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Search Results: 1 - 10 of 243325 matches for " Dale C. Zheng "
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Protein Phosphatase 1 β Paralogs Encode the Zebrafish Myosin Phosphatase Catalytic Subunit
Vaishali Jayashankar, Michael J. Nguyen, Brandon W. Carr, Dale C. Zheng, Joseph B. Rosales, Joshua B. Rosales, Douglas C. Weiser
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0075766
Abstract: Background The myosin phosphatase is a highly conserved regulator of actomyosin contractility. Zebrafish has emerged as an ideal model system to study the in vivo role of myosin phosphatase in controlling cell contractility, cell movement and epithelial biology. Most work in zebrafish has focused on the regulatory subunit of the myosin phosphatase called Mypt1. In this work, we examined the critical role of Protein Phosphatase 1, PP1, the catalytic subunit of the myosin phosphatase. Methodology/Principal Findings We observed that in zebrafish two paralogous genes encoding PP1β, called ppp1cba and ppp1cbb, are both broadly expressed during early development. Furthermore, we found that both gene products interact with Mypt1 and assemble an active myosin phosphatase complex. In addition, expression of this complex results in dephosphorylation of the myosin regulatory light chain and large scale rearrangements of the actin cytoskeleton. Morpholino knock-down of ppp1cba and ppp1cbb results in severe defects in morphogenetic cell movements during gastrulation through loss of myosin phosphatase function. Conclusions/Significance Our work demonstrates that zebrafish have two genes encoding PP1β, both of which can interact with Mypt1 and assemble an active myosin phosphatase. In addition, both genes are required for convergence and extension during gastrulation and correct dosage of the protein products is required.
Investigating the role of Wnt signalling in lobuloalveolar development of the mammary gland
RJ Evans, C Dale
Breast Cancer Research , 2006, DOI: 10.1186/bcr1563
Abstract:
Sarah Glynn, ed., Where the Other Half Lives: Lower Income Housing in a Neoliberal World
Dale C Spencer
The Canadian Journal of Sociology , 2010,
Abstract: Book review
The Relationship between Complementary and Alternative Medicine Use and Breast Cancer Early Detection: A Critical Review
Laura C. Dale,Carolyn C. Gotay
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/506978
Abstract:
The Relationship between Complementary and Alternative Medicine Use and Breast Cancer Early Detection: A Critical Review
Laura C. Dale,Carolyn C. Gotay
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/506978
Abstract: Objective. Complementary and alternative medicine (CAM) use is prevalent. Concurrently, breast cancer is the most common cancer in women worldwide, with early detection techniques widely available. This paper examined the overlap between participation in allopathic breast cancer early detection activities and CAM use. Methods. A systematic review examined the association between breast screening behaviors and CAM use. Searches were conducted on the PubMed, Embase, CINAHL, and NCCAM databases and gray literature between 1990 and 2011. STROBE criteria were used to assess study quality. Results. Nine studies met the search criteria. Four focused on CAM use in women at high breast cancer risk and five on average risk women. CAM use in women ranged from 22% to 82% and was high regardless of breast cancer risk. Correlations between CAM use and breast cancer early detection were not strong or consistent but significant relationships that did emerge were positive. Conclusions. Populations surveyed, and measures used to assess CAM, breast cancer screening, and correlates, varied widely. Many women who obtained allopathic screening also sought out CAM. This provides a foundation for future interventions and research to build on women’s motivation to enhance health and develop ways to increase the connections between CAM and allopathic care. 1. Introduction Complementary and alternative medicine (CAM) is defined as medical practices infrequently taught in medical schools nor widely available in hospitals, the latter being defined as “allopathic medicine” [1]. According to the National Center for Complementary and Alternative Medicine (NCCAM), CAM can be described using broad categories: that is, natural products, mind body practices, manipulative and body-based practices, and other approaches [2]. Over time, CAM practices may become accepted and integrated into allopathic medicine [2]. In a recent national survey of Americans, most people using CAM did so in complement with allopathic medicine [3]. CAM usage was positively associated with the number of personal health conditions and the number of doctor visits in the past 12 months. Only a small percentage used CAM to replace allopathic medicine and such “alternative medicine users” may have poorer health than complementary users [4]. In addition to many cultural factors contributing to variations in CAM use, it is important to better understand how CAM use and health practices influence and inform each other. A nationally representative study found that women in better health reported higher CAM use [5]. CAM
Reasoning with Higher-Order Abstract Syntax in a Logical Framework
Raymond C. McDowell,Dale A. Miller
Computer Science , 2000,
Abstract: Logical frameworks based on intuitionistic or linear logics with higher-type quantification have been successfully used to give high-level, modular, and formal specifications of many important judgments in the area of programming languages and inference systems. Given such specifications, it is natural to consider proving properties about the specified systems in the framework: for example, given the specification of evaluation for a functional programming language, prove that the language is deterministic or that evaluation preserves types. One challenge in developing a framework for such reasoning is that higher-order abstract syntax (HOAS), an elegant and declarative treatment of object-level abstraction and substitution, is difficult to treat in proofs involving induction. In this paper, we present a meta-logic that can be used to reason about judgments coded using HOAS; this meta-logic is an extension of a simple intuitionistic logic that admits higher-order quantification over simply typed lambda-terms (key ingredients for HOAS) as well as induction and a notion of definition. We explore the difficulties of formal meta-theoretic analysis of HOAS encodings by considering encodings of intuitionistic and linear logics, and formally derive the admissibility of cut for important subsets of these logics. We then propose an approach to avoid the apparent tradeoff between the benefits of higher-order abstract syntax and the ability to analyze the resulting encodings. We illustrate this approach through examples involving the simple functional and imperative programming languages PCF and PCF:=. We formally derive such properties as unicity of typing, subject reduction, determinacy of evaluation, and the equivalence of transition semantics and natural semantics presentations of evaluation.
Water-shedding ability of waterfowl and the brachistochrone problem  [PDF]
Dale L. Schruben
Natural Science (NS) , 2012, DOI: 10.4236/ns.2012.41005
Abstract: The hypothesis is taken that the shape of a duck breast is as to shed water drops in minimum time. If a water drop is further assumed to be a frictionless bead, then analogy arises with the classic brachistochrone problem. Here a frictionless bead is one constrained to fall along a wire threading it so that it travels between two arbitrary points without friction. The brachistochrone problem is to specify the shape of that wire so that the bead completes its fall in minimum time. The shape of that wire is called a cycloid curve and it is the solution to the brachistochrone problem. Waterfowl might desire that water drops shed their breast region in minimum time and those drops resemble beads in the brachistochrone problem. Thus it might be expected that waterfowl breast profiles resemble the brachistochrone curve (cycloid), and strikingly they do. We find further this match is statistically significant compared to the general bird population, in support of the hypothesis.
A Case of Endometriosis in the Abdominal Wall Post Caesarean Section  [PDF]
Emerson Budhoo, Dale Maharaj
Surgical Science (SS) , 2013, DOI: 10.4236/ss.2013.42023
Abstract:

We report the case of a 33 year old female who presented with endometriosis of the anterior abdominal wall following Caesarean Section at the surgical incision site. Abdominal Incisional Site Endometriosis can pose a diagnostic dilema owing to its relative rarity and vagueosity of symptoms, vis-a-vis, cyclical abdominal pain and occasional palpable mass associated with menstruation. A greater index of suspicion should be prompted in such patients especially if symptoms occur following pelvic surgery such as Caesarean Sections, hysterotomy, and myomectomy.

An Alternative Funding Model for Agribusiness Research in Canada  [PDF]
Adam Dale, Elliott Currie
Agricultural Sciences (AS) , 2015, DOI: 10.4236/as.2015.69093
Abstract: Canadian governments have moved towards a matching funding model for agricultural research. Agricultural organizations can take advantage of this if Canadian Controlled Private Corporations are established to fund research through matching grants, tax credits and investments. A low risk options strategy is presented which uses index options and is a diagonal put spread where an in-the-money put is bought which expires in 1 to 2 years and out-of-the-money puts are sold which expire monthly. In summary, “A small Canadian Controlled Private Corporation can, for a $100,000 up front initial investment, generate at least $100,000 annually in research funding, in perpetuity”.
Descending Necrotising Mediastinitis: A Case Report Illustrating a Trend in Conservative Management
B. A. P. Jayasekera,O. T. Dale,R. C. Corbridge
Case Reports in Otolaryngology , 2012, DOI: 10.1155/2012/504219
Abstract: The mortality rate from descending necrotising mediastinitis (DNM) has declined since its first description in 1938. The decline in mortality has been attributed to earlier diagnosis by way of contrast-enhanced computed tomographic (CT) scanning and aggressive surgical intervention in the form of transthoracic drainage. We describe a case of DNM with involvement of anterior and posterior mediastinum down to the diaphragm, managed by cervicotomy and transverse cervical drainage with placement of corrugated drains and a pleural chest drain, with a delayed mediastinoscopy and mediastinal drain placement. We advocate a conservative approach with limited debridement and emphasis on drainage of infection in line with published case series.
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