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Search Results: 1 - 10 of 503 matches for " Claudine Imhof "
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Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice
Dimitrije Krstic, Amrita Madhusudan, Jana Doehner, Prisca Vogel, Tina Notter, Claudine Imhof, Abigail Manalastas, Martina Hilfiker, Sandra Pfister, Cornelia Schwerdel, Carsten Riether, Urs Meyer, Irene Knuesel
Journal of Neuroinflammation , 2012, DOI: 10.1186/1742-2094-9-151
Abstract: The viral mimic, polyriboinosinic-polyribocytidilic acid (PolyI:C) was used to stimulate the immune system of experimental animals. Wild-type (WT) and transgenic mice were exposed to this cytokine inducer prenatally (gestation day (GD)17) and/or in adulthood. Behavioral, immunological, immunohistochemical, and biochemical analyses of AD-associated neuropathologic changes were performed during aging.We found that a systemic immune challenge during late gestation predisposes WT mice to develop AD-like neuropathology during the course of aging. They display chronic elevation of inflammatory cytokines, an increase in the levels of hippocampal amyloid precursor protein (APP) and its proteolytic fragments, altered Tau phosphorylation, and mis-sorting to somatodendritic compartments, and significant impairments in working memory in old age. If this prenatal infection is followed by a second immune challenge in adulthood, the phenotype is strongly exacerbated, and mimics AD-like neuropathologic changes. These include deposition of APP and its proteolytic fragments, along with Tau aggregation, microglia activation and reactive gliosis. Whereas Aβ peptides were not significantly enriched in extracellular deposits of double immune-challenged WT mice at 15 months, they dramatically increased in age-matched immune-challenged transgenic AD mice, precisely around the inflammation-induced accumulations of APP and its proteolytic fragments, in striking similarity to the post-mortem findings in human patients with AD.Chronic inflammatory conditions induce age-associated development of an AD-like phenotype in WT mice, including the induction of APP accumulations, which represent a seed for deposition of aggregation-prone peptides. The PolyI:C mouse model therefore provides a unique tool to investigate the molecular mechanisms underlying the earliest pathophysiological changes preceding fibrillary Aβ plaque deposition and neurofibrillary tangle formations in a physiological context of
Subterranean structures and mycotrophy of the achlorophyllous Dictyostega orobanchoides (Burmanniaceae)
Revista de Biología Tropical , 2001,
Abstract: plants of dictyostega orobanchoides arise from about 1 mm thick rhizomes, which are densely covered by sessile, imbricate, peltate scale leaves. the resulting interfoliar spaces are inhabited by fungal hyphae up to 6 μm thick, often developing vesicle-like bladders. the fungus also colonizes the tissue of the scale leaves, inter- as well as intracellularly, forming vesicles but no arbuscules, and it even penetrates the vascular bundles of the leaves. the rhizome itself does not become infected. the 200 μm thick roots emerge from the rhizome and have a 2-layered cortex and voluminous rhizodermis, which both are delicate and often disrupted or missing. in contrast, the strongly reinforced, tertiary endodermis and the central cylinder are durable and have a considerable tensile strength. although the roots grow through the hyphal masses in the interfoliar spaces when emerging from the rhizome, they only become infected from the rhizosphere. a collar of rhizomogenous tissue hinders the interfoliar hyphae from direct contact to the roots. only within the rhizodermis, the mycorrhizal fungus builds coils of heteromorphic hyphae, arbuscule-like structures, and vesicles. hence, the mycorrhiza in d. orobanchoides is assigned to the arbuscular mycorrhiza. it is hypothezised, that the ephemeral mycorrhizal tissue combined with the durable vascular system of the roots is a strategy to avoid the high costs of protecting the large rhizodermal surface area. the rhizomogenous collar is explained as an extra protection to the tender, young roots, when emerging from the rhizome. the necessity to include other subterranean plant organs along with the roots in future mycorrhizal studies is emphasized.
Wolfgang Imhof
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809011039
Abstract: The title compound, [Fe(C5H5)(C13H9F3N)], was prepared by a condensation reaction from ferrocenylcarbaldehyde and 4-(trifluoromethyl)aniline. The cyclopentadienyl (Cp) rings are coplanar [dihedral angle = 1.4 (3)°] and the imine function is situated in the same plane. The aromatic substituent is bent out of the plane of the Cp ring to which the imine group is attached by 44.5 (4)°. The F atoms of the trifluoromethyl substituent are disordered [occupancies 0.52 (2)/0.48 (2)].
Wolfgang Imhof
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809006291
Abstract: The title compound, C17H21NS, was prepared by the condensation of thiophene-2-carbaldehyde with 2,6-diisopropylaniline. It crystallizes with two molecules in the asymmetric unit. The molecules are interconnected via a C—H...N hydrogen bond. The dihedral angles between the thiophene and phenyl rings are 81.7 (7) and 85.5 (7)°.
Wolfgang Imhof
Acta Crystallographica Section E , 2013, DOI: 10.1107/s160053681205057x
Abstract: The title compound, C14H16N2, is a pyrrole-2-carbaldimine ligand that shows an E conformation at the imine double bond. The dihedral angle between the rings is 78.3 (1)°. In the crystal, pairs of molecules form centrosymmetric dimers [graph-set descriptor is presumably R22(10)] via N—H...N hydrogen bonds between the pyrrole N—H group and the imine N atom of a neighbouring molecule.
Wolfgang Imhof
Acta Crystallographica Section E , 2013, DOI: 10.1107/s1600536813000573
Abstract: The title compound, [Pd(C14H15N2)2], is a square-planar palladium complex composed of two deprotonated pyrrole-2-carbaldimine ligands coordinating a central PdII atom. In the crystal, three crystallographically independent complex molecules are observed, one of which is located in a general position, whereas the PdII atoms of the other molecules are situated on crystallographic inversion centers. The aromatic substituents at the imine N atoms in the three molecules show dihedral angles of 87.6 (7)/83.64 (7), 74.3 (7) and 88.3 (7)° with respect to the corresponding PdN4 plane.
Wolfgang Imhof
Acta Crystallographica Section E , 2012, DOI: 10.1107/s1600536812048143
Abstract: In the title complex, [Pd(C11H9N2)2], the PdII atom is located on an inversion centre and has a square-planar coordination geometry. The phenyl substituents at the imine N atoms make a dihedral angle of 75.0 (6)° with respect to the PdN4 plane.
Die Stammzelle aus der Nabelschnur - Gewinnung, Verarbeitung, Lagerung, Verwendung
Imhof M
Speculum - Zeitschrift für Gyn?kologie und Geburtshilfe , 2001,
Wolfgang Imhof
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536808040397
Abstract: The title compound, C26H27N, was prepared by the elimination of water from N-(2,6-diisopropylphenyl)-2,2-diphenylacetamide. The angle at the central C atom of the cumulene measures 172.5 (4)°. Molecules are connected into infinite chains by intermolecular C—H...N interactions.
Mikron hrstoffe in der Fertilit tsbehandlung: Klinische Ergebnisse
Imhof M
Journal für Urologie und Urogyn?kologie , 2009,
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