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Search Results: 1 - 10 of 7953 matches for " Cui DX "
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Egg white-mediated green synthesis of silver nanoparticles with excellent biocompatibility and enhanced radiation effects on cancer cells
Lu RQ, Yang DP, Cui DX, Wang ZY, Guo L
International Journal of Nanomedicine , 2012, DOI: http://dx.doi.org/10.2147/IJN.S29762
Abstract: g white-mediated green synthesis of silver nanoparticles with excellent biocompatibility and enhanced radiation effects on cancer cells Original Research (4604) Total Article Views Authors: Lu RQ, Yang DP, Cui DX, Wang ZY, Guo L Published Date April 2012 Volume 2012:7 Pages 2101 - 2107 DOI: http://dx.doi.org/10.2147/IJN.S29762 Received: 08 January 2012 Accepted: 21 February 2012 Published: 24 April 2012 Renquan Lu1, Dapeng Yang2, Daxiang Cui2, Zhongyang Wang3, Lin Guo1 1Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai, 2Department of Bio-Nano-Science and Engineering, National Key Laboratory of Nano/Micro Fabrication Technology, Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiao Tong University, Shanghai, 3College of Chemistry and Chemical Engineering, Yantai University, Shan Dong Province, People's Republic of China Abstract: A simple, cost-effective, and environmentally friendly approach to the aqueous-phase synthesis of silver (Ag) nanoparticles was demonstrated using silver nitrate (AgNO3) and freshly extracted egg white. The bio-conjugates were characterized by UV-visible spectroscopy, transmission electron microscopy, Fourier transform infrared spectrometry, and dynamic light scattering. These results indicated that biomolecule-coated Ag nanoparticles are predominantly spherical in shape with an average size of 20 nm. The proteins of egg white, which have different functional groups, played important roles in reducing Ag+ and maintaining product attributes such as stability and dispersity. In vitro cytotoxicity assays showed that these Ag-protein bio-conjugates showed good biocompatibility with mouse fibroblast cell lines 3T3. Furthermore, X-ray irradiation tests on 231 tumor cells suggested that the biocompatible Ag-protein bio-conjugates enhanced the efficacy of irradiation, and thus may be promising candidates for use during cancer radiation therapy.
RGD-conjugated gold nanorods induce radiosensitization in melanoma cancer cells by downregulating αvβ3 expression
Xu WC, Luo T, Li P, Zhou CQ, Cui DX, Pang B, Ren QS, Fu S
International Journal of Nanomedicine , 2012, DOI: http://dx.doi.org/10.2147/IJN.S28314
Abstract: onjugated gold nanorods induce radiosensitization in melanoma cancer cells by downregulating αvβ3 expression Original Research (3276) Total Article Views Authors: Xu WC, Luo T, Li P, Zhou CQ, Cui DX, Pang B, Ren QS, Fu S Published Date February 2012 Volume 2012:7 Pages 915 - 924 DOI: http://dx.doi.org/10.2147/IJN.S28314 Received: 16 November 2011 Accepted: 29 December 2011 Published: 27 February 2012 Wencai Xu1, Teng Luo2, Ping Li1, Chuanqing Zhou2, Daxiang Cui3, Bo Pang4, Qiushi Ren4, Shen Fu1 1Department of Radiation Oncology, Shanghai Sixth People's Hospital, 2School of Biomedical Engineering, and 3National Key Laboratory of Nano/Micro Fabrication Technology, Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiao Tong University, Shanghai, 4Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, People's Republic of China Background: Melanoma is known to be radioresistant and traditional treatments have been intractable. Therefore, novel approaches are required to improve the therapeutic efficacy of melanoma treatment. In our study, gold nanorods conjugated with Arg-Gly-Asp peptides (RGD-GNRs) were used as a sensitizer to enhance the response of melanoma cells to 6 mV radiation. Methods and materials: A375 melanoma cells were treated by gold nanorods or RGD-GNRs with or without irradiation. The antiproliferative impact of the treatments was measured by MTT assay. Radiosensitizing effects were determined by colony formation assay. Apoptosis and cell cycle data were measured by flow cytometry. Integrin αvβ3expression was also investigated by flow cytometry. Results: Addition of RGD-GNRs enhanced the radiosensitivity of A375 cells with a dose-modifying factor of 1.35, and enhanced radiation-induced apoptosis. DNA flow cytometric analysis indicated that RGD-GNRs plus irradiation induced significant G2/M phase arrest in A375 cells. Both spontaneous and radiation-induced expressions of integrin αvβ3 were downregulated by RGD-GNRs. Conclusion: Our study indicated that RGD-GNRs could sensitize melanoma A375 cells to irradiation. It was hypothesized that this was mainly through downregulation of radiation-induced αvβ3, in addition to induction of a higher proportion of cells within the G2/M phase. The combination of RGD-GNRs and radiation needs further investigation.
Biosynthesis of gold nanoparticles using chloroplasts
Zhang YX, Zheng J, Gao G, Kong YF, Zhi X, Wang K, Zhang XQ, Cui DX
International Journal of Nanomedicine , 2011, DOI: http://dx.doi.org/10.2147/IJN.S24785
Abstract: iosynthesis of gold nanoparticles using chloroplasts Methodology (4247) Total Article Views Authors: Zhang YX, Zheng J, Gao G, Kong YF, Zhi X, Wang K, Zhang XQ, Cui DX Published Date November 2011 Volume 2011:6 Pages 2899 - 2906 DOI: http://dx.doi.org/10.2147/IJN.S24785 Yi Xia Zhang1, Jun Zheng2, Guo Gao1, Yi Fei Kong1, Xiao Zhi1, Kan Wang1, Xue Qing Zhang1, Da Xiang Cui1 1Department of Bio-Nano-Science and Engineering, National Key Laboratory of Nano/Micro Fabrication Technology, Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiao Tong University, Shanghai, 2Wheat Research Institute, Academy of Agricultural Sciences, Linfen, Shan Xi, People's Republic of China Abstract: In this paper, a new method of one-pot biosynthesizing of gold nanoparticles (GNPs), using chloroplasts as reductants and stabilizers is reported. The as-prepared GNPs were characterized by ultraviolet visible spectroscopy, transmission electron microscopy, X-ray powder diffraction, and Fourier transform infrared spectroscopy (FTIR). The cytotoxicity of the GNPs was evaluated using the 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method against gastric mucous cell line GES-1 and gastric cancer cell line MGC-803. Rhodamine 6G as a Raman probe was used for investigating surface-enhanced Raman spectroscopy (SERS) enhancement of GNPs. The transmission electron microscopy results indicated that the GNPs were spherical in structure and almost 20 nm in diameter. Ultraviolet visible spectroscopy exhibited an absorption peak at 545 nm. The GNPs exhibited high crystallinity, with the (111) plane as the predominant orientation, clarified by X-ray powder diffraction. In addition, a potential mechanism was proposed to interpret the formation process of GNPs, mainly based on the analysis of FTIR results. The FTIR spectrum confirmed that the GNPs were carried with N–H groups. Toxicological assays of as-prepared GNPs revealed that the green GNPs were nontoxic. SERS analysis revealed that the GNPs without any treatment could substantially enhance the Raman signals of rhodamine 6G. The Raman enhancement factor was calculated to be nearly 1010 orders of magnitude. In conclusion, the GNPs with good biocompatibility and excellent SERS effect were successfully synthesized using chloroplasts. These biogenetic GNPs have great potential for ultrasensitive detection of biomarkers in vitro and in vivo based on SERS.
Bayesian Factorized Cointegration Analysis  [PDF]
Kai Cui, Wenshan Cui
Open Journal of Statistics (OJS) , 2012, DOI: 10.4236/ojs.2012.25065
Abstract: The concept of cointegration is widely used in applied non-stationary time series analysis to describe the co-movement of data measured over time. In this paper, we proposed a Bayesian model for cointegration test and analysis, based on the dynamic latent factor framework. Efficient computational algorithms are also developed based on Markov Chain Monte Carlo (MCMC). Performance and efficiency of the the model and approaches are assessed by simulated and real data analysis.
Spike-and-Slab Dirichlet Process Mixture Models  [PDF]
Kai Cui, Wenshan Cui
Open Journal of Statistics (OJS) , 2012, DOI: 10.4236/ojs.2012.25066
Abstract: In this paper, Spike-and-Slab Dirichlet Process (SS-DP) priors are introduced and discussed for non-parametric Bayesian modeling and inference, especially in the mixture models context. Specifying a spike-and-slab base measure for DP priors combines the merits of Dirichlet process and spike-and-slab priors and serves as a flexible approach in Bayesian model selection and averaging. Computationally, Bayesian Expectation-Maximization (BEM) is utilized to obtain MAP estimates. Two simulated examples in mixture modeling and time series analysis contexts demonstrate the models and computational methodology.
Bayesian Markov Regime-Switching Models for Cointegration  [PDF]
Kai Cui, Wenshan Cui
Applied Mathematics (AM) , 2012, DOI: 10.4236/am.2012.312259
Abstract: This paper introduces a Bayesian Markov regime-switching model that allows the cointegration relationship between two time series to be switched on and off over time. Unlike classical approaches for testing and modeling cointegration, the Bayesian Markov switching method allows for estimation of the regime-specific model parameters via Markov Chain Monte Carlo and generates more reliable estimation. Inference of regime switching also provides important information for further analysis and decision making.
Isolation of dimorphic chloroplasts from the single-cell C4 species Bienertia sinuspersici
Shiu-Cheung Lung, Makoto Yanagisawa, Simon DX Chuong
Plant Methods , 2012, DOI: 10.1186/1746-4811-8-8
Abstract: The majority of terrestrial plants house chloroplasts primarily in one major cell type of leaves (i.e. mesophyll cells), and perform C3 photosynthesis to assimilate atmospheric CO2 into a 3-carbon product, 3-phosphoglyceric acid. In C4 species, on the other hand, a Kranz-type leaf anatomy featuring the second type of chlorenchyma cells surrounding the vascular bundles (i.e. bundle sheath cells) was reported as early as in the late 1800's [1]. In these species, the initial carbon fixation into 4-carbon acids was first documented in the 1960's [2,3]. The physiological relevance of the Kranz anatomy in relation to the C4 photosynthetic pathways, however, had not been elucidated until the successful separation of the two types of chlorenchyma cells and their respective dimorphic chloroplasts. With the development of various mechanical and enzymatic methods for separating the mesophyll and bundle sheath cells, the biochemistry of C4 cycles has been intensively studied over the past few decades focusing explicitly on characterizing the enzymatic properties and determining their precise subcellular locations in these cell types (for review, see [4]), leading to the current C4 models. In the C4 model, atmospheric CO2 is initially converted into C4 acids by phosphoenolpyruvate carboxylase (PEPC) in mesophyll cells. The C4 acids are broken down by a C4 subtype-specific decarboxylation enzyme in bundle sheath cells, and the liberated CO2 is subsequently re-fixed by ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco). The C4 pathway concentrates CO2 at the site of Rubisco and minimizes the photorespiration process, an unfavorable oxygenase activity of Rubisco with O2.The indispensable relationship between the Kranz anatomy and C4 photosynthesis has been an accepted feature until the discovery of three terrestrial single-cell C4 species, Suaeda aralocaspica (formerly called Borszczowia aralocaspica) [5], Bienertia cycloptera [6,7], and B. sinuspersici [8] in the Chenopodia
A COMPONENT-SPECIFIC ALLOY DESIGN OF TiAl INTERMETALLICS
JZhang,DX Zou,ZZ Zhang,Z Y Zhong,

金属学报(英文版) , 1996,
Abstract: ACOMPONENT-SPECIFICALLOYDESIGNOFTiAlINTERMETALLICSJ.Zhang;D.X.Zou;Z.Z.ZhangandZ.YZhong(CentralIron&SteelResearchInstitute,Bei...
Improvement of Mechanical Properties of Martensitic Stainless Steel by Plasma Nitriding at Low Temperature

YT Xi,DX Liu,D Han,ZF Han,

金属学报(英文版) , 2008,
Abstract: A series of experiments were carried out to study the influence of low temperature plasma nitriding on the mechanical properties of AISI 420 martensitic stainless steel. Plasma nitriding ezperiments were carried out for 15 h at 350℃ by means of DC-pulsed plasma in 25%N2 75%H2 atmosphere. The microstructure, phase composition, and residual stresses profiles of the nitrided layers were determined by optical microscopy and X-ray diffraction. The microhardness profiles of the nitridied surfaces were also studied. The fatigue life, sliding wear, and erosion wear loss of the untreated specimens and plasma nitriding specimens were determined on the basks of a rotating bending fatigue tester, a ball-on-disc wear tester, and a solid particle erosion tester. The results show that the 350℃ nitrided surface is dominated by ε-Fe3N and αN, which is supersaturated nitrogen solid solution. They have high hardness and chemical stabilities. So the low temperature plasma nitriding not only increases the surface hardness values but also improves the wear and erosion resistance. In addition, the fatigue limit of AISI 420 steel can also be improved by plasma nitriding at 350℃ because plasma nitriding produces residual compressive stress inside the modified layer.
Research on Video on Demand Based on P2P Network  [PDF]
Min Cui
Intelligent Information Management (IIM) , 2010, DOI: 10.4236/iim.2010.25041
Abstract: A P2P approaches to extend the ability of Video on Demand systems to serve more users. In the proposed system users share with each other the media data obtained and the media server is no longer the only source to get data from, thereby, the load on the media server could be greatly alleviated and the overall system capacity increases and more users could be served. The P2P streaming system introduces efficient searching; data transfer dynamically monitoring and initial buffering to maintain a high quality of playback. Its provider selection policy helps to reduce the load of the underlying network by avoiding remote data transfer.
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