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Search Results: 1 - 10 of 194575 matches for " Dárcio Kitakawa "
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Peripheral calcifying cystic odontogenic tumour of the maxillary gingiva
Ana Lima, Dárcio Kitakawa, Janete Almeida, Adriana Aigotti Brand?o, Ana Anbinder
BMC Research Notes , 2012, DOI: 10.1186/1756-0500-5-455
Abstract: Authors report a rare case of a peripheral calcifying cystic odontogenic tumor of the maxillary gingiva. A 39-year-old male patient presented with a fibrous mass on the attached buccal gingiva of the upper left cuspid teeth. It was 0.7-cm-diameter, painless and it was clinically diagnosed as a peripheral ossifying fibroma. After an excisional biopsy, the diagnosis was peripheric calcifying cystic odontogenic tumor. The patient was monitored for five years following the excision, and no recurrence was detected.All biopsy material must be sent for histological examination. If the histological examination of gingival lesions with innocuous appearance is not performed, the frequency of peripheral calcifying cystic odontogenic tumor and other peripheral odontogenic tumors may be underestimated.A calcifying cystic odontogenic tumor (CCOT) is an extremely rare benign cystic neoplasm that is characterized by an ameloblastoma-like epithelium and ghost cells that have the potential to undergo calcification [1]. Originally, CCOTs were referred to as calcifying odontogenic cysts (COC). The structure was first described by Gorlin in 1962 as a distinct entity and was therefore called Gorlin cyst [2]. COC was considered as a developmental odontogenic cyst in the jaw. In their first report, Gorlin et al. [2] considered this lesion to be a possible analogue of the cutaneous calcifying epithelioma of Malherbe (the pilomatrixoma). COC accounted for approximately 1% of jaw cysts. In 1981, Praetorius et al. [3] studied and reevaluated 16 cases of COC and proposed that the group actually contained two entities, a cyst and a neoplasm. Since then, neoplastic potential has been investigated.In 2005, the World Health Organization (WHO) designated Gorlin’s cyst as a tumor and described it as belonging to a group of related neoplasms, including the benign cystic-type (CCOT), the benign solid-type dentinogenic ghost cell tumor, and the malignant ghost cell odontogenic carcinoma [1]. The dentino
Necrotizing sialometaplasia as a cause of a non-ulcerated nodule in the hard palate: a case report
M?nica Oliveira Alves, Dárcio Kitakawa, Yasmin Carvalho, Luiz Guimar?es Cabral, Janete Almeida
Journal of Medical Case Reports , 2011, DOI: 10.1186/1752-1947-5-406
Abstract: We report the case of a healthy 25-year-old Caucasian woman with a three-week history of a painless lump on her hard palate. Oral examination revealed a nodule consisting of two lobules on the right side that measured 2.5 cm. Her mucosa was normal in color and a fluctuant area was detected in the posterior region upon palpation. Our patient was submitted to incisional biopsy and histopathological examination. The histological diagnosis was necrotizing sialometaplasia. The lesion had healed spontaneously after 30 days, with observed signs of involution of the nodule.Histopathological examination is necessary for the diagnosis of necrotizing sialometaplasia because the clinical features of this condition can mimic other diseases, particularly malignant neoplasms.Necrotizing sialometaplasia is a benign, self-limiting and rare inflammatory disease of the minor salivary glands [1-6], which was first described as a distinct entity by Abrams et al. in 1973 [7]. Knowledge about the disease is required because it mimics malignant neoplasms on clinical and histological examination, particularly squamous cell carcinoma and mucoepidermoid carcinoma [2-4,6,8]. We report the clinical and histopathological features of a case of necrotizing sialometaplasia presenting initially without ulceration in a young adult woman.A healthy 25-year-old Caucasian woman was seen at our stomatology outpatient clinic with a three-week history of a lump on her hard palate, which was non-tender upon oral examination. Our patient reported the presence of a stabbing pain radiating to the region of the temporomandibular joint in the previous week. The patient was a dentist and made a self-diagnosis of an abscess.Clinical examination revealed a submucosal nodule on the right side of her hard palate that measured almost 2.5 cm in its major diameter. The color of the mucosal surface was normal (Figure 1A) and a fluctuant area was detected in the posterior region upon palpation. Occlusal radiography reveale
Incontinentia pigmenti presenting as hypodontia in a 3-year-old girl: a case report
Dárcio Kitakawa, Patrícia Fontes, Fernando Magalh?es, Janete Almeida, Luiz Cabral
Journal of Medical Case Reports , 2009, DOI: 10.1186/1752-1947-3-116
Abstract: We report the case of a 3-year-old girl with ophthalmologic and neurologic disturbances, cutaneous manifestations and hypodontia. Since the patient did not present more damaging manifestations such as neurologic and/or ophthalmologic problems, her most severe complications were related to dental anomalies. The importance of integrated dental treatment, which combines pediatric dentistry, orthodontics and conventional prosthesis, is emphasized.Hypodontia is a frequent finding in incontinentia pigmenti, and dentists should be aware of this condition in order to help with the diagnosis.Incontinentia pigmenti (IP) or Bloch-Sulzberger syndrome is a rare X-linked dominant genodermatosis which mainly affects women. The disease is systemic and involves tissues of ectodermic and mesodermic origin including cutaneous tissue, teeth, eyes and the central nervous system (CNS), amongst other organs [1-4]. The name incontinentia pigmenti is related to the histological characteristics of the disease, that is, melanin incontinence by melanocytes in the basal epidermal layer and its presence in the superficial dermis in the final stage of the disease [5].IP is a single-gene disorder caused by mutations in the NEMO/IKK-γ gene. The function of NEMO, a 23-kb gene consisting of 10 exons, is to permit cells to respond to external signals such as growth factors [5]. This gene encodes a protein that regulates the function of various chemokines, cytokines and adhesion molecules, and is essential for protection against tumour necrosis factor-induced apoptosis [1,5,6].The inheritance of a mutant copy of this X-linked gene is generally lethal in antenatal males. Although there are many case reports of men with IP submitted to mutation analysis, none of these patients has been shown to carry the common NEMO deletion. Several studies have demonstrated the presence of hypomorphic NEMO alleles, a finding suggesting that less severe NEMO mutations permit the survival of affected men [6,7]. There are
Contact Urticaria Syndrome from Tofu  [PDF]
Maki Kitakawa, Tokio Nakada
Case Reports in Clinical Medicine (CRCM) , 2016, DOI: 10.4236/crcm.2016.56038
Abstract: A-52-year-old woman ate dinner after preening roses in her garden. Immediately, she developed oralaryngeal malaise and pruritic rash. Nasal obstruction and increase of cutaneous lesions were seen although she took betamethasone, 2 mg, orally. Physical examination revealed geographic wheal on trunk and extremities, and no overt mucosal lesions. History demonstrated that she had developed such reactions four times before: three of the four were seen shortly after eating soybean. Tofu was examined by prick-by-prick testing, and prick testing was performed with a petal, a piece of stem and rose leaf, positive and negative control. Positive reactions to tofu (wheal, 5 × 7 mm) and positive control (wheal 5 × 5 mm) and negative ones to others were noted. Although sensitization to soybean seemed to antedate pollen allergy on the basis of interview, oral allergy syndrome could be complicated because of various pollens-specific IgE. Since soy-bean specific IgE was class 2, such titer was not an effective predictor of clinical severity. This case should be classified into stage 3 of contact urticaria syndrome (CUS). Since CUS can be fatal, we must be careful in management for such patients.
Importancia do metabolismo no planejamento de fármacos
Pereira, Dárcio Gomes;
Química Nova , 2007, DOI: 10.1590/S0100-40422007000100029
Abstract: it is widely recognized that pharmacokinetic optimization needs to be addressed early in drug discovery to reduce the high failure rate in bringing drugs to market. poor absorption, too short duration of action due to high elimination rate, or the presence of active metabolites are examples of properties that can potentially lead to unsuccessful clinical programmes. here i describe a brief overview of advantages and molecular strategies for improving metabolic and pharmacokinetic properties applied to the discovery of fluconazol, b-blockers, ritonavir and ezetimibe and to the development of the prodrugs enalapril and bambuterol.
Inner Membrane Protein YhcB Interacts with RodZ Involved in Cell Shape Maintenance in Escherichia coli
Gaochi Li,Kentaro Hamamoto,Madoka Kitakawa
ISRN Molecular Biology , 2012, DOI: 10.5402/2012/304021
Fuzzy Modelling for Predicting the Risk of Recurrence and Progression of Superficial Bladder Tumors  [PDF]
Laércio L. Vendite, Kenia D. Savergnini, Ubirajara Ferreira, Wagner E. Matheus
Applied Mathematics (AM) , 2018, DOI: 10.4236/am.2018.910074
Nowadays, bladder cancer is the fourth most common cancer in adults and the second most frequent urogenital tumor. Predicting recurrence and progression of superficial bladder tumors, with available clinical information to decide the therapy to be used is a difficult task. In this work, two mathematical models were developed to help specialists on the decision process. The mathematical tool used to formulate the model was the fuzzy sets theory, due to its capacity in dealing with uncertainties inherent in medical concepts. In the first model, Stage, Grade and Size of the tumor were also considered input variables and Risk of Recurrence of a superficial bladder tumor as output variable of the first Fuzzy Rule-Based Systems (FRBS). In the second model, in addition to the Stage, Grade and Size of the tumor, it was also considered as input variable of a second FRBS Carcinoma in situ and, the Risk of Progression of superficial tumors as an output variable. For each model, simulations were made with data originated from of patients of the Clinics Hospital/ UNICAMP and A. C. Camargo Hospital of São Paulo, with the aim to verify the reliability of results generated by the two systems. From a database and the possibility found by FRBS, after the possibility-probability transformation, we can generate the real probability of each fuzzy output set.
Assessing Cleaner Energy Alternatives for Bus Transit in Rio de Janeiro: A Life Cycle Inventory Analysis  [PDF]
rcio de Almeida D’Agosto, Cintia Machado de Oliveira, Fabiana do Couto Assump??o, Ana Carolina Peixoto Deveza
Journal of Environmental Protection (JEP) , 2015, DOI: 10.4236/jep.2015.611107
Abstract: From 2003 to 2009 in Brazilian municipalities of over 60,000 inhabitants, buses accounted for more than 25% of urban trips. This trend is not expected to change in the medium term. Worldwide, buses rely on petroleum diesel as fuel. In Brazil, alternative fuels such as biodiesel, natural gas and ethanol are available and the choice among them should depend on the assessment of the entire life cycle of such fuels. This paper uses a Life Cycle Inventory, which is essential to the implementation of a Life Cycle Assessment, to assess six energy alternatives: petroleum diesel, biodiesel, petroleum diesel with 5% of biodiesel, compressed natural gas, additivated hydrous ethanol and dual-fuel system composed by petroleum diesel with 5% of biodiesel and compressed natural gas. In saving total energy consumption, pure petroleum diesel or mixed with 5% biodiesel and dual-fuel systems stand out, in that order. If renewable energy use and net carbon dioxide emissions reduction are the goals, ethanol and biodiesel should be given preference. The addition of 5% of biodiesel in petroleum diesel increases the share of renewable energy in the supply chain of petroleum diesel by 47.5% with an increase of 0.58% in total energy consumption and a reduction of 3.8% in net CO2 emissions during the life cycle. In the case of biodiesel, the addition of 5% of biodiesel in petroleum diesel increases the share of renewable energy in the supply chain by 51.15% with an increase of 0.03% in the total energy consumption and a decrease of 7% in net CO2 emissions in the life cycle. The use of 5% of biodiesel in petroleum diesel does not significantly affect the use of renewable energy (+0.69%) or total energy consumption (+0.04%) in ethanol supply chain, which already shows a great use of renewable energy input. However, a decrease of 9.29% in the net CO2 emissions in the supply chain occurs, which reaches 5.28% in the life cycle.
Molecular aspects of esophageal squamous cell carcinoma carcinogenesis
Lehrbach, Dárcio Matenhauer;Nita, Marcelo Eidi;Cecconello, Ivan;,;
Arquivos de Gastroenterologia , 2003, DOI: 10.1590/S0004-28032003000400011
Abstract: background: the development of human esophageal cancer is a multistep, progressive process. an early indicator of this process is an increased proliferation of esophageal epithelial cells morphologically including basal cell hyperplasia, dysplasia, carcinoma in situ and advanced esophageal squamous cell carcinoma. the process of tumorigenesis at cellular level is related to disorders of the control of cell proliferation and differentiation and controlled cell death (apoptosis). most of cancer cells contain genetic alterations related to the control of these processes, including transcription factors and apoptosis related proteins. aim: in this review, the current knowledge of the genetic profile of this subtype of esophageal tumor is discussed, focusing on the potential of the development of novel tools for clinical management of esophageal squamous cell carcinoma. conclusions: the advances in the field of molecular biology have let us to deeper our knowledge of the process of carcinogenesis of esophagus. ideally, this knowledge should be translated in benefits for patients suffering from cancer. thus, better understanding of molecular alterations during carcinogenesis is expected to improve tumor control and prevention and also may lead to better disease management.
Confiabilidade dos dados do Sistema de Informa??es sobre Nascidos Vivos em Teresina, Estado do Piauí, Brasil - 2002
Mascarenhas,rcio Dênis Medeiros; Gomes,Keila Rejane Oliveira;
Ciência & Saúde Coletiva , 2011, DOI: 10.1590/S1413-81232011000700055
Abstract: this article aims to evaluate the reliability of the data available in the information system for live birth (sinasc) in the city of teresina, piauí state, brazil for the year of 2002. the proportion of data completeness was analyzed, and concordance between variables for data reported to sinasc and hospital records (sinasc-p) was estimated using the kappa index. this study demonstrated that variables in sinasc presented a higher level of completeness (>90%) than those in sinasc-p (>74%), and the concordance was excellent (kappa>0.80) for the following variables: maternal age, marital status, number of live births, type of delivery, and the sex and weight of newborn infants. concordance for the number of stillbirths, prenatal visits, educational level and gestational age was categorized from fair-to-adequate (0.20
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