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Search Results: 1 - 10 of 153 matches for " Come Ialy-Radio "
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Cholesterol Depletion Disorganizes Oocyte Membrane Rafts Altering Mouse Fertilization
Jorgelina Buschiazzo, Come Ialy-Radio, Jana Auer, Jean-Philippe Wolf, Catherine Serres, Brigitte Lefèvre, Ahmed Ziyyat
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0062919
Abstract: Drastic membrane reorganization occurs when mammalian sperm binds to and fuses with the oocyte membrane. Two oocyte protein families are essential for fertilization, tetraspanins and glycosylphosphatidylinositol-anchored proteins. The firsts are associated to tetraspanin-enriched microdomains and the seconds to lipid rafts. Here we report membrane raft involvement in mouse fertilization assessed by cholesterol modulation using methyl-β-cyclodextrin. Cholesterol removal induced: (1) a decrease of the fertilization rate and index; and (2) a delay in the extrusion of the second polar body. Cholesterol repletion recovered the fertilization ability of cholesterol-depleted oocytes, indicating reversibility of these effects. In vivo time-lapse analyses using fluorescent cholesterol permitted to identify the time-point at which the probe is mainly located at the plasma membrane enabling the estimation of the extent of the cholesterol depletion. We confirmed that the mouse oocyte is rich in rafts according to the presence of the raft marker lipid, ganglioside GM1 on the membrane of living oocytes and we identified the coexistence of two types of microdomains, planar rafts and caveolae-like structures, by terms of two differential rafts markers, flotillin-2 and caveolin-1, respectively. Moreover, this is the first report that shows characteristic caveolae-like invaginations in the mouse oocyte identified by electron microscopy. Raft disruption by cholesterol depletion disturbed the subcellular localization of the signal molecule c-Src and the inhibition of Src kinase proteins prevented second polar body extrusion, consistent with a role of Src-related kinases in fertilization via signaling complexes. Our data highlight the functional importance of intact membrane rafts for mouse fertilization and its dependence on cholesterol.
Um laboratório das rela??es de trabalho: o ABC paulista nos anos 90
Rodrigues, Iram Jácome;
Tempo Social , 2002, DOI: 10.1590/S0103-20702002000100007
Abstract: this study discusses the main questions present in union action in the paulista abc area in relation to national experience. based on a large survey of the deals made between the metal workers union and the automobile manufacturers in the 901s, this paper makes a balance of the industrial relations in recent years and discusses the perspectives for unionism in the near future.
Estratégia operária e neocapitalismo
Rodrigues, Iram Jácome;
Tempo Social , 2009, DOI: 10.1590/S0103-20702009000100004
Abstract: this text discusses some of the questions raised by andré gorz in his book working-class strategy and neocapitalism, published in the mid 1960s. it situates this work as part of a wider set of studies by the author in which he explores the transformations in capitalism in central countries after the second world war, focusing on how these prompted the need for new action strategies among the working-class and union movements. the first theme discussed is the relationship between general and specific demands and the role performed by reformism in working-class action. secondly, based on this new phase, the article reflects on andré gorz's studies concerning overall changes within capitalism and, by extension, within the more developed capitalist societies. finally, the article analyzes in more detail the question of the workplace, company, factory and production as a fundamental locus in the fight for working-class emancipation.
Virginia Apgar y la anestesiología obstétrica: aportes, anécdotas y aficiones Virginia Apgar and obstetric anaesthesia: contributions, anecdotes and likings
Alfredo Jácome Roca
Revista Colombiana de Obstetricia y Ginecología , 2002,
Abstract:
Reconfiguración del sicario en Felicidad quizás de Mario Salazar Montero y Los restos del vellocino de oro de Alfredo Vanín
Margarita Jácome
Perífrasis : Revista de Literatura, Teoría y Crítica , 2012,
Abstract: Este artículo analiza la transformación de la figura del sicario como personaje de ficción en la novela colombiana reciente sobre la base de su representación en los textos Felicidad quizás de Mario Salazar Montero y Los restos del vellocino de oro de Alfredo Vanín. Además de estudiar dicha representación en cada novela en particular, se la compara y contrasta con el perfil del asesino a sueldo establecido por la novela sicaresca de los a os noventa, para proponer algunas características de la evolución del género evidenciadas en textos enmarcados en diversos tipos de violencia.This article analyzes the transformation of the hit-man - sicario - as a fictional character in recent Colombian narratives, based upon its representation in Felicidad quizás by Mario Salazar Montero and Los restos del vellocino de oro by Alfredo Vanín. Besides studying the sicario figure in each novel, this article compares and contrasts the recent image of the hired assassin to the one established by the sicaresca novel of the 90′s. Additionally, this methodology helps pointing out some characteristics in the evolution of this literary genre within the context of diverse types of violence.
A las puertas del abismo. Las implicaciones del TLC para Ecudor
come E., Hugo
Iconos : Revista de Ciencias Sociales , 2004,
Abstract:
A tradi o do trabalho: a experiência dos metalúrgicos do Rio de Janeiro
Rodrigues Iram Jácome
Revista Brasileira de Ciências Sociais , 2002,
Abstract:
O modelo sindical corporativo mudou?
Rodrigues Iram Jácome
Revista Brasileira de Ciências Sociais , 2000,
Abstract:
Patrones espaciales en las elecciones locales del 2007 en Bogotá, Colombia
come Javier
Cuadernos de Geografía - Revista Colombiana de Geografía , 2013,
Abstract: La presente investigación estudia las preferencias de los electores de Bogotá para las elecciones de alcalde y Concejo en el 2007. El texto inicia con una breve revisión teórica sobre el estudio de las elecciones y el papel de la geografía en este; posteriormente se estudian los puestos de votación en dos localidades de la ciudad, analizando la distancia que recorren los votantes el día de las elecciones, el tama o del puesto de votación, su capacidad de atraer votantes en función de su ubicación, y, además, la relación entre el estrato socioeconómico y los patrones de votación. Finalmente, se utilizan los coeficientes de autocorrelación global y local de Morán para analizar las principales opciones en contienda, encontrando como resultado la existencia de un comportamiento no aleatorio.
A dimens o regional da a o sindical: os metalúrgicos do ABC The local dimension of syndical action: the metallurgists of ABC
Iram Jácome Rodrigues
Estudos de Sociologia , 2007,
Abstract: O objetivo deste trabalho é fazer uma reflex o sobre a a o do Sindicato Trabalhadores Metalúrgicos do ABC – STM ABC - no período recente, entendendo as transforma es ocorridas na atividade dessa institui o como uma nova fase da a o dos metalúrgicos. Discute-se o papel desempenhado pelas estratégias sindicais adotadas para cria o de uma nova dinamica, focada no desenvolvimento local e regional do espa o territorial de sua jurisdi o. A atividade do sindicato tem sido, desde a década de 90, formular, negociar, e coordenar formas de desenvolvimento regional/local. Nucleia tal atividade do sindicato um forte papel aglutinador. Palavras-chave: A o sindical. Rela es de trabalho. Metalúrgicos-ABC. Desenvolvimento regional. The aim of this work is to reflect on the action of the Metallurgist Workers Union of ABC – STM ABC – in the recent period, understanding the transformations occurred in the activity of this institution as a new phase in the action of metallurgists. We discuss the role of union strategies adopted to create a new dynamics, which focuses on the local development of the territorial area in its jurisdiction. The activity of the union has been, since the decade of 1990, to formulate, negotiate and coordinate local development forms. In the center of the union activity is a strong agglutinant role. Keywords: Syndical action. Work relations. Metallurgists of ABC. Local development.
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