Abstract:
We performed a phase III, prospective, randomised, open-label study including patients with objectively diagnosed VKA-associated intracranial haemorrhage between November 2008 and April 2011 in 22 centres in France. Patients were randomised to receive 25 or 40 IU/kg of 4-factor PCC. The primary endpoint was the International Normalised Ratio (INR) 10 minutes after the end of 4-factor PCC infusion. Secondary endpoints were changes in coagulation factors, global clinical outcomes and incidence of adverse events (AEs).A total of 59 patients were randomised: 29 in the 25 IU/kg and 30 in the 40 IU/kg group. Baseline demographics and clinical characteristics were comparable between the groups. The mean INR was significantly reduced to 1.2 - and [lessthan or equal to] 1.5 in all patients of both groups - 10 min after 4-factor PCC infusion. The INR in the 40 IU/kg group was significantly lower than in the 25 IU/kg group 10 min (p=0.001), 1 hour (p=0.001) and 3 hours (p=0.02) after infusion. The 40 IU/kg dose was also effective in replacing coagulation factors such as PT (p=0.038), FII (p=0.001), FX (p<0.001), protein C (p=0.002) and protein S (0.043), 10 min after infusion. However, no differences were found in hematoma volume or global clinical outcomes between the groups. Incidence of death and thrombotic events was similar between the groups.Rapid infusion of both doses of 4-factor PCC achieved an INR of 1.5 or less in all patients with a lower INR observed in the 40 IU/kg group. No safety concerns were raised by the 40 IU/kg dose. Further trials are needed to evaluate the impact of the high dose of 4-factor PCC on functional outcomes and mortality. Trial registration: Eudra CT number 2007-000602-73.

Abstract:
We examine the possibility of generating
net forces on concave isolated objects from backgrounds consisting of randomly
created waves carrying momentum. This issue is examined first for waves at the
surface of a liquid, and second for quantum vacuum electromagnetic waves, both
in relation with a one-side-open rectangular structure whose interior embodies
a large number of parallel reflecting plates. Using known results about the
Casimir-like effect and the original Casimir effect for parallel plates, we explain
why and how such rectangular hollow structures should feel net oriented forces.
We briefly describe real systems that would allow testing these theoretical
results.

Abstract:
The standard model of particle physics forms a consistent system for
universe description. After following quantum mechanics, it derives particles
from relativistic quantum fields. Since it does not include gravitation, it
describes only one aspect of the universe. In extension of general relativity,
Einstein had proposed a symmetrical and complementary approach of physics. In
his program, he privileged a relativist field based on representations for
physical phenomena, before a precise mathematical description. It allows completing
and unifying the universe description, like both eyes for relief vision, and
both ears for stereophonic audition. We propose to show it with many simple
examples.

Abstract:
The Einstein’s program permits to conciliate gravitation and
electromagnetism. Besides the standard model, it forms a consistent system for
universe description, founded upon a scalar field propagating at the speed of
light c. Matter corresponds to standing waves. Adiabatic variations of
frequencies lead to electromagnetic interaction constituted by progressive
waves. Classical domain corresponds to geometrical optics approximation, when
frequencies are infinitely high, and then hidden. As interactions for matter,
Gravitation and Electromagnetism derive from variations of its energy E = mc^{2}.
Electromagnetic interaction energy derives from mass variation dE = c^{2}dm,
and gravitation from speed of light variation dE = mdc^{2}. Contrarily
to gravitation, only electromagnetic interaction serves as a bridge between
classical and quantum frames, since it leans directly upon the wave property of
matter: its energy dE = hdν = c^{2}dm derives from variations of matter
energy E = hν = mc^{2}.

Abstract:
A thorough characterization of the {\gamma}, {\beta} and glass phases of deuterated 1,1,2,2 Tetrachloroethane (C2D2Cl4) via Nuclear Quadrupole Resonance and Molecular Dynamic Simulations (MDS) is reported. The presence of molecular reorientations was experimentally observed in the glass phase and in the {\beta} phase. In the {\beta} phase, and from MDS, these reorientations are attributed to two possible movements, i.e. a $180^o$ reorientation around the C2 molecular symmetry axis and a reorientation of the molecule between non-equivalent positions. In the glass phase, the spin-lattice relaxation time T1 is of the order of 16 times lower that T1 in the crystalline phase and varies as $T^{-1}$ below 100 K in good agreement with the strong quadrupolar relaxation observed in amorphous materials and in the glassy state of molecular organic systems. The activation energy of molecular reorientations in the glass phase (19 kJ/mol) is comparable to that observed in the glassy crystal of a "molecular cousin" compound, Freon 112 (C2F2Cl4), for the secondary {\beta}-relaxation. Moreover, the on-site orientational motion of Tetrachloroethane molecules offers a new indirect evidence of the prominent role of such orientational disorder in glassy dynamics.

This
article proves the existence of a hyper-precise global numerical
meta-architecture unifying, structuring, binding and controlling the billion
triplet codons constituting the sequence of
single-stranded DNA of the entire human genome. Beyond the evolution and
erratic mutations like transposons within the genome, it’s as if the memory of
a fossil genome with multiple symmetries persists. This recalls the “intermingling” of information characterizing the
fractal universe of chaos theory. The result leads to a balanced and perfect
tuning between the masses of the two strands of the huge DNA molecule that
constitute our genome. We show here how codon populations forming the
single-stranded DNA sequences can constitute a critical approach to the
understanding of junk DNA function. Then, we suggest revisiting certain methods
published in our 2009 book “Codex Biogenesis”. In fact, we demonstrate here how
the universal genetic code table is a powerful analytical filter to
characterize single-stranded DNA sequences constituting chromosomes and
genomes. We can then show that any genomic DNA sequence is featured by three numbers,
which characterize it and its 64 codon populations with correlations greater
than 99%. The number “1” is
common to all sequences, expressing the second law of Chargaff. The other 2
numbers are related to each specific DNA sequence case characterizing life
species. For example, the entire human genome is characterized by three remarkable
numbers 1, 2, and Phi = 1.618 the golden ratio. Associated with each of these
three numbers, we can match three axes of symmetry, then “imagine” a kind of
hyperspace formed by these codon populations. Then we revisit the value (3-Phi)/2
which is probably universal and common to both the scale of quarks and atomic
levels, balancing and tuning the whole human genome codon population. Finally,
we demonstrate a new kind of duality between “form and substance” overlapping
the whole human genome: we will show that—simultaneously with the duality
between genes and junk DNA—there is a second layer of embedded hidden structure
overlapping all the DNA of the whole human genome, dividing it into a second
type of duality information/redundancy involving golden ratio proportions.

The study
done in this paper brings out the effect of the viscoelasticity on the
reflection/transmission coefficients. The knowledge of this effect can be
useful for several applications, such as enhancing the resolution of the
seismic sections, fluid and fracture detection. It can also have other applications different from the geophysical
domain, as the study of the bonding between the materials in the civil
engineering domain. We use the complex Lame coefficients in the
continuity equations at the boundary layers to get the analytical expressions
of the reflection/transmission coefficients in viscoelastic media. The
coefficients can be divided into two parts, the first part is independent from
the quality factor, and it corresponds to the elastic reflection/transmission
coefficients. The second part is dependent on the quality factor contrast and
it represents the contribution of the viscoelasticity on the
reflection/transmission coefficients. From the numerical study it appears that
the effect of the viscoelasticity is significant near to the critical angles.
This effect is not clear and it is difficult to interpret and we do not know if
it has a physical meaning or it is only a mathematical artifact that is why it
is better to be far from the critical angles for seismic investigation.

With the right and the left waves of an electron, plus the left wave of
its neutrino, we write the tensorial densities coming from all associations of
these three spinors. We recover the wave equation of the electro-weak theory. A
new non linear mass term comes out. The wave equation is form invariant, then
relativistic invariant, and it is gauge invariant under the U(1)×SU(2), Lie
group of electro-weak interactions. The invariant form of the wave equation has
the Lagrangian density as real scalar part. One of the real equations equivalent
to the invariant form is the law of conservation of the total current.

We show how the metric of a five-dimensional hyperspace-time can be used to model the quantum nature of electromagnetic interactions. The space-time neighborhood of the point where such an interaction takes place bends according to the curl and the derivative of the local electromagnetic four-potential, both calculated in the direction of the latter. In this geometric setting, the presence of a non-gravitational field is needed to induce the discretization of any gravitational field. We also exploit two variants of the classical Kaluza-Klein five-dimensional theory to obtain coupled generalizations of Einstein’s and Maxwell’s equations. The first variant involves an unspecified scalar field that may be related to the inflaton. The equations of the second variant show a direct interdependency of gravitation and electromagnetism that would emerge or be activated through the production of electromagnetic waves.

A wave equation
with mass term is studied for all fermionic particles and antiparticles of the
first generation: electron and its neutrino, positron and antineutrino, quarks u and d with three states of color and antiquarks and . This wave
equation is form invariant under the group generalizing the relativistic
invariance. It is gauge invariant under the U(1)×SU(2)×SU(3) group of the standard model of quantum
physics. The wave is a function of space and time with value in the Clifford
algebra Cl_{1,5}. Then many features of the standard model, charge
conjugation, color, left waves, and Lagrangian formalism, are obtained in the
frame of the first quantization.