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Search Results: 1 - 10 of 3201 matches for " Clara Fumiko Tachibana;Lampe "
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Identification of hepatitis C virus subtype 2c by sequencing analysis in patients from Córdoba, Argentina
, Viviana;Contigiani, Marta;Yoshida, Clara Fumiko Tachibana;Lampe, Elisabeth;
Memórias do Instituto Oswaldo Cruz , 2007, DOI: 10.1590/S0074-02762007000800016
Abstract: in argentina, most information on hepatitis c virus (hcv) genotype distribution comes from studies carried out in buenos aires (east province). in order to identify hcv subtypes in central argentina, nucleotide sequencing of core region was performed in samples from 36 patients living in córdoba, the second most populated province of argentina. the sequence analysis identified subtype 2c as the most prevalent (50%), followed by subtype 1b (33%) and to a lesser extent by subtypes 1a (11%), 3a (3%) and 4a (3%). this is the first report of circulation of hcv subtype 2c in this region of argentina and also such high prevalence has never been found before in the genotype distribution of south america.
Geographic distribution of HBsAg subtypes in Brazil
Gaspar, Ana Maria Coimbra;Yoshida, Clara Fumiko Tachibana;
Memórias do Instituto Oswaldo Cruz , 1987, DOI: 10.1590/S0074-02761987000200013
Abstract: hbsag positive serum samples (896) from five brazilian regions were analysed for hbsag subtypes. the presence of five different subtypes (ayw2, ayw3, ayw4, adw2 and adw4) was detected. in northern region subtypes adw4 (41.2%) and adw2 (37.2%) were predominant. in the north east only subtype adw2 was encountered. in central west, south-east and south, subtypes ayw2, ayw3, adw2 and adw4 were present, with predominance of adw2 in central west and south east (84.3% and 69.4% respectively) whereas in the south the predominant subtype was ayw3 (41.9%) followed by ayw2 (36.4%). subtypes ayw1, ayr and adr were not found among the samples studied. these results show the difference in the incidence of hbsag subtypes in the different regions of brazil and their significance in relation to the colonization and migrations in this country.
Reflex?es éticas acerca dos estudos de soroprevelência de hepatites virais
Gaze, Rosangela;Carvalho, Diana Maul de;Yoshida, Clara Fumiko Tachibana;Tura, Luiz Fernando Rangel;
Revista da Associa??o Médica Brasileira , 2006, DOI: 10.1590/S0104-42302006000300017
Abstract: background: epidemiological studies on viral hepatitis (vh) using new technologies raise ethical issues especially concerning community-based studies on seroprevalence (css), sentinel surveillance-based studies (sbs) the use of blood-bank registers (bbr) and serum stocks (ss). methods: positive (pa) and negative (na) aspects of these different designs are discussed, pointing to alternatives, according to resolution cns no 196/96. results: priority for research is justified by vh magnitude, severity, and vulnerability, and need for development of diagnosis/therapy protocols and prevention/control strategies. with respect to css, pa was identified as: subject autonomy; adequate samples and as na: costs override benefits, and availability of information from other sources. in relation to sbs, pa are: vh monitoring has lower operational costs than css; absence of additional injuries to subject; while na is: relative restriction of representativeness. for bbr, pa is: the low cost of monitoring of hbv/hcv in blood donors and with no additional risk. pa has limited representativeness. ss studies present as pa: benefits higher than risks/costs; possibility of identification of new morbidity and offering of adequate diagnosis and treatment. na is: biological material and research data can be used for other researches. conclusion: the choice of study designs must take into account arguments for ethical investigation and consensus on the use of new technology.
Prevalência elevada de hepatite C no distrito de Botafogo, cidade de Bebedouro, interior do Estado de S?o Paulo, Brasil, 2007
Ferr?o, Sabrina de Brito Ramalho Luz;Figueiredo, José Fernando de Castro;Yoshida, Clara Fumiko Tachibana;Passos, Afonso Dinis Costa;
Cadernos de Saúde Pública , 2009, DOI: 10.1590/S0102-311X2009000200025
Abstract: this article aimed to estimate the prevalence of hepatitis c in botafogo, a district of bebedouro, s?o paulo state, brazil, and investigate possible risk factors. one individual over 18 years of age was selected from each household to answer a questionnaire on socio-demographic variables and factors associated with hepatitis c. blood samples were also drawn for immunoenzymatic tests. positive hcv-antibody samples were submitted to viral rna detection. hcv prevalence was 8.8% (95%ci: 5.8-11.7), and independent variables associated with risk of infection were: male gender, time of local residence > 30 years, and history of injected medication using non-disposable material, sterilized by boiling. the high prevalence of hepatitis c infection in this relatively isolated rural population appears to result from previous exposure to injections with inadequately sterilized material, with some evidence suggesting a specific elderly pharmacy employee who customarily applied such injections and may have been a chronic hcv carrier.
Viral Hepatitis Markers in Antepartum and Postpartum Women in Rio de Janeiro, Brazil
Lewis-Ximenez, Lia Laura;Gaspar, Ana Maria Coimbra;D'Oro, Antonio Carlos Cavalieri;Mercadante, Luiz Antonio Chilelli;Ginuino, Cleber Ferreira;Yoshida, Clara Fumiko Tachibana;
Memórias do Instituto Oswaldo Cruz , 2002, DOI: 10.1590/S0074-02762002000200011
Abstract: a seroprevalence study was carried out among a group of women in rio de janeiro to determine the prevalence of different markers for viral hepatitis given the limited data among healthy populations. blood samples collected and tested from 874 women before or after delivery in a public county maternity hospital demonstrated age to be directly related to markers for hepatitis a virus and hepatitis b virus (hbv) infection. the prevalence of hbv and hepatitis c virus infection were lower than that observed in the blood donor population and might be explained by the younger age group and gender.
"The first shot": the context of first injection of illicit drugs, ongoing injecting practices, and hepatitis C infection in Rio de Janeiro, Brazil
Oliveira, Maria de Lourdes Aguiar;Hacker, Mariana A.;Oliveira, Sabrina Alberti Nóbrega de;Telles, Paulo Roberto;ó, Kycia Maria Rodrigues do;Yoshida, Clara Fumiko Tachibana;Bastos, Francisco I.;
Cadernos de Saúde Pública , 2006, DOI: 10.1590/S0102-311X2006000400024
Abstract: the context of first drug injection and its association with ongoing injecting practices and hcv (hepatitis c virus) infection were investigated. injection drug users (idus) (n = 606) were recruited in "drug scenes" (public places, bars) in rio de janeiro, brazil, interviewed, and tested for hcv. sharing of needles/syringes was more prevalent at the first injection (51.3%) than at the baseline interview (36.8%). those who shared syringes/needles at first injection were more likely to be currently engaged in direct/indirect sharing practices. among young injectors (< 30 years), those reporting sharing of needles/ syringes at the first injection were about four times more likely to have been infected by hcv. hepatitis c virus prevalence among active idus (n = 272) was 11%. prison history and longer duration of drug injection were identified as independent predictors of hcv infection. to effectively curb hcv transmission among idus and minimize harms associated with risk behaviors, preventive strategies should target individuals initiating drug injection beginning with their very first injection and discourage the transition from non-injecting use to the self-injection of illicit drugs.
Perfil soroepidemiológico da infec??o pelo vírus da hepatite B em profissionais das unidades de hemodiálise de Goiania-Goiás, Brasil Central
Lopes, Carmen Luci Rodrigues;Martins, Regina Maria Bringel;Araújo Teles, Sheila;Silva, Simone Almeida e;Maggi, Priscila Souza;Yoshida, Clara Fumiko Tachibana;
Revista da Sociedade Brasileira de Medicina Tropical , 2001, DOI: 10.1590/S0037-86822001000600008
Abstract: in order to investigate the hepatitis b virus (hbv) infection profile in hemodialysis staff (n = 152) of goiania,goiás, blood samples were tested for detection of hbsag, anti-hbs and anti-hbc markers. an overall hbv infection prevalence of 24.3% (ci 95%: 17.8 - 32) was found. multivariate analysis of risk factors showed that length of employment, history of occupational exposure and nonuse of protective equipment were significantly associated with hbv seropositivity. of 40 staff members who were susceptible to this infection, 20 agreed to participate in the vaccination program. after three vaccine doses (euvax-b), 18 (90%) seroconverted to anti-hbs with titers 3 10 iu/l. these data suggest the dialytic environmental as a possible source of occupational transmission of hbv, and emphasize the need to evaluate strategies of control and prevention to be followed in these units.
Marcadores sorológicos da hepatite B em usuários de um Centro de Testagem para o HIV
Monteiro, Maria Rita de Cassia Costa;Passos, Afonso Dinis Costa;Figueiredo, José Fernando de Castro;Gaspar, Ana Maria Coimbra;Yoshida, Clara Fumiko Tachibana;
Revista da Sociedade Brasileira de Medicina Tropical , 2001, DOI: 10.1590/S0037-86822001000100009
Abstract: the objective of this investigation was to study the prevalence of serological markers of hepatitis b and possible risk factors for this disease in a sample of 404 people who attended a testing and couseling center for hiv in the city of ribeir?o preto, s?o paulo state, brazil. the overall prevalence of serologic hepatitis b markers was 14.6%, equal to that obtained for anti-hbc. hbsag and anti-hbc igm showed prevalences of 1%. after adjustment using logistic regression, hepatitis b markers showed association with the following variables: age, place of residence, use of injectable drugs and positivity to anti-hiv. the overall prevalence of human immunodeficiency virus infection was 6.9%. hepatitis b markers were detected in 55.6% among intravenous drug users and in 42.9% among those who tested positive for hiv, confirming literature findings which indicates high levels of infection in these specific population groups.
Hepatitis B among female sex workers in Ribeir?o Preto - S?o Paulo, Brazil
Passos, Afonso Dinis Costa;Figueiredo, José Fernando de Castro;Martinelli, Ana de Lourdes Candolo;Villanova, Márcia Guimar?es;Nascimento, Margarida Pásseri do;Gaspar, Ana Maria Coimbra;Yoshida, Clara Fumiko Tachibana;
Revista Brasileira de Epidemiologia , 2007, DOI: 10.1590/S1415-790X2007000400010
Abstract: objective: to estimate the prevalence of hepatitis b markers and to study the risk factors for this disease among female sex workers in the city of ribeir?o preto, brazil. methods: a questionnaire was given to 449 female sex workers in order to obtain information about demographic, socioeconomic and behavioral variables. blood samples were collected and analyzed by immunoenzymatic techniques for detection of hbsag, anti-hbs, anti-hbc and anti-hcv markers. results: the mean age of participants was 23 years, varying from 13 to 64 years. a high spatial mobility was observed, with 47.9% of participants residing in places out of the region of ribeir?o preto or in other brazilian states. complete absence of previous vaccine against hepatitis b was referred by 98.2%. overall, the presence of any hepatitis b marker was observed in 106 participants (prevalence of 23.6%; 95% ci: 19.7 27.5), with 84 positive for anti-hbs (18.7%), 100 for anti-hbc (22.3%), and only 3 for hbsag (0.7%). the logistic regression analysis showed association between hepatitis b markers and the following co-variables: residence in ribeir?o preto, age, low socioeconomic level, consumption of crack, intercourse with hiv-infected individuals, history of previous hepatitis, intercourse with a case of hepatitis, and positivity for hepatitis c. conclusions: ribeir?o preto's female sex workers present several risk factors for hepatitis b and almost absence of previous specific vaccination, making it necessary to emphasize this low-cost preventive measure, preferably through the use of a mobile team, taking the vaccine to their places of work.
Hepatitis C virus genotypes in Cordoba, Argentina unexpected high prevalence of genotype 2
V. Re,E Lampe,C Fumiko Yoshida,J Mendes de Oliveira
Medicina (Buenos Aires) , 2003,
Abstract: To determine hepatitis C virus (HCV) genotypes circulating in the central region of Argentina, 96 consecutive anti-HCV positive subjects were studied. The presence of HCV RNA was detected in 60 samples by RT-nested PCR of the 5' noncoding region (5' NCR). Genotyping was performed by restriction fragment length polymorphism analysis of 5' NCR region combined with PCR using type-specific primers of the core region. The groups of individuals in this study included hemophilia and hemodialysis patients, injecting drug users, screened blood donors, and patients with acute or chronic liver disease, all from Córdoba, Argentina. Overall, genotype 2 was the most prevalent (55.0%), followed by genotypes 1 (38.3 %), and 3 (5.0%). Within genotype 1, subtype 1b was the most prevalent. An unexpected high prevalence of genotype 2 (61.9%) was found among patients with acute or chronic HCV infection (without known risk factors). These figures differ from other cohorts from East-Argentina where genotype 1 has been found as the most prevalent. This indicates that regional differences of genotype distribution might exist between Central and East Argentina. A fin de determinar los genotipos del virus de la hepatitis C (HCV) circulantes en la región central de Argentina, se estudiaron 96 individuos anti-HCV positivos. La presencia del ARN de HCV se detectó en 60 muestras mediante RT-nested PCR de la región 5' no codificante (5' NCR). La genotipificación se realizó mediante restricción enzimática y el análisis del polimorfismo de los fragmentos largos de la región 5' NCR combinada con PCR usando primers tipo específico de la región del core. El grupo de individuos estudiados incluyó pacientes hemofílicos y hemodializados, drogadictos intravenosos, donantes de sangre y pacientes con enfermedad hepática aguda y crónica, todos provenientes de Córdoba, Argentina. El genotipo 2 fue el más prevalente (55.0%), seguido por los genotipos 1 (38.3 %), con mayor prevalencia del subtipo 1b, y el genotipo 3 (55.0%). Una inesperada alta prevalencia de genotipo 2 (61.9%) se encontró entre pacientes con infección aguda o crónica por el virus HCV (sin factor de riesgo conocido). Estos hallazgos difieren de otros resultados encontrados en trabajos realizados con pacientes provenientes de la región este de Argentina, en los cuales el genotipo 1 fue encontrado como el más prevalente. Esto indica que pueden existir diferencias regionales en la distribución de genotipos HCV entre la región centro y este de Argentina.
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