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Search Results: 1 - 10 of 10487 matches for " Claudio Emilio Bonduki "
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Gene Expression Analysis of Extracellular Matrix and Cytokines after Uterine Artery Embolization  [PDF]
André Bernardo, Tatiana Carvalho de Souza Bonetti, Ismael Dale Cotrim Guerreiro da Silva, Mariano Tamura Vieira Gomes, Rodrigo Aquino Castro, Manoel Jo?o Batista Castello Gir?o, Claudio Emilio Bonduki
Open Journal of Obstetrics and Gynecology (OJOG) , 2014, DOI: 10.4236/ojog.2014.415132
Abstract: Arterial embolization of myomas (AEM) is an established option for the conservative treatment of uterine leio-myomas; it treats all present uterine nodules at once, is less invasive than other procedures and effective in controlling symptoms, and does not require long term hospitalizations. Nevertheless, the potential impact on endometrial morphological and functional outcomes after the procedure is still controversial based on reports of endometritis or eventual transient ischemia. This study evaluated endometrial reorganization in uterine leiomyoma patients, before and after AEM, through gene expression analyses of extracellular matrix and cytokines genes in theendometrial tissue. Eight patients with leiomyomas were evaluated before AEM and 6 months after. The examinations included transvaginal pelvic ultrasonography, dosing of the follicle-stimulating hormone, and endometrial biopsy during the second phase of the menstrual cycle. RNA was extracted from endometrial samples, cDNA was synthesized, and applied on PCR arrayTM plates to evaluate the expression of extracellular matrix (ECM) genes and cytokines and their receptors’ genes (CYT). The ECM overexpressed genes were MMP (1, 3, 10, 11, and 14), CTGF1, ICAM1, TBHS1, ITGA2, ITGA3, ITGB3, COL7A1, COL12A, SPP1, and TNC; ADAMTS8 was underexpressed. The CYT overexpressed genes were SPP1, BCL6, CXCL12, IL-8, and CEBPB; CXCL13 and CCL21 were underexpressed. The ECM results showed overexpression of proteases that are responsible for dysfunctions in the ECM, and of genes responsible for adhesion and membrane components. The CYT results showed overexpression of chemokines responsible for endometrial repair, and underexpression of cytokines involved in inflammatory processes in the endometrial tissue. AEM treatment did not negatively affect the endometrial function at 6 months after embolization. This study broadens the knowledge about using a procedure that is relevant to the treatment of leiomyomas and contributes to the establishment of future guidelines for the decision making process for physicians and patients.
Impacto da emboliza??o arterial do leiomioma uterino no volume uterino, diametro do mioma dominante e na fun??o ovariana
Bernardo, André;Gomes, Mariano Tamura Vieira;Castro, Rodrigo Aquino;Gir?o, Manoel Jo?o Batista Castello;Bonduki, Claudio Emilio;Yokoyama, Claudio Atsushi;
Revista Brasileira de Ginecologia e Obstetrícia , 2011, DOI: 10.1590/S0100-72032011000800006
Abstract: purpose: to evaluate the impact of uterine artery embolization (uae) on uterine volume (uv), greater myoma diameter (gmd) and ovarian function three months after the procedure, by transvaginal pelvic ultrasonography (tvpus) and by the determination of follicle-stimulating hormone (fsh). methods: thirty patients with leiomyomas were submitted to uae. tvpus and fsh determination were performed before and three months after uae. uv was determined in cm3, gmd in cm and fsh in iu/ml. data are reported as as mean standard deviation (sd) and were analyzed statistically by the nonparametric mann-whitney test. results: twenty-nine patients were analyzed. before uae, mean uv was 402.4 165.9 cm3 and gmd was 5.9 2.1 cm. after uae, mean uv was 258.9 118.6 cm3 and gmd was 4.6 1.8 cm. mean fsh concentration was 4.9 3.5 iu/ml before uae and 5.5 4.7 iu/ml after uae, with p=0.5. there was a 35% reduction of uv and a 22% reduction of gmd, with no changes in fsh values after three months. conclusion: the procedure significantly reduced uv and gmd but did not cause a significant increase in fsh levels, thus causing no changes in ovarian function.
La nueva política nacional de vivienda en Brasil: Desafíos y limitaciones/The New National Housing Policy in Brazil: Challenges and Limitations
Nabil Bonduki
Revista de Ingeniería , 2011,
Abstract: Este artículo pretende dar a conocer la política y el plan nacional de vivienda de Brasil. Para esto, está dividido en dos partes. La primera parte, trata de una trayectoria histórica de la política de vivienda de este país, que resulta importante para reflexionar debido los errores hechos en el pasado, que pueden cometerse de nuevo, y a los avances que pueden rescatarse para ser aplicados de nuevo si hay una posibilidad de nuestra política. La segunda parte está dedicada a lo que se está haciendo actualmente.The purpose of this article is to present Brazil's national housing policy and housing plan. It is divided into two parts. The first part is about the historical trajectory of the country's housing policy. Reviewing this trajectory is crucial if the repetition of past mistakes is to be avoided and is also useful in terms of learning from advances that were made in the past that can be applied again. The second part is dedicated to the current state of affairs. Este artículo pretende dar a conocer la política y el plan nacional de vivienda de Brasil.
Propiedades físicas y mecánicas de la madera de Pinus canariensis crecido en el secano de la Región del Maule, Chile
Rodríguez,Claudio; Vergara,Emilio;
Bosque (Valdivia) , 2008, DOI: 10.4067/S0717-92002008000300002
Abstract: physical and mechanical properties were evaluated in 46 year-old pinus canariensis wood, growing in dry lands of maule′s region in chile. the wood was conditioned to 12% moisture content and mechanical testing was according to chilean standards. the basic density was 0.503 ± 0.03 g/cm3. the results of mechanical properties were lower compared with those gotten in spain and australia. concerning pinus radiata wood, properties were within the range or over, except for perpendicular tension strength. according to chilean standard nch1989, p. canariensis wood is classified in es4 group, as native woods like coigüe, laurel, lenga and roble. because of its structural properties, according to sallenave classifications, this species is specially appropriated for building and other structural applications.
Propiedades físicas y mecánicas de la madera de Pinus canariensis crecido en el secano de la Región del Maule, Chile Wood physical and mechanical properties of Pinus canariensis grown on the dry lands in Maule’s Region, Chile
Claudio Rodríguez,Emilio Vergara
Bosque (Valdivia) , 2008,
Abstract: En este estudio se evaluaron las propiedades físicas y mecánicas de la madera de Pinus canariensis de 46 a os crecido en el secano de la Región del Maule, Chile. La madera se acondicionó a 12% de humedad, y los ensayos físicos y mecánicos se efectuaron de acuerdo a las normas chilenas. La densidad básica alcanzó 0,503 ± 0,03 g/cm3. Las propiedades mecánicas resultaron inferiores a datos de la misma especie provenientes de Espa a y Australia. Con relación al Pinus radiata crecido en el país, las determinaciones estuvieron dentro del rango o sobre su límite superior, con excepción de la resistencia a la tracción perpendicular. Según la norma chilena NCh1989, la madera de P. canariensis clasifica en el grupo de resistencia ES4, junto con nativas como coigüe, laurel, lenga y roble. Sus propiedades estructurales, conforme a la clasificación de Sallenave, la hacen especialmente atractiva para edificación y otras aplicaciones estructurales. Physical and mechanical properties were evaluated in 46 year-old Pinus canariensis wood, growing in dry lands of Maule′s Region in Chile. The wood was conditioned to 12% moisture content and mechanical testing was according to Chilean standards. The basic density was 0.503 ± 0.03 g/cm3. The results of mechanical properties were lower compared with those gotten in Spain and Australia. Concerning Pinus radiata wood, properties were within the range or over, except for perpendicular tension strength. According to chilean standard NCh1989, P. canariensis wood is classified in ES4 group, as native woods like coigüe, laurel, lenga and roble. Because of its structural properties, according to Sallenave classifications, this species is specially appropriated for building and other structural applications.
The ACTH test in the diagnosis of hirsutism
Lima, Marco Fábio Prata;Nunes, Márcia Gaspar;Bonduki, Cláudio Emilio;Haidar, Mauro Abi;Lima, Geraldo Rodrigues;Baracat, Edmund Chada;
Sao Paulo Medical Journal , 1997, DOI: 10.1590/S1516-31801997000200006
Abstract: the acth test has been used to confirm the diagnosis of adrenal insufficiency and the classic and the non-classic adrenal hyperplasia due to the 3-hsd, 21 oh e 110h deficiencies. this article reviews the historical aspects of the use of acth in the diagnosis of hirsutism and points out its mains indications. in spite of new biological molecular advances in the diagnosis of adrenal enzymatic deficiencies, the use of the acth test can help the physician to predict both genothipus and fenothipus in populations with hyperandrogenic manifestations due to non-classical or late-onset congenital adrenal hyperplasia.
Effect of estrogen-progestin hormonal replacement therapy on blood coagulation and fibrinolysis in postmenopausal women
Bonduki, Claudio E;Louren?o, Dayse M;Motta, Eduardo L.A. da;Soares Jr, José Maria;Haidar, Mauro Abi;Baracat, Edmund C.;
Clinics , 2007, DOI: 10.1590/S1807-59322007000500004
Abstract: objective: to evaluate antithrombin iii (at), thrombin (fragment 1+2 [f1+2] and thrombin-antithrombin [tat]) generation markers, as well as other coagulation parameters, such as prothrombin time, partial activated thromboplastin time, thrombin time, fibrinogen, euglobulin lysis time, and platelet count, in postmenopausal women after hormonal therapy. study design: forty-five patients who received either 0.625 mg/day unopposed oral conjugated equine estrogen (cee), 0.625 mg/day oral cee plus medroxyprogesterone acetate (mp), or 50 μg/day transdermal 17beta-estradiol plus mp, were included. tests were performed before (t0) and after 3 (t3), 6 (t6) and 12 (t12) months of treatment. at was determined by an amidolytic method, whereas f1+2 and tat complex were measured by elisa. results: there was a significant reduction in the at level of patients who received oral cee plus mp at t3. there was no at reduction in patients taking either oral cee alone or transdermal 17beta-estradiol plus mp. f1+2 increased in all patients, but it reached statistical significance only in patients receiving transdermal 17beta-estradiol mp at t3. conclusions: the cee associated with mp treatment may reduce at levels, whereas unopposed cee or transdermal 17beta-estradiol plus mp does not change at. these changes might not be clinically relevant in the general population; however, hormonal replacement therapy may increase the risk of thrombosis in women with congenital or acquired thrombophilia.
Gravidez e parto após emboliza??o arterial para tratamento de leiomioma uterino
Bonduki, Cláudio Emilio;Gon?alves, Patrícia;Yokohama, Cláudio;Costa, Odon Ferreira da;Baracat, Edmund Chada;Lima, Geraldo Rodrigues de;Gir?o, Manoel Jo?o Batista Castello;
Revista Brasileira de Ginecologia e Obstetrícia , 2006, DOI: 10.1590/S0100-72032006001000005
Abstract: purpose: to analyze gestation evolution and deliveries after myoma treatment by embolization of the uterine arteries. methods: in the initial evaluation, 112 patients submitted to embolization of uterine arteries were included for treatment of myoma. from those, only nine wanted to be submitted to conservative treatment in order to keep their reproductive capacity. this procedure was indicated to the nine patients, since they were not susceptible to a conservative surgical treatment. they were submitted to embolization of the uterine arteries with particles of polyvinyl alcohol or embospheres with diameters ranging from 500 to 700 μm, and they have evolved without intercurrence. results: during the follow-up of these patients, there was a good clinical response with significant reduction in the uterus and myoma volumes. four of them got pregnant, two had an early abortion and two evolved normally till the end of gestation with a term delivery. one of these had twins. conclusion: embolization of the uterine arteries is an option for the treatment of uterine myoma, and presents good clinical and anatomical results, allowing patients to preserve their reproductive capacity.
Co-evolution of domesticated crops and associated weeds
Guglielmini,Antonio C; Ghersa,Claudio M; Satorre,Emilio H;
Ecolog?-a austral , 2007,
Abstract: crops and weeds co-evolve in particular plant communities that are assembled in agro-ecosystems. in this essay we discuss the mechanisms determining this co-evolution and the processes regulating the success of individual populations within crop-weed communities as a starting point to evaluate and interpret which are the risks of promoting invasive species due to technological changes introduced into cropping activities. we follow a framework considering co-evolutionary mechanisms (namely, genetic variation, breeding system and selective forces) and demographical processes (namely, establishment, competition, dispersion) as a way to predict, not only how weeds will evolve in agricultural land, and thus how new problems for production of food and fibre arise but, also to evaluate the risk of generating species that might affect other semi natural and natural ecosystems.
Capital humano e ingresos en la manufactura de Tijuana y Mexicali, 1994-2001
Cabrera, Claudio;Mungaray, Alejandro;Varela, Rogelio;Hernández, Emilio;
Estudios fronterizos , 2008,
Abstract: this work study the income of the tijuana and mexicali industrial manufacturing worker as a function of the schooling level and work experience through a human capital econometric model. information from the national survey of urban employment (eneu), was used in a representative data base with a sample of 184 observations for tijuana between 1994 and 2001 (8 years and 23 industrial branches) and 112 observations for mexicali between 1998 and 2001 (4 years and 28 industrial branches). schooling was most important than work experience in the income determination of the tijuana and mexicali industrial workers. this means that in the local labor market, the educational level is a key factor in the wage negotiation.
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