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Search Results: 1 - 10 of 3334 matches for " Claude Negrier "
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A French multicenter randomised trial comparing two dose-regimens of prothrombin complex concentrates in urgent anticoagulation reversal
Delphine Kerebel, Luc-Marie Joly, Didier Honnart, Jeannot Schmidt, Damien Galanaud, Claude Negrier, Friedrich Kursten, Pierre Coriat, Lex206 Investigator Group
Critical Care , 2013, DOI: 10.1186/cc11923
Abstract: We performed a phase III, prospective, randomised, open-label study including patients with objectively diagnosed VKA-associated intracranial haemorrhage between November 2008 and April 2011 in 22 centres in France. Patients were randomised to receive 25 or 40 IU/kg of 4-factor PCC. The primary endpoint was the International Normalised Ratio (INR) 10 minutes after the end of 4-factor PCC infusion. Secondary endpoints were changes in coagulation factors, global clinical outcomes and incidence of adverse events (AEs).A total of 59 patients were randomised: 29 in the 25 IU/kg and 30 in the 40 IU/kg group. Baseline demographics and clinical characteristics were comparable between the groups. The mean INR was significantly reduced to 1.2 - and [lessthan or equal to] 1.5 in all patients of both groups - 10 min after 4-factor PCC infusion. The INR in the 40 IU/kg group was significantly lower than in the 25 IU/kg group 10 min (p=0.001), 1 hour (p=0.001) and 3 hours (p=0.02) after infusion. The 40 IU/kg dose was also effective in replacing coagulation factors such as PT (p=0.038), FII (p=0.001), FX (p<0.001), protein C (p=0.002) and protein S (0.043), 10 min after infusion. However, no differences were found in hematoma volume or global clinical outcomes between the groups. Incidence of death and thrombotic events was similar between the groups.Rapid infusion of both doses of 4-factor PCC achieved an INR of 1.5 or less in all patients with a lower INR observed in the 40 IU/kg group. No safety concerns were raised by the 40 IU/kg dose. Further trials are needed to evaluate the impact of the high dose of 4-factor PCC on functional outcomes and mortality. Trial registration: Eudra CT number 2007-000602-73.
Generating Net Forces from Backgrounds of Randomly Created Waves  [PDF]
Claude Gauthier
Journal of Modern Physics (JMP) , 2014, DOI: 10.4236/jmp.2014.516158
Abstract: We examine the possibility of generating net forces on concave isolated objects from backgrounds consisting of randomly created waves carrying momentum. This issue is examined first for waves at the surface of a liquid, and second for quantum vacuum electromagnetic waves, both in relation with a one-side-open rectangular structure whose interior embodies a large number of parallel reflecting plates. Using known results about the Casimir-like effect and the original Casimir effect for parallel plates, we explain why and how such rectangular hollow structures should feel net oriented forces. We briefly describe real systems that would allow testing these theoretical results.
Wave-Particle Duality in Einstein-de Broglie Programs  [PDF]
Claude Elbaz
Journal of Modern Physics (JMP) , 2014, DOI: 10.4236/jmp.2014.518213
Abstract: The standard model of particle physics forms a consistent system for universe description. After following quantum mechanics, it derives particles from relativistic quantum fields. Since it does not include gravitation, it describes only one aspect of the universe. In extension of general relativity, Einstein had proposed a symmetrical and complementary approach of physics. In his program, he privileged a relativist field based on representations for physical phenomena, before a precise mathematical description. It allows completing and unifying the universe description, like both eyes for relief vision, and both ears for stereophonic audition. We propose to show it with many simple examples.
Gravitation and Electromagnetism Conciliated Following Einstein’s Program  [PDF]
Claude Elbaz
Journal of Modern Physics (JMP) , 2015, DOI: 10.4236/jmp.2015.65072
Abstract: The Einstein’s program permits to conciliate gravitation and electromagnetism. Besides the standard model, it forms a consistent system for universe description, founded upon a scalar field propagating at the speed of light c. Matter corresponds to standing waves. Adiabatic variations of frequencies lead to electromagnetic interaction constituted by progressive waves. Classical domain corresponds to geometrical optics approximation, when frequencies are infinitely high, and then hidden. As interactions for matter, Gravitation and Electromagnetism derive from variations of its energy E = mc2. Electromagnetic interaction energy derives from mass variation dE = c2dm, and gravitation from speed of light variation dE = mdc2. Contrarily to gravitation, only electromagnetic interaction serves as a bridge between classical and quantum frames, since it leans directly upon the wave property of matter: its energy dE = hdν = c2dm derives from variations of matter energy E = hν = mc2.
Dynamic characterization of crystalline and glass phases of deuterated 1,1,2,2 Tetrachloroethane
Silvina Perez,Mariano Zuriaga,Pablo Serra,Alberto Wolfenson,Philippe Negrier,Josep Tamarit
Physics , 2015, DOI: 10.1063/1.4931824
Abstract: A thorough characterization of the {\gamma}, {\beta} and glass phases of deuterated 1,1,2,2 Tetrachloroethane (C2D2Cl4) via Nuclear Quadrupole Resonance and Molecular Dynamic Simulations (MDS) is reported. The presence of molecular reorientations was experimentally observed in the glass phase and in the {\beta} phase. In the {\beta} phase, and from MDS, these reorientations are attributed to two possible movements, i.e. a $180^o$ reorientation around the C2 molecular symmetry axis and a reorientation of the molecule between non-equivalent positions. In the glass phase, the spin-lattice relaxation time T1 is of the order of 16 times lower that T1 in the crystalline phase and varies as $T^{-1}$ below 100 K in good agreement with the strong quadrupolar relaxation observed in amorphous materials and in the glassy state of molecular organic systems. The activation energy of molecular reorientations in the glass phase (19 kJ/mol) is comparable to that observed in the glassy crystal of a "molecular cousin" compound, Freon 112 (C2F2Cl4), for the secondary {\beta}-relaxation. Moreover, the on-site orientational motion of Tetrachloroethane molecules offers a new indirect evidence of the prominent role of such orientational disorder in glassy dynamics.
The “3 Genomic Numbers” Discovery: How Our Genome Single-Stranded DNA Sequence Is “Self-Designed” as a Numerical Whole  [PDF]
Jean-Claude Perez
Applied Mathematics (AM) , 2013, DOI: 10.4236/am.2013.410A2004

This article proves the existence of a hyper-precise global numerical meta-architecture unifying, structuring, binding and controlling the billion triplet codons constituting the sequence of single-stranded DNA of the entire human genome. Beyond the evolution and erratic mutations like transposons within the genome, it’s as if the memory of a fossil genome with multiple symmetries persists. This recalls the intermingling of information characterizing the fractal universe of chaos theory. The result leads to a balanced and perfect tuning between the masses of the two strands of the huge DNA molecule that constitute our genome. We show here how codon populations forming the single-stranded DNA sequences can constitute a critical approach to the understanding of junk DNA function. Then, we suggest revisiting certain methods published in our 2009 book “Codex Biogenesis”. In fact, we demonstrate here how the universal genetic code table is a powerful analytical filter to characterize single-stranded DNA sequences constituting chromosomes and genomes. We can then show that any genomic DNA sequence is featured by three numbers, which characterize it and its 64 codon populations with correlations greater than 99%. The number “1” is common to all sequences, expressing the second law of Chargaff. The other 2 numbers are related to each specific DNA sequence case characterizing life species. For example, the entire human genome is characterized by three remarkable numbers 1, 2, and Phi = 1.618 the golden ratio. Associated with each of these three numbers, we can match three axes of symmetry, then “imagine” a kind of hyperspace formed by these codon populations. Then we revisit the value (3-Phi)/2 which is probably universal and common to both the scale of quarks and atomic levels, balancing and tuning the whole human genome codon population. Finally, we demonstrate a new kind of duality between “form and substance” overlapping the whole human genome: we will show that—simultaneously with the duality between genes and junk DNA—there is a second layer of embedded hidden structure overlapping all the DNA of the whole human genome, dividing it into a second type of duality information/redundancy involving golden ratio proportions.

Analytical and Numerical Study of the Reflection/Transmission Coefficients in Slight Viscoelastic Medium  [PDF]
Fateh Bouchaala, Claude Guennou
International Journal of Geosciences (IJG) , 2014, DOI: 10.4236/ijg.2014.59079

The study done in this paper brings out the effect of the viscoelasticity on the reflection/transmission coefficients. The knowledge of this effect can be useful for several applications, such as enhancing the resolution of the seismic sections, fluid and fracture detection. It can also have other applications different from the geophysical domain, as the study of the bonding between the materials in the civil engineering domain. We use the complex Lame coefficients in the continuity equations at the boundary layers to get the analytical expressions of the reflection/transmission coefficients in viscoelastic media. The coefficients can be divided into two parts, the first part is independent from the quality factor, and it corresponds to the elastic reflection/transmission coefficients. The second part is dependent on the quality factor contrast and it represents the contribution of the viscoelasticity on the reflection/transmission coefficients. From the numerical study it appears that the effect of the viscoelasticity is significant near to the critical angles. This effect is not clear and it is difficult to interpret and we do not know if it has a physical meaning or it is only a mathematical artifact that is why it is better to be far from the critical angles for seismic investigation.

Relativistic Gauge Invariant Wave Equation of the Electron-Neutrino  [PDF]
Claude Daviau, Jacques Bertrand
Journal of Modern Physics (JMP) , 2014, DOI: 10.4236/jmp.2014.511102

With the right and the left waves of an electron, plus the left wave of its neutrino, we write the tensorial densities coming from all associations of these three spinors. We recover the wave equation of the electro-weak theory. A new non linear mass term comes out. The wave equation is form invariant, then relativistic invariant, and it is gauge invariant under the U(1)×SU(2), Lie group of electro-weak interactions. The invariant form of the wave equation has the Lagrangian density as real scalar part. One of the real equations equivalent to the invariant form is the law of conservation of the total current.

Discretization and Interaction of Fields via the Classical Kaluza-Klein Theory  [PDF]
Doris LaChance, Claude Gauthier
Journal of Modern Physics (JMP) , 2013, DOI: 10.4236/jmp.2013.412199

We show how the metric of a five-dimensional hyperspace-time can be used to model the quantum nature of electromagnetic interactions. The space-time neighborhood of the point where such an interaction takes place bends according to the curl and the derivative of the local electromagnetic four-potential, both calculated in the direction of the latter. In this geometric setting, the presence of a non-gravitational field is needed to induce the discretization of any gravitational field. We also exploit two variants of the classical Kaluza-Klein five-dimensional theory to obtain coupled generalizations of Einsteins and Maxwells equations. The first variant involves an unspecified scalar field that may be related to the inflaton. The equations of the second variant show a direct interdependency of gravitation and electromagnetism that would emerge or be activated through the production of electromagnetic waves.

A Wave Equation including Leptons and Quarks for the Standard Model of Quantum Physics in Clifford Algebra  [PDF]
Claude Daviau, Jacques Bertrand
Journal of Modern Physics (JMP) , 2014, DOI: 10.4236/jmp.2014.518210

A wave equation with mass term is studied for all fermionic particles and antiparticles of the first generation: electron and its neutrino, positron and antineutrino, quarks u and d with three states of color and antiquarks \"\" and \"\". This wave equation is form invariant under the \"\" group generalizing the relativistic invariance. It is gauge invariant under the U(1)×SU(2)×SU(3) group of the standard model of quantum physics. The wave is a function of space and time with value in the Clifford algebra Cl1,5. Then many features of the standard model, charge conjugation, color, left waves, and Lagrangian formalism, are obtained in the frame of the first quantization.

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