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Search Results: 1 - 10 of 1645 matches for " Connie Price "
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More than skin deep: moisturizing body milk and Burkholderia cepacia
Amy E Irwin, Connie Price
Critical Care , 2008, DOI: 10.1186/cc6781
Abstract: It appears that the potentially fatal pathogen Burkholderia cepacia has taken hold of another reservoir for transmission – in the form of moisturizing body milk [1]. B. cepacia, a Gram-negative rod bacterium known for its affinity towards and its virulence in moist environments, presents a clinical challenge in the treatment and management of susceptible populations and in the subsequent identification of causative sources during nosocomial outbreaks. Capable of person-to-person transmission and transmission through contact with surfaces such as medical devices and medicines, B. cepacia is an opportunistic pathogen highly resistant to most antimicrobial agents and it possesses a 42% mortality rate [2]. The need for all clinicians to examine more closely their environments in an effort to halt the spread of B. cepacia is therefore critical.Alvarez-Lerma and colleagues observed over an 18-day period that five critically ill patients admitted to a multidisciplinary 18-bed intensive care unit contracted the nosocomial infection B. cepacia [1]. Microbiologic analysis was performed on the collected oropharyngeal mucosa, urine, and bronchial aspirates from all patients in the intensive care unit and on samples of antiseptics, eau de Cologne, and moisturizing body milk used in routine nursing care. It was determined that the strains of B. cepacia isolated from the patients and from the moisturizing body milk were of the same clone, indicating the lotion was the source of the outbreak. Upon this discovery, the hospital immediately withdrew the product from routine nursing care hospital wide and notified the manufacturing company about the B. cepacia contamination.Alvarez-Lerma and colleagues strongly recommend cosmetic products that do not guarantee sterilization during the manufacturing process should not be used in critical care settings [1]. From an all or nothing perspective and within the context that B. cepacia only survived in moisturizing body milk, this approach wou
Eradication of multidrug-resistant Acinetobacter baumannii in a female patient with total hip arthroplasty, with debridement and retention: a case report
Alison M Beieler, Robert W Belknap, Michael R Dayton, Connie S Price, Steve J Morgan
Journal of Medical Case Reports , 2009, DOI: 10.1186/1752-1947-3-45
Abstract: The patient, a 47-year-old woman, had previously had a prior total hip arthroplasty at 16 years of age for a complex femoral neck fracture, and multiple subsequent revisions. This time, she underwent a fifth revision secondary to pain. Surgery was complicated by hypotension resulting in transfer to the intensive care unit and prolonged respiratory failure. She received peri-operative cefazolin but postoperatively developed surgical wound drainage requiring debridement of a hematoma. Cultures of this grew ampicillin-sensitive Enterococcus and Acinetobacter baumannii (sensitive only to amikacin and imipenem). The patient was started on imipenem. Removal of the total hip arthroplasty was not recommended because of the recent surgical complications, and the patient was eventually discharged home. She was seen weekly for laboratory tests and examinations and, after 4 months of therapy, the imipenem was discontinued. She did well clinically for 7 months before recurrent pain led to removal of the total hip arthroplasty. Intra-operative cultures grew ampicillin-sensitive Enterococcus and coagulase-negative Staphylococcus but no multidrug-resistant Acinetobacter baumannii. The patient received ampicillin for 8 weeks and had not had recurrent infection at the time of writing, 37 months after discontinuing imipenem.We describe the successful treatment of an acute infection from multidrug-resistant Acinetobacter baumannii with debridement and retention of the total hip arthroplasty, using monotherapy with imipenem. This case challenges the general assumption that all orthopedic-device infections due to multidrug-resistant gram-negative organisms will require hardware removal. Further studies are needed to determine if organisms such as multidrug-resistant Acinetobacter baumannii are amenable to treatment with hardware retention.Acinetobacter baumannii has become an important cause of healthcare-associated infections worldwide [1]. The organism has developed substantial antimic
Steric Determinants of Pt/DNA Interactions and Anticancer Activity
Trevor W. Hambley,Susan J. Berners-Price,Murray S. Davies,Connie I. Diakos
Metal-Based Drugs , 1998, DOI: 10.1155/mbd.1998.197
Interaction of Cryptococcus neoformans Rim101 and Protein Kinase A Regulates Capsule
Teresa R. O'Meara,Diana Norton,Michael S. Price,Christie Hay,Meredith F. Clements,Connie B. Nichols,J. Andrew Alspaugh
PLOS Pathogens , 2010, DOI: 10.1371/journal.ppat.1000776
Abstract: Cryptococcus neoformans is a prevalent human fungal pathogen that must survive within various tissues in order to establish a human infection. We have identified the C. neoformans Rim101 transcription factor, a highly conserved pH-response regulator in many fungal species. The rim101Δ mutant strain displays growth defects similar to other fungal species in the presence of alkaline pH, increased salt concentrations, and iron limitation. However, the rim101Δ strain is also characterized by a striking defect in capsule, an important virulence-associated phenotype. This capsular defect is likely due to alterations in polysaccharide attachment to the cell surface, not in polysaccharide biosynthesis. In contrast to many other C. neoformans capsule-defective strains, the rim101Δ mutant is hypervirulent in animal models of cryptococcosis. Whereas Rim101 activation in other fungal species occurs through the conserved Rim pathway, we demonstrate that C. neoformans Rim101 is also activated by the cAMP/PKA pathway. We report here that C. neoformans uses PKA and the Rim pathway to regulate the localization, activation, and processing of the Rim101 transcription factor. We also demonstrate specific host-relevant activating conditions for Rim101 cleavage, showing that C. neoformans has co-opted conserved signaling pathways to respond to the specific niche within the infected host. These results establish a novel mechanism for Rim101 activation and the integration of two conserved signaling cascades in response to host environmental conditions.
The Human Nasal Microbiota and Staphylococcus aureus Carriage
Daniel N. Frank,Leah M. Feazel,Mary T. Bessesen,Connie S. Price,Edward N. Janoff,Norman R. Pace
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0010598
Abstract: Colonization of humans with Staphylococcus aureus is a critical prerequisite of subsequent clinical infection of the skin, blood, lung, heart and other deep tissues. S. aureus persistently or intermittently colonizes the nares of ~50% of healthy adults, whereas ~50% of the general population is rarely or never colonized by this pathogen. Because microbial consortia within the nasal cavity may be an important determinant of S. aureus colonization we determined the composition and dynamics of the nasal microbiota and correlated specific microorganisms with S. aureus colonization.
The Hole in Holistic Patient Care  [PDF]
Connie Drury, Jennifer Hunter
Open Journal of Nursing (OJN) , 2016, DOI: 10.4236/ojn.2016.69078
Abstract: Throughout its history, the nursing profession has claimed to provide holistic patient care, which is defined as bio-psycho-socio-spiritual care. Today, however, many nurses do not feel comfortable with the “spiritual” element of care and are uncertain about their professional role in the assessment and delivery of spiritual care. Discomfort and avoidance of attending to the spiritual needs of human beings creates “a hole” in holistic patient care. Contributing factors to the “hole in holistic patient care” include: 1) blurring of boundaries in the language and definitions of “spirituality” and “religion”, 2) insufficient attention to definitions of spirituality and spiritual distress; 3) confusion and role conflict with professional identity among disciplines related to responsibility for spiritual care; 4) insufficient education and skill development for nurses and other healthcare professionals in the assessment, intervention and appropriate referral of patients experiencing spiritual distress. The purpose of this article is to explore the history of holistic nursing as it pertains to the human dimension of spirituality and conclude with practice models for spiritual assessment and spiritual care that can “fill” the hole in holistic nursing care.
A General Framework For Determining the Temporal and Evolutionary Dynamics of Religion-Based Website Popularity on the Internet  [PDF]
Michael R. Golinski, Connie Petersen
Open Journal of Statistics (OJS) , 2012, DOI: 10.4236/ojs.2012.24052
Abstract: Religion-based websites are fast becoming a major pipeline for disseminating religious information to broad populations of individuals in the United States.Both mainstream religions and fringe religions are easily accessible to a large population of internet users. The purpose of this review is to develop and examine a general framework that uses simple mathematical and statistical models to interpret and measure temporal ‘snap shots’ in the popularity of religious websites. We extend this framework to include an evolutionary model that has the potential to predict long-term shifts or changes in the popularity of religious websites over time. Ultimately, the goal of this review is to introduce a new modeling framework for research into how the internet is changing the accessibility and views of populations of individuals who follow various religions on the internet and how this may in-turn affect the distribution of religion in the ‘real world’.
Connie Susilawati
Civil Engineering Dimension , 2005,
Abstract: The opening of free market in 2003, leads into the stridently escalating business competition both in domestic and global market. The company, therefore, is trying to win the competition by obtaining ISO 9000 certification which can be applied in the construction business. The purpose of the research is to investigate the reason, the obstacles, the gap between expectation and reality of using ISO 9000, as well as the main priority to be implemented in the company. This research uses survey on contractor companies in Surabaya and Gresik which has implemented ISO 9000. The statistical results show that the main reason to implement ISO 9000 is to increase consistency and to improve its quality. Meanwhile, the main obstacle is time constraint to complete the implementation. Companies still need to increase customer satisfaction and attend on customer focus principle to increase the quality of their outcomes. Abstract in Bahasa Indonesia : Akibat terbukanya perdagangan bebas di tahun 2003, persaingan bisnis makin meningkat tajam baik di pasar domestik (nasional) maupun global (internasional). Salah satu upaya perusahaan untuk memenangkan persaingan dengan peningkatan mutu produk atau jasa adalah mendapatkan sertifikasi ISO 9000 yang dapat diterapkan juga dalam bisnis konstruksi. Adapun tujuan penelitian ini untuk mengetahui alasan, hambatan, perbedaaan antara harapan dan realita, dan prioritas utama ISO 9000 yang harus diterapkan oleh perusahaan. Penelitian ini menggunakan survei terhadap perusahaan-perusahaan kontraktor di Surabaya dan Gresik yang sudah menerapkan ISO 9000. Hasil analisa statistik menunjukkan bahwa perusahaan menerapkan ISO 9000 terutama agar mencapai konsistensi dalam pelaksanaan dan memperbaiki mutu. Sedangkan hambatan terbesar yaitu waktu yang diperlukan untuk melengkapi penerapan. Perusahaan-perusahaan kontraktor tersebut masih perlu meningkatkan kepuasan pelanggan dan menerapkan prinsip fokus pelanggan sebagai prioritas utama untuk meningkatkan mutu perusahaan.
Connie Susilawati
Civil Engineering Dimension , 2001,
Abstract: Dormitory is a very important facility which have to be provided by a university. A survey to Petra Christian University’s students has been conducted to understand the required facilities and their financial ability. Linear programming has been used to calculate number of rooms and area of each facility which could satisfy the constraints and to obtain optimum profit. Number of bedrooms, number of bathrooms, and area of each facility, such as: living room, dining room, common room, cafeteria, book shop, mini market, phone booths, sport facilities, and parking space are recommended. Since the investment is financially feasible, the dormitory could be built in the future.
Connie Susilawati
Civil Engineering Dimension , 2002,
Abstract: Petra Christian University plans to build a Student Center, which functions as a place for students to gather in an informal meeting, a place for student activities, and a place with social and cultural facilities for students, but still fit with the purpose of the university. To prepare a more suitable plan for the students as the main users, their voices should be considered. A survey to 1087 students has been done to gather their voices. This study evaluates level of need and level of importance of the room that will be provided in the Student Centre. The level of satisfaction of the existing facilities’ size has been evaluated to the student guild. This study has recommended rooms under seven categories which have to be provided, such as: rooms for student union, academic support, administration, social, religious rooms, commercial room and some complementary rooms Abstract in Bahasa Indonesia : Universitas Kristen Petra merencanakan untuk mendirikan Student Center yang merupakan tempat berkumpulnya mahasiswa dan sivitas akademika dalam pertemuan informal, tempat aktivitas mahasiswa dan tempat yang menyediakan fasilitas rekreasi, sosial, dan kultural sesuai dengan dasar dan tujuan universitas. Agar perencanaanya lebih sesuai dengan kebutuhan pengguna utamanya, yaitu mahasiswa, maka pendapat mereka perlu menjadi bahan pertimbangan. Untuk mengetahui pendapat mahasiswa telah dilakukan survey kepada 1087 responden mahasiswa aktifis dan non aktifis. Studi ini menilai tingkat kebutuhan dan tingkat kepentingan dari ruangan yang akan disediakan di dalam Student Center tersebut. Mengingat sebagian ruangan-ruangan tersebut sudah ada, maka dilakukan juga evaluasi kepuasan pengguna ruangan terhadap luas ruangan yang diwakili oleh aktivis mahasiswa. Hasil akhir dari penelitian ini adalah rekomendasi ruangan yang perlu disediakan dapat dikategorikan sebagai ruangan untuk organisasi mahasiswa, ruang penunjang akademik, ruang spriritual, ruang administrasi, ruang sosial dan dilengkapi dengan beberapa ruang komersial serta ruang pelengkap.
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