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Search Results: 1 - 10 of 178694 matches for " Cyntia Cajado de Souza "
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Sickle cell disease: Only one road, but different pathways for inflammation  [PDF]
Wendell Vilas-Boas, Bruno Ant?nio Veloso Cerqueira, Thassila Nogueira Pitanga, Magda Oliveira Seixas, Joelma Menezes, Cyntia Cajado de Souza, Elisangela Vitória Adorno, Marilda Souza Goncalves
Advances in Bioscience and Biotechnology (ABB) , 2012, DOI: 10.4236/abb.2012.324071
Abstract: Sickle cell disease (SCD) is a genetic disorder characterized by a chronic inflammatory process, and new biomarkers have been studied as promising molecules for understanding the inflammation in its pathophysiology. The hemolysis and the release of molecules associated to the hemoglobin (Hb) catabolism, such as free Hb, iron, and heme, generating a oxidant environment with production of reactive oxygen and nitrogen species. The immune system plays a very important role in the inflammation, with cells secreting pro-inflammatory cytokines and chemokines. There is also a nitric oxide (NO) resistance state, with an impaired NO bioactivity, leading to a vascular dys-function; activation of platelet, leukocytes, erythrocytes, and endothelial cells, with expression of adhesion molecules and its ligands, and several receptors, that altogether participate at inflammatory process. During inflammation, there is an increase of dendritic cells (DCs) expresse toll like receptors (TLR), but the role of DCs and TLR in SCD pathogenesis is unclear. Also, there are molecules contributing for enhance the endothelium dysfunction, such as homocysteine that has been associated with vascular complications in the pathology of other diseases and it may contribute to the vascular complications presented by SCD patients. Circulating microparticules (MPs) levels are augmented in several diseases and have been described in SCD, where cells membrane compounds are associated to cell’s thrombotic and coagulation state, such as tissue factor and phosphatidylserine (PS), which may contribute to endothelial dysfunction. The knowledge of all these biomarkers may contribute to new therapeutic approach discover, improveing SCD patient life quality.
Literatura infantil e juvenil: sele o de livros e textos, justificativas das escolhas sob o olhar do professor do ensino fundamental
Souza, Renata Junqueira de,Girotto, Cyntia Graziella Guizelim Sim?es
Letras de Hoje , 2008,
Abstract: N o possui resumo
Estratégias de leitura: uma alternativa para o início da educa o literária
Renata Junqueira de Souza,Cyntia Graziella Guizelim Sim?es Girotto
álabe , 2011,
Abstract: Introduzir as estratégias de leitura como alternativa metodológica para a educa o literária das crian as é o propósito de nossos estudos. Essa perspectiva norte-americana (pautada, principalmenteem Harvey e Goudvis (2007), mas também de Hampton e Resnick (2008), Fisher, Frey e Lapp (2009), Mills (2009), Owocki (2003), Athampe Deveni (2008), Wedwich e Wutz (2008), Fuchs e Vaughn (2008), Cohen (2008), Black e Stave (2007), Graves (2009), Pilonieta e Medina (2009), Zambo e Brozo (2008) e Wood et al. (2007), Flippo,Holland, McCarthy, Swinning (2009), Morrisson e Wlodarczyk (2009), dentre outros) vem sendo descoberta e pesquisada aos poucos noBrasil. Dados, como o do PISA 2002, revelam que a competência leitora é ainda muito frágil entre crian as e jovens brasileiros e que o gosto de ler literatura ainda n o é um dado cultural em nosso país. Com o objetivo de atrair e despertar o interesse da crian a para a atividade de leitura e, a um só tempo, contribuir para a sua educa o literária,associamos literatura infantil e a abordagem das estratégias de compreens o leitora. Desenvolvido com crian as do ensino fundamental, em seus anos iniciais, o projeto de pesquisa, realizado entre os anos de 2006 a 2010, no oeste paulista, em sua terceira fase, comprova resultados bastante animadores e conclui que essa “nova” abordagempode ser usada com sucesso em aulas de leitura e literatura, já para as crian as pequenas. Pois, após a qualifica o docente, os professores mostraramse mais confiantes e alunos mais interessados,compreendendo melhor o texto literário. Neste artigo, discutimos as possibilidades do ensino das estratégias de leitura a partir de textos literários.
UMA ANáLISE SOBRE O CONCEITO DE APRENDIZAGEM NA PERSPECTIVA DE INTERNACIONALIZA O
Cyntia Vilasboas Calixto,Yeda Swirski de Souza,Sílvio Luís de Vasconcellos,Ivan Lapuente Garrido
InternexT : Revista Eletr?nica de Negócios Internacionais da ESPM , 2011,
Abstract: O presente estudo visa analisar o conceito de aprendizagem nos estudos sobre internacionaliza o. Considerando-se que as rela es entre aprendizagem e internacionaliza o tiveram origem na abordagem da Escola de Uppsala, esbo ou-se a trajetória das principais publica es derivadas dessa Escola e dos modelos de processo de internacionaliza o por eles desenvolvidos a fim de compreender a evolu o do conceito de aprendizagem segundo essa perspectiva. Ainda, tendo em vista a amplia o das rela es entre os estudos acerca de aprendizagem e da internacionaliza o, este estudo analisa as conex es entre os estudos da aprendizagem organizacional e sua contribui o para a análise e desenvolvimento dos processos de internacionaliza o. A contribui o deste trabalho está na revis o crítica do entendimento sobre aprendizagem nos estudos de Uppsala e na indica o de uma operacionaliza o do conceito de aprendizagem à luz dos desenvolvimentos mais recentes desse conceito.
OCORRêNCIA DE Campylobacter EM GRANJAS E ABATEDOURO AVíCOLAS NA MESORREGI O METROPOLITANA DE BELéM, PA, BRASIL
Sílvio Orlan de Castro Chaves,Cyntia Oliveira de Souza,José de Arimatéia Freitas,Dolores Dias dos Santos
Ciência Animal Brasileira , 2010,
Abstract: The aim of the present study was to observe the occurrence of Campylobacter in chicken farms and in a slaughterhouse. A total of 120 samples were collected in three chicken farms: cloacal swabs (n=30), poultry litter (n=30), feed (n=30) and water (n=30) samples. In the slaughterhouse, 126 samples were collected: water samples (n=36), neck and chest skins (n=30), livers (n=30) and gizzards (n=30). Campylobacter was isolated in 40 (33.33%) chicken farm samples: 29 (96.6%) cloacal swabs, ten (33.3%) poultry litter and one (3.3%) water sample. Campylobacter jejuni was identified in 33 (82.5%) strains from chicken farms. In the slaugtherhouse, all the eleven (8.73%) isolated strains were identified as C. jejuni: ten (27.8%) water samples and one (3.3%) gizzard sample. The main contamination sources in chicken farms were the cloacal swabs, the poultry litter and, in small proportion, the water. In the slaughterhouse, the main critical points were the water from poultry evisceration and the gizzard collected from the small cooling tank.
Antimicrobial potential of medicaments used in healing process in dogs' teeth with apical periodontitis
Estrela, Carlos;Holland, Roberto;Bernabé, Pedro Felício Estrada;Souza, Valdir de;Estrela, Cyntia R.A.;
Brazilian Dental Journal , 2004, DOI: 10.1590/S0103-64402004000300003
Abstract: the objective of this study was to evaluate the influence of irrigants on the antimicrobial potential of calcium hydroxide paste in dogs' teeth with apical periodontitis. forty-eight premolar teeth of adult mongrel dogs had their root canals opened to the oral environment for 6 months. the root canals were prepared and treated with different irrigating solutions and intracanal medicaments, according to the following groups: 1) 2.5% sodium hypochlorite (naocl) + calcium hydroxide paste (chp); 2) 2% chlorhexidine (chx) + chp; 3) vinegar + chp; 4) vinegar + vinegar. in group 4, both the irrigating solution and intracanal medicament were vinegar, which was renewed every 7 days. each sample was collected by using two paper points maintained in position for 1 min, and individually transported and immersed in 7 ml of letheen broth (lb), followed by incubation at 37oc for 48 h. microbial growth was analyzed by two methods: turbidity of the culture medium and subculture on a specific nutrient broth (brain heart infusion). after 21 days, all experimental groups had microbial growth, however, in different percentages: group 1 - 30%; group 2 - 30%; group 3 - 40%; group 4 - 60%. all materials tested had antimicrobial potential; however, the influence of calcium hydroxide paste on the control of microorganisms must be remembered.
Evolu o da ocorrência (1980-1999) da doen a de Crohn e da retocolite ulcerativa idiopática e análise das suas características clínicas em um hospital universitário do sudeste do Brasil
SOUZA Marcellus Henrique L. P.,TRONCON Luiz Ernesto de A.,RODRIGUES Carla Maria,VIANA Cyntia F. G.
Arquivos de Gastroenterologia , 2002,
Abstract: Racional - A doen a de Crohn e a retocolite ulcerativa idiopática s o consideradas pouco freqüentes nos países em desenvolvimento, sendo escassos os estudos sobre a sua ocorrência no Brasil. Objetivos - Estudar a freqüência de admiss o de casos da doen a de Crohn e da retocolite ulcerativa inespecífica em um hospital universitário ao longo de 20 anos (1980-99) e descrever características demográficas e clínicas desses casos. Métodos - Calculou-se a freqüência de admiss o de casos da doen a de Crohn e da retocolite ulcerativa inespecífica de janeiro de 1980 a dezembro de 1999 e analisaram-se todos os casos destas doen as admitidos nos últimos 10 anos desse período. Resultados - No período estudado, registraram-se 257 casos novos, sendo 126 da doen a de Crohn e 131 da retocolite ulcerativa inespecífica. A freqüência de admiss o de casos de ambas as doen as aumentou de 40 para 61 casos/10.000 atendimentos, do primeiro para o segundo qüinqüênio, com menor crescimento subseqüente, sendo que a doen a de Crohn tornou-se, gradualmente, mais freqüente que a retocolite ulcerativa inespecífica. Em ambas as doen as, houve predomínio de casos do gênero feminino, na faixa etária entre 20 e 50 anos, da cor branca, do estado civil casado e de n o-tabagistas. Ambas as doen as apresentaram-se com os sintomas digestivos próprios e n o houve diferen as entre elas quanto às freqüências de manifesta es sistêmicas e extra-intestinais (29,5% vs 23,3%), incluindo as tromboembólicas (5,9% vs 5,5%). Na doen a de Crohn, 59,2% dos casos apresentaram complica es (obstru o e/ou perfura o), enquanto que 53,7% dos casos de retocolite ulcerativa inespecífica foram de formas mais graves. Nos casos de doen a de Crohn com obstru o, o tabagismo foi significativamente mais freqüente que nas formas n o-complicadas. Na retocolite ulcerativa inespecífica, as manifesta es sistêmicas e as extra-intestinais, bem como o acometimento de todo o cólon, foram significativamente mais freqüentes nas formas mais graves. Conclus es - Houve aumento da freqüência das doen as inflamatórias intestinais, com a doen a de Crohn tornando-se mais comum que a retocolite ulcerativa inespecífica. Tanto uma como outra das afec es, apresentaram-se com as características habituais, destacando-se o predomínio das formas mais graves.
Concomitant thyroid Malt lymphoma and papillary thyroid carcinoma
Melo, Giulianno Molina de;Sguilar, Danilo Anunciatto;Petiti, Cyntia Moniz Figueira;Eichstaedt, André Gustavo Gumz;Caiado, Rogério Ramos;Souza, Ricardo Antenor de Souza e;
Arquivos Brasileiros de Endocrinologia & Metabologia , 2010, DOI: 10.1590/S0004-27302010000400013
Abstract: the objective of this study was to describe the rare thyroid malt lymphoma concomitant with papillary thyroid carcinoma in a male patient who was submitted to total thyroidectomy. treatment and follow-up issues are addressed. male patient complains of fast thyroid enlargement without lymphadenophaty and normal clinical exams. total thyroidectomy was indicated and performed without any complications. the pathology showed multicentric papillary thyroid carcinoma, concomitant thyroid malt lymphoma and hashimoto's thyroiditis. the immunohistochemistry assay was positive for cd 20, cd 43, cd 79, ae1/ae3. the staging studies showed no evidence of both metastasis, ann harbor stage ie, without b symptoms. after rit no further radiotherapy or chemotherapy was indicated. nowadays the thyroglobulin is undetectable, without recurrences at two years of follow-up. it was concluded that primary thyroid malt lymphoma is uncommon being the papillary thyroid carcinoma more frequent. both occurring concomitantly is very rare and the treatment has to prioritize the tumor of worst prognosis at the discovery moment.
Desempenho de bovinos jovens alimentados com dietas contendo gr?o úmido de milho ou sorgo
Igarasi, Mauricio Scoton;Arrigoni, Mário de Beni;Souza, André Alves de;Silveira, Antonio Carlos;Martins, Cyntia Ludovico;Oliveira, Henrique Nunes de;
Revista Brasileira de Zootecnia , 2008, DOI: 10.1590/S1516-35982008000300017
Abstract: the differences on performance of young cattle fed diets with high moisture corn or sorghum were evaluated in two treatments, where the main energy source of the total diet was composed of high moisture corn (hmc) or sorghum (hms). ninety angus ′ nelore crossbred young bulls, averaging 8 month of age and 240 kg bw and fed during 172 days were allotted to two experimental treatments as a completely randomized design. no treatment effect on average daily gain, total weight gain and slaughter final weight was observed. regarding the carcass, ribeye area, subcutaneous fat thickness and rump fat thickness also did not differ between treatments. in conclusion, the totally replacement of high moisture corn by high moisture sorghum did not affect performance of feedlot young cattle.
Biochemical properties, enterohaemolysin production and plasmid carriage of Shiga toxin-producing Escherichia coli strains
Souza, Mario RSM;Klassen, Giseli;Toni, Fabiana De;Rigo, Liu U;Henkes, Caroline;Pigatto, Caroline P;Dalagassa, Cibelle de Borba;Fadel-Picheth, Cyntia MT;
Memórias do Instituto Oswaldo Cruz , 2010, DOI: 10.1590/S0074-02762010000300013
Abstract: thirty-eight strains of shiga toxin-producing escherichia coli (stec) were characterised in terms of biochemical properties, enterohaemolysin production and plasmid carriage. a wide variation in the biochemical properties was observed among the stec, with 14 distinct biotypes identified. biotype 1 was the most common, found in 29% of the strains. enterohaemolysin production was detected in 29% of the strains. most of the bacterial strains (95%) carried one or more plasmids and considerable heterogeneity in size and combinations was observed. seven distinct plasmid profiles were identified. the most common profile, characterised by the presence of a single plasmid of ~90 kb, was found in 50% of these strains. these data indicate extensive diversity among stec strains. no correlation was found among biotype, serotype, enterohaemolysin production and plasmid profile.
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