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Search Results: 1 - 10 of 120035 matches for " Connie T. Nielsen "
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The Politics of Mental Illness and Involvement—A Discourse Analysis of Danish Anti-Stigma and Social Inclusion Campaigns  [PDF]
Jeppe Oute, Lotte Huniche, Connie T. Nielsen, Anders Petersen
Advances in Applied Sociology (AASoci) , 2015, DOI: 10.4236/aasoci.2015.511026
Abstract: The present study is a part of a broader multisited field study on involvement of relatives in Danish psychiatry. The article aims to elucidate which political classifications of normality and mental illness that are displayed in two health political campaigns regarding anti-stigmatization and social inclusion and how such classifications co-constitute the subjectivity of individuals suffering from mental illness and their relatives. Drawing on a discourse theoretical perspective laid out by political theorists Laclau and Mouffe, we analyze how the campaigns bring into effect a weak and ineffective subject of deviance and how it is constituted by a subject of normality characterized by opposing traits. The article takes up the discussion of how the campaigns’ articulations of the subjects of normality and deviance are imbedded in a hegemonic discourse of neoliberalism and individualism that asserts involvement as an expanded division of responsibility for the identification, classification and regulation of mentally ill subjects between public and private spheres of the Danish welfare state.
A case of cola dependency in a woman with recurrent depression
Charles Boy Kromann, Connie Thuroee Nielsen
BMC Research Notes , 2012, DOI: 10.1186/1756-0500-5-692
Abstract: The patient is a 40-year-old woman, who when feeling down used cola to give her an energy boost and feel better about herself. During the past seven years her symptoms increased, and she was prescribed antidepressant medication by her family doctor. Due to worsening of symptoms she was hospitalised and later referred to a specialised outpatient clinic for affective disorders. At entry to the clinic she suffered from constant tiredness, lack of energy, failing concentration, problems falling asleep as well as interrupted sleep. She drank about three litres of cola daily, and she had developed a metabolic syndrome.The patient fulfilled the ICD-10 criteria for dependency, and on the Yale Food Addiction Scale (YFAS) she scored 40 points. Her clinical mental status was at baseline assessed by the Major Depression Inventory (MDI) = 41, Hamilton Depression - 17 item Scale (HAMD-17) = 14, Young Mania Rating Scale (YMRS) = 2 and the Global Assessment of Functioning (GAF) Scale = 45.During cognitive therapy sessions she was guided to stop drinking cola and was able to moderate her use to an average daily consumption of 200 ml of cola Her concentration improved and she felt mentally and physically better. At discharge one year after entry her YFAS was zero. She was mentally stable (MDI =1, HAMD-17 = 0, YMRS = 0 and GAF = 85) and without antidepressant medication. She had lost 7.2 kg, her waistline was reduced by 13 cm and the metabolic syndrome disappeared.This case serves as an example of how the overconsumption of a caffeinated soft drink likely was causing or accentuating the patient's symptoms of mental disorder. When diagnosing and treating depression, health professionals should pay attention to potential overuse of cola or other caffeinated beverages.
Relative Number and Distribution of Murine Hypothalamic Proopiomelanocortin Neurons Innervating Distinct Target Sites
Connie M. King, Shane T. Hentges
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0025864
Abstract: Proopiomelanocortin (POMC) neurons send projections widely throughout the brain consistent with their role in regulating numerous homeostatic processes and mediating analgesia and reward. Recent data suggest that POMC neurons located in the rostral and caudal extents of the arcuate nucleus of the hypothalamus may mediate selective actions, however it is not clear if POMC neurons in these regions of the arcuate nucleus innervate specific target sites. In the present study, fluorescent microspheres and cholera toxin B were used to retrogradely label POMC neurons in POMC-DsRed transgenic mice. The number and location of POMC cells projecting to the supraoptic nucleus, periaqueductal gray, ventral tegmental area, paraventricular nucleus, lateral hypothalamic nucleus, amygdala and the dosal vagal complex was determined. Tracer injected unilaterally labeled POMC neurons in both sides of the arcuate nucleus. While the total number of retrogradely labeled cells in the arcuate nucleus varied by injection site, less than 10% of POMC neurons were labeled with tracer injected into any target area. Limited target sites appear to be preferentially innervated by POMC neurons that reside in the rostral or caudal extremes of the arcuate nucleus, whereas the majority of target sites are innervated by diffusely distributed POMC neurons. The modest number of cells projecting to each target site indicates that relatively few POMC neurons may mediate potent and specific physiologic responses and therefore disturbed signaling in a very few POMC neurons may have significant consequences.
Brief communication "Improving the actual coverage of subsampling confidence intervals in atmospheric time series analysis"
A. Gluhovsky,T. Nielsen
Nonlinear Processes in Geophysics (NPG) , 2012,
Abstract: In atmospheric time series analysis, where only one record is typically available, subsampling (which works under the weakest assumptions among resampling methods), is especially useful. In particular, it yields large-sample confidence intervals of asymptotically correct coverage probability. Atmospheric records, however, are often not long enough, causing a substandard coverage of subsampling confidence intervals. In the paper, the subsampling methodology is extended to become more applicable in such practically important cases.
Antisense Gene Silencing: Therapy for Neurodegenerative Disorders?
Troels T. Nielsen,J?rgen E. Nielsen
Genes , 2013, DOI: 10.3390/genes4030457
Abstract: Since the first reports that double-stranded RNAs can efficiently silence gene expression in C . elegans, the technology of RNA interference (RNAi) has been intensively exploited as an experimental tool to study gene function. With the subsequent discovery that RNAi could also be applied to mammalian cells, the technology of RNAi expanded from being a valuable experimental tool to being an applicable method for gene-specific therapeutic regulation, and much effort has been put into further refinement of the technique. This review will focus on how RNAi has developed over the years and how the technique is exploited in a pre-clinical and clinical perspective in relation to neurodegenerative disorders.
Regula??o em rede do ambiente de trabalho
Kamp, Annette;Nielsen, Klaus T.;
Revista Brasileira de Saúde Ocupacional , 2009, DOI: 10.1590/S0303-76572009000100003
Abstract: this article discusses the concept of network governance as a supplement to the conventional understanding of regulation in the field of working environment. how networks can stimulate change in working environment regulation is studied in two cases in denmark. the first case concerns the problem with musculoskeletal strains in the care sector - manual handling of people. in denmark a network has grown from below, and this network has generated a storyline that connects the problem with new solutions, in particular the creation of the 'transfer instructor' - 'we transfer people, we don't lift'. the second case deals with an effort to integrate health promotion with occupational health thinking; two fields (public health and ohs) that for years have been separated in a danish context. the problem in this case was/is a profound social inequality in health. this network was initiated from above, and has so far not managed to stabilize a network that is able to successfully promote the integrate approach of workplace health promotion. both cases point at the importance of bridging gaps between various professional groups if the efforts are to be truly innovative and successful. and they point at the importance of the state as a meta-governor in processes that aim at invigorating the regulation; the concept of network governance can be taken to celebrate the absence of the state; our cases don't.
The Hole in Holistic Patient Care  [PDF]
Connie Drury, Jennifer Hunter
Open Journal of Nursing (OJN) , 2016, DOI: 10.4236/ojn.2016.69078
Abstract: Throughout its history, the nursing profession has claimed to provide holistic patient care, which is defined as bio-psycho-socio-spiritual care. Today, however, many nurses do not feel comfortable with the “spiritual” element of care and are uncertain about their professional role in the assessment and delivery of spiritual care. Discomfort and avoidance of attending to the spiritual needs of human beings creates “a hole” in holistic patient care. Contributing factors to the “hole in holistic patient care” include: 1) blurring of boundaries in the language and definitions of “spirituality” and “religion”, 2) insufficient attention to definitions of spirituality and spiritual distress; 3) confusion and role conflict with professional identity among disciplines related to responsibility for spiritual care; 4) insufficient education and skill development for nurses and other healthcare professionals in the assessment, intervention and appropriate referral of patients experiencing spiritual distress. The purpose of this article is to explore the history of holistic nursing as it pertains to the human dimension of spirituality and conclude with practice models for spiritual assessment and spiritual care that can “fill” the hole in holistic nursing care.
A General Framework For Determining the Temporal and Evolutionary Dynamics of Religion-Based Website Popularity on the Internet  [PDF]
Michael R. Golinski, Connie Petersen
Open Journal of Statistics (OJS) , 2012, DOI: 10.4236/ojs.2012.24052
Abstract: Religion-based websites are fast becoming a major pipeline for disseminating religious information to broad populations of individuals in the United States.Both mainstream religions and fringe religions are easily accessible to a large population of internet users. The purpose of this review is to develop and examine a general framework that uses simple mathematical and statistical models to interpret and measure temporal ‘snap shots’ in the popularity of religious websites. We extend this framework to include an evolutionary model that has the potential to predict long-term shifts or changes in the popularity of religious websites over time. Ultimately, the goal of this review is to introduce a new modeling framework for research into how the internet is changing the accessibility and views of populations of individuals who follow various religions on the internet and how this may in-turn affect the distribution of religion in the ‘real world’.
The Influence of Bovine Milk High or Low in Isoflavones on Hepatic Gene Expression in Mice
Mette T. Skaanild,Tina S. Nielsen
Journal of Toxicology , 2010, DOI: 10.1155/2010/423179
Abstract: Isoflavones have generated much attention due to their potential positive effects in various diseases. Phytoestrogens especially equol can be found in bovine milk, as feed ration for dairy cows is comprised of plants containing phytoestrogens. The aim of this study was to analyze the changes in hepatic gene expression after dietary intake of milk high and low in isoflavones. In addition to pelleted feed female NMRI mice were offered water, water added either 17 -estradiol, equol, Tween 80, and milk high and low in isoflavone content for a week. Gene expression was analyzed using an array qPCR kit. It was revealed that Tween 80 and 17 -estradiol upregulated both phase I and phase II genes to the same extent whereas equol alone, high and low isoflavone milk did not alter the expression of phase I genes but decreased the expression of phase II genes. This study shows that dietary isoflavones can regulate the transcription of especially phase II liver enzymes which potentially could give rise to an increase in reactive oxygen metabolites that may contribute to the development of cancer. 1. Introduction In recent years isoflavones (a group of phytoestrogens) have generated much attention both in science and in public due to their potential health beneficial effects in relation to diseases such as atherosclerosis, breast, endometrial, and prostate cancer, but also osteoporosis reviewed by Duncan et al., 2003 [1]. Especially leguminous plants, such as clover and soya bean, have high natural contents of phytoestrogens, the most predominant being daidzein, genistein, formononetin, and biochanin. These phytoestrogens can be found in bovine milk [2], as a large proportion of the feed ration for dairy cows is comprised of leguminous plants. Apart from these plant isoflavones, equol may also be present in bovine milk. Equol is produced from daidzein in the rumen of cows and the human intestine by the micro flora [3, 4]. Equol is of special interest since it may directly exert cancer preventive effects [5]. However, only about one third of people in the Western populations can produce equol, likely due to the large interindividual variability in the intestinal flora. As isoflavones can change the phase 1 and phase 2 metabolisms [6], they have the potential to change the metabolism of endogenous compounds such as hormones and xenobiotic compounds including drugs. This may cause a change in homeostasis and/or change the oxidative tress of liver which may give rise to cancer. Most of these studies, however, have been made in vitro. A recent in vivo study revealed that
Desensitization of ovalbumin-sensitized mice by repeated co-administrations of di-(2-ethylhexyl) phthalate and ovalbumin
S?ren T Larsen, Gunnar D Nielsen
BMC Research Notes , 2009, DOI: 10.1186/1756-0500-2-225
Abstract: Compared to the OVA-sensitised control mice, multiple co-exposures to DEHP+OVA reduced the IgG1 level and reduced the IgE/IgG2a ratio. This suggests that DEHP may attenuate allergic sensitisation, as the IgE/IgG2a ratio has been shown to correlate with the degree of anaphylaxis. Nevertheless, no effect of DEHP exposures was seen on inflammatory cells in bronchoalveolar lavage fluid and on cytokine levels in spleen cell culture.Data from humane and murine studies suggest that DEHP may attenuate the allergic response. More studies are necessary in order to assess the size of this effect and to rule out the underlying mechanism.The plastizicer di-(2-ethylhexyl) phthalate (DEHP) is widely distributed in the environment and DEHP is, for example, present in house dust [1], which also contains allergens e.g. from house dust mites. Therefore, the potential allergy-promoting effect of DEHP and other phthalates was evaluated in several recent studies [2]. Although some of the epidemiological studies suggested that phthalates promote allergic sensitisation [3,4], these findings could not be confirmed in controlled animal studies [5-7]. In mice, co-administration of DEHP with the model allergen ovalbumin (OVA) stimulated production of the immunoglobulins IgG1 and IgG2a but not IgE [6,7]. IgE plays a central role in many allergic diseases, whereas the role of IgG1 is less clear. IgG1 is a Th2-dependent antibody that may be anaphylactic in the mouse at high allergen exposures [8,9]. On the other hand, it has been proposed that IgG1 may constitute the murine equivalent to the human IgG4 isotype, which may protect against symptoms of allergy [10]. In mice, decreased IgG1 and increased IgG2a have been associated with the development of mucosal tolerance towards inhaled allergens [11]. If DEHP selectively promote formations of IgG1 and IgG2a without stimulating the IgE response, it could be hypothesized that DEHP may be able to suppress elicitation of an allergic response. This hypot
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