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Search Results: 1 - 10 of 1280 matches for " Damien Grinsell "
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Free Anterolateral Thigh Perforator Flap for Head and Neck Cancer Resection in a Nonagenarian  [PDF]
Frank Lin, Damien Grinsell
Modern Plastic Surgery (MPS) , 2012, DOI: 10.4236/mps.2012.21001
Abstract: With an aging population, free flap reconstruction for head and neck cancer ablation in the elderly is becoming more commonplace. In nonagenarians, however, such major operations are still rarely offered due to its physiological demands. We report the first case of successful resection and reconstruction of head and neck cancer with a free perforator flap in a 96 year old patient. We feel that with careful patient and flap selection, careful preoperative workup and close collaboration between treating teams, age alone should not preclude patients from receiving the best possible curative treatment and reconstruction in head and neck cancers. Even in nonagenarians, perforator free flaps, such as the anterolateral thigh flap, can be used safely to achieve good functional and aesthetic outcomes.
Functional Reconstruction of Sarcoma Defects Utilising Innervated Free Flaps
Damien Grinsell,Claudia Di Bella,Peter F. M. Choong
Sarcoma , 2012, DOI: 10.1155/2012/315190
Abstract: Soft-tissue reconstruction following preoperative radiotherapy and wide resection of soft tissue sarcoma remains a challenge. Pedicled and free tissue transfers are an essential part of limb sparing surgery. We report 22 cases of sarcoma treated with radiotherapy and wide excision followed by one-stage innervated free or pedicled musculocutaneous flap transfers. The resection involved the upper limb in 3 cases, the lower limb in 17, and the abdominal wall in 2. The flaps used for the reconstruction were mainly latissimus dorsi and gracilis. The range of motion was restored fully in 14 patients. The muscle strength of the compartment reconstructed was of grades 4 and 5 in all patients except one. The overall function was excellent in all the cases with functional scores of 71.2% in the upper limb and 84% in the lower limb. The only 2 major complications were flap necrosis, both revised with another flap, one of which was innervated with restoration of function. Innervated flaps are valuable alternatives for reconstruction after sarcoma resection in the extremity and in the abdominal wall. The excellent functional results are encouraging, and we believe that innervated muscle reconstruction should be encouraged in the treatment of sarcoma after radiotherapy and wide resection.
Functional Reconstruction of Sarcoma Defects Utilising Innervated Free Flaps
Damien Grinsell,Claudia Di Bella,Peter F. M. Choong
Sarcoma , 2012, DOI: 10.1155/2012/315190
Abstract: Soft-tissue reconstruction following preoperative radiotherapy and wide resection of soft tissue sarcoma remains a challenge. Pedicled and free tissue transfers are an essential part of limb sparing surgery. We report 22 cases of sarcoma treated with radiotherapy and wide excision followed by one-stage innervated free or pedicled musculocutaneous flap transfers. The resection involved the upper limb in 3 cases, the lower limb in 17, and the abdominal wall in 2. The flaps used for the reconstruction were mainly latissimus dorsi and gracilis. The range of motion was restored fully in 14 patients. The muscle strength of the compartment reconstructed was of grades 4 and 5 in all patients except one. The overall function was excellent in all the cases with functional scores of 71.2% in the upper limb and 84% in the lower limb. The only 2 major complications were flap necrosis, both revised with another flap, one of which was innervated with restoration of function. Innervated flaps are valuable alternatives for reconstruction after sarcoma resection in the extremity and in the abdominal wall. The excellent functional results are encouraging, and we believe that innervated muscle reconstruction should be encouraged in the treatment of sarcoma after radiotherapy and wide resection. 1. Introduction In the mid-1970s the rate of amputation for extremity soft tissue sarcomas was 40–50% [1]. During this period, radiation therapy (RT) was considered a palliative rather than curative modality for the large tumour masses [2]. A decade later, however, Rosenberg and colleagues reported that when compared with amputation, wide excision with external beam RT was associated with equivalent 5-year disease-free and overall survival [3]. Since then, the combination of surgery and RT has been proven to yield superior local control of tumour compared to local excision alone and has been fundamental to the adoption of limb-sparing surgery for high-risk extremity STS [4–7]. Preoperative RT is preferred at our Institute because of smaller RT targets [8, 9]. lower RT dose due to better limb perfusion and oxygenation, [6, 10]. and decreased late toxicity [11] compared with postoperative RT despite a slighter higher rate of wound complications. Surgical margins are the most important factor associated with local tumour control [12]. In many cases, obtaining good oncologic margins can result in extensive or critical loss of muscle/tendon units. Not only are the reconstructions required after such resections likely to be challenging, wound healing difficulties in the postoperative
An Inquiry into the Effectiveness of Student Generated MCQs as a Method of Assessment to Improve Teaching and Learning  [PDF]
Damien Hutchinson, Jason Wells
Creative Education (CE) , 2013, DOI: 10.4236/ce.2013.47A2014
Abstract:

In anticipation of helping students mature from passive to more active learners while engaging with the issues and concepts surrounding computer security, a student generated Multiple Choice Question (MCQ) learning strategy was designed and deployed as a replacement for an assessment task that was previously based on students providing solutions to a series of short-answer questions. To determine whether there was any educational value in students generating their own MCQs students were required to design MCQs. Prior to undertaking this assessment activity each participant completed a pre-test which consisted of 45 MCQs based on the topics of the assessment. Following the assessment activity the participants completed a post-test which consisted of the same MCQs as the pre-test. The pre and post test results as well as the post test and assessment activity results were tested for statistical significance. The results indicated that having students generate their own MCQs as a method of assessment did not have a negative effect on the learning experience. By providing a framework to the students based on the literature to support their engagement with the learning material, we believe the creation of well-structured MCQs resulted in a more advanced understanding of the relationships between the concepts of the learning material as compared with plainly answering a series of short-answer questions from a textbook. Further study is required to determine to what degree this learning strategy encouraged a deeper approach to learning.

What Is the Natural Weight of the Current Old?  [PDF]
Damien Gaumont, Daniel Leonard
Theoretical Economics Letters (TEL) , 2013, DOI: 10.4236/tel.2013.35043
Abstract: We consider a simple overlapping generations model with an externality à la Arrow-Romer [1,2] and a government with fiscal powers. If it wishes to maximize a criterion depending on the lifelong utility of agents, is there a natural weight for the utility of the current old? We show in a simple example that this weight depends on the specific features of the model, in particular the length of the horizon, and cannot be chosen arbitrarily. Our result has a neat economic interpretation [2].
Evaluation of Tobacco Use and Her-2 Receptor Expression in Breast Cancer in an Ethnically Diverse Inner-City Population  [PDF]
Damien M. Hansra, Judith Hurley
Open Journal of Epidemiology (OJEpi) , 2014, DOI: 10.4236/ojepi.2014.42014
Abstract: Background: Tobacco is linked to most cancers however despite overwhelming biological plausibility and decades of epidemiological studies, no association has been established between tobacco and breast cancer. Although estrogen receptor status has been looked at as a variable there has been no evaluation of the role of Her-2 and smoking in breast cancer. Methods: Review of records from patients treated at the University of Miami/Jackson Memorial Hospital from 1998-2012. The incidence of smoking and Her-2 expression in1255 women was evaluated. Data was analyzed by age, race, ethnic group, menopausal status, tumor stage, and ER/PR/Her-2 receptor status. Results: 1255 charts were analyzed with 1094 having full information. Overall rate of Her-2 expression 18.1%. The rate of Her-2 expression was 21.4% in smokers and 17.0% in non-smokers (p = 0.10). The rate of Her-2 expression was 10.8% in Caucasian smokers and 9.8% in Caucasian non-smokers (p = 0.88); 24.5% in smokers of African descent and 17.3% in non-smokers of African descent (p = 0.24); 22.9% in Latino smokers and 17.4% in Latino non-smokers (p = 0.10). The rate of Her-2/ER expression was 9.4% in smokers and 7.9% in non-smokers (p = 0.42); 5.4% in Caucasian smokers and 4.9% in Caucasian non-smokers (p = 0.916); 12.2% in smokers of African descent and 5.9% in non-smokers of African descent (p = 0.11); 9.5% in Latin smokers and 8.8% in Latin non-smokers (p = 0.77). Conclusions: We found non-statistically significant positive associations in all analyses between Her-2 expression with or without ER expression and tobacco exposure when analyzed by ethnicity.
F-box proteins: more than baits for the SCF?
Damien Hermand
Cell Division , 2006, DOI: 10.1186/1747-1028-1-30
Abstract: Recent evidences in various species suggest that some F-box proteins have functions not directly related to the SCF complex raising questions about the actual connection between the large F-box protein family and protein degradation, but also about their origins and evolution.The small polypeptide ubiquitin (76 amino acids) is used in many processes including signal transduction, DNA repair, transcription and chromatin remodelling [1-5]. However, ubiquitin is best characterized has a post-translational modification required to label proteins for recognition and degradation by the proteasome [6]. Ubiquitin contains seven lysine residues used to form poly-ubiquitin chains and chains linked to lysine 48 are the most commonly used to target a substrate for proteolysis. Ubiquitin conjugation is catalysed by enzymes designated E1, E2 and E3. The E3 ubiquitin ligase determines substrate specificity. E3 complexes of the SCF subfamily typically contain at least four subunits: Skp1, a cullin, a RING finger protein (Rbx1, also called Hrt1 or Roc1), and a member of the large family of F-box adaptor protein directly involved in the substrates recruitment (for a review, see [7]). The F-box is a degenerated sequence of about 70 amino acids required but not sufficient for the interaction between a given F-box protein and Skp1 [8]. Structure-function studies in yeast and mammals have demonstrated that the cullin functions as a scaffold in assembling the different subunits of the SCF complex. The cullin interacts at its carboxyl terminus with the RING domain protein Rbx1 to form the catalytic domain, and at its amino terminus end with Skp1 (Figure 1A). Protein degradation mediated by the SCF complexes has been shown to influence a variety of cellular processes such as the cell cycle, signal transduction and gene expression [9-14]. Beside the canonical SCF, it appears that in some cases, Skp1 and F-box proteins may function in non-SCF complexes and that some F-box proteins have functi
Los Modos de Acción Eterior de la Unión Europea:(1) El Caso del Caucaso del sur
Helly,Damien;
Análisis Político , 2006,
Abstract: this article proposes a framework for the analysis of the european union?s foreign action system, to contribute to an understanding of its functioning. based on the concept of modes of foreign action, this article studies the case of the south caucasus. it attempts to describe, understand, and explain european foreign actions in a region about which there is practically no literature available concerning the policies of the eu and its member states, and in which their policies and actions only partially reflect their power logic and determining factors.
Pouvoir et sexualité. Le discours féministe sur la prostitution en France (1968-1986).
Damien Simonin
Genre & Histoire , 2010,
Abstract: Cette recherche porte sur les discours sur la prostitution dans la presse féministe, entre 1968 et 1986 en France. Durant cette période, le mouvement féministe est composé de courants conflictuels (courants réformistes et révolutionnaires, différentialistes et universalistes) et il porte des discours hétérogènes (informations sur la prostitution, analyses théoriques et politiques, témoignages de prostituées). Pourtant, ces discours s'accordent sur la revendication d'une libération des rapport...
Que ensino da ergonomia aos estudantes de engenharia?
Damien Cru
Laboreal , 2012,
Abstract: The teaching of ergonomics to engineering students requires a definition of its goal and a consequent pedagogy. The synthesis of the author’s nine years of working experience as an Associate Professor at the Institut des Sciences et Techniques de l'Ingénieur d'Angers – ISTIA (Angers Institute of Sciences and Techniques of the Engineer) allowed a non-dogmatic orientation when approaching this subject.
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