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Search Results: 1 - 10 of 192361 matches for " D Lynn Kalinoski "
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Biochemical enrichment and biophysical characterization of a taste receptor for L-arginine from the catfish, Ictalurus puntatus
William Grosvenor, Yuri Kaulin, Andrew I Spielman, Douglas L Bayley, D Lynn Kalinoski, John H Teeter, Joseph G Brand
BMC Neuroscience , 2004, DOI: 10.1186/1471-2202-5-25
Abstract: Both PHA-E and RCA-I almost exclusively labeled an 82–84 kDa protein band of an SDS-PAGE of solubilized barbel taste epithelial membranes. Further, both rhodamine-conjugated RCA-I and polyclonal antibodies raised to the 82–84 kDa electroeluted peptides labeled the apical region of catfish taste buds. Because of the specificity shown by RCA-I, lectin affinity was chosen as the first of a three-step procedure designed to enrich the presumed LGICR for L-Arg. Purified and CHAPS-solubilized taste epithelial membrane proteins were subjected successively to (1), lectin (RCA-I) affinity; (2), gel filtration (Sephacryl S-300HR); and (3), ion exchange chromatography. All fractions from each chromatography step were evaluated for L-Arg-induced ion channel activity by reconstituting each fraction into a lipid bilayer. Active fractions demonstrated L-Arg-induced channel activity that was inhibited by D-arginine (D-Arg) with kinetics nearly identical to those reported earlier for L-Arg-stimulated ion channels of native barbel membranes reconstituted into lipid bilayers. After the final enrichment step, SDS-PAGE of the active ion channel protein fraction revealed a single band at 82–84 kDa which may be interpreted as a component of a multimeric receptor/channel complex.The data are consistent with the supposition that the L-Arg receptor is a LGICR. This taste receptor remains active during biochemical enrichment procedures. This is the first report of enrichment of an active LGICR from the taste system of vertebrata.The initial event in taste transduction involves recognition of taste stimuli by plasma membrane-associated receptor proteins. These proteins are concentrated at the apical end of specialized neuro-epithelial cells (taste cells) found within multicellular end-organs known as taste buds [1,2]. The recognition binding sites for most taste stimuli face the exterior environment. The interaction of a taste stimulus with this recognition site triggers a chain of metabolic an
Complexity of Interaction in a Second Language Conversation Group: An Exploratory Study  [PDF]
Melanie Lynn D’Amico
Open Journal of Modern Linguistics (OJML) , 2015, DOI: 10.4236/ojml.2015.54031
Abstract: The aim of this research was to explore the nature of conversation in a weekly second language Italian conversation group. Analysis of conversations focused on the range of topics and verbal structures used by learners. Additional analysis was completed to determine if learners engaged in negotiation of meaning or form during conversations. Results revealed that learners used a range of topics and verbal structures from Beginner level to Advanced level indicating that learners challenged themselves to produce high quality, natural conversation. Learners also showed some use of negotiation during conversations to repair communication breakdowns, principally to address meaning; however, the amount of negotiation was low when compared to task-based interaction designed to elicit negotiation.
Lessons without limit: how free-choice learning is transforming science and technology education
Dierking, Lynn D.;
História, Ciências, Saúde-Manguinhos , 2005, DOI: 10.1590/S0104-59702005000400008
Abstract: societies are becoming nations of lifelong learners supported by a vast infrastructure of learning organizations. the centers of this learning revolution are not schools, but a network of organizations and media (museums, libraries, television, books, and increasingly the internet) supporting the public's ever-growing demand for free-choice learning - learning guided by a person's needs and interests. science learning is an important part of this revolution. traditional boundaries and roles distinguishing groups of science educators and institutions are disappearing. to not understand and embrace these changes will impede our ability to enhance science learning worldwide.
Radio Stars and Their Lives in the Galaxy
Lynn D. Matthews
Physics , 2013, DOI: 10.1086/670019
Abstract: This paper summarizes the three-day international workshop "Radio Stars and Their Lives in the Galaxy", held at the Massachusetts Institute of Technology Haystack Observatory on 2012 October 3-5. The workshop was organized to provide a forum for the presentation and discussion of advances in stellar and solar astrophysics recently (or soon to be) enabled by the latest generation of state-of-the-art observational facilities operating from meter to submillimeter wavelengths. The meeting brought together both observers and theorists to discuss how radio wavelength observations are providing new and unique insights into the workings of stars and their role in the Galactic ecosystem. Topics covered included radio emission from hot and cool stars (from the pre- to post-main-sequence), the Sun as a radio star, circumstellar chemistry, planetary nebulae, white dwarf binaries and novae, supernova progenitors, and radio stars as probes of the Galaxy.
Confiabilidade da declara??o da causa básica de óbitos neonatais: implica??es para o estudo da mortalidade prevenível
Carvalho,Márcia L.; Silver,Lynn D.;
Revista de Saúde Pública , 1995, DOI: 10.1590/S0034-89101995000500002
Abstract: the main causes of neonatal mortality, the reliability of the underlying cause of death registered in the death certificate, and the impact of problems of reliability on the analysis of preventable death were studied. the information on death certificates from a 15% sample of neonatal deaths between may 1986 and april 1987 in the greater metropolitan region of rio de janeiro was compared to the information in the hospital records of the 452 deceased infants. a "modified underlying cause" considered most correct according to disease classification rules was identified from the records. the great majority of deaths (87%) were due to perinatal causes. agreement between the originally declared and modified underlying causes of death was poor: 38% for 3 digits of the international classification of diseases codes (cid-9) and 33% for 4 digits. the modified underlying causes are more weighted towards maternal conditions and complications, which increased by a factor of 12.8, and towards complications of the placenta, umbilical cord, labour and delivery, which rose by a factor of 6.2 in relation to the original causes. the utilization of the "modified" underlying cause elevated considerably (58%) the proportion of deaths considered reducible by the classification of neonatal death proposed by the seade foundation. seventy-five percent (75%) of deaths were considered reducible or partially reducible. one hundred and seven (24%) of the deaths of them being in infants of normal birthweight, of which 60% considered preventable. four (4) deaths from congenital syphilis, 3 from perinatal hemolytic diseases, and 21 unattended home deaths of infants were also identified. in summary, important problems were identified in the reliability of the declaration of the underlying causes of neonatal death, whose correction tends to elevate the proportion considered reducible or preventable. the potential for the use of death certificate data for the monitoring of quality is evident, nonethe
Confiabilidade da declara o da causa básica de óbitos neonatais: implica es para o estudo da mortalidade prevenível
Carvalho Márcia L.,Silver Lynn D.
Revista de Saúde Pública , 1995,
Abstract: Analisam-se as principais causas de morte neonatal, a confiabilidade da causa básica constante nas declara es de óbito e o impacto dos problemas de confiabilidade na análise de morte prevenível. A informa o constante nas declara es de óbito de urna amostra de 15% dos óbitos neonatais, ocorridos entre maio de 1986 e abril de 1987, na Regi o Metropolitana do Rio de Janeiro, Brasil, é comparada com a dos prontuários hospitalares de 452 crian as falecidas. Identificou-se no prontuário o diagnóstico, denominado "causa básica modificada", considerada mais correta segundo as regras de classifica o de doen as. A grande maioria dos óbitos foram devidos às causas perinatais (87%). A concordancia simples entre a causa básica original e a modificada foi baixa - 38% para 3 dígitos da Classifica o Internacional de Doen as e 33% para 4 dígitos. As causas básicas modificadas mostram maior peso das afec es e complica es maternas, com aumento de 12,8 vezes, e das complica es relacionadas com a placenta, cord o, trabalho de parto ou parto, que aumentaram 6,2 vezes em rela o as causas originalmente declaradas. A utiliza o da causa básica modificada elevou consideravelmente (58%) o percentual de óbitos considerados "reduzíveis" pela classifica o de mortalidade neonatal proposta pela Funda o Sistema Estadual de Análise de Dados. Do total dos óbitos, 75% foram considerados reduzíveis ou parcialmente reduzíveis. Foram identificados 107 (24%) óbitos em crian as com adequado peso ao nascer, 60% dos quais foram considerados como reduzível ou parcialmente reduzível, bem como 4 óbitos por sífilis congênita, 3 por doen a hemolítica perinatal, e 21 crian as que vieram a morrer no domicílio. Em conclus o, foram constatados importantes problemas na confiabilidade da declara o da causa básica de óbitos neonatais, cuja corre o tende a elevar a propor o considerada reduzível ou prevenível. Fica evidente o potencial de utiliza o do atestado de óbito para o monitoramento de qualidade, entretanto sendo necessário um aprimoramento da qualidade do seu preenchimento.
Sub-Canopy Temperature Dynamics of a Native Tree Plantation from a Lowland Tropical Rainforest in Costa Rica  [PDF]
Traci-Lynn Hirai, Víctor D. Carmona-Galindo, Stacie Samuelson, Cherie Hale, Elizabeth Braker
Open Journal of Forestry (OJF) , 2014, DOI: 10.4236/ojf.2014.43025

With urbanization encroaching upon forestlands, characterizing microclimates in secondary forests will be important for the sustainable management of microclimates in agroforestry systems. We used micro-sensors to characterize changes in temperature at different heights in the sub-canopy of both secondary forest and 15-year-old agroforestry plots. Results show that while agroforestry plots had different temperature profiles from the secondary forest, the monoculture plot (consisting of Pentaclethra macroloba) had temperatures similar to the profile found in the secondary forest. This suggests that the replication of temperature profiles in a secondary forest may be independent of the number of tree species in a plot (e.g. polyculture), but may instead depend on the density of a given trees species. These findings further suggest that characterizing temperature microclimates in secondary forests can serve to improve the ecological sustainability of agro-forestry systems.

B and V CCD Photometry of Southern, Extreme Late-Type Spiral Galaxies
Lynn D. Matthews,John S. Gallagher
Physics , 1997, DOI: 10.1086/118613
Abstract: We present B and V CCD aperture photometry for a morphologically-selected sample of forty-nine southern, extreme late-type spiral galaxies. All objects are moderate-to-low surface brightness Local Supercluster field galaxies that were detected previously in HI surveys. Our sample features objects that have optical luminosities, optical sizes, and HI masses which are at the low end for spiral galaxies. These objects are not a new class of galaxy, but are examples of a common type of spiral galaxy that has been under-represented in nearby galaxy samples. (Abridged).
Bounded gaps between primes in special sequences
Lynn Chua,Soohyun Park,Geoffrey D. Smith
Mathematics , 2014,
Abstract: We use Maynard's methods to show that there are bounded gaps between primes in the sequence $\{\lfloor n\alpha\rfloor\}$, where $\alpha$ is an irrational number of finite type. In addition, given a superlinear function $f$ satisfying some properties described by Leitmann, we show that for all $m$ there are infinitely many bounded intervals containing $m$ primes and at least one integer of the form $\lfloor f(q)\rfloor$ with $q$ a positive integer.
VEGF and Pleiotrophin Modulate the Immune Profile of Breast Cancer
Kristi D. Lynn,Christina L. Roland,Rolf A. Brekken
Cancers , 2010, DOI: 10.3390/cancers2020970
Abstract: Angiogenesis, the sprouting of the existing vascular network to form new vessels, is required for the growth of solid tumors. For this reason, the primary stimulant of angiogenesis, vascular endothelial growth factor-A (VEGF), is an attractive target for tumor therapy. In fact, there are currently numerous anti-VEGF therapies in clinical development for the treatment of various cancers, including breast cancer. VEGF signals through two primary VEGF receptors, VEGFR1 and VEGFR2. VEGFR2 is the primary angiogenic receptor, and VEGFR1 has been implicated in macrophage chemotaxis and tumor cell survival and invasion. It has only been appreciated recently that the VEGFRs are expressed not only on endothelial cells and tumor cells but also on many host immune cells. Therefore, to better understand the effects of anti-VEGF therapy it is important to consider the effects of VEGF on all cells in the tumor microenvironment, including immune cells. Bevacizumab (Avastin ?, Genetech), which binds VEGF and inhibits interaction with VEGFR1 and VEGFR2, was approved for the treatment of metastatic HER2/NEU-negative breast cancer in 2008, however, the majority of human mammary tumors are either innately resistant or will acquire resistance to anti-VEGF therapy. This suggests that these tumors activate alternate angiogenesis pathways. Pleiotrophin (PTN) is an important angiogenic cytokine in breast cancer and is expressed at high levels in approximately 60% of human breast tumors. PTN functions as an angiogenic factor and promotes remodeling of the tumor microenvironment as well as epithelial-mesenchymal transition (EMT). In addition, PTN can have profound effects on macrophage phenotype. The present review focuses on the functions of VEGF and PTN on immune cell infiltration and function in breast cancer. Furthermore, we will discuss how anti-VEGF therapy modulates the immune cell profile.
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