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Search Results: 1 - 10 of 934 matches for " Cornelia Schwerdel "
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Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice
Dimitrije Krstic, Amrita Madhusudan, Jana Doehner, Prisca Vogel, Tina Notter, Claudine Imhof, Abigail Manalastas, Martina Hilfiker, Sandra Pfister, Cornelia Schwerdel, Carsten Riether, Urs Meyer, Irene Knuesel
Journal of Neuroinflammation , 2012, DOI: 10.1186/1742-2094-9-151
Abstract: The viral mimic, polyriboinosinic-polyribocytidilic acid (PolyI:C) was used to stimulate the immune system of experimental animals. Wild-type (WT) and transgenic mice were exposed to this cytokine inducer prenatally (gestation day (GD)17) and/or in adulthood. Behavioral, immunological, immunohistochemical, and biochemical analyses of AD-associated neuropathologic changes were performed during aging.We found that a systemic immune challenge during late gestation predisposes WT mice to develop AD-like neuropathology during the course of aging. They display chronic elevation of inflammatory cytokines, an increase in the levels of hippocampal amyloid precursor protein (APP) and its proteolytic fragments, altered Tau phosphorylation, and mis-sorting to somatodendritic compartments, and significant impairments in working memory in old age. If this prenatal infection is followed by a second immune challenge in adulthood, the phenotype is strongly exacerbated, and mimics AD-like neuropathologic changes. These include deposition of APP and its proteolytic fragments, along with Tau aggregation, microglia activation and reactive gliosis. Whereas Aβ peptides were not significantly enriched in extracellular deposits of double immune-challenged WT mice at 15 months, they dramatically increased in age-matched immune-challenged transgenic AD mice, precisely around the inflammation-induced accumulations of APP and its proteolytic fragments, in striking similarity to the post-mortem findings in human patients with AD.Chronic inflammatory conditions induce age-associated development of an AD-like phenotype in WT mice, including the induction of APP accumulations, which represent a seed for deposition of aggregation-prone peptides. The PolyI:C mouse model therefore provides a unique tool to investigate the molecular mechanisms underlying the earliest pathophysiological changes preceding fibrillary Aβ plaque deposition and neurofibrillary tangle formations in a physiological context of
Maintaining Nursing Care Quality—Clinical Care Guidelines for Cystic Fibrosis: Outpatient and Inpatient  [PDF]
Melanie Koeller, Cornelia Meyer
Case Reports in Clinical Medicine (CRCM) , 2016, DOI: 10.4236/crcm.2016.510055
Abstract: The Care Committee of the Mukoviszidose e.V., headed by Cornelia Meyer, has drawn up a completely revised version of the German Guidelines to Care in Cystic Fibrosis. It addresses all nursing staff concerning children, adolescents or adults with cystic fibrosis (CF) either in an inpatient and outpatient setting or in rehab clinics. The guidelines evolve along with the increased life expectancy of cystic fibrosis patients and improved quality of life which is described by CF patients and can be observed by the therapeutic CF team. For example, the treatment of secondary diseases like CFDR (CF related diabetes) which comes along with an increased life expectancy has been added over the years. It is essential that within such a complex disease pattern, professional experience of care staff who worked in specialized CF care centers (50+ patients per year) for many years has to be transferred to other nursing stuff or beginners. This is especially important in the context of the heterogeneous characteristics of this disease. Often it can be seen that the quality of the care for CF patients depends on the know-how and professional experience of the interdisciplinary CF therapists team. Moreover, it depends on the knowledge which the patient has gathered by himself by experience or learning. And, of course, it depends also on the knowledge of the relatives especially parents or partner respectively.
Response Inhibition and Memory Retrieval of Emotional Target Words: Evidence from an Emotional Stop-Signal Task  [PDF]
Cornelia Herbert, Stefan Sütterlin
Journal of Behavioral and Brain Science (JBBS) , 2011, DOI: 10.4236/jbbs.2011.13020
Abstract: Previous research suggests that emotional stimuli capture attention and guide behavior often automatically. The present study investigated the relationship between emotion-driven attention capture and motor response inhibition to emotional words in the stop-signal task. By experimental variations of the onset of motor response inhibition across the time-course of emotional word processing, we show that processing of emotional information significantly interferes with motor response inhibition in an early time-window, previously related to automatic emotion-driven attention capture. Second, we found that stopping reduced memory recall for unpleasant words during a subsequent surprise free recall task supporting assumptions of a link between mechanisms of motor response inhibition and memory functions. Together, our results provide behavioral evidence for dual competition models of emotion and cognition. This study provides an important link between research focusing on different sub-processes of emotion processing (from perception to action and from action to memory).
Loss of anti-predator behaviors in cattle and the increased predation losses by wolves in the Northern Rocky Mountains  [PDF]
Cornelia Fl?rcke, Temple Grandin
Open Journal of Animal Sciences (OJAS) , 2013, DOI: 10.4236/ojas.2013.33037
Abstract: Managing livestock near Yellowstone National Park has become an increasing challenge since conservation of wolves restricts ranchers from interfering. Even though wolves are beneficial for the ecosystem, rising predation incidences on livestock (depredations) create animosity in local farmers. Temperament selection of cattle, measured by the facial hair whorl pattern (HW)1, occurred during the last 15 years and the industry prefers calmer temperament animals. Six HWs occur in cattle (high, middle, low, abnormal, multiple and none), which are mutually exclusive and can be identified by using the eye-line as a reference point. We analyzed depredation of calves near Council, ID in 2011. A herd of 588 Black Angus × Charolais crossbreds (age range: 5 - 17 years) was observed. By analyzing the HW and age of cows in relation to depredations, we could identify a connection between these three factors (P < 0.001). The HW of a cow influenced the probability of losing the calf to predation (P < 0.001). Cows without the facial HW faced an increased percentage of losses (probability of 19.6% of losing the calf) compared to other HW (probability between 0% - 6.1%). An age effect on the probability of losing the calf was also found (P = 0.023). Cows over the age of 10 years are more likely to lose their calves. Our findings suggest that behavioral differences between cows with different HWs exist. Differences in protectiveness or vigilance towards the surroundings in cows without a facial HW may lead to an increased probability of losing their calves.
Separation Behavior for Parturition of Red Angus Beef Cows  [PDF]
Cornelia Fl?rcke, Temple Grandin
Open Journal of Animal Sciences (OJAS) , 2014, DOI: 10.4236/ojas.2014.42007
Abstract: Increased predation losses in beef cattle in the Northern Rocky Mountains raise the importance of research concerning maternal behavior around the time of parturition. Separation behavior of multiparous cows at parturition was studied by measuring the distance (m) between the birth place and the main herd with a GPS device. Age of cows and forehead hair whorl pattern (HW) were analyzed as possible factors affecting separation distance. A total of 333 cows (95% Red Angus and 5% Angus × Hereford commercial crossbreds; age range: 3 - 6 yrs) were studied. Separation distance was determined by approaching the cow-calf pair with a utility vehicle that gradually decreased the distance to the pair. The geographic coordinates per pair were recorded and the separation distance was calculated as a straight line between each pair and the main herd. The HW on the forehead of each animal was used as a measure of individual differences in temperament. Age and HW were collected when the animals were held in a squeeze chute. HW was classified into one of six groups: high, middle, low, abnormal, multiple HWs and no HW. The age of a cow influenced the separation distance for parturition (P < 0.001). Four-year-old cows were on average about 150 m further away than other aged cows when calving. Eighty-eight percent of cows separated more than 100 m from the herd. The hair whorl position had no influence on the separation distance (P = 0.405). Distinct separation behavior for parturition was observed in this herd which appears to be an innate behavior that is influenced by the individual temperament of the cow.
Spaces of Sobolev type with positive smoothness on ?n, embeddings and growth envelopes
Cornelia Schneider
Journal of Function Spaces and Applications , 2009, DOI: 10.1155/2009/815676
Abstract: We characterize Triebel-Lizorkin spaces with positive smoothness on ℝn, obtained by different approaches. First we present three settings Fp,qs(ℝn),Fp,qs(ℝn),ℑp,qs(ℝn) associated to definitions by differences, Fourier-analytical methods and subatomic decompositions. We study their connections and diversity, as well as embeddings between these spaces and into Lorentz spaces. Secondly, relying on previous results obtained for Besov spaces 𝔅p,qs(ℝn), we determine their growth envelopes 𝔈G(Fp,qs(ℝn)) for 0≺p≺∞, 0≺q≤∞, s≻0, and finally discuss some applications.
Estrategias de la izquierda en el gobierno de Berlín: La experiencia de Vivantes
Revista Venezolana de Economía y Ciencias Sociales , 2006,
Abstract: this article analyzes the political situation in germany after the elections celebrated in september 2005. the election results revealed the fragility of the two parties that have dominated the political scene since the second world war, the social democratic spd and the christian democratic cdu. they also indicated the presence of a new left-wing political actor as a result of an alliance between party for democratic socialism (pds) and a split-off from the spd (wasg). within this context, the article discusses the potential relevance for the new left-wing party, of the pds experience in berlin since 2001, as the minor partner in a government coalition dominated by the spd. special attention is directed towards the problem of how to confront the problem of the health system because the defense of health rights is fundamental for any left-wing party, while the recent schroeder government emphasized the need to rationalize health expenditure in view of the overall fiscal crisis. the author examines how pds responsibility for the health ministry in the berlin government was reflected in the measures adopted.
Revista de la ciencia del suelo y nutrición vegetal , 2008, DOI: 10.4067/S0718-27912008000200006
Abstract: the influence of 31 years of stubble burning on the carbon storage as well of chemical composition of soil organic matter (som) was studied in agricultural soil of a long-term field experiment. additionally, the potential of black carbon (bc) produced by burning of harvesting residues, to be lost by horizontal as well as vertical transport was quantified during a rainfall simulation experiment. our results show that 31 years of stubbie burning as a regular agricultural practice did not change carbon storage or the chemical composition of som. this is most likely due to a small quantitative input of highly stable aromatic carbon into the soil. a significant portion of bc deposited on the soil surface by the fire may have been exported from the site as shown during the rainfall simulation experiment.
Geodesic Equations on Diffeomorphism Groups
Cornelia Vizman
Symmetry, Integrability and Geometry : Methods and Applications , 2008,
Abstract: We bring together those systems of hydrodynamical type that can be written as geodesic equations on diffeomorphism groups or on extensions of diffeomorphism groups with right invariant $L^2$ or $H^1% metrics. We present their formal derivation starting from Euler's equation, the first order equation satisfied by the right logarithmic derivative of a geodesic in Lie groups with right invariant metrics.
Tracing a West African Past: Rock Art Recording in Sub-Saharan Mali
Cornelia Kleinitz
Papers from the Institute of Archaeology , 2000, DOI: 10.5334/pia.145
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