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Search Results: 1 - 10 of 1453 matches for " Daisuke Kinose "
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Longitudinal Study of Spatially Heterogeneous Emphysema Progression in Current Smokers with Chronic Obstructive Pulmonary Disease
Naoya Tanabe, Shigeo Muro, Susumu Sato, Shiro Tanaka, Tsuyoshi Oguma, Hirofumi Kiyokawa, Tamaki Takahashi, Daisuke Kinose, Yuma Hoshino, Takeshi Kubo, Toyohiro Hirai, Michiaki Mishima
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0044993
Abstract: Background Cigarette smoke is the main risk factor for emphysema, which is a key pathology in chronic obstructive pulmonary disease (COPD). Low attenuation areas (LAA) in computed tomography (CT) images reflect emphysema, and the cumulative size distribution of LAA clusters follows a power law characterized by the exponent D. This property of LAA clusters can be explained by model simulation, where mechanical force breaks alveolar walls causing local heterogeneous lung tissue destruction. However, a longitudinal CT study has not investigated whether continuous smoking causes the spatially heterogeneous progression of emphysema. Methods We measured annual changes in ratios of LAA (LAA%), D and numbers of LAA clusters (LAN) in CT images acquired at intervals of ≥3 years from 22 current and 31 former smokers with COPD to assess emphysema progression. We constructed model simulations using CT images to morphologically interpret changes in current smokers. Results D was decreased in current and former smokers, whereas LAA% and LAN were increased only in current smokers. The annual changes in LAA%, D, and LAN were greater in current, than in former smokers (1.03 vs. 0.37%, p = 0.008; ?0.045 vs. ?0.01, p = 0.004; 13.9 vs. 1.1, p = 0.007, respectively). When LAA% increased in model simulations, the coalescence of neighboring LAA clusters decreased D, but the combination of changes in D and LAN in current smokers could not be explained by the homogeneous emphysema progression model despite cluster coalescence. Conversely, a model in which LAAs heterogeneously increased and LAA clusters merged somewhat in relatively advanced emphysematous regions could reflect actual changes. Conclusions Susceptibility to parenchymal destruction induced by continuous smoking is not uniform over the lung, but might be higher in local regions of relatively advanced emphysema. These could result in the spatially heterogeneous progression of emphysema in current smokers.
Relationship between peripheral airway function and patient-reported outcomes in COPD: a cross-sectional study
Akane Haruna, Toru Oga, Shigeo Muro, Tadashi Ohara, Susumu Sato, Satoshi Marumo, Daisuke Kinose, Kunihiko Terada, Michiyoshi Nishioka, Emiko Ogawa, Yuma Hoshino, Toyohiro Hirai, Kazuo Chin, Michiaki Mishima
BMC Pulmonary Medicine , 2010, DOI: 10.1186/1471-2466-10-10
Abstract: We aimed to identify relationships between IOS measurements and patient-reported outcomes in 65 outpatients with stable COPD. We performed pulmonary function testing, IOS, high-resolution computed tomography (CT), and assessment of health status using the St. George's Respiratory Questionnaire (SGRQ), dyspnea using the Medical Research Council (MRC) scale and psychological status using the Hospital Anxiety and Depression Scale (HADS). We then investigated the relationships between these parameters. For the IOS measurements, we used lung resistance at 5 and 20 Hz (R5 and R20, respectively) and reactance at 5 Hz (X5). Because R5 and R20 are regarded as reflecting total and proximal airway resistance, respectively, the fall in resistance from R5 to R20 (R5-R20) was used as a surrogate for the resistance of peripheral airways. X5 was also considered to represent peripheral airway abnormalities.R5-R20 and X5 were significantly correlated with the SGRQ and the MRC. These correlation coefficients were greater than when using other objective measurements of pulmonary function, R20 on the IOS and CT instead of R5-R20 and X5. Multiple regression analyses showed that R5-R20 or X5 most significantly accounted for the SGRQ and MRC scores.IOS measurements, especially indices of peripheral airway function, are significantly correlated with health status and dyspnea in patients with COPD. Therefore, in addition to its simplicity and non-invasiveness, IOS may be a useful clinical tool not only for detecting pulmonary functional impairment, but also to some extent at least estimating the patient's quality of daily life and well-being.Health status, dyspnea and psychological status of anxiety and depression are important outcomes in chronic obstructive pulmonary disease (COPD). Improved health status and relief of symptoms are listed as the goals of effective management in the Global Initiative for Chronic Obstructive Lung Disease (GOLD) [1].Mortality is also an important outcome in C
Oxidative stress induced Interleukin-32 mRNA expression in human bronchial epithelial cells
Megumi Kudo, Emiko Ogawa, Daisuke Kinose, Akane Haruna, Tamaki Takahashi, Naoya Tanabe, Satoshi Marumo, Yuma Hoshino, Toyohiro Hirai, Hiroaki Sakai, Shigeo Muro, Hiroshi Date, Michiaki Mishima
Respiratory Research , 2012, DOI: 10.1186/1465-9921-13-19
Abstract: Human bronchial epithelial (HBE) cells were stimulated with H2O2 and IFNγ, and IL-32 expression was evaluated. The cell viability was confirmed by MTT assay. The intracellular signaling pathways regulating IL-32 expression were investigated by examining the regulatory effects of MAPK inhibitors and JAK inhibitor after treatment with H2O2 and IFNγ, and by using a ChIP assay to identify transcription factors (i.e. c-Jun, CREB) binding to the IL-32 promoter. Promoter activity assays were conducted after mutations were introduced into binding sites of c-Jun and CREB in the IL-32 promoter. IL-32 expression was also examined in HBE cells in which the expression of either c-Jun or CREB was knocked out by siRNA of indicated transcription factors.There were no significant differences of cell viability among groups. After stimulation with H2O2 or IFNγ for 48 hours, IL-32 expression in HBE cells was increased by IFNγ and synergistically upregulated by the addition of H2O2. The H2O2 augmented IFNγ induced IL-32 mRNA expression was suppressed by a JNK inhibitor, but not by MEK inhibitor, p38 inhibitor, and JAK inhibitor I. Significant binding of c-Jun and CREB to the IL-32 promoter was observed in the IFNγ + H2O2 stimulated HBE cells. Introducing mutations into the c-Jun/CREB binding sites in the IL-32 promoter prominently suppressed its transcriptional activity. Further, knocking down CREB expression by siRNA resulted in significant suppression of IL-32 induction by IFNγ and H2O2 in HBE cells.IL-32 expression in airway epithelium may be augmented by inflammation and oxidative stress, which may occur in COPD acute exacerbation. c-Jun and CREB are key transcriptional factors in IFNγ and H2O2 induced IL-32 expression.Chronic obstructive pulmonary disease (COPD) is characterized by non-fully reversible airflow obstruction and persistent inflammation in the airways and lung parenchyma [1-3]. Airway epithelial cells are one of the most important sources of inflammatory mediators that
Emphysema distribution and annual changes in pulmonary function in male patients with chronic obstructive pulmonary disease
Naoya Tanabe, Shigeo Muro, Shiro Tanaka, Susumu Sato, Tsuyoshi Oguma, Hirofumi Kiyokawa, Tamaki Takahashi, Daisuke Kinose, Yuma Hoshino, Takeshi Kubo, Emiko Ogawa, Toyohiro Hirai, Michiaki Mishima
Respiratory Research , 2012, DOI: 10.1186/1465-9921-13-31
Abstract: We followed up 131 male patients with COPD for a median of 3.7?years. We measured wall area percent (WA%) in right apical segmental bronchus, total lung volume, percent low attenuation volume (LAV%), and the standard deviation (SD) of LAV% values from CT images of 10 isovolumetric partitions (SD-LAV) as an index of cranial-caudal emphysema heterogeneity. Annual changes in FEV1 were then determined using a random coefficient model and relative contribution of baseline clinical parameters, pulmonary function, and CT indexes including LAV%, SD-LAV, and WA% to annual changes in FEV1 were examined.The mean (SD) annual change in FEV1 was ?44.4 (10.8) mL. Multivariate random coefficient model showed that higher baseline FEV1, higher LAV%, current smoking, and lower SD-LAV independently contributed to an excessive decline in FEV1, whereas ratio of residual volume to total lung capacity, ratio of diffusing capacity to alveolar ventilation, and WA% did not, after adjusting for age, height, weight, and ratio of CT-measured total lung volume to physiologically-measured total lung capacity.A more homogeneous distribution of emphysema contributed to an accelerated decline in FEV1 independently of baseline pulmonary function, whole-lung emphysema severity, and smoking status. In addition to whole-lung analysis of emphysema, CT assessment of the cranial-caudal distribution of emphysema might be useful for predicting rapid, progressive disease and for developing a targeted strategy with which to prevent disease progression.
Thioredoxin-1 Protects against Neutrophilic Inflammation and Emphysema Progression in a Mouse Model of Chronic Obstructive Pulmonary Disease Exacerbation
Naoya Tanabe, Yuma Hoshino, Satoshi Marumo, Hirofumi Kiyokawa, Susumu Sato, Daisuke Kinose, Kazuko Uno, Shigeo Muro, Toyohiro Hirai, Junji Yodoi, Michiaki Mishima
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0079016
Abstract: Background Exacerbations of chronic obstructive pulmonary disease (COPD) are characterized by acute enhancement of airway neutrophilic inflammation under oxidative stress and can be involved in emphysema progression. However, pharmacotherapy against the neutrophilic inflammation and emphysema progression associated with exacerbation has not been established. Thioredoxin-1 has anti-oxidative and anti-inflammatory properties and it can ameliorate neutrophilic inflammation through anti-chemotactic effects and prevent cigarette smoke (CS)-induced emphysema. We aimed to determine whether thioredoxin-1 can suppress neutrophilic inflammation and emphysema progression in a mouse model of COPD exacerbation and if so, to reveal the underlying mechanisms. Results Mice were exposed to CS and then challenged with polyinosine-polycytidylic acid [poly(I:C)], an agonist for virus-induced innate immunity. Airway neutrophilic inflammation, oxidative stress and lung apoptosis were enhanced in smoke-sensitive C57Bl/6, but not in smoke-resistant NZW mice. Exposure to CS and poly(I:C) challenge accelerated emphysema progression in C57Bl/6 mice. Thioredoxin-1 suppressed neutrophilic inflammation and emphysema progression. Poly(I:C) caused early neutrophilic inflammation through keratinocyte-derived chemokine and granulocyte-macrophage colony-stimulating factor (GM-CSF) release in the lung exposed to CS. Late neutrophilic inflammation was caused by persistent GM-CSF release, which thioredoxin-1 ameliorated. Thioredoxin-1 enhanced pulmonary mRNA expression of MAP kinase phosphatase 1 (MKP-1), and the suppressive effects of thioredoxin-1 on prolonged GM-CSF release and late neutrophilic inflammation disappeared by inhibiting MKP-1. Conclusion Using a mouse model of COPD exacerbation, we demonstrated that thioredoxin-1 ameliorated neutrophilic inflammation by suppressing GM-CSF release, which prevented emphysema progression. Our findings deepen understanding of the mechanisms underlying the regulation of neutrophilic inflammation by thioredoxin-1 and indicate that thioredoxin-1 could have potential as a drug to counteract COPD exacerbation.
Consideration on Poverty Problem of Young People in Industrialized Countries and Their Solutions  [PDF]
Daisuke Hirahara
Modern Economy (ME) , 2018, DOI: 10.4236/me.2018.91013
Abstract: Increase of irregular workers called working-poor is a problem. This unstable employment makes the poor more poverty. The possibility that a simple work is deprived by the development of artificial intelligence is increasing. From this background, restructuring of social structure and policies become important. In Japan, as the declining birthrate and aging population progresses, there is concern that more people need medical care and nursing care services, so increasing social security expenses is also a problem.
Comparison between 3D-IR-BTFE Method and Conventional Method in Contrast Head MRI Examination  [PDF]
Daisuke Hirahara
Open Journal of Medical Imaging (OJMI) , 2018, DOI: 10.4236/ojmi.2018.83005
Abstract: MRI using gadolinium contrast media is useful in diagnosis; however, nephrogenic systemic fibrosis is a serious side effect of gadolinium exposure. Moreover, it turns out that gadolinium deposits in the brain. This has escalated the necessity for a suitable method to use gadolinium contrast media. I developed a new imaging method that had excellent contrast. This study examined the usefulness of that new imaging method and found the method is highly effective.
Carbon Dioxide Emissions and Energy Self-Sufficiency of Woody Biomass Utilization for Residential Heating: A Case Study of Nishiwaga, Japan  [PDF]
Daisuke Sawauchi, Daisuke Kunii, Yasutaka Yamamoto
Journal of Environmental Protection (JEP) , 2015, DOI: 10.4236/jep.2015.64032
Abstract: Renewable energy sources, including bioenergy, are presently attracting considerable attention as possible substitutes for fossil fuels. Among the various sources of bioenergy, biomass can arguably play a significant role in the reduction of greenhouse gases and the provision of a stable energy supply. However, the use of fossil fuels continues in the production of bioenergy. Consequently, the overall extent to which biomass utilization for energy can reduce carbon dioxide emissions as a substitute for fossil fuels and whether this can improve the energy self-sufficiency rate remains largely unknown. This study responds to these questions using a case of a Japanese rural community using firewood for residential heating. The results showed that woody biomass utilization for energy is able to both reduce the dependence on fossil fuels and mitigate climate change. These findings offer new insights into the development of sustainability in rural communities.
Claisen and Intermolecular Rearrangement of Cinnamyloxynaphthalenes  [PDF]
Yutaka Okada, Daisuke Imanari
International Journal of Organic Chemistry (IJOC) , 2012, DOI: 10.4236/ijoc.2012.21007
Abstract: Rearrangements of the 1- and 2-cinnamyloxynaphthalenes undergo in diethylene glycol and decalin with solvent de-pendence. In 2-cinnamyloxynaphthalene, the Claisen rearrangement occurs regardless of the solvents. However, for the 1-analogue, the Claisen rearrangement occurs in decalin, while both the Claisen and intermolecular rearrangements occur at higher temperatures in diethylene glycol.
Novel Synthetic Method for the Vilsmeier-Haack Reagent and Green Routes to Acid Chlorides, Alkyl Formates, and Alkyl Chlorides  [PDF]
Yoshikazu Kimura, Daisuke Matsuura
International Journal of Organic Chemistry (IJOC) , 2013, DOI: 10.4236/ijoc.2013.33A001
Abstract: An environmentally benign and practical preparation method for the Vilsmeier-Haack reagent (VH) has been developed by using phthaloyl dichloride with DMF in toluene or 2-chlorotoluene. Phthalic anhydride as the byproduct was recovered in high yield by simple filtration. Some aromatic acids have been transformed into the corresponding acid chlorides in good yields by employing the isolated VH. Treatment of primary or secondary alcohols with VH gave alkyl formates or alkyl chlorides by depending on the reaction conditions.
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