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Search Results: 1 - 10 of 198536 matches for " Claudio G. Salgado "
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Clinic-epidemiological evaluation of ulcers in patients with leprosy sequelae and the effect of low level laser therapy on wound healing: a randomized clinical trial
Josafá G Barreto, Claudio G Salgado
BMC Infectious Diseases , 2010, DOI: 10.1186/1471-2334-10-237
Abstract: Clinic-epidemiological evaluation of patients with leprosy sequelae was performed at the reference unit in sanitary dermatology of the state of Pará in Brazil. We conducted anamnesis, identification of the regions affected by the lesions and measurement of ulcer depth and surface area. After that, we performed a randomized clinical trial. Fifty-one patients with ulcers related to leprosy were evaluated, twenty-five of them were randomly assigned to a low level laser therapy group or a control group. Patients were treated 3 times per week for 12 weeks. Outcome measures were ulcer surface area, ulcer depth and the pressure ulcer scale for healing score (PUSH).Ninety-seven ulcers were identified, with a mean (SD) duration of 97.6 (111.7) months, surface area of 7.3 (11.5) cm2, and depth of 6.0 (6.2) mm. Statistical analysis of the data determined that there were no significant differences in the variables analyzed before and after treatment with low level laser therapy.Ulcers in patients with leprosy remain a major source of economic and social losses, even many years after they have been cured of M. leprae infection. Our results indicate that it is necessary to develop new and more effective therapeutic tools, as low level laser therapy did not demonstrate any additional benefits to ulcer healing with the parameters used in this study.The trial was registered at ClinicalTrials.gov as NCT00860717.Leprosy is a chronic infectious disease caused by Mycobacterium leprae, the only pathogenic bacteria able to infect peripheral nerves. About 30% of people with leprosy develop nerve damage. Neural impairment results in a set of sensitive, motor and autonomic disturbances, with ulcers originating primarily on the hands and feet. Neuropathic ulcers are one of the most common sequelae of leprosy, but little is known about their clinical and epidemiological aspects. They are very disabling to the patient and can result in deformity and/or amputation of the affected limb [1,2].Braz
Effects of immunomodulatory drugs on TNF-α and IL-12 production by purified epidermal langerhans cells and peritoneal macrophages
Simone R Campelo, Moises B da Silva, José LF Vieira, Jorge P da Silva, Claudio G Salgado
BMC Research Notes , 2011, DOI: 10.1186/1756-0500-4-24
Abstract: All drugs inhibited TNF-α production by Langerhans cells after 36 hours of treatment at two different concentrations, while prednisone and thalidomide decreased IL-12 secretion significantly, amitriptyline caused a less pronounced reduction and cyclosporine A had no effect. Additionally, TNF-α and IL-12 production by macrophages decreased, but IL-10 levels were unchanged after all treatments.Our results demonstrate that these drugs modulate the immune response by regulating pro-inflammatory cytokine production by purified epidermal Langerhans cells and peritoneal macrophages, indicating that these cells are important targets for immunosuppression in various clinical settings.Dendritic cells (DC) are professional antigen-presenting cells (APC) that possess the unique ability to stimulate na?ve T cells and initiate a primary immune response [1]. In the skin, the main DC populations present include epidermal DC (Langerhans cells) and dermal DC (myeloid DC and plasmacytoid DC). Langerhans cells (LC) are immature cells that reside in the epidermal layer and are distinct from other DC subsets [2].In medicine, LC are often studied due to their role in numerous skin diseases, including psoriasis and contact and allergic dermatitis [3], and their ability to uptake antigen is crucial to inducing dermal immune response and tolerance [4]. Upon activation, LC gain the ability to produce chemokines [5] and pro-inflammatory cytokines, including tumor necrosis factor-α (TNF-α) and IL-12 [6], which coordinate local and systemic inflammatory responses. TNF- α is a pleiotropic cytokine, produced primarily by monocytes and macrophages, which plays an important role in host immune responses. Antigen-presenting cells and phagocytic cells, including monocytes and macrophages, dendritic cells, and neutrophils, also are the primary producers of IL-12, an important regulatory cytokine that has a function central to the initiation and regulation of the adaptive immune response [7]. IL-10 is a
Fisiopatología del colesteatoma originado a partir de un bolsillo de retracción
Cohen,Mauricio; Callejas,Claudio; Salgado,Mauricio;
Revista de otorrinolaringología y cirugía de cabeza y cuello , 2006, DOI: 10.4067/S0718-48162006000100007
Abstract: cholesteatoma is a cystic structure delimited by stratified epithelium keratinized with expansive growth. they are classified according to their origin as congenital and acquired. cholesteatomas originated from a retraction pocket belong to this last group. the pathogenesis of its formation is multifactorial. it begins with the formation of a retractable pocket in which disfunction of the eustachian tube and majoritarily the pneumatization of the mastoid, participate. numerous theories have tried to explain the transition from this retractable pocket to the appearance of the cholesteatoma. sudoffet al, by combining the theory of imagination and that of the basal cells solves this problem in part. however it maintains interrogations such as the mechanisms that start the cellular migration and cellular proliferation. this is the knowledge barrier to this date. numerous hypothesis have tried to solve this question, among them, the hypothesis that atypical infections such as biofilms or infection due to c pneumoniae as agents involved in the genesis of the cholesteatomas originated from retraction pockets. in this line of investigation several new concepts have risen as the use ofmibl and mif for potential use to predict the aggressiveness and recurrency of the cholesteatomas. however, until now the presence of atypical infections has only been found in cholesteatomas, but no investigation line has appeared correlating them to an increase in cellular activity, in order to relate them casually to a higher clinical aggressiveness. in this sense, the chilean society of otolaryngology has recently granted financing for an investigation program that will seek to correlate the presence of infection by c pneumoniae and a higher clinical and molecular aggressiveness of the cholesteatomas, measured by mib1. this way we expect to obtain more information in order to understand this challenging disease
Fisiopatología del colesteatoma originado a partir de un bolsillo de retracción Physiopathology of the cholesteatoma originated from a retraction pocket
Mauricio Cohen,Claudio Callejas,Mauricio Salgado
Revista de Otorrinolaringología y Cirugía de Cabeza y Cuello , 2006,
Abstract: El colesteatoma es una estructura quística delimitada por epitelio estratificado queratinizado con crecimiento expansivo. Se clasifican según su origen en congénitos y adquiridos. Los colesteatomas originados a partir de un bolsillo de retracción pertenecen a este último grupo. La patogénesis de su formación es multifactorial. Se inicia con la formación de un bolsillo de retracción en la que participan la disfunción de la trompa de Eustaquio y mayoritariamente la neumatización de la mastoides. Numerosas teorías han tratado de explicar la transición desde este bolsillo de retracción hasta la aparición del colesteatoma. Sudoffet al, al combinar la teoría de la Invaginación y la de las células básales resuelve en parte este problema. Sin embargo, deja en pie Interrogantes como los mecanismos que desencadenan la migración celular y la proliferación celular. Esta es la barrera del conocimiento hoy en día. Numerosas hipótesis han tratado de resolver esta interrogante, entre ellas, la hipótesis de las infecciones atípicas como los biofilms o la infección por C pneumoniae como agentes involucrados en la génesis de los colesteatomas originados a partir de bolsillos de retracción. En este camino de investigación han surgido novedosos conceptos como el uso del MIB í y el MIF para uso potencial en poder predecir la agresividad y recurrencia de los colesteatomas. Sin embargo, hasta ahora sólo se ha encontrado la presencia de infecciones atípicas en colesteatomas, pero no ha surgido ninguna línea de investigación que las correlacione con un aumento en la actividad celular, de manera de relacionarlas causalmente con una mayor agresividad clínica. En este rumbo, recientemente la Sociedad Chilena de Otorrinolaringología ha otorgado financiamiento para un proyecto de investigación que buscará correlacionar la presencia de infección por C pneumoniae y una mayor agresividad clínica y molecular de los colesteatomas, medidas por MIB1. Esperamos que de esta manera se arroje mayor luz para comprender esta desafiante enfermedad Cholesteatoma is a cystic structure delimited by stratified epithelium keratinized with expansive growth. They are classified according to their origin as congenital and acquired. Cholesteatomas originated from a retraction pocket belong to this last group. The pathogenesis of its formation is multifactorial. It begins with the formation of a retractable pocket in which disfunction of the Eustachian tube and majoritarily the pneumatization of the mastoid, participate. Numerous theories have tried to explain the transition from this retractable pocket to t
Clinical Oxidative Stress during Leprosy Multidrug Therapy: Impact of Dapsone Oxidation
Taysa Ribeiro Schalcher, Rosivaldo S. Borges, Michael D. Coleman, Jo?o Batista Júnior, Claudio G. Salgado, Jose Luiz F. Vieira, Pedro R. T. Rom?o, Fabio R. Oliveira, Marta Chagas Monteiro
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0085712
Abstract: This study aims to assess the oxidative stress in leprosy patients under multidrug therapy (MDT; dapsone, clofazimine and rifampicin), evaluating the nitric oxide (NO) concentration, catalase (CAT) and superoxide dismutase (SOD) activities, glutathione (GSH) levels, total antioxidant capacity, lipid peroxidation, and methemoglobin formation. For this, we analyzed 23 leprosy patients and 20 healthy individuals from the Amazon region, Brazil, aged between 20 and 45 years. Blood sampling enabled the evaluation of leprosy patients prior to starting multidrug therapy (called MDT 0) and until the third month of multidrug therapy (MDT 3). With regard to dapsone (DDS) plasma levels, we showed that there was no statistical difference in drug plasma levels between multibacillary (0.518±0.029 μg/mL) and paucibacillary (0.662±0.123 μg/mL) patients. The methemoglobin levels and numbers of Heinz bodies were significantly enhanced after the third MDT-supervised dose, but this treatment did not significantly change the lipid peroxidation and NO levels in these leprosy patients. In addition, CAT activity was significantly reduced in MDT-treated leprosy patients, while GSH content was increased in these patients. However, SOD and Trolox equivalent antioxidant capacity levels were similar in patients with and without treatment. These data suggest that MDT can reduce the activity of some antioxidant enzyme and influence ROS accumulation, which may induce hematological changes, such as methemoglobinemia in patients with leprosy. We also explored some redox mechanisms associated with DDS and its main oxidative metabolite DDS-NHOH and we explored the possible binding of DDS to the active site of CYP2C19 with the aid of molecular modeling software.
The Evolution of Official Lessons: The Japanese Experience of the “Big Four” Pollution Diseases through the Lens of International Aid
Oscar A. Gómez Salgado
Journal of Alternative Perspectives in the Social Sciences , 2008,
Abstract: Experience is an overtly accepted source of lessons but, as asocial phenomenon, it is not static. This essay is an examination of the use of the ‘four’ big pollution diseases experience inside Japanese initiatives on international aid, looking for the changes in understanding such tragic events. Attention is placed on the elements introduced and the nuances of meaning among them. The period reviewed, from the late 80’s to 2005, indicates a positive movement of the official view towards a comprehensive recognition of the history, not without voids and pending challenges.
Incorporation of Real-Time PCR into Routine Public Health Surveillance of Culture Negative Bacterial Meningitis in S?o Paulo, Brazil
Claudio T. Sacchi, Lucila O. Fukasawa, Maria G. Gon?alves, Maristela M. Salgado, Kathleen A. Shutt, Telma R. Carvalhanas, Ana F. Ribeiro, Brigina Kemp, Maria C. O. Gorla, Ricardo K. Albernaz, Eneida G. L. Marques, Angela Cruciano, Eliseu A. Waldman, M. Cristina C Brandileone, Lee H. Harrison, S?o Paulo RT-PCR Surveillance Project Team
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0020675
Abstract: Real-time (RT)-PCR increases diagnostic yield for bacterial meningitis and is ideal for incorporation into routine surveillance in a developing country. We validated a multiplex RT-PCR assay for Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae in Brazil. Risk factors for being culture-negative, RT-PCR positive were determined. The sensitivity of RT-PCR in cerebrospinal fluid (CSF) was 100% (95% confidence limits, 96.0%–100%) for N. meningitidis, 97.8% (85.5%–99.9%) for S. pneumoniae, and 66.7% (9.4%–99.2%) for H. influenzae. Specificity ranged from 98.9% to 100%. Addition of RT-PCR to routine microbiologic methods increased the yield for detection of S. pneumoniae, N. meningitidis, and H. influenzae cases by 52%, 85%, and 20%, respectively. The main risk factor for being culture negative and RT-PCR positive was presence of antibiotic in CSF (odds ratio 12.2, 95% CI 5.9-25.0). RT-PCR using CSF was highly sensitive and specific and substantially added to measures of meningitis disease burden when incorporated into routine public health surveillance in Brazil.
Consenso Manejo racional del paciente con cáncer, neutropenia y fiebre: Rational approach towards the patient with cancer, fever and neutropenia
Santolaya de P,María Elena; Rabagliati B,Ricardo; Bidart H,Teresa; Payá G,Ernesto; Guzmán D,Ana M; Morales I,Ricardo; Braun J,Stephanie; Bronfman F,Lucía; Ferrés G,Marcela; Flores P,Claudio; García C,Patricia; Letelier S,Luz M; Puga L,Bárbara; Salgado M,Carmen; Thompson M,Luis; Tordecilla C,Juan; Zubieta A,Marcela;
Revista chilena de infectología , 2005, DOI: 10.4067/S0716-10182005000500001
Abstract: the severity and duration of post chemotherapy neutropenia were recognized during the 1960s as main predisposing factors for infections in cancer patients. at the beginning of the 70’s a standard management approach for all febrile neutropenia (fn) episodes was proposed, based on hospitalization and intravenous empirical broad spectrum antibiotic therapy. widespread use of this approach resulted in a significant reduction in mortality attributable to bacterial infections. during the last 10 to 15 years, reappraisal of this standard approach has been done by several research groups who question the benefit of treating all fn patients similarly without taking in to consideration differences in severity of the fn episodes. this reappraisal has led during the 1990s to the development of the concept of high and low risk fn episodes that has been the base for the adoption of selective therapies based on the risk categorization of the individual patient. the chilean infectious diseases society called upon two government national programs responsible for the appropriate distribution of chemotherapeutic drugs to all pediatric and adults cancer patients within the public health system, and upon the chilean hematology society for the development of a consensus on diagnosis, treatment and prevention of infections during fn episodes in cancer patients. the need for this consensus is based on two main aspects: the new approaches proposed during the past year for management of these episodes, and the increasing population of cancer patients receiving improved chemotherapeutic agents that has increased there survival possibilities as well as there possibility to suffer a fn episode. the topics discussed in this document are based on an updated systematic and analytic review of the medical literature including epidemiology, laboratory diagnostics, risk categorization, treatment and prophylaxis. national data was included when available in order to provide the healthcare personnel th
Saving Dupinga Watershed in Gabaldon, Nueva Ecija Philippines: Insights from Community Based Forest Management Model  [PDF]
Arneil G. Gabriel, Eric G. Claudio, Feliciano A. Bolisay
Open Journal of Ecology (OJE) , 2017, DOI: 10.4236/oje.2017.72011
Abstract: The world is losing its forest. The study described the multi-sectoral initiatives done to protect the Dupinga watershed. By using Community Based Forest Management (CBFM) as theoretical framework and analytic descriptive method of research, issues and concerns related to watershed protection are discussed. The study argued that the multi-sectoral collaboration of the Local Government Unit of Gabaldon, the Department of Environment and Natural Resources (DENR), Peoples Organizations, Non Government Organizations (NGO) and Community Organization is a CBFM in progress. Alternative source of income and community tourism may strengthen and sustain the multi-stake-holders collaboration existing in the area while capacity building program for community participation and forest management may provide insights for a sustainable watershed protection and management.
Prognosis of Workplace Bullying in Selected Health Care Organizations in the Philippines  [PDF]
Gloria M. Alcantara, Eric G. Claudio, Arneil G. Gabriel
Open Journal of Social Sciences (JSS) , 2017, DOI: 10.4236/jss.2017.59012
Abstract: The major objective of the paper is to determine the existence of workplace bullying in selected health care organizations in the Philippines. The approach used in the study is a mixture of qualitative and quantitative research methods. The findings show that a median range of score on six factors to workplace bullying was established. Results also found that: no significant relationship exists between demographic profile of participants and their diagnosis of work-place bullying. The statistical treatment of t-test proved that there is no significant difference between the mean scores of the two groups as shown by a t-value of 2.02 in a two tailed test. The overall bullying prevalence scale is moderate as determined by individual responses of the participants. Human resource officers and organizational leaders may find the study useful in designing program intervention against workplace bullying. The implication of the study is the need for intervention program to prevent workplace bullying and revisit certain areas and policies where the degree of risk for frustration and dissents among medical personnel is high. The hospital managers must consider periodic review of personnel behaviour and policies as well as regular observation on bullying factors present in the organization to prevent its emergence. The study established the need to prevent bullying at its early stage to save organizational resources from wastage arising from workplace aggressive behavior.
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