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Search Results: 1 - 10 of 513 matches for " Csaba Csonka "
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Dietary red palm oil supplementation decreases infarct size in cholesterol fed rats
Gergo Szucs, Dirk J Bester, Krisztina Kupai, Tamas Csont, Csaba Csonka, Adriaan J Esterhuyse, Peter Ferdinandy, Jacques Van Rooyen
Lipids in Health and Disease , 2011, DOI: 10.1186/1476-511x-10-103
Abstract: Male Wistar rats were fed either a standard rat chow diet (Norm) or a 2% cholesterol-enriched diet (Chol) for nine weeks. Additionally, two more groups received the same treatment, however, at the week 4, diet was supplemented with RPO for the last five weeks (Norm+RPO and Chol+RPO), respectively. After the feeding period hearts were isolated, perfused according to Langendorff and subjected to 30 minutes of normothermic global ischaemia followed by two hours of reperfusion. Infarct size was measured by 2,3,5-triphenyltetrazolium chloride staining at the end of reperfusion.Cholesterol-enriched diet increased myocardial infarct size from 23.5 ± 3.0% to 37.2 ± 3.6% (p < 0.05) when compared to normal diet. RPO supplementation significantly reduced infarct size either in Norm+RPO or in Chol+RPO (to 9.2 ± 1.0% and 26.9 ± 3.0%), respectively. Infarct size in Chol+RPO was comparable to the Norm group. MMP2 activity before ischaemia was significantly reduced in the Chol+RPO group when compared to the Chol group. However, the MMP2 activity of the hearts of the RPO fed rats was significantly increased when compared to the normal diet group after ischaemia.For the first time it was shown that dietary RPO supplementation attenuated the increased susceptibility of the hearts in cholesterol fed rats to ischaemia/reperfusion injury. This was shown by reduced infarct size. For the first time we also show that red palm oil supplementation altered pre-ischaemic levels of MMP-2, which may indicate that myocardial MMP2 may be implicated as a possible role player in RPO mediated protection against ischaemia/reperfusion injury in hearts of cholesterol supplemented rats.Many cardiovascular ischaemia/reperfusion injury studies use healthy rats for their research protocols. In clinical conditions, unhealthy diets and lifestyle are normally associated with increased risk of myocardial infarction [1]. Previous studies using healthy animals contributed to elucidating certain mechanisms of cardi
Dietary red palm oil supplementation reduces myocardial infarct size in an isolated perfused rat heart model
Dirk J Bester, Krisztina Kupai, Tamas Csont, Gergu Szucs, Csaba Csonka, Adriaan J Esterhuyse, Peter Ferdinandy, Jacques Van Rooyen
Lipids in Health and Disease , 2010, DOI: 10.1186/1476-511x-9-64
Abstract: Male Wistar rats were divided into three groups and fed a standard rat chow diet (SRC), a SRC supplemented with RPO, or a SRC supplemented with sunflower oil (SFO), for a five week period, respectively. After the feeding period, hearts were excised and perfused on a Langendorff perfusion apparatus. Hearts were subjected to thirty minutes of normothermic global ischaemia and two hours of reperfusion. Infarct size was determined by triphenyltetrazolium chloride staining. Coronary effluent was collected for the first ten minutes of reperfusion in order to measure MMP2 activity by gelatin zymography.Dietary RPO-supplementation decreased myocardial infarct size significantly when compared to the SRC-group and the SFO-supplemented group (9.1 ± 1.0% versus 30.2 ± 3.9% and 27.1 ± 2.4% respectively). Both dietary RPO- and SFO-supplementation were able to decrease MMP2 activity when compared to the SRC fed group. PKB/Akt phosphorylation (Thr 308) was found to be significantly higher in the dietary RPO supplemented group when compared to the SFO supplemented group at 10 minutes into reperfusion. There was, however, no significant changes observed in ERK phosphorylation.Dietary RPO-supplementation was found to be more effective than SFO-supplementation in reducing myocardial infarct size after ischaemia/reperfusion injury. Both dietary RPO and SFO were able to reduce MMP2 activity, which suggests that MMP2 activity does not play a major role in protection offered by RPO. PKB/Akt phosphorylation may, however, be involved in RPO mediated protection.Little is known about the effects of dietary edible oil supplementation on myocardial infarct size. Previous studies demonstrated that dietary RPO supplementation offers protection against ischaemia/reperfusion injury by improved aortic output recovery [1-4]. Engelbrecht and co-workers (2006) found that 6 weeks of dietary RPO supplementation was associated with increased PKB/Akt and p38 phosphorylation and decreased phosphorylation of
Problems with classification of spa waters used in balneology  [PDF]
Csaba Varga
Health (Health) , 2010, DOI: 10.4236/health.2010.211187
Abstract: Recently, several measurements have indicated the presence of biologically active organic micropollutants or trace components in different types of waters, including spa and medicinal waters. The wide spectrum and abundance of organic components of spa waters in the Carpathian basin and other European regions has been demonstrated by gas-chromatographic analyses. These components may have main role in the therapeutic and preventive mechanisms. Considering the new analytical data, traditional European classification of spa waters based on the quality and quantity of inorganic ions (salts) should be reevaluated. The association of inorganic components and the therapeutic effects is also necessary to reconsider.
Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats
Márta Sárk?zy, ágnes Zvara, Nóra Gyémánt, Veronika Fekete, Gabriella F Kocsis, Judit Pipis, Gerg? Sz?cs, Csaba Csonka, László G Puskás, Péter Ferdinandy, Tamás Csont
Cardiovascular Diabetology , 2013, DOI: 10.1186/1475-2840-12-16
Abstract: Fasting blood glucose, serum insulin, cholesterol and triglyceride levels were measured at 6, 16, and 25 wk of age in male ZDF and lean control rats. Oral glucose tolerance test was performed at 16 and 25 wk of age. At week 25, total RNA was isolated from the myocardium and assayed by rat oligonucleotide microarray for 14921 genes. Expression of selected genes was confirmed by qRT-PCR.Fasting blood glucose, serum insulin, cholesterol and triglyceride levels were significantly increased, glucose tolerance and insulin sensitivity were impaired in ZDF rats compared to leans. In hearts of ZDF rats, 36 genes showed significant up-regulation and 49 genes showed down-regulation as compared to lean controls. Genes with significantly altered expression in the heart due to metabolic syndrome includes functional clusters of metabolism (e.g. 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2; argininosuccinate synthetase; 2-amino-3-ketobutyrate-coenzyme A ligase), structural proteins (e.g. myosin IXA; aggrecan1), signal transduction (e.g. activating transcription factor 3; phospholipase A2; insulin responsive sequence DNA binding protein-1) stress response (e.g. heat shock 70kD protein 1A; heat shock protein 60; glutathione S-transferase Yc2 subunit), ion channels and receptors (e.g. ATPase, (Na+)/K+ transporting, beta 4 polypeptide; ATPase, H+/K+ transporting, nongastric, alpha polypeptide). Moreover some other genes with no definite functional clusters were also changed such as e.g. S100 calcium binding protein A3; ubiquitin carboxy-terminal hydrolase L1; interleukin 18. Gene ontology analysis revealed several significantly enriched functional inter-relationships between genes influenced by metabolic syndrome.Metabolic syndrome significantly alters cardiac gene expression profile which may be involved in development of cardiac pathologies in the presence of metabolic syndrome.
One World, One Reality, and the Everett Relaltive State Interpretation of Quantum Mechanics
Paul L. Csonka
Physics , 2009,
Abstract: We modify the Relative State Interpretation (RSI) of Quantum Mechanics so that it does not imply many worlds and parallel realities. We drop the assumption that probability amplitudes correspond one-to-one with reality: Not all information is contained in amplitudes, and not all amplitudes need be realized. Amplitudes do not "collapse" after a measurement, but evolve continuously, including unrealized ones. After each "event" only one possible outcome is realized. Therefore, if a value is measured, that value is real, all others are not; there is only one reality and one world. Reality content is "quantized" : unity for realized outcomes, zero for all others. It is "conserved": can move along any possible sequence of events, but only one at a time. The modified RSI is is strictly deterministic in the sense that the "global" probability amplitudes of the universe are determined for all times by the laws of physics and the initial conditions. They guide all events. But it is not deterministic in the sense that from the amplitudes one can not predict which outcome actually happens; that represents new information that accumulates as history unfolds. To the extent that information is part of the physical world, the coming into being of the universe is ongoing, even after the Big Bang. All predictions of the two versions agree, except possibly in esoteric, untested cases.
Pricing of a Risk Averse Monopoly in the Presence of Stochastic Demand  [PDF]
Kolos Csaba ágoston
Theoretical Economics Letters (TEL) , 2015, DOI: 10.4236/tel.2015.52026
Abstract: In the paper, we investigate the pricing behavior of a risk averse monopoly. Since the focus is on the risk averse attitude of the firm, we ignore cost in our model. Demand is considered to be stochastic demand: as price decreases, the expected number of customers increases, but it has a variation. Although demand is uncertain, it relates to the aggregation method of individual demands and the individual demand has the usual form. In our framework a risk neutral (or profit maximizer) monopoly does not change the product’s price as the number of clients increases. On product markets the risk averse monopoly with DARA utility function always increases the price as the number of clients grows, but in insurance markets the implication can be the opposite: the price of insurance may decrease as the number of clients increases.
An examination of the correlations between the institutional development and application level of e-learning and the elabortion of electronic learning materials at the Eszterházy Károly College
Komlo Csaba
Technológia vzdelávania , 2011,
Abstract: Andrew H. Rosen (2004) and Stephen Gilfus (2010) established five main levels of the evolution of e-Learning in higher education institutions in addition to four transitory stages between the respective levels. This e-Learning development model enables a higher education institution to define its progress on the continuum of e-Learning adaptation along with outlining the tasks required for achieving the next level. In this paper I would like to show the correlation between the developmental level of the given e-Learning system and the educational material elaboration process. As a conclusion it must be noted, that this type of learning can be effective only if both components are approximately at the same level of development.
The Kaizen principle of personality
Csaba Titkos
Perspectives of Innovations, Economics and Business , 2012,
Abstract: The study deals with a new aspect of training and development. By defining the validity and the competencies of the training method, the importance and the possible methodology of personality development are introduced. It is assumed that a mature personality, as a product of the individualizing process described by Jung, is a behavior-determining competency. Depending on the situation at times teaching is needed, at other times trainings, or in other cases the causes of failure related to behavior should be analyzed. If cognitive understanding is to be influenced, a teaching method should be applied, if behavioral change is aimed at, training is to be implemented, and if the causes of the behavior are to be explored other methods should be found
Computing nilpotent quotients in finitely presented Lie rings
Csaba Schneider
Discrete Mathematics & Theoretical Computer Science , 1997,
Abstract: A nilpotent quotient algorithm for finitely presented Lie rings over Z (and Q) is described. The paper studies the graded and non-graded cases separately. The algorithm computes the so-called nilpotent presentation for a finitely presented, nilpotent Lie ring. A nilpotent presentation consists of generators for the abelian group and the products expressed as linear combinations for pairs formed by generators. Using that presentation the word problem is decidable in L. Provided that the Lie ring L is graded, it is possible to determine the canonical presentation for a lower central factor of L. Complexity is studied and it is shown that optimising the presentation is NP-hard. Computational details are provided with examples, timing and some structure theorems obtained from computations. Implementation in C and GAP interface are available.
COMPETITIVENESS AND INNOVATION OF THE ROMANIAN COMPANIES
Csaba Nagy
Annals of the University of Oradea : Economic Science , 2010,
Abstract: In front of the Romanian economy which has been integrated only for a few years, lies the challenge of competitiveness which in many cases is associated with innovation. To turn from a close center oriented economy to market economy required an enormous effort from the population and from the companies as well, but the real challenge is still to come. The requirements of competitiveness and innovation of the United European Market are compulsory, from the point of view of the Romanian entrepreneurs is vital for their survival and development. The studies made so far are not very promising. There are many things to be done, many problems are still not solved in the European Union. The European Union is behind its traditional competitors USA and Japan. This is why one of the major concerns of the EU is competitiveness and innovation.
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