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Search Results: 1 - 10 of 10726 matches for " Craig Ivanyi and Chris Shaw "
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Proteomic and Genomic Studies on Lizard Venoms in the Last Decade
Hang Fai Kwok, Craig Ivanyi, Andrew Morris and Chris Shaw
Proteomics Insights , 2012, DOI: 10.4137/PRI.S3693
Abstract: Traditionally man has looked to nature to provide cures for diseases. This approach still exists today in the form of ‘bio-prospecting’ for therapeutically-active compounds in venoms. For example, the venoms of many reptiles offer a spectacular laboratory of bioactive molecules, including peptides and proteins. In the last 10–15 years, there have been a number of major proteomic and genomic research breakthroughs on lizard venoms. In this current review, the key findings from these proteomic and genomic studies will be critically discussed and suggestions will be offered for future focused investigations. It is our intention that this article will not only provide a comprehensive picture of the state of current knowledge of the components of lizard venoms, but also engender awareness in readers of the need to protect and conserve such uniquely precious natural resources for several reasons, including the potential benefit of humankind.
DNA in Amphibian and Reptile Venom Permits Access to Genomes Without Specimen Sacrifice
Hang Fai Kwok, Tianbao Chen, Craig Ivanyi and Chris Shaw
Genomics Insights , 2012,
Abstract: Amphibian defensive skin secretions and reptile venoms are rich sources of bioactive peptides with potential pharmacological/pharmaceutical applications. As amphibian and reptile populations are in rapid global decline, our research group has been developing analytical methods that permit generation of robust molecular data from non-invasive skin secretion samples and venom samples. While previously we have demonstrated that parallel proteome and venom gland transcriptome analyses can be performed on such samples, here we report the presence of DNA that facilitates the more widely-used applications of gene sequencing, such as molecular phylogenetics, in a non-invasive manner that circumvents specimen sacrifice. From this “surrogate” tissue, we acquired partial 12S and 16S rRNA gene sequences that are presented for illustration purposes. Thus from a single sample of amphibian skin secretion and reptile venom, robust and complementary proteome, transcriptome and genome data can be generated for applications in diverse scientific disciplines.
The use of monoclonal antibodies for the characterization and production of Mycobacterium leprae antigens
Ivanyi, J.;
Memórias do Instituto Oswaldo Cruz , 1987, DOI: 10.1590/S0074-02761987000600022
Abstract: similar immunizations of mice and hybridoma technology were used by several investigators to raise monoclonal antibodies which identified a limited range of epitopes and antigenic molecules. further studies would have the scope for revealing yet more novel structures. the existing mabs are agreed standard reagents, avaiable to investigators and valuable for several applications. at least six epitopes specific for m. leprae were defined in molecular terms. monoclonal antibody based immunoassays proved to be invaluable for the screening of recombinant dna clones and for the topographic study of individual epitopes. purification of antigens using affinity chromatography requires further development of techniques whilst serology of leprosy is open for clinical and epidemiological evaluation.
FIFO anomaly is unbounded
Peter Fornai,Antal Ivanyi
Computer Science , 2010,
Abstract: Virtual memory of computers is usually implemented by demand paging. For some page replacement algorithms the number of page faults may increase as the number of page frames increases. Belady, Nelson and Shedler constructed reference strings for which page replacement algorithm FIFO produces near twice more page faults in a larger memory than in a smaller one. They formulated the conjecture that 2 is a general bound. We prove that this ratio can be arbitrarily large.
Assessment of tissue oxygen tension: comparison of dynamic fluorescence quenching and polarographic electrode technique
Andrew D Shaw, Zheng Li, Zach Thomas, Craig W Stevens
Critical Care , 2002, DOI: 10.1186/cc1457
Abstract: Both systems measured PO2 accurately in the tonometer, and there was excellent correlation between them (r2 = 0.99). The polarographic system exhibited proportional bias that was not evident with the fluorescence method. In vivo, the fluorescence quenching technique provided a readily recordable signal that varied as expected.Measurement of tissue PO2 using fluorescence quenching is at least as accurate as measurement using the Eppendorf needle electrode in vitro, and may prove useful in vivo for assessment of tissue oxygenation.Accurate measurement of PO2 in biologic tissues has been of interest to both researchers and clinicians for many years [1]. For basic scientists measurement of PO2 provides insight into the complexities of oxygen flux at the tissue level, whereas for clinicians it moves the monitoring window a step closer to the cell. PO2 monitoring has been exploited most effectively by radiation oncologists, who have used intratumoral PO2 measurements to plan and guide radiotherapy [2]. Many articles in the anesthesia and critical care literature report the application of different technologies designed to measure tissue PO2[1,3,4,5,6,7,8,9,10,11,12,13,14], but the clinical use of PO2 measurement has largely been limited to assessment of brain tissue [15,16].Existing technologies for measuring tissue PO2 are either too expensive for everyday clinical use [14] or are based on polarographic principles [17], meaning that oxygen is consumed in the measurement process. In time this oxygen consumption affects the signal itself, and this effect persists as tissue PO2 decreases, perhaps making polarographic devices less suitable for detection of tissue hypoxia. We hypothesized that a PO2 measurement technique based on dynamic fluorescence quenching would provide a way to overcome the limitations of the current polarographic technique. We report here a head-to-head bench comparison of PO2 measurement using polarography versus measurement using dynamic fluorescence
Mixing of scalar glueballs and flavour-singlet scalar mesons
UKQCD Collaboration,Craig McNeile,Chris Michael
Physics , 2000, DOI: 10.1103/PhysRevD.63.114503
Abstract: We discuss in detail the extraction of hadronic mixing strengths from lattice studies. We apply this to the mixing of a scalar glueball and a scalar meson in the quenched approximation. We also measure correlations appropriate for flavour-singlet scalar mesons using dynamical quark configurations from UKQCD. This enables us to compare the results from the quenched study of the mixing with the direct determination of the mixed spectrum. Improved methods of evaluating the disconnected quark diagrams are also presented.
Hadron spectroscopy of twisted mass lattice QCD at beta = 6.0
UKQCD collaboration,Craig McNeile,Chris Michael
Physics , 2001, DOI: 10.1016/S0920-5632(01)01679-6
Abstract: Simulations that use the clover action in quenched QCD calculations have a lower limit to the quark mass that can be reached, because of the fluctuations caused by exceptional configurations. From this low statistics study, we find that the twisted clover action, recently introduced by the ALPHA collaboration, can be used to simulate quenched QCD at quark masses below those attainable by simulations that use the clover action.
Secure and Verifiable Electronic Voting in Practice: the use of vVote in the Victorian State Election
Craig Burton,Chris Culnane,Steve Schneider
Computer Science , 2015,
Abstract: The November 2014 Australian State of Victoria election was the first statutory political election worldwide at State level which deployed an end-to-end verifiable electronic voting system in polling places. This was the first time blind voters have been able to cast a fully secret ballot in a verifiable way, and the first time a verifiable voting system has been used to collect remote votes in a political election. The code is open source, and the output from the election is verifiable. The system took 1121 votes from these particular groups, an increase on 2010 and with fewer polling places.
Large Magellanic Cloud Planetary Nebula Morphology: Probing Stellar Populations and Evolution
Letizia Stanghellini,Richard A. Shaw,Bruce Balick,J. Chris Blades
Physics , 2000, DOI: 10.1086/312667
Abstract: Planetary Nebulae (PNe) in the Large Magellanic Cloud (LMC) offer the unique opportunity to study both the Population and evolution of low- and intermediate-mass stars, by means of the morphological type of the nebula. Using observations from our LMC PN morphological survey, and including images available in the HST Data Archive, and published chemical abundances, we find that asymmetry in PNe is strongly correlated with a younger stellar Population, as indicated by the abundance of elements that are unaltered by stellar evolution (Ne, Ar, S). While similar results have been obtained for Galactic PNe, this is the first demonstration of the relationship for extra-galactic PNe. We also examine the relation between morphology and abundance of the products of stellar evolution. We found that asymmetric PNe have higher nitrogen and lower carbon abundances than symmetric PNe. Our two main results are broadly consistent with the predictions of stellar evolution if the progenitors of asymmetric PNe have on average larger masses than the progenitors of symmetric PNe. The results bear on the question of formation mechanisms for asymmetric PNe, specifically, that the genesis of PNe structure should relate strongly to the Population type, and by inference the mass, of the progenitor star, and less strongly on whether the central star is a member of a close binary system.
Identification of HCV Inhibitors from a Cell-Based Sub-Genomic Replicon Screen  [PDF]
David C. Pryde, Thien-Duc Tran, Mark Gardner, Chris Pickford, Stephen M. Shaw, Mike Westby, Tanya Parkinson, Caroline Smith-Burchnell, Rob Webster, Satish Dayal
Open Journal of Medicinal Chemistry (OJMC) , 2013, DOI: 10.4236/ojmc.2013.31003

A high throughput screen of the Pfizer compound collection was carried out using a hepatitis C virus (HCV) genotype 1b subgenomic replicon cell line. Those confirmed hits that demonstrated broad spectrum activity without overt cytotoxicity were further evaluated, leading to the identification of a series of pyrrolopyridines with excellent antiviral activity in a fully infectious HCV cell-based assay and pharmacokinetic properties.

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