase of sympathetic activity, thereby regulating cardiovascular function. The current study was designed to test the hypothesis that the central orexin-A (OXA) could be involved in the cardiovascular dysfunction of acute myocardial infarction (AMI) by releasing NAD(P)H oxidase-derived superoxide anion (O2?) generation in RVLM, AMI rat model established by ligating the left anterior descending (LAD) coronary artery to induce manifestation of cardiac dysfunction, monitored by the indicators as heart rate (HR), heart rate variability (HRV), mean arterial pressure (MAP) and left intraventricular pressure. The results showed that the expressions of OXA in LHA and orexin 1 receptor (OX1R) increased in RVLM of AMI rats. The double immunofluorescent staining indicated that OX1R positive cells and NAD(P)H oxidative subunit gp91phox or p47phox-immunoreactive (IR) cells were co-localized in RVLM. Microinjection of OXA into the cerebral ventricle significantly increased O2? production and mRNA expression of NAD(P)H oxidase subunits when compared with aCSF-treated ones. Exogenous OXA administration in RVLM produced pressor and tachycardiac effects. Furthermore, the antagonist of OX1R and OX2R (SB-408124 and TCS OX2 29, respectively) or apocynin (APO), an inhibitor of NAD(P)H oxidase, partly abolished those cardiovascular responses of OXA. HRV power spectral analysis showed that exogenous OXA led to decreased HF component of HRV and increased LF/HF ratio in comparison with aCSF, which suggested that OXA might be related to sympathovagal imbalance. As indicated by the results, OXA might participate in the central regulation of cardiovascular activities by disturbing the sympathovagal balance in AMI, which could be explained by the possibility that OXR and NAD(P)H-derived O2? in RVLM mediates OXA-induced cardiovascular responses.
The Effects of Angiotensin II and Angiotensin-(1–7) in the Rostral Ventrolateral Medulla of Rats on Stress-Induced Hypertension
Dongshu Du, Jun Chen, Min Liu, Minxia Zhu, Haojia Jing, Jie Fang, Linlin Shen, Danian Zhu, Jerry Yu, Jin Wang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0070976
Abstract: We have shown that angiotensin II (Ang II) and angiotensin-(1–7) [Ang-(1–7)] increased arterial blood pressure (BP) via glutamate release when microinjected into the rostral ventrolateral medulla (RVLM) in normotensive rats (control). In the present study, we tested the hypothesis that Ang II and Ang-(1–7) in the RVLM are differentially activated in stress-induced hypertension (SIH) by comparing the effects of microinjection of Ang II, Ang-(1–7), and their receptor antagonists on BP and amino acid release in SIH and control rats. We found that Ang II had greater pressor effect, and more excitatory (glutamate) and less inhibitory (taurine and γ-aminobutyric acid) amino acid release in SIH than in control animals. Losartan, a selective AT1 receptor (AT1R) antagonist, decreased mean BP in SIH but not in control rats. PD123319, a selective AT2 receptor (AT2R) antagonist, increased mean BP in control but not in SIH rats. However, Ang-(1–7) and its selective Mas receptor antagonist Ang779 evoked similar effects on BP and amino acid release in both SIH and control rats. Furthermore, we found that in the RVLM, AT1R, ACE protein expression (western blot) and ACE mRNA (real-time PCR) were significantly higher, whereas AT2R protein, ACE2 mRNA and protein expression were significantly lower in SIH than in control rats. Mas receptor expression was similar in the two groups. The results support our hypothesis and demonstrate that upregulation of Ang II by AT1R, not Ang-(1–7), system in the RVLM causes hypertension in SIH rats by increasing excitatory and suppressing inhibitory amino acid release.
Acid Sensing Ion Channel 1 in Lateral Hypothalamus Contributes to Breathing Control
Nana Song, Guihong Zhang, Wenye Geng, Zibing Liu, Weizhong Jin, Li Li, Yinxiang Cao, Danian Zhu, Jerry Yu, Linlin Shen
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0039982
Abstract: Acid-sensing ion channels (ASICs) are present in neurons and may contribute to chemoreception. Among six subunits of ASICs, ASIC1 is mainly expressed in the central nervous system. Recently, multiple sites in the brain including the lateral hypothalamus (LH) have been found to be sensitive to extracellular acidification. Since LH contains orexin neurons and innervates the medulla respiratory center, we hypothesize that ASIC1 is expressed on the orexin neuron and contributes to acid-induced increase in respiratory drive. To test this hypothesis, we used double immunofluorescence to determine whether ASIC1 is expressed on orexin neurons in the LH, and assessed integrated phrenic nerve discharge (iPND) in intact rats in response to acidification of the LH. We found that ASIC1 was co-localized with orexinA in the LH. Microinjection of acidified artificial cerebrospinal fluid increased the amplitude of iPND by 70% (pH 7.4 v.s. pH 6.5:1.05±0.12 v.s. 1.70±0.10, n = 6, P<0.001) and increased the respiratory drive (peak amplitude of iPND/inspiratory time, PA/Ti) by 40% (1.10±0.23 v.s. 1.50±0.38, P<0.05). This stimulatory effect was abolished by blocking ASIC1 with a nonselective inhibitor (amiloride 10 mM), a selective inhibitor (PcTX1, 10 nM) or by damaging orexin neurons in the LH. Current results support our hypothesis that the orexin neuron in the LH can exert an excitation on respiration via ASIC1 during local acidosis. Since central acidification is involved in breathing dysfunction in a variety of pulmonary diseases, understanding its underlying mechanism may improve patient management.
Variation of the grand mean value of Si-O distances in metamorphic reactions
Danian Ye,Zhe Li,Wei He
Chinese Science Bulletin , 2001, DOI: 10.1007/BF03182841
Abstract: The grand mean values of Si-O distances in both the left and the right sides of 33 metamorphic reaction equations have been calculated on the basis of data of single crystal structural refinement analysis. The results showed that the grand mean value of Si-O distances tends to decrease at high temperature, whereas that tends to increase at high pressure during a metamorphic reaction.
Theoretical calculation of the coefficients of thermal expansion for various AB type halides
Zhang Zhenyu,Ye Danian,Liu Weiling
Chinese Science Bulletin , 1998, DOI: 10.1007/BF02884553
Abstract: By analyzing rhe relationship between thermal expansion coefficients of AB type halides and their crystal chemistry properties, an empirical formula for theoretical calculation of their thermal expansion coefficients is drawn. The formula has a simple form and a high accuracy with an averagc error of 2.4%
Theoretical calculation of the coefficients of thermal expansion for various AB type halides

Zhang Zhenyu,Ye Danian,Liu Weiling,

科学通报(英文版) , 1998,
Abstract: By analyzing rhe relationship between thermal expansion coefficients of AB type halides and their crystal chemistry properties, an empirical formula for theoretical calculation of their thermal expansion coefficients is drawn. The formula has a simple form and a high accuracy with an averagc error of 2.4%
Variation of the grand mean value of Si-O distances in metamorphic reactions

YE Danian,LI Zhe,HE Wei,

科学通报(英文版) , 2001,
Abstract: The grand mean values of Si-O distances in both the left and the right sides of 33 metamorphic reaction equations have been calculated on the basis of data of single crystal structural refinement analysis. The results showed that the grand mean value of Si-O distances tends to decrease at high temperature, whereas that tends to increase at high pressure during a metamorphic reaction.
The planimetric unfold method of fullerene cage structure
Danian Ye,Desheng Ai,Wei He,Wendong Xu
Chinese Science Bulletin , 2000, DOI: 10.1007/BF02886301
Abstract: Two kinds of planimetric diagrams, which consist of the boat form F6 and F5, the storm petrel form F6 and F5, respectively, were proposed to express the geometric structure of fullerene cage in this study. There are two chief advantages using the diagrams: (i) the spatial symmetrical characteristic of fullerene cage is not destroyed; (ii) the coordination forms of F5 and F6 in the structure can be clearly expressed. This work has laid the foundation for studying the structural geometry of fullerene cage and its quantum chemistry and property.
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