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Search Results: 1 - 10 of 167871 matches for " Coskun E "
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Oxidative Stress and Mitochondrial Dysfunction in Down’s Syndrome: Relevance to Aging and Dementia
Pinar E. Coskun,Jorge Busciglio
Current Gerontology and Geriatrics Research , 2012, DOI: 10.1155/2012/383170
Abstract: Genome-wide gene deregulation and oxidative stress appear to be critical factors determining the high variability of phenotypes in Down’s syndrome (DS). Even though individuals with trisomy 21 exhibit a higher survival rate compared to other aneuploidies, most of them die in utero or early during postnatal life. While the survivors are currently predicted to live past 60 years, they suffer higher incidence of age-related conditions including Alzheimer’s disease (AD). This paper is centered on the mechanisms by which mitochondrial factors and oxidative stress may orchestrate an adaptive response directed to maintain basic cellular functions and survival in DS. In this context, the timing of therapeutic interventions should be carefully considered for the successful treatment of chronic disorders in the DS population. 1. Introduction Down’s syndrome (DS) or trisomy 21 is a prevalent genetic cause of intellectual disability due to full or partial triplication of chromosome 21 (HSA21). The presentation varies greatly between individuals. The molecular bases of this variation is “the gene dosage effect” caused by the extra chromosome 21, which leads to a global imbalance on gene expression [1]. However, the molecular mechanisms by which such gene dosage imbalance causes DS-specific abnormalities remain unclear. Albeit trisomy 21 is the most common aneuploidy that infants can survive, the rate of miscarriage of fetuses with DS during the first trimester is almost 50% [2]. The survival rate for the first 18 years of life of DS individuals is 50.3% of the total DS population, and the greatest percent of deaths is observed during the first 5 years of life (35.9%). The death rate drops to 13.1% between 19 and 40 years, and DS individuals of 40+ years have a greater chance to live beyond 60 years of age in developed countries, especially those without congenital heart disease [3]. A remarkable feature of the syndrome is the presence of Alzheimer’s disease (AD) neuropathology in the brain of nearly all DS individuals, the majority of which develop dementia with age [4]. Besides dementia, other aging features appear prematurely such as cataracts, diabetes, hair graying, leukemia, and hearing and visual impairment. Together, they define DS as a “segmental progeroid syndrome” [5–7]. Mitochondria represent both a principal source as well as a target of free radicals, which in turn cause structural damage and activate signaling pathways associated with ageing and age-related diseases [8–10]. Both oxidative stress and mitochondrial dysfunction are prominent features of
Botulinum toxin injections for blepharospasm prior to ocular surgeries
Okumus S,Coskun E,Erbagci ?,Tatar MG
Clinical Ophthalmology , 2012,
Abstract: Seydi Okumus1, Erol Coskun1, brahim Erbagci1, M Gürkan Tatar2, Aysegul Comez1, Erdal Kaydu1, Ramazan Yayuspayi1, Bulent Gurler11Department of Ophthalmology, University of Gaziantep, 2Ophthalmology Clinic, Nizip State Hospital, Nizip, Gaziantep, TurkeyPurpose: The aim of this study was to show the efficiency of preoperative botulinum toxin A (Botox A) in patients with benign essential blepharospasm who were to undergo ocular surgery with local anesthesia.Materials and methods: Twenty-eight benign essential blepharospasm patients who were administered unilateral Botox A prior to ocular surgery between January 2004 and May 2011 were included in this study. Eleven cases had pterygiums, ten had cataracts, and four had glaucomas, while the remaining three had aphakia. All cases’ severity of spasm (stage 0–4) and eyelid closing forces (stage 1–4) were evaluated according to the Jankovic scale prior to the injection, at 3 days, 14 days, 1 month, and 3 months after Botox A injection.Results: Of the patients enrolled in the study, 16 were female and 12 were male, with an average age of 55.52 ± 1.53 years (52–65). Average onset of the Botox injection's effect was 2.8 ± 0.9 (2–5) days. Its effect lingered for about 11.5 ± 3.6 (8–22) weeks. The severity of spasm and eyelid closing forces of all the patients enrolled were compared prior to the injection at 3 and 14 days and the first and third months after the injection. There were statistically significant differences between prior to the injection and 3 days (P = 0.001), 14 days (P < 0.001) and 1 month after the injection (P <0.001). There was no statistically significant difference between prior to the injection and 3 months after the injection (P = 0.513). Fourteen days following the injection, the surgeries were successfully performed.Conclusion: Botox A administered prior to ocular surgery will control both blepharospasm and lower the risks that can be encountered before and during surgery, thus increasing the comfort of the patient and the surgeon.Keywords: botulinum toxin A, blepharospasm, ocular surgery
On the Inverse Problem of Dupire’s Equation with Nonlocal Boundary and Integral Conditions  [PDF]
Coskun Guler, Volkan Oban
Journal of Mathematical Finance (JMF) , 2017, DOI: 10.4236/jmf.2017.74051
Abstract: In this study, Inverse Problem for Dupire’s Equation with nonlocal boundary and integral conditions is studied. Then, by means of the some transformation, this equation is converted to diffusion equation. The conditions for the existence and uniqueness of a classical solution of the problem under consideration are established and continuous dependence of (p, v) on the data is shown. It is emphasized that this problem is well-posed.
Cold Therapy in Migraine Patients: Open-label, Non-controlled, Pilot Study
Serap Ucler,Ozlem Coskun,Levent E. Inan,Yonca Kanatli
Evidence-Based Complementary and Alternative Medicine , 2006, DOI: 10.1093/ecam/nel035
Abstract: Some patients with headache report that they have frequently used physical therapies such as application of cold to relieve their headache. There are only a few reported studies related to cold therapies in patients with migraine. In this study, we investigated the effect of cold application on migraine patients. Twenty-eight migraine patients were included. Cold therapy was administered to them by gel cap. Patients used this cap during their two migraine attacks. Before and after the cold therapy, headache severity was recorded by using visual analogue scale (VAS). Patients used this cap for 25 min in each application. They recorded their VAS score just after the therapy and 25 min, 1 h, 2 h and 3 h later. Two patients could not use this therapy due to side effects (one due to cold intolerance and one due to vertigo) in both applications. Therefore, therapeutic efficacy was evaluated in 26 patients. Twenty-five minutes after treatment of the first attack, VAS score was decreased from 7.89 ± 1.93 to 5.54 ± 2.96 (P < 0.01). Twenty-five minutes after treatment of the second attack, VAS score was decreased from 7.7 ± 1.8 to 5.4 ± 3.55 (P < 0.01). Cold application alone may be effective in some patients suffering from migraine attacks. Its combination with conventional drugs should be investigated in future studies.
Using Rerouting to Improve Aggregate Based Resource Allocation
Ali E. Helvaci,Coskun Cetinkaya,Mehmet B. Yildirim
Journal of Networks , 2008, DOI: 10.4304/jnw.3.6.1-12
Abstract: This paper studies the effect of rerouting for augmenting aggregate based resource allocation in the trade-off between overhead and utilization. Aggregation is a common approach used to address the scalability issue in resource allocation. However, resources committed in bulk may be under utilized while other resource requests are being turned down for lack of resources in some shared links. The aim of rerouting is to free up committed resources for better utilization by reusing resources vacated by terminated flows and by moving existing flows to alternative paths. Our results show that rerouting improves performance over a wide range of network loads on two different network topologies.
Delegated dynamic portfolio management under mean-variance preferences
Coskun Cetin
Advances in Decision Sciences , 2006, DOI: 10.1155/jamds/2006/61895
Abstract: We consider a complete financial market with deterministic parameters where an investor and a fund manager have mean-variance preferences. The investor is allowed to borrow with risk-free rate and dynamically allocate his wealth in the fund provided his holdings stay nonnegative. The manager gets proportional fees instantaneously for her management services. We show that the manager can eliminate all her risk, at least in the constant coefficients case. Her own portfolio is a proportion of the amount the investor holds in the fund. The equilibrium optimal strategies are independent of the fee rate although the portfolio of each agent depends on it. An optimal fund weight is obtained by the numerical solution of a nonlinear equation and is not unique in general. In one-dimensional case, the investor's risk is inversely proportional to the weight of the risky asset in the fund. We also generalize the problem to the case of multiple managers and provide some examples.
Relocating Sensor Nodes to Maximize Cumulative Connected Coverage in Wireless Sensor Networks
Vedat Coskun
Sensors , 2008, DOI: 10.3390/s8042792
Abstract: In order to extend the availability of the wireless sensor network and to extract maximum possible information from the surveillance area, proper usage of the power capacity of the sensor nodes is important. Our work describes a dynamic relocation algorithm called MaxNetLife, which is mainly based on utilizing the remaining power of individual sensor nodes as well as properly relocating sensor nodes so that all sensor nodes can transmit the data they sense to the sink. Hence, the algorithm maximizes total collected information from the surveillance area before the possible death of the sensor network by increasing cumulative connected coverage parameter of the network. A deterministic approach is used to deploy sensor nodes into the sensor field where Hexagonal Grid positioning is used to address and locate each sensor node. Sensor nodes those are not planned to be actively used in the close future in a specific cell are preemptively relocated to the cells those will be in need of additional sensor nodes to improve cumulative connected coverage of the network. MaxNetLife algorithm also includes the details of the relocation activities, which include preemptive migration of the redundant nodes to the cells before any coverage hole occurs because of death of a sensor node. Relocation Model, Data Aggregation Model, and Energy model of the algorithm are studied in detail. MaxNetLife algorithm is proved to be effective, scalable, and applicable through simulations.
A Comparison of Some Physical and Chemical Soil Quality Indicators Influenced by Different Crop Species
Coskun Gulser
Pakistan Journal of Biological Sciences , 2004,
Abstract: The effects of six different crop species on some physical and chemical soil quality indicators of a clay soil were compared with a fallow plot. Cropping treatments increased the soil organic matter (OM) content from 2.28% for bare soil to 3.18% for the bromegrass treatment. Increases in OM content due to different cropping regimes were obtained in the following order: bare soil
Adult Immunization
Omer Coskun
TAF Preventive Medicine Bulletin , 2008,
Abstract: Despite the many advances in modern medicine, each year thousands of people in the world die from diseases that are easily prevented by safe and effective vaccines. Few measures in preventive medicine are of such proven value and as easy to implement as routine immunization against infectious diseases. Prevention of infection by immunization is a lifelong process. There are a number of vaccines that all adults ( I18 years) require. There are also other vaccines that need to be tailored to meet individual variations in risk resulting from occupation, foreign travel, underlying illness, lifestyle and age. In this study, we tried to review this important subject. [TAF Prev Med Bull. 2008; 7(2): 159-166]
Teaching Connected Speech
Abdullah Coskun
Humanising Language Teaching , 2011, DOI: 17559715
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