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Search Results: 1 - 10 of 28433 matches for " Dall’Era MA "
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Validation study of a computer-based open surgical trainer: SimPraxis simulation platform
Tran LN, Gupta P, Poniatowski LH, Alanee S, DallEra MA, Sweet RM
Advances in Medical Education and Practice , 2013, DOI: http://dx.doi.org/10.2147/AMEP.S38422
Abstract: lidation study of a computer-based open surgical trainer: SimPraxis simulation platform Original Research (322) Total Article Views Authors: Tran LN, Gupta P, Poniatowski LH, Alanee S, Dall’Era MA, Sweet RM Published Date March 2013 Volume 2013:4 Pages 23 - 30 DOI: http://dx.doi.org/10.2147/AMEP.S38422 Received: 22 September 2012 Accepted: 05 December 2012 Published: 20 March 2013 Linh N Tran,1 Priyanka Gupta,2 Lauren H Poniatowski,2 Shaheen Alanee,3 Marc A Dall’Era,4 Robert M Sweet2 1Department of Internal Medicine, Loma Linda University, Loma Linda, CA, 2Department of Urology, University of Minnesota, Minneapolis, MN, 3Urology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, 4Department of Urology, University of California, Davis, CA, USA Background: Technological advances have dramatically changed medical education, particularly in the era of work-hour restrictions, which increasingly highlights a need for novel methods to teach surgical skills. The purpose of this study was to evaluate the validity of a novel, computer-based, interactive, cognitive simulator for training surgeons to perform pelvic lymph node dissection (PLND). Methods: Eight prostate cancer experts evaluated the content of the simulator. Contextual aspects of the simulator were rated on a five-point Likert scale. The experts and nine first-year residents completed a simulated PLND. Time and deviations were logged, and the results were compared between experts and novices using the Mann–Whitney test. Results: Before training, 88% of the experts felt that a validated simulator would be useful for PLND training. After testing, 100% of the experts felt that it would be more useful than standard video training. Eighty-eight percent stated that they would like to see the simulator in the curriculum of residency programs and 56% thought it would be useful for accreditation purposes. The experts felt that the simulator aided in overall understanding, training indications, concepts and steps of the procedure, training how to use an assistant, and enhanced the knowledge of anatomy. Median performance times taken by experts and interns to complete a PLND procedure on the simulator were 12.62 and 23.97 minutes, respectively. Median deviation from the incorporated procedure pathway for experts was 24.5 and was 89 for novices. Conclusion: We describe an interactive, computer-based simulator designed to assist in mastery of the cognitive steps of an open surgical procedure. This platform is intuitive and flexible, and could be applied to any stepwise medical procedure. Overall, experts outperformed novices in their performance on the trainer. Experts agreed that the content was acceptable, accurate, and representative.
Active Surveillance for Localized Prostate Cancer – Current Practices and Recommendations
Jennifer N. Wu,Marc A. Dall'Era
The Scientific World Journal , 2010, DOI: 10.1100/tsw.2010.227
Abstract:
Immunodiagnosis of Trypanosoma cruzi (Chagas' Disease) Infection in Naturally Infected Dogs
Lauricella, MA;Casta?era, MB;Gürtler, RE;Segura, EL;
Memórias do Instituto Oswaldo Cruz , 1998, DOI: 10.1590/S0074-02761998000400016
Abstract: this study reports on the standardization of an enzyme-linked immunosorbent assay (elisa) for detecting specific antibodies anti-trypanosoma cruzi in naturally infected dogs. sera from 182 mongrel dogs of all ages residing in four rural villages in santiago del estero, argentina, were collected in november 1994 and preserved in buffered neutral glycerin. all sera were tested by indirect hemagglutination test (ihat), indirect immunofluorescence test (ifat), and elisa using the flagellar fraction of t. cruzi as antigen. dog sera from an area without vectorial transmission were used to calculate elisa specificity and cut-off value. eighty-six percent of sera had concordant results for all tests. all sera reactive for ihat and ifat were also reactive for elisa, except in one case. sera tested by elisa when diluted 1:200 allowed a clearer division between non-reactive and reactive sera than when 1:100 with greater agreement among serologic techniques. the specificity of elisa was 96.2%. among 34 adult dogs with a positive xenodiagnosis, sensitivity was 94% both for elisa and ifat. elisa is the first choice for screening purposes and one of the pair of techniques recommended for diagnostic studies in dog populations
Immunodiagnosis of Trypanosoma cruzi (Chagas' Disease) Infection in Naturally Infected Dogs
Lauricella MA,Casta?era MB,Gürtler RE,Segura EL
Memórias do Instituto Oswaldo Cruz , 1998,
Abstract: This study reports on the standardization of an enzyme-linked immunosorbent assay (ELISA) for detecting specific antibodies anti-Trypanosoma cruzi in naturally infected dogs. Sera from 182 mongrel dogs of all ages residing in four rural villages in Santiago del Estero, Argentina, were collected in November 1994 and preserved in buffered neutral glycerin. All sera were tested by indirect hemagglutination test (IHAT), indirect immunofluorescence test (IFAT), and ELISA using the flagellar fraction of T. cruzi as antigen. Dog sera from an area without vectorial transmission were used to calculate ELISA specificity and cut-off value. Eighty-six percent of sera had concordant results for all tests. All sera reactive for IHAT and IFAT were also reactive for ELISA, except in one case. Sera tested by ELISA when diluted 1:200 allowed a clearer division between non-reactive and reactive sera than when 1:100 with greater agreement among serologic techniques. The specificity of ELISA was 96.2%. Among 34 adult dogs with a positive xenodiagnosis, sensitivity was 94% both for ELISA and IFAT. ELISA is the first choice for screening purposes and one of the pair of techniques recommended for diagnostic studies in dog populations
Association of Sweet's Syndrome and Systemic Lupus Erythematosus
J. L. Barton,L. Pincus,J. Yazdany,N. Richman,T. H. McCalmont,L. Gensler,M. Dall'Era,K. H. Fye
Case Reports in Rheumatology , 2011, DOI: 10.1155/2011/242681
Abstract: Sweet's syndrome is an acute febrile neutrophilic dermatosis which usually presents as an idiopathic disorder but can also be drug induced, associated with hematopoetic malignancies and myelodysplastic disorders, and more, infrequently, observed in autoimmune disorders. Sweet's syndrome has been reported in three cases of neonatal lupus, three cases of hydralazine-induced lupus in adults, and in nine pediatric and adult systemic lupus erythematosus (SLE) patients. We describe three additional adult cases of Sweet's associated with SLE and provide a focused review on nondrug-induced, nonneonatal SLE and Sweet's. In two of three new cases, as in the majority of prior cases, the skin rash of Sweet's paralleled underlying SLE disease activity. The pathogenesis of Sweet's remains elusive, but evidence suggests that cytokine dysregulation may be central to the clinical and pathological changes in this condition, as well as in SLE. Further research is needed to define the exact relationship between the two conditions.
Differential expression of CD10 in prostate cancer and its clinical implication
Marc A Dall'Era, Lawrence D True, Andrew F Siegel, Michael P Porter, Tracy M Sherertz, Alvin Y Liu
BMC Urology , 2007, DOI: 10.1186/1471-2490-7-3
Abstract: Eighty-seven patients, 53 with and 34 without pathologically organ confined prostate cancer at the time of radical prostatectomy (RP), were used for the study. Fourteen patients with lymph node metastasis found at the time of surgery were identified and included in this study. Serial sections from available frozen tumor specimens in OCT were processed for CD10 immunohistochemistry. Cancer glands were graded for the presence and intensity of CD10 staining, and overall percentage of glands staining positive was estimated. Clinical characteristics including pre- and post-operative PSA and Gleason score were obtained. A similar study as a control for the statistical analysis was performed with CD13 staining. For statistical analysis, strong staining was defined as > 20% positivity based on the observed maximum separation of the cumulative distributions.CD10 expression significantly correlated with Gleason grade, tumor stage, and with pre-operative serum PSA. Seventy percent of RP specimens from patients with node metastasis showed strong staining for CD10, compared to 30% in the entire cohort (OR = 3.4, 95% CI: 1.08–10.75, P = 0.019). Increased staining for CD10 was associated with PSA recurrence after RP. CD13 staining did not correlate significantly with any of these same clinical parameters.These results suggest that the expression of CD10 by prostate cancer corresponds to a more aggressive phenotype with a higher malignant potential, described histologically by the Gleason score. CD10 offers potential clinical utility for stratifying prostate cancer to predict biological behavior of the tumor.The cluster designation (CD) antigens are cell surface molecules first defined on human leukocytes and later found to be expressed by a variety of human cell types in both normal and pathologic states. The human prostate has been CD immunophenotyped and differences in the expression of several CD molecules were seen between cancer and normal prostate tissue [1]. Among these is
Tortuosidad retiniana vascular en neurofibromatosis tipo 1
Asensio-Sánchez,VM; Torreblanca-Agüera,B; Mi?ambres-Villar,MA;
Archivos de la Sociedad Espa?ola de Oftalmología , 2005, DOI: 10.4321/S0365-66912005001000009
Abstract: case report: we report a 4-year-old patient with neurofibromatosis type 1 (nf-1) who had tortuous retinal vessels of first, second and third order which ended in a corkscrew appearance. discussion: vascular retinal abnormalities can be present in patients with nf-1.
Tortuosidad retiniana vascular en neurofibromatosis tipo 1 Tortuous retinal vessels in neurofibromatosis type 1
VM Asensio-Sánchez,B Torreblanca-Agüera,MA Mi?ambres-Villar
Archivos de la Sociedad Espa?ola de Oftalmología , 2005,
Abstract: Caso clínico: Se describe un paciente de 4 a os con neurofibromatosis tipo 1 (NF-1) y vasos retinianos tortuosos de primer, segundo y tercer orden que terminaban en forma de sacacorcho. Discusión: Los pacientes con NF-1 pueden tener anomalías retinianas vasculares. Case report: We report a 4-year-old patient with neurofibromatosis type 1 (NF-1) who had tortuous retinal vessels of first, second and third order which ended in a corkscrew appearance. Discussion: Vascular retinal abnormalities can be present in patients with NF-1.
Comparative study of tight-binding and ab initio electronic structure calculations focused on magnetic anisotropy in ordered CoPt alloy
J. Zemen,J. Ma?ek,J. Ku?era,J. A. Mol,P. Motloch,T. Jungwirth
Physics , 2013, DOI: 10.1016/j.jmmm.2013.12.040
Abstract: An empirical multiorbital (spd) tight binding (TB) model including magnetism and spin-orbit coupling is applied to calculations of magnetic anisotropy energy (MAE) in CoPt L1_0 structure. A realistic Slater-Koster parametrisation for single-element transition metals is adapted for the ordered binary alloy. Spin magnetic moment and density of states are calculated using a full-potential linearized augmented plane-wave (LAPW) ab initio method and our TB code with different variants of the interatomic parameters. Detailed mutual comparison of this data allows for determination of a subset of the compound TB parameters tuning of which improves the agreement of the TB and LAPW results. MAE calculated as a function of band filling using the refined parameters is in broad agreement with ab initio data for all valence states and in quantitative agreement with ab initio and experimental data for the natural band filling. Our work provides a practical basis for further studies of relativistic magnetotransport anisotropies by means of local Green's function formalism which is directly compatible with our TB approach.
Przegl d badań klinicznych prezentowanych w czasie Kongresu Heart Failure 2011, G teborg 21-24.05.2011
Tymoteusz ?era
Polish Journal of Cardiology , 2011,
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