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Search Results: 1 - 10 of 347 matches for " Dalia Kalabat "
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Voltage-gated sodium channels in taste bud cells
Na Gao, Min Lu, Fernando Echeverri, Bianca Laita, Dalia Kalabat, Mark E Williams, Peter Hevezi, Albert Zlotnik, Bryan D Moyer
BMC Neuroscience , 2009, DOI: 10.1186/1471-2202-10-20
Abstract: We describe the molecular and histological expression profiles of cation channels involved in electrical signal transmission from apical to basolateral membrane domains. TRPM5 was positioned immediately beneath tight junctions to receive calcium signals originating from sweet, bitter, and umami receptor activation, while PKD2L1 was positioned at the taste pore. Using mouse taste bud and lingual epithelial cells collected by laser capture microdissection, SCN2A, SCN3A, and SCN9A voltage-gated sodium channel transcripts were expressed in taste tissue. SCN2A, SCN3A, and SCN9A were expressed beneath tight junctions in subsets of taste cells. SCN3A and SCN9A were expressed in TRPM5 cells, while SCN2A was expressed in TRPM5 and PKD2L1 cells. HCN4, a gene previously implicated in sour taste, was expressed in PKD2L1 cells and localized to cell processes beneath the taste pore.SCN2A, SCN3A and SCN9A voltage-gated sodium channels are positioned to sense initial depolarizing signals stemming from taste receptor activation and initiate taste cell action potentials. SCN2A, SCN3A and SCN9A gene products likely account for the tetrodotoxin-sensitive sodium currents in taste receptor cells.Taste buds house specialized neuroepithelial cells that sense and transmit information regarding the composition of food [1]. These taste cells express receptors for sweet, bitter, umami (the savory taste of glutamate), sour and salty tastants in apical microvilli facing the saliva [2,3]. Following taste receptor activation, taste cells depolarize and fire action potentials resulting in the release of neurotransmitters to nerve fibers innervating basolateral membranes [4,5]. Segregation of taste receptors at the taste pore from the machinery involved in transmitting signals to nerve fibers is mediated by tight junctions, specialized protein networks that separate apical and basolateral membrane domains [6].Information regarding the composition of food flows from the apical to the basolateral doma
Expression of Genes Encoding Multi-Transmembrane Proteins in Specific Primate Taste Cell Populations
Bryan D. Moyer,Peter Hevezi,Na Gao,Min Lu,Dalia Kalabat,Hortensia Soto,Fernando Echeverri,Bianca Laita,Shaoyang Anthony Yeh,Mark Zoller,Albert Zlotnik
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0007682
Abstract: Using fungiform (FG) and circumvallate (CV) taste buds isolated by laser capture microdissection and analyzed using gene arrays, we previously constructed a comprehensive database of gene expression in primates, which revealed over 2,300 taste bud-associated genes. Bioinformatics analyses identified hundreds of genes predicted to encode multi-transmembrane domain proteins with no previous association with taste function. A first step in elucidating the roles these gene products play in gustation is to identify the specific taste cell types in which they are expressed.
Genome-Wide Analysis of Gene Expression in Primate Taste Buds Reveals Links to Diverse Processes
Peter Hevezi, Bryan D. Moyer, Min Lu, Na Gao, Evan White, Fernando Echeverri, Dalia Kalabat, Hortensia Soto, Bianca Laita, Cherry Li, Shaoyang Anthony Yeh, Mark Zoller, Albert Zlotnik
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0006395
Abstract: Efforts to unravel the mechanisms underlying taste sensation (gustation) have largely focused on rodents. Here we present the first comprehensive characterization of gene expression in primate taste buds. Our findings reveal unique new insights into the biology of taste buds. We generated a taste bud gene expression database using laser capture microdissection (LCM) procured fungiform (FG) and circumvallate (CV) taste buds from primates. We also used LCM to collect the top and bottom portions of CV taste buds. Affymetrix genome wide arrays were used to analyze gene expression in all samples. Known taste receptors are preferentially expressed in the top portion of taste buds. Genes associated with the cell cycle and stem cells are preferentially expressed in the bottom portion of taste buds, suggesting that precursor cells are located there. Several chemokines including CXCL14 and CXCL8 are among the highest expressed genes in taste buds, indicating that immune system related processes are active in taste buds. Several genes expressed specifically in endocrine glands including growth hormone releasing hormone and its receptor are also strongly expressed in taste buds, suggesting a link between metabolism and taste. Cell type-specific expression of transcription factors and signaling molecules involved in cell fate, including KIT, reveals the taste bud as an active site of cell regeneration, differentiation, and development. IKBKAP, a gene mutated in familial dysautonomia, a disease that results in loss of taste buds, is expressed in taste cells that communicate with afferent nerve fibers via synaptic transmission. This database highlights the power of LCM coupled with transcriptional profiling to dissect the molecular composition of normal tissues, represents the most comprehensive molecular analysis of primate taste buds to date, and provides a foundation for further studies in diverse aspects of taste biology.
Synthesis, Characterization, Anti-Bacterial and Anti-Fungal Activities of New Quinoxaline 1,4-di-N-Oxide Derivatives  [PDF]
Dalia Hussein Soliman
International Journal of Organic Chemistry (IJOC) , 2013, DOI: 10.4236/ijoc.2013.33A007
Abstract:

A new series of quinoxaline 1,4-di-N-oxides were synthesized and evaluated for their antibacterial and antifungal activities. The best result was demonstrated by 3-amino-N-(4-methoxyphenyl)-2-quinoxalinecarboxamide 1,4-di-N-oxide 4e, MIC (0.24 μg/ml) against Aspergillus fumigatus, and (0.12 μg/ml) against Streptococcus pneumonia.

Inverse Bayesian Estimation of Gravitational Mass Density in Galaxies from Missing Kinematic Data  [PDF]
Dalia Chakrabarty, Prasenjit Saha
American Journal of Computational Mathematics (AJCM) , 2014, DOI: 10.4236/ajcm.2014.41002
Abstract:

In this paper, we focus on a type of inverse problem in which the data are expressed as an unknown function of the sought and unknown model function (or its discretised representation as a model parameter vector). In particular, we deal with situations in which training data are not available. Then we cannot model the unknown functional relationship between data and the unknown model function (or parameter vector) with a Gaussian Process of appropriate dimensionality. A Bayesian method based on state space modelling is advanced instead. Within this framework, the likelihood is expressed in terms of the probability density function (pdf) of the state space variable and the sought model parameter vector is embedded within the domain of this pdf. As the measurable vector lives only inside an identified sub-volume of the system state space, the pdf of the state space variable is projected onto the space of the measurables, and it is in terms of the projected state space density that the likelihood is written; the final form of the likelihood is achieved after convolution with the distribution of measurement errors. Application motivated vague priors are invoked and the posterior probability density of the model parameter vectors, given the data are computed. Inference is performed by taking posterior samples with adaptive MCMC. The method is illustrated on synthetic as well as real galactic data.

Recurrent Implantation Failure and Low Molecular Weight Heparin  [PDF]
Dalia Khalife, Ghina Ghazeeri
Open Journal of Obstetrics and Gynecology (OJOG) , 2018, DOI: 10.4236/ojog.2018.82018
Abstract: Implantation of the embryo into the endometrium is the first step in the establishment of pregnancy. This process is complex, and depends on many factors. Recurrent implantation failure is a source of distress to patients and specialists. It is defined as failure to achieve a viable pregnancy, following “>3 embryo transfers with high quality embryos or the transfer of ≥ 10 embryos in multiple transfers”. Thrombophilic conditions that contribute to recurrent implantation failure are the main concern in this review. The mechanism of implantation failure is believed to be due to decreased blood flow to the endometrium and placenta which can hinder normal endometrial receptivity leading to miscarriage. Defects in early placentation resulting in pregnancy failure, have focused attention on the therapeutic potential of low molecular weight heparin in the implantation process. Heparin has a role at all stages of implantation to improve pregnancy outcomes. There are controversies in literature regarding the association between thrombophilia and recurrent implantation failure and available literature regarding this issue is very heterogeneous. Various investigators, have shown that women with RIF are more likely to have a thrombophilia disorder, yet a clear cause cannot be acknowledged from these studies. Heparin treatment has been evaluated in several studies, showing conflicting evidence. However, several studies have pointed out that it may play a role in a subset of patients who presents a thrombophilia mutation, thus the group of patients that might benefit is needed to be identified. This review is dedicated to evaluate the published literature about the role of low molecular weight heparin in case of recurrent implantation failure with or without the presence of thrombophilia.
Significance of Fruit and Seed Coat Morphology in Taxonomy and Identification for Some Species of Brassicaceae  [PDF]
Dalia G. Gabr
American Journal of Plant Sciences (AJPS) , 2018, DOI: 10.4236/ajps.2018.93030
Abstract: Fruit, seed morphology and seed coat sculpturing were recorded for 10 species belongs to 9 genera and five tribes of Brassicaceae in eastern region of Saudi Arabia by using light microscope (LM) and scanning electron microscope (SEM). Four seed patterns were recognized based on surface sculpturing pattern; Reticulate, with four subtypes, undulate, verrucate and ocellate. The results of numerical analysis showed that species were grouped into two major clusters and each cluster divided into two groups. The cluster analysis indicates that the characters of fruit and seed are very important characters for identification and taxonomical classification of the tribes. The results indicate that the most tribes of Brassicaceae are polyphyletic, and some are related to each other’s as Lepidieae, Alyssieae and Sisymbrieae.
Between Management and Leadership—A Comparative Study with Reference to (Sheikh Zayed AL Nahyan and Nelson Mandela)  [PDF]
Dalia Mohamed Mostafa Mabrouk
Open Journal of Social Sciences (JSS) , 2018, DOI: 10.4236/jss.2018.69003
Abstract: In this paper, I am reflecting on Abraham Zaleznik’s paper “managers and leaders: are they different?” He was a prominent Harvard business school professor who attacked management style for depending only on rationality and achieving goals. He believed that managers and leaders are totally different persons. He described managers as inscrutable, detached and manipulative. Plus, while managers are interested in control and how things are done, leaders are more concerned with ideas and innovation. I try to probe into various questions related to both management and leadership to approach a clearer opinion for these inquires: do managers and leaders really have completely different personalities? Or are they both competing for the same target of getting work done through people? Is management upgradable with more knowledge and hard work? Are leaders more empathetic than managers? What makes managers inscrutable and manipulative? Is this innate or acquired? In which way leaders are different? Seems a huge task but I will tackle this issue by conducting a comparative study among two prominent figures as Sheikh Zayed Al Nahyan and Nelson Mandela. I will trace some points of similarities and differentiations based on the timeless lessons from their life stories that will endure for years to come. Both were gifted visionary individuals who exercised full range of cognitive, emotional and behavioral abilities to bring about profound change in their countries.
Selectivity of Acrylic Acid Radiation Grafted Non-Woven Polypropylene Sheets towards Some Heavy Metals Ions  [PDF]
Dalia El-Sayed Hegazy
Open Journal of Polymer Chemistry (OJPChem) , 2012, DOI: 10.4236/ojpchem.2012.21002
Abstract: Graft polymerization has been considered as a general method for the modification of the physical and chemical properties of polymeric materials and of particular interest for synthesis of the hydrophilic membrane. In this study, hydrophilic carboxylic acid groups were introduced by radiation-induced grafting of acrylic acid (AAc) onto non-woven polypropylene fabric (NWPP). Different irradiation doses and (AAc) monomer concentrations were used to optimize grafting yield. Characterization and properties of the prepared graft copolymer were studied by employing X-ray Dif-fraction (XRD), Thermogravimetric Analysis (TGA), Scanning Electron Microscope (SEM ), Fourier Transform Infrared Spectrometry (FTIR) and differential scanning calorimeter (DSC). The prepared grafted materials were used for removing some heavy metals ions. The results showed that the non-woven PP grafted with (AAc) has good affinity toward Cu, Ni and Co.
Literatūros mokslas ir teologija: dialogi ko santykio realijos ir krik ioni kos mistin s tradicijos laukas. Literaturwissenschaft und Theologie: Realien des dialogischen Verh ltnisses und das Feld der mystischen Erfahrung
Dalia Jakait?
Literatura , 2011,
Abstract: Das wichtigste Ziel des vorliegenden Artikels ist eine Bedeutung der Mystik für die Autoren des Dialogs zwischen der Literatur(wissenschaft) und Theologie zu zeigen. Dabei wird die Tradition der frühchristlichen Kirche aktualisiert. Die christliche Tradition der Mystik kommt schon in der Bibel zum Vorschein, so z. B. in der Paulusrede auf dem Areopag, die mit der Literaturtheologie in Beziehung gesetzt wird. Als Untersuchungsgegenstand dienen theoretische Studien und einige Arbeiten der Literaturkritik. Die Erfahrung erscheint als ein wesentliches Problem im Bereich der Literatur und Theologie.Kuschel, als Verbindungskette zweier bedeutungsvoller Forschungsetappen des Dialogs zwischen Literatur und Theologie in Deutschland, formuliert einen sich dynamisch ver ndernden Netz der strukturellen Analogien, der Theopoetik und anderer Begriffe. Als eine der wichtigsten S ulen dient in seinen Arbeiten die Steiners Konzeption der Kunstmetaphysik, die auch für andere nach einem interdisziplin ren Dialog suchenden Autoren aktuell ist. Braungart betont die sthetische Richtung der Theologie, die Literaturwissenschaft wird laut Braungart in Zusammenhang mit sthetisch und exegetisch-hermeneutisch orientierter Theologie gesetzt. Das sthetische Kriterium für die Bewertung der Literatur wird in Arbeiten von S lle durch ein starkes theologisches Interesse erg nzt. Diese Autorin sucht nach Unterstützung des dialogischen Denkens und bedient sich der figurischen Methode in Auffassung von Auerbach. Im Rahmen dieser Problematik wird kontraverse Betrachtung des Begriffs der Literaturtheologie deutlich, zum Verst ndnis dessen Mieths Ansicht von gro er Bedeutung ist. Seiner Meinung nach sei die Literaturtheologie ohne Autonomie der Poesie nicht zu gerechtfertigen, Theologie sei genausoviel ideologisch gef hrlich wie gef hrlich eine für die Literaturwissenschaft typische leere Ideologie sei.Die Mystik der Kircheenv ter und des Mittelaters weist Gemeinsamkeiten im Bereich der Weltauffassung und des Stils auf und kann mit der Kunst- und Poesieauffassung moderner Autoren verglichen werden. Das Verst ndnis der Mysterie der poetischen Versuchung“ und des mystischen Wissens in Arbeiten von Clemens von Alexandria erscheint erneut in der Kunstmetaphysik von Steiner und Kuschel, in der Reflexion der Beziehung zwischen der Literatur und Theologie. Für die moderne Problematik der Beziehung zwischen Literatur und Theologie sind wichtig die metaphysische Raum- und Lichtsymbolik in Schriften von Augustinus, der Vergleich Gottes und der menschlichen Kunst, die Anpreisung Gottes und seiner Sch
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