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Search Results: 1 - 10 of 146954 matches for " Claus B Andersen "
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Review of Survey activities 2009: Late Cretaceous basin development of the southern Danish Central Graben
Jakobsen, Finn,Andersen, Claus
Geological Survey of Denmark and Greenland Bulletin , 2010,
Abstract:
Development of health and depressive symptoms among Danish adolescents—Socioeconomic differences and effects of life-style  [PDF]
Johan Hviid Andersen, Merete Labriola, Thomas Lund, Claus D. Hansen
Open Journal of Preventive Medicine (OJPM) , 2013, DOI: 10.4236/ojpm.2013.31013
Abstract: While the existence of social inequality in health in childhood as well as among adults is well established, research of mechanisms underlying this inequality is still sparse. The study aim was to report on the development of self-rated health and depressive symptoms from age 15 to18 years in a cohort study of Danish adolescents. Methods: The cohort comprised 3,681 individuals born in 1989, 3058 individuals answered the baseline questionnaire in 2004, and 2400 responded to a follow-up questionnaire in 2007, with 2181 individuals participating in both rounds (59% of the original cohort). Social background information of the participants was derived from a national register. For the analysis two variables indicating change in the two health indicators was computed by subtracting the 2007 levels of the variables from the levels experienced in 2004. Results: After 3 years, mean self-rated health (SRH) deteriorated slightly in adolescents (-0.24; 95% CI = -0.28 to -0.19) across all socioeconomic status (SES) groups and depressive symptoms increased (0.64; 95% CI = 0.52 to 0.75). High household income was protective for decrease in SRH (0.62; 0.43 - 0.91). Negative lifestyle changes were associated with poorer SRH and more depressive symptoms. Conclusions: Self-rated health and depressive symptoms changed to the worse among Danish adolescents from age 15 to 18 years. Negative changes in several lifestyle factors were found to accompany the deterioration of health. This result stresses the intrinsic relationship between lifestyle changes and health and the possible positive effect of maintaining and enhancing positive lifestyle factors.
What is the Clinical Relevance of Follicle-Stimulating Hormone Isoforms in Fertility Treatment?
Claus Yding Andersen and Diego Ezcurra
Reproductive Biology Insights , 2012, DOI: 10.4137/RBI.S7362
Abstract: Follicle-stimulating hormone, both naturally synthesized and as commercial preparations, exists as different isoforms. Variation in the process of glycosylation, particularly in the number of terminal sialic-acid residues, gives rise to isoforms of varying acidic profiles with differences in half-life and bioactivity. Based on the known follicle-stimulating hormone isoform variation across the reproductive cycle, it is possible that the follicle-stimulating hormone isoform profile used in controlled ovarian stimulation may impact follicular recruitment and clinical treatment outcomes. In light of the uncertainty regarding the clinical relevance of follicle-stimulating hormone isoforms in fertility treatment, published studies exploring this topic are reviewed.
Myocardial impulse propagation is impaired in right ventricular tissue of Zucker Diabetic Fatty (ZDF) rats
Kristine Boisen Olsen, Lene Nygaard Axelsen, Thomas Hartig Braunstein, Charlotte Mehlin S?rensen, Claus B Andersen, Thorkil Ploug, Niels-Henrik Holstein-Rathlou, Morten Schak Nielsen
Cardiovascular Diabetology , 2013, DOI: 10.1186/1475-2840-12-19
Abstract: We used Zucker Diabetic Fatty (ZDF) rats, as a model of type 2 diabetes, and their lean controls Zucker Diabetic Lean (ZDL) rats to investigate CV and its response to the anti-arrhythmic peptide analogue AAP10. Gap junction remodeling was examined by immunofluorescence and western blotting. Cardiac histomorphometry was examined by Masson`s Trichrome staining and intracellular lipid accumulation was analyzed by Bodipy staining.CV was significantly slower in ZDF rats (56±1.9 cm/s) compared to non-diabetic controls (ZDL, 66±1.6 cm/s), but AAP10 did not affect CV in either group. The total amount of Connexin43 (C×43) was identical between ZDF and ZDL rats, but the amount of lateralized C×43 was significantly increased in ZDF rats (42±12 %) compared to ZDL rats (30±8%), p<0.04. Judged by electrophoretic mobility, C×43 phosphorylation was unchanged between ZDF and ZDL rats. Also, no differences in cardiomyocyte size or histomorphometry including fibrosis were observed between groups, but the volume of intracellular lipid droplets was 4.2 times higher in ZDF compared to ZDL rats (p<0.01).CV is reduced in type 2 diabetic ZDF rats. The CV disturbance may be partly explained by increased lateralization of C×43, but other factors are likely also involved. Our data indicates that lipotoxicity potentially may play a role in development of conduction disturbances and arrhythmias in type 2 diabetes.Diabetes is a major risk factor for sudden cardiac death and ventricular tachy-arrhythmias are suspected to be the predominant mechanism [1]. The prevalence of ventricular arrhythmias is increased in patients with diabetes and although ischemia is suspected to be an important trigger, the increased risk is independent of co-morbidities like coronary heart disease or heart failure [2,3].The electrocardiogram (ECG) of the diabetic heart is often characterized by a prolonged QT interval, reflecting an increase in action potential duration. In support of this, both the IKto- and delayed rec
PPARγ Pro12Ala polymorphism and risk of acute coronary syndrome in a prospective study of Danes
Ulla Vogel, Stine Segel, Claus Dethlefsen, Anne Tj?nneland, Anne Saber, H?kan Wallin, Majken K Jensen, Erik B Schmidt, Paal Andersen, Kim Overvad
BMC Medical Genetics , 2009, DOI: 10.1186/1471-2350-10-52
Abstract: A case-cohort study including 1031 ACS cases and a sub-cohort of 1703 persons was nested within the population-based prospective study Diet, Cancer and Health of 57,053 individuals.Homozygous male variant allele carriers of PPARγ2 Pro12Ala were at higher risk of ACS (HR = 2.12, 95% CI: 1.00–4.48) than homozygous carriers of the Pro-allele. Among men, there was a statistically significant interaction between genotypes and alcohol intake such that homozygous variant allele carriers with a low alcohol intake were at higher risk of ACS (HR = 25.3, CI: 16.5–38.7) compared to homozygous common allele carriers (p for interaction < 0.0001). Overall, the association was only observed among homozygous variant allele carriers. Thus, all the observed associations were obtained in subgroups including small numbers of cases. It is therefore possible that the observed associations were due to chance.In the present study, there were no consistent associations between PPARγ Pro12Ala and risk of ACS, and no consistent interaction with alcohol, BMI, NSAID or smoking in relation to ACS.Acute coronary syndrome (ACS) is a major cause of morbidity and mortality in the western world. Peroxisome proliferator-activated receptor γ (PPARγ) plays a key role in the regulation of the energy balance, adipocyte differentiation and lipid biosynthesis [1]. PPARγ regulates the expression of many adipose-specific genes via binding of a heterodimer of PPARγ and RXR (Retinoid × receptor) to regulatory response elements in target gene promoters [2].The PPARγ Pro12Ala polymorphism results in a Pro to Ala amino acid substitution at codon 12 which is only present in the PPARγ2 isoform [2]. PPARγ2 is primarily expressed in adipose tissue. The polymorphism is the only commonly occurring missense polymorphism in Caucasians [2]. In vitro, the PPARγ2 Pro12Ala variant is a less active transcription factor, resulting in lower transcription levels of target genes [3-5]. There is evidence that the resulting mutant tr
Ovarian Volume throughout Life: A Validated Normative Model
Thomas W. Kelsey, Sarah K. Dodwell, A. Graham Wilkinson, Tine Greve, Claus Y. Andersen, Richard A. Anderson, W. Hamish B Wallace
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0071465
Abstract: The measurement of ovarian volume has been shown to be a useful indirect indicator of the ovarian reserve in women of reproductive age, in the diagnosis and management of a number of disorders of puberty and adult reproductive function, and is under investigation as a screening tool for ovarian cancer. To date there is no normative model of ovarian volume throughout life. By searching the published literature for ovarian volume in healthy females, and using our own data from multiple sources (combined n = 59,994) we have generated and robustly validated the first model of ovarian volume from conception to 82 years of age. This model shows that 69% of the variation in ovarian volume is due to age alone. We have shown that in the average case ovarian volume rises from 0.7 mL (95% CI 0.4–1.1 mL) at 2 years of age to a peak of 7.7 mL (95% CI 6.5–9.2 mL) at 20 years of age with a subsequent decline to about 2.8 mL (95% CI 2.7–2.9 mL) at the menopause and smaller volumes thereafter. Our model allows us to generate normal values and ranges for ovarian volume throughout life. This is the first validated normative model of ovarian volume from conception to old age; it will be of use in the diagnosis and management of a number of diverse gynaecological and reproductive conditions in females from birth to menopause and beyond.
The Jurassic of Denmark and Greenland: Upper Jurassic – Lower Cretaceous of the Danish Central Graben: structural framework and nomenclature
Japsen, Peter,Britze, Peter,Andersen, Claus
Geological Survey of Denmark and Greenland Bulletin , 2003,
Abstract: The Danish Central Graben is part of the mainly Late Jurassic complex of grabens in the central and southern North Sea which form the Central Graben. The tectonic elements of the Danish Central Graben in the Late Jurassic are outlined and compared to those in the Early Cretaceous based on reduced versions of published maps (1:200 000), compiled on the basis of all 1994 public domain seismic and well data. The Tail End Graben, a half-graben which stretches for about 90 km along the East North Sea High, is the dominant Late Jurassic structural feature. The Rosa Basin (new name) is a narrow, north-south-trending basin extending from the south-western part of the Tail End Graben. The Tail End Graben ceased to exist as a coherent structural element during the Early Cretaceous and developed into three separate depocentres: the Iris and Gulnare Basins to the north and the Roar Basin to the south (new names). The Early Cretaceous saw a shift from subsidence focused along the East North Sea High during the Late Jurassic to a more even distribution of minor basins within the Danish Central Graben. The depth to the top of the Upper Jurassic - lowermost Cretaceous Farsund Formation reaches a maximum of 4800 m in the northern part of the study area, while the depth to the base of the Upper Jurassic reaches 7500 m in the Tail End Graben, where the Upper Jurassic attains a maximum thickness of 3600 m. The Lower Cretaceous Cromer Knoll Group attains a maximum thickness of 1100 m in the Outer Rough Basin.
Circulating Levels of MicroRNA from Children with Newly Diagnosed Type 1 Diabetes and Healthy Controls: Evidence That miR-25 Associates to Residual Beta-Cell Function and Glycaemic Control during Disease Progression
Lotte B. Nielsen,Cheng Wang,Kaspar S rensen,Claus H. Bang-Berthelsen,Lars Hansen,Marie-Louise M. Andersen,Philip Hougaard,Anders Juul,Chen-Yu Zhang,Flemming Pociot,Henrik B. Mortensen
Experimental Diabetes Research , 2012, DOI: 10.1155/2012/896362
Abstract: This study aims to identify key miRNAs in circulation, which predict ongoing beta-cell destruction and regeneration in children with newly diagnosed Type 1 Diabetes (T1D). We compared expression level of sera miRNAs from new onset T1D children and age-matched healthy controls and related the miRNAs expression levels to beta-cell function and glycaemic control. Global miRNA sequencing analyses were performed on sera pools from two T1D cohorts (n = 275 and 129, resp.) and one control group (n = 151). We identified twelve upregulated human miRNAs in T1D patients (miR-152, miR-30a-5p, miR-181a, miR-24, miR-148a, miR-210, miR-27a, miR-29a, miR-26a, miR-27b, miR-25, miR-200a); several of these miRNAs were linked to apoptosis and beta-cell networks. Furthermore, we identified miR-25 as negatively associated with residual beta-cell function (est.: −0.12, P = 0.0037), and positively associated with glycaemic control (HbA1c) (est.: 0.11, P = 0.0035) 3 months after onset. In conclusion this study demonstrates that miR-25 might be a “tissue-specific” miRNA for glycaemic control 3 months after diagnosis in new onset T1D children and therefore supports the role of circulating miRNAs as predictive biomarkers for tissue physiopathology and potential intervention targets.
Erratum to “Circulating Levels of MicroRNA from Children with Newly Diagnosed Type 1 Diabetes and Healthy Controls: Evidence That miR-25 Associates to Residual Beta-Cell Function and Glycaemic Control during Disease Progression”
Lotte B. Nielsen,Cheng Wang,Kaspar S?rensen,Claus H. Bang-Berthelsen,Lars Hansen,Marie-Louise M. Andersen,Philip Hougaard,Anders Juul,Chen-Yu Zhang,Flemming Pociot,Henrik B. Mortensen
Journal of Diabetes Research , 2012, DOI: 10.1155/2012/672865
Abstract: The following sentence: Furthermore, miR-25 one month after diagnosis was positively associated with residual beta-cell function , and negatively associated with glycaemic control (HbA1c) 3 months after disease onset, should replace this sentence in the abstract of the existing paper: Furthermore, we identified miR-25 as negatively associated with residual beta-cell function (est.: ?0.12, , and positively associated with glycaemic control (HbA1c) (est.: 0.11, 3 months after onset.
Circulating Levels of MicroRNA from Children with Newly Diagnosed Type 1 Diabetes and Healthy Controls: Evidence That miR-25 Associates to Residual Beta-Cell Function and Glycaemic Control during Disease Progression
Lotte B. Nielsen,Cheng Wang,Kaspar S?rensen,Claus H. Bang-Berthelsen,Lars Hansen,Marie-Louise M. Andersen,Philip Hougaard,Anders Juul,Chen-Yu Zhang,Flemming Pociot,Henrik B. Mortensen
Journal of Diabetes Research , 2012, DOI: 10.1155/2012/896362
Abstract: This study aims to identify key miRNAs in circulation, which predict ongoing beta-cell destruction and regeneration in children with newly diagnosed Type 1 Diabetes (T1D). We compared expression level of sera miRNAs from new onset T1D children and age-matched healthy controls and related the miRNAs expression levels to beta-cell function and glycaemic control. Global miRNA sequencing analyses were performed on sera pools from two T1D cohorts (n = 275 and 129, resp.) and one control group (n = 151). We identified twelve upregulated human miRNAs in T1D patients (miR-152, miR-30a-5p, miR-181a, miR-24, miR-148a, miR-210, miR-27a, miR-29a, miR-26a, miR-27b, miR-25, miR-200a); several of these miRNAs were linked to apoptosis and beta-cell networks. Furthermore, we identified miR-25 as negatively associated with residual beta-cell function (est.: ?0.12, P = 0.0037), and positively associated with glycaemic control (HbA1c) (est.: 0.11, P = 0.0035) 3 months after onset. In conclusion this study demonstrates that miR-25 might be a “tissue-specific” miRNA for glycaemic control 3 months after diagnosis in new onset T1D children and therefore supports the role of circulating miRNAs as predictive biomarkers for tissue physiopathology and potential intervention targets. 1. Introduction As an autoimmune disease-type 1 diabetes (T1D) results from an immune-mediated destruction of the insulin producing beta-cells reflected by the appearance of the pancreatic autoantibodies. The destruction of these cells implies a progressive, irreversible loss of the endogenous insulin production, leading to daily treatment with exogenous insulin. At time of diagnosis a child with T1D is estimated to have lost approx. 80–90% of the insulin producing beta-cell function/mass. Shortly after the initial insulin treatment, several children experience a period of increased endogenous insulin production followed by a reduced need of exogenous insulin, referred to as the remission phase [1]. The regenerative potential that exists within this time interval particularly in children gives a unique possibility of intervention treatment, that is, with beta-cell growth factors to maintain the individual insulin production, leading to improved glycaemic control and fewer complications in eyes, kidneys, and nerves. The hypothesis of the study is that potential new biomarkers (miRNAs and/or miRNA patterns) in serum from children with newly diagnosed T1D can predict destruction or regeneration of the endogenous residual beta-cell function. miRNAs are small noncoding RNAs involved in posttranscriptional
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