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Search Results: 1 - 10 of 463712 matches for " Dale A Fisher "
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Changing trends in colorectal cancer: possible cause and clinical implications  [PDF]
Mikhail Fisher, Leon Fisher, Bruce Waxman, Alexander A. Fisher
Health (Health) , 2010, DOI: 10.4236/health.2010.28127
Abstract: OBJECTIVES: The aims of this study were to determine whether pattern of patients presenting with colorectal cancer (CRC) in the last few years differs significantly from that previously reported in Australia, and to relate the trends, if present, to use of hormone replacement therapy (HRT). METHODS: We examined demographic and pathological characteristics of 145 consecutive CRC patients (65 females) treated in our institution in calendar years 2006-2007. Comparisons were made with data on 12536 CRC patients obtained from the Australian Association on Cancer Registries (AACR) for the year 2003, most recent available. Prescribing data for HRT were obtained from the Australian Commonwealth Department of Health and Ageing. RESULTS: The distribution of colon, sigmoid and rectal cancers in our series was 40%, 24.8% and 35.2%, respectively, which differs significantly from 65%, 8.1% and 26.9% in the AACR data (p < 0.01). Our cohort was significantly younger (65.4 ± 12.1 vs. 69.5 ± 12.3 years), especially females (63.0 ± 12.7 vs. 70.3 ± 13.0 years; p < 0.001). The proportion of female patients aged < 55 and < 60 years was significantly higher (30.8% vs. 13.8% and 41.5% vs. 21.4%, respectively). Younger patients have more aggressive and advanced cancers. In Australia HRT use declined since 2001 and fell by a half in 2006. CONCLUSIONS: In the changing CRC pattern of greatest concern is a significantly higher proportion of younger patients, especially females, with higher prevalence of more advanced and aggressive cancers, coincident with decreased prescribing of HRT. These findings may have important implications for refining screening and preventive strategies and on demand for radiotherapy services.
Confirmed adult dengue deaths in Singapore: 5-year multi-center retrospective study
Yee-Sin Leo, Tun L Thein, Dale A Fisher, Jenny G Low, Helen M Oh, Rajmohan L Narayanan, Victor C Gan, Vernon J Lee, David C Lye
BMC Infectious Diseases , 2011, DOI: 10.1186/1471-2334-11-123
Abstract: We conducted a multi-center retrospective chart review of all confirmed adult dengue deaths in Singapore from 1 January 2004 to 31 December 2008.Of 28 adult dengue deaths, median age was 59 years. Male gender comprised 67.9% and co-morbidities existed in 75%. From illness onset, patients presented for admission at a median of 4 days and death occurred at a median of 12 days. Intensive care admission was required in 71.4%. Probable dengue was diagnosed in 32.1% by WHO 1997 criteria and 78.6% by WHO 2009. The earliest warning sign was persistent vomiting at a median of 1.5 days. Hematocrit change ≥20% concurrent with platelet count <20 × 10^9/L was associated with the shortest interval to death at a median of 3 days. Only 35.7% of death cases fulfilled DHF criteria by WHO 1997 versus severe dengue in 100.0% by WHO 2009 criteria. Deaths were due to shock and organ failure. Acute renal impairment occurred in 71.4%, impaired consciousness 57.1% and severe hepatitis 53.6%.In our adult fatal dengue cohort, WHO 2009 criteria had higher sensitivity in diagnosing probable dengue and severe dengue compared with WHO 1997. As warning signs, persistent vomiting occurred early and hematocrit change ≥20% concurrent with platelet count <20 × 10^9/L preceded death most closely.Dengue is the most important arthropod-borne viral disease in humans. The World Health Organization (WHO) has estimated that 1.8 billion people, or more than 70% of the global at-risk population, live in the WHO Southeast Asia and the Western Pacific regions which account for nearly 75% of current global disease burden from dengue [1]. Singapore, a developed island city-state in Southeast Asia has experienced resurgent dengue epidemics since the 1990s after previous decades of vector control effectively reduced the Aedes house index [2]. In addition, dengue infections in Singapore in recent years have shifted from primarily a childhood disease to that of adults [2]. With this resurgence, the classification of d
Risk Factors for Fatality among Confirmed Adult Dengue Inpatients in Singapore: A Matched Case-Control Study
Tun-Linn Thein, Yee-Sin Leo, Dale A. Fisher, Jenny G. Low, Helen M. L. Oh, Victor C. Gan, Joshua G. X. Wong, David C. Lye
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0081060
Abstract: Objectives To identify demographic, clinical and laboratory risk factors for death due to dengue fever in adult patients in Singapore. Methods Multi-center retrospective study of hospitalized adult patients with confirmed dengue fever in Singapore between 1 January 2004 and 31 December 2008. Non-fatal controls were selected by matching age and year of infection with fatal cases. World Health Organization 1997, 2009 criteria were applied to define dengue hemorrhagic fever (DHF), warning signs and severe dengue. Statistical significance was assessed by conditional logistic regression modeling. Results Significantly more fatal cases than matched controls had pre-existing co-morbid conditions, and presented with abdominal pain/tenderness. Median pulse rates were significantly higher while myalgia was significantly less frequent in cases. . Fatal cases also had higher leucocyte counts, platelet counts, serum sodium, potassium, urea, creatine and bilirubin levels on admission compared to controls. There was no statistical significant difference between the prevalence of DHF and hematocrit level among cases and controls. Multivariate analysis showed myalgia and leucocyte count at presentation were independent predictors of fatality (adjusted odds ratios 0.09 and 2.94 respectively). None of the controls was admitted to intensive care unit (ICU) or given blood transfusion, while 71.4% and 28.6% of fatal cases received ICU admission and blood transfusion. Conclusions Absence of myalgia and leucocytosis on admission were independently associated with fatality in our matched case-control study. Fatalities were also commonly associated with co-morbidities and clinicians should be alarmed if dengue patients fulfilled severe dengue case definition on admission.
Editorial
A. Dale Whittaker
JPUR : Journal of Purdue Undergraduate Research , 2012,
Abstract:
Supernova Remnant Shock - Molecular Cloud Interactions: Masers as tracers of hadronic particle acceleration
Dale A. Frail
Physics , 2011,
Abstract: We review the class of galactic supernova remnants which show strong interactions with molecular clouds, revealed through shock-excited hydroxyl masers. These remnants are preferentially found among the known GeV and TeV detections of supernova remnants. It has been argued that the masers trace out the sites of hadronic particle acceleration. We discuss what is known about the physical conditions of these shocked regions and we introduce a potential new maser tracer for identifying the sites of cosmic ray acceleration. This review includes a reasonably complete bibliography for researchers new to the topic of shock-excited masers and supernova remnants.
B(eo)W(u)LF: Facilitating recurrence analysis on multi-level language
A. Paxton,R. Dale
Computer Science , 2013,
Abstract: Discourse analysis may seek to characterize not only the overall composition of a given text but also the dynamic patterns within the data. This technical report introduces a data format intended to facilitate multi-level investigations, which we call the by-word long-form or B(eo)W(u)LF. Inspired by the long-form data format required for mixed-effects modeling, B(eo)W(u)LF structures linguistic data into an expanded matrix encoding any number of researchers-specified markers, making it ideal for recurrence-based analyses. While we do not necessarily claim to be the first to use methods along these lines, we have created a series of tools utilizing Python and MATLAB to enable such discourse analyses and demonstrate them using 319 lines of the Old English epic poem, Beowulf, translated into modern English.
F-Waves – Physiology and Clinical Uses
Morris A. Fisher
The Scientific World Journal , 2007, DOI: 10.1100/tsw.2007.49
Abstract:
Cooper pair tunnelling into a Quantum Hall fluid
Matthew P. A. Fisher
Physics , 1993, DOI: 10.1103/PhysRevB.49.14550
Abstract: Transport through a tunnel junction connecting a superconductor to a spin-aligned quantum Hall fluid at filling $\nu$ is studied theoretically. The dominant transport channel at low temperatures is the tunnelling of Cooper pairs into edge states of the quantum Hall fluid. This process, which is greatly suppressed at low energies due to both Coulomb and Pauli exclusion effects, leads to a tunnelling conductance which vanishes with temperature as $T^{4/\nu -2}$, for $\nu^{-1}$ an odd integer. For integer fillings with $\nu >1$ the "Pauli blockade" is circumvented and a non-vanishing conductance is predicted.
Lower limit on decoherence introduced by entangling two spatially-separated qubits
A. J. Fisher
Physics , 2002,
Abstract: It is shown that a generalization of the fluctuation-dissipation theorem places an upper bound on the figure of merit for any quantum gate designed to entangle spatially-separated qubits. The bound depends solely on the spectral properties of the environment. The bound applies even to systems performing a quantum computation within a decoherence-free subspace, but might be optimized by the use of non-equilibrium squeezed states of the environment, or by using an environment system constructed to have response confined to certain frequencies.
The Bunch Injection Controller for the PEP-II Storage Rings
R. Chestnut,A. Fisher
Physics , 2001,
Abstract: The PEP-II storage rings at SLAC each have 3492 'buckets' into which electrons and positrons can be injected into the high- and low-energy rings. Equipment to measure the currents of all the individual buckets was originally provided by the Lawrence Berkeley Laboratory and is implemented in VXI-based hardware. Data from this equipment as well as high precision direct current measurement provide the hard data for the Bunch Injection Controller. A large number of parameters determined by injection design considerations as well as set by operators for different circumstances are also used by the software algorithms to determine the desired bucket injection order and charge quantity for each injection pulse. These requests are then passed on to the venerable SLAC master pattern generator, which provides beams for other applications as well. This highly visible and highly successful system is implemented using the EPICS toolkit, and fits well into the merged SLAC EPICS/SLC control system. The Bunch Injection Controller hardware is a VME-based EPICS IOC, which makes extensive use of shared memory for communicating with the VXI measurement equipment and the SLAC master pattern generator.
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