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Search Results: 1 - 10 of 55390 matches for " Da Jung Jung "
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Inser??o de profissionais de fisioterapia na equipe de saúde da família e Sistema único de Saúde: desafios na forma??o
Silva,Daysi Jung da; Ros,Marco Aurélio Da;
Ciência & Saúde Coletiva , 2007, DOI: 10.1590/S1413-81232007000600028
Abstract: this paper presents the role of the physiotherapist in the family health program, particularly with regard to all-round care, analyzing the academic education of physiotherapists in terms of this program from the standpoint of the players involved, based on an analysis of the physiotherapy course at the tubar?o campus of the southern santa catarina state university (unisul). similar to a case study, a qualitative survey was conducted, interviewing three family health program nurses, three teachers, two interns and the deputy coordinator of this course. the data were analyzed through an examination of the contents of the collected responses. the closing remarks of this paper stress that the understanding of the nurses and the students of the role played by the physiotherapist in the family health program is guided by diseases. this indicates a need for better-informed lecturers and coordination on this matter to avoid this repercussion, extending experiences in the family health program built up during the course and preparing practitioners for working in teams providing all-round care.
Display of Multimeric Antimicrobial Peptides on the Escherichia coli Cell Surface and Its Application as Whole-Cell Antibiotics
Ju Ri Shin, Ki Jung Lim, Da Jung Kim, Ju Hyun Cho, Sun Chang Kim
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0058997
Abstract: Concerns over the increasing emergence of antibiotic-resistant pathogenic microorganisms due to the overuse of antibiotics and the lack of effective antibiotics for livestock have prompted efforts to develop alternatives to conventional antibiotics. Antimicrobial peptides (AMPs) with a broad-spectrum activity and rapid killing, along with little opportunity for the development of resistance, represent one of the promising novel alternatives. Their high production cost and cytotoxicity, however, limit the use of AMPs as effective antibiotic agents to livestock. To overcome these problems, we developed potent antimicrobial Escherichia coli displaying multimeric AMPs on the cell surface so that the AMP multimers can be converted into active AMP monomers by the pepsin in the stomach of livestock. Buf IIIb, a strong AMP without cytotoxicity, was expressed on the surface of E. coli as Lpp-OmpA-fused tandem multimers with a pepsin substrate residue, leucine, at the C-terminus of each monomer. The AMP multimers were successfully converted into active AMPs upon pepsin cleavage, and the liberated Buf IIIb-L monomers inhibited the growth of two major oral infectious pathogens of livestock, Salmonella enteritidis and Listeria monocytogenes. Live antimicrobial microorganisms developed in this study may represent the most effective means of providing potent AMPs to livestock, and have a great impact on controlling over pathogenic microorganisms in the livestock production.
Fluorescence modulation sensing of positively and negatively charged proteins on lipid bilayers
Aaron D Robison, Da Huang, Hyunsook Jung, Paul S Cremer
Biointerphases , 2013, DOI: 10.1186/1559-4106-8-1
Abstract: Supported lipid membranes containing ortho-conjugated rhodamine B-POPE (1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine), which fluoresces in its protonated but not in its deprotonated form, were utilized as sensor platforms for biotin-avidin and biotin-streptavidin binding events. The membranes contained 5 mol% biotin-PE (1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-(cap biotinyl) (sodium salt) as a capture ligand. Supported lipid bilayers were formed in the channels of microfluidic devices and the fluorescence intensity of the dye was monitored as protein was introduced.The binding of avidin, which is positively charged at pH 7.2, made the bilayer surface charge more positive, which in turn deprotonated the ortho-rhodamine B dye, reducing its fluorescence. The binding of streptavidin, which is negatively charged at pH 7.2, had the opposite effect. Reducing the ionic strength of the analyte solution by removing 150 mM NaCl from the 10 mM phosphate buffered saline (PBS) solution raised the apparent pKa of the ortho-rhodamine B titration point by about 1 pH unit. This could be exploited in conjunction with bulk solution pH changes to turn the rhodamine B-POPE dye into a sensor for streptavidin involving a decrease, rather than an increase, in the fluorescence response, at pH values below streptavidin’s pI value.This study demonstrates the ability to monitor ligand-receptor interactions on supported lipid bilayers through the protonation or deprotonation of reporter dyes for both negatively and positively charged analytes over a range of pH and ionic strength conditions. Specifically, the sensitivity and pH-operating range of this technique can be optimized by modulating the sensing conditions which are employed.The ability to monitor ligand-receptor interactions is vital for biotechnological advances as well as for a fundamental understanding of cell biology. The single-molecule sensitivity that fluorescent labeling can provide and the relat
Investigations on Non-Condensation Gas of a Heat Pipe  [PDF]
Jung-Chang Wang
Engineering (ENG) , 2011, DOI: 10.4236/eng.2011.34043
Abstract: This paper utilizes numerical analysis method to determine the influence of non-condensation gas on the thermal performance of a heat pipe. The temperature difference between the evaporation and condensation sections of a single heat pipe and maximum heat capacity are the index of the thermal performance of a heat pipe for a thermal module manufacturer. The thermal performance of a heat pipe with lower temperature difference between the evaporation and condensation sections is better than that of higher temperature dif- ference at the same input power. The results show that the maximum heat capacity reaches the highest point, as the amount of the non-condensation gas of a heat pipe is the lowest value and the temperature difference between evaporation and condensation sections is the smallest one. The temperature difference is under 1?C while the percentage of the non-condensation gas is under 8 × 10?5%, and the heat pipe has the maximum heat capacity.
Investigation of Stresses on Tie Band Used to Wrap and Fasten Rolled Coils  [PDF]
Chongsun Lee, Ilsup Jung
Modern Mechanical Engineering (MME) , 2012, DOI: 10.4236/mme.2012.23011
Abstract: The research was motivated to establish a scientific basis for the required number of steel tie bands used in wrapping and fastening hot rolled coils produced in steel manufacture lines for safe delivery and storage. Strain gages were installed on the tie bands and stress was recorded during the banding and delivery procedure of rolls in the field. The stress developing in the bands due to fastening of the roll and that due to springback of the coil were clearly distinguishable from the strain gage signals. Twelve hot rolled coils having different yield strength, thickness, width, and weight were tested in the recoiling field. The results showed the average tensile stress developing in the bands due to the fastening of the roll to be 151.7 ± 53.8MPa, which corresponded to one fourth of the failure strength of the steel band in the buckle region. In addition to the stress caused by fastening, average tensile stress caused by springback of the rolled coils was estimated to be 33 MPa. It increased to 79 MPa when one of the tie bands was removed from the roll. Comparing the measured stress due to springback with the theoretical stress formula yielded a proportional constant value of 0.219, and a correlation coefficient of 0.914, which demonstrate the formula to be useful in predicting springback stress. The average safety factor of the tie band was found to be 3.26 and it decreased to 2.60 when one of the bands was removed from the roll. The safety factor of the band was found to decrease with increased coil thickness because the current factory standard on the number of bands does not significantly take into account of increase in the springback force with increased coil thickness.
Ballistic Behavior of Heracron®-Based Composites: Effect of the Number Multifilaments on High-Speed Projectiles  [PDF]
Jung Seop Lim
Modeling and Numerical Simulation of Material Science (MNSMS) , 2013, DOI: 10.4236/mnsms.2013.33011
Abstract: In this study, two Heracron? woven fabrics, HT840-1 and HT840-2, were fabricated with different multifilament fibers, and their resistance to ballistic impact was investigated. For the same weight and number of plies, the HT840-2 fabric showed improved ballistic properties, compared with HT840-1; this result is contrary to the fiber and fabric properties. With the exception of the yarn’s physical properties, this behavior can be explained in terms of the number of multifilaments, which strongly influenced the ballistic mechanism, i.e., a greater number of multifilament fibers facilitates energy dissipation from a high-speed ballistic projectile. In summary, establishing this optimal number of multifilaments is the key to optimizing the ballistic properties of any given fabric.
Methylene blue protects mitochondrial respiration from ethanol withdrawal stress  [PDF]
Marianna Jung, Daniel Metzger
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.47A2004
Abstract: Methylene blue (MB), a tricyclic phenothiazine drug, has been reported to enhance mitochondrial functions including mitochondrial respiration. By comparison, stress associated with abrupt ethanol withdrawal (EW) impedes mitochondrial functions. We investigated whether MB protects mitochondrial respiration and cell survival from EW stress through a key mitochondrial enzyme, cytochrome c oxidase (COX). We also investigated whether the MB’s protection involves the inhibition of an excitatory neurotransmitter, glutamate. Male rats were exposed to and withdrawn from ethanol-diet (7.5%, 5 weeks). MB (0.5 mg/kg, intraperitoneal) was injected for the last 5 days of ethanol-diet and on the first day of EW. Cerebellum was then harvested to measure mitochondrial respiration and COX expression using real-time XF respirometer and immunohistochemistry, respectively. Separately, HT22 cells (a murine hippocampal cell line) were exposed to and abruptly withdrawn for 4 hours from chronic ethanol (100 mM, 3 days). MB was administered during EW with or without a COX inhibitor (NaN3) or glutamate. Mitochondrial respiration, COX content, and cell viability were then assessed using real-time XF respirometer, an immunoblot method, and Calcein assay, respectively. MB attenuated the suppressing effects of EW on mitochondrial respiration, COX content, and cell survival. This protection was reduced after NaN3 or glutamate cotreatment. These results suggest that MB treatment help maintain mitochondrial respiratory and cellular integrity through COX-upregulation and glutamateinhibition upon EW stress. MB treatment may help identify mitochondrial mechanisms underlying hyperexcitatory CNS disorders.
Purkinje-neuron-specific down-regulation of p38 protects motoric function from the repeated use of benzodiazepine  [PDF]
Marianna Jung, Daniel Metzger
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.46A009
Abstract:

Benzodiazepine (BZD) is the most prescribed CNS depressant in America to treat hyper-excitatory disorders such as anxiety and insomnia. However, the chronic use of BZD often creates adverse effects including psychomotor deficit. In this study, we investigated a novel mechanism by which chronic BZD impedes motoric function in female mice. We used female mice because BZD use is much more prevalent in female than male populations. We tested the hypothesis that the accumulation of p38 (stress-activated protein) in cerebellar Purkinje neurons mediates motoric deficit induced by chronic BZD. To test this hypothesis, we generated transgenic mice that lack p38 incerebellar Purkinje neurons by crossing Pcp2 (Purkinje cell protein 2)-Cre mice with p38loxP/loxP mice. p38-knockdown mice and wild-type mice received BZD (lorazepam, 0.5 mg/kg) for 14 days. During this period, they were tested for motoric performance using Rotarod assay in which a quicker fall from rotating rod indicates poorer motoric performance. Cerebellum was then collected to detect p38 inPurkinje neurons and to measure mitochondrial respiration using immunohistochemistry and real-time XF respirometry, respectively. Compared to vehicletreated mice, BZD-treated mice showed poorer motoric performance, a higher number of Purkinje neurons containing p38, and lower mitochondrial respiration. These effects of BZD were much smaller in p38-knockdown mice. These results suggest that the excessive accumulation of p38 incerebellar Purkinje neurons contributes to motoric deficit associated with chronic BZD. They also suggest that Purkinje neuronal p38 mediates BZD-induced mitochondrial respiratory inhibition in cerebellum. Our findings may provide a new mechanistic insight into chronic BZD-induced motoric deficit.

Green Investment Cost Optimization Model in the Supply Chain  [PDF]
Seungbae Sim, Hosang Jung
American Journal of Operations Research (AJOR) , 2013, DOI: 10.4236/ajor.2013.36044
Abstract:

The objective of this study is to develop a model that determines the optimal points for investment in green management by defining a mathematical relationship between carbon trading profits and investments in green management using a company’s supply chain information. To formulate this model, we first define and analyze a green supply chain in a multi-dimensional and quantitative manner. The green investment alternatives considering in our model are as follows: 1) purchasing eco-friendly raw materials that cost more than conventional raw materials but whose use in production results in lower CO2 emissions; 2) replacing current facilities with new eco-friendly facilities that have the capability to reduce CO2 emissions; and 3) changing modes of transport from less eco-friendly to more eco-friendly modes. We propose a green investment cost optimization (GICO) model that enables us to determine the optimal investment points. The proposed GICO model can support decision-making processes in green supply chain management environments.

Using Concept Mapping Instruction in Mobile Phone to Learning English Vocabulary  [PDF]
Chiu-Jung Chen
Creative Education (CE) , 2014, DOI: 10.4236/ce.2014.51002
Abstract:

Mobile technologies have enabled various new learning approaches. The researcher investigated the effectiveness of using Short Message Service (SMS) with concept mapping for English as Foreign Language learners’ vocabulary learning. The results indicated that after receiving English vocabulary lessons via SMS, the concept mapping group performed significantly better than the random group on the test scores, especially on the translation part.

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