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Search Results: 1 - 10 of 963 matches for " Ciro Indolfi "
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Outcome of open and endovascular repair in acute type B aortic dissection: a retrospective and observational study
Pasquale Mastroroberto, Francesco Onorati, Saverio Zofrea, Attilio Renzulli, Ciro Indolfi
Journal of Cardiothoracic Surgery , 2010, DOI: 10.1186/1749-8090-5-23
Abstract: Retrospective and observational analysis with patient inclusion between January 2001-December 2008 and follow-up ranged from 2 to 96 months (median = 47.2) was performed. Out of 51 consecutive patients with B AAD, 11 (21.6%) had to undergo open surgery (OS) and 13 (25.5%) endovascular treatment (TEVAR).There was a significantly difference in early mortality in the TEVAR group (0/13,0%) vs OS group (4/11,36.4%, P < 0.05) and in the incidence of paraplegia/paraparesis (OS 2,28.6% vs TEVAR 1,7.7%, P < 0.05), renal failure (OS 3, 42.8% vs TEVAR 1, 7.7%, P < 0.05), respiratory failure (OS 2,28.6% vs TEVAR 1,7.7%, P < 0.05) and cerebrovascular accident (OS 1,14.3% vs TEVAR 0,0%, P < 0.05). The late mortality at a follow-up was 30.8% (4/13) in the TEVAR group and 42.8% (3/7) in the OS group, respectively (P = not significant). The cumulative survival rate after 1, 3 and 8 years was 93%, 84%, and 69% in the TEVAR group and 86%, 71% and 57% in the OS group, respectively. Endoleaks were diagnosed in 2/13 endovascular patients (15.4%).TEVAR group had a significantly reduction in early mortality and postoperative complications. No significant differences were found in terms of cumulative survival at follow-up. On this basis TEVAR could be considered an option in the treatment of these complex cases with all proper reservation especially related to the small sample sizes examined.The treatment of Stanford type B acute aortic dissection (B AAD) still remains a formidable challenge in complicated cases and the options are medical therapy, conventional surgery or endovascular repair. The method of choice is conservative with aggressive medical therapy [1,2] using β- blockers, calcium-channel blockers and nitroglycerin to control heart rate and to maintain a systolic blood pressure less than 110 mmHg so lowering aortic wall tension. A surgical approach is reserved in all cases with complicated course such as persisted pain, rupture or impending rupture, visceral and/or leg ischemia
The margination propensity of spherical particles for vascular targeting in the microcirculation
Francesco Gentile, Antonio Curcio, Ciro Indolfi, Mauro Ferrari, Paolo Decuzzi
Journal of Nanobiotechnology , 2008, DOI: 10.1186/1477-3155-6-9
Abstract: In the early diagnosis, treatment and imaging of diseases, as cancer and cardiovascular, the use of microparticles and nanoparticles is emerging as a powerful tool [1,2]. These are sufficiently small 'vectors' of therapeutic or/and imaging agents to be systemically administered, transported by the blood flow along the circulatory system and eventually recognize the diseased microenvironment (diseased cells). A nanoparticle comprises an internal core with the active agents and an external coating whit tailored physico-chemical properties. The interaction of the vectors with the biological target (diseased cell) is generally governed by specific forces, mediated by the formation and destruction of molecular bonds [3], and by non-specific interactions regulated by short ranged forces as van der Waals, electrostatic and steric [4].Two different delivery strategies are currently under investigation and development: a passive targeting of the diseased microenvironment relying on the permeability of the blood vessels (enhanced retention and permeability effect), and an active targeting of the diseased microvasculature relying on the recognition of specific molecules overexpressed at the site of interest [5]. It is known that tumor microvessels exhibit a significant increase in permeability to large molecules with intercellular openings and intercellular gaps as large as a micron [6], which could be crossed by sufficiently small particles. However the level of permeability is strongly dependent on the type of tumor, the site where the tumor is developing, the state of the tumor and the therapeutic treatment, and significant differences can be observed between human and xenografts tumors [7]. In addition to this, diseases other than cancer do no show any significant vessel permeability, thus making a passive targeting strategy non appropriate. On the other hand, a growing body of evidences support the idea that specific molecules are overexpressed at the surface of a disease
Non-Coding RNAs: The “Dark Matter” of Cardiovascular Pathophysiology
Claudio Iaconetti,Clarice Gareri,Alberto Polimeni,Ciro Indolfi
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms141019987
Abstract: Large-scale analyses of mammalian transcriptomes have identified a significant number of different RNA molecules that are not translated into protein. In fact, the use of new sequencing technologies has identified that most of the genome is transcribed, producing a heterogeneous population of RNAs which do not encode for proteins (ncRNAs). Emerging data suggest that these transcripts influence the development of cardiovascular disease. The best characterized non-coding RNA family is represented by short highly conserved RNA molecules, termed microRNAs (miRNAs), which mediate a process of mRNA silencing through transcript degradation or translational repression. These microRNAs (miRNAs) are expressed in cardiovascular tissues and play key roles in many cardiovascular pathologies, such as coronary artery disease (CAD) and heart failure (HF). Potential links between other ncRNAs, like long non-coding RNA, and cardiovascular disease are intriguing but the functions of these transcripts are largely unknown. Thus, the functional characterization of ncRNAs is essential to improve the overall understanding of cellular processes involved in cardiovascular diseases in order to define new therapeutic strategies. This review outlines the current knowledge of the different ncRNA classes and summarizes their role in cardiovascular development and disease.
Inflammatory Myofibroblastic Bladder Tumor in a Patient with Wolf-Hirschhorn Syndrome
Antonio Marte,Paolo Indolfi,Carmine Ficociello,Daniela Russo,Matilde Oreste,Gaetano Bottigliero,Giovanna Gualdiero,Ciro Barone,Elena Vigliar,Cristiana Indolfi,Fiorina Casale
Case Reports in Urology , 2013, DOI: 10.1155/2013/675059
Abstract: Inflammatory myofibroblastic tumor (IMT) is a rare neoplasm described in several tissues and organs including genitourinary system, lung, head, and neck. The etiology of IMT is contentious, and whether it is a postinflammatory process or a true neoplasm remains controversial. To our knowledge, we report the first reported case of IMT of urinary bladder in a pediatric patient with Wolf-Hirschhorn (WHS). We also review the literature about patients with associated neoplasia. 1. Introduction IMT is a rare neoplasm usually seen in children and adolescents, mostly occurring between 2–16 years of age. Females are affected slightly more commonly than males. It is also known as cellular inflammatory pseudotumor, plasma cell granuloma, and inflammatory fibrosarcoma and is composed of spindle cells with associated inflammatory cells infiltrate [1]. This type of tumor has been described in several organs and anatomical sites including genitourinary system where the tumor usually originates in the bladder, but it has also been reported in the kidney, urethra, prostate, ureter, and rete testis [2]. The etiology of IMT, its behavior, and its cell of origin remain matters of debate [1]. Originally considered a lesion with a benign clinical course, it is now clear that IMT can have an aggressive behavior and, occasionally, an unfavorable prognosis [3]. For this reason, it is important to differentiate this lesion from sarcoma for therapeutic management, and this can be difficult both clinically and histologically [3]. To gain more knowledge about this rare tumor, we reported a case of IMT of the urinary bladder in a girl with WHS. 2. Case Report A previously healthy 8-year-old female, with WHS, was admitted to our clinic in February 2012 for a persistent abdominal pain and macroscopic hematuria. Abdominal ultrasound revealed a multilobated tumor in the bladder adhering to the left bladder wall. A computerized tomography (CT) scan of abdomen confirmed these findings, and a solid mass (approximate size 5 × 4.5?cm) infiltrating the dome and the left bladder wall not extending to perivesical tissues nor lymph node enlargement was revealed. Due to ultrasonographic (Figure 1) and CT scan features (large base, poor vascularization, multilobated appearance, and size >4?cm), the patient underwent cystoscopic multiple biopsies. Histopathology revealed a spindle cell lesion with mixed inflammatory cells in the background. According to histopathology and immunohistochemical characteristics, a provisional diagnosis of IMT was made. Because of the size of the tumor, a complete
MicroRNA-1 Downregulation Increases Connexin 43 Displacement and Induces Ventricular Tachyarrhythmias in Rodent Hypertrophic Hearts
Antonio Curcio, Daniele Torella, Claudio Iaconetti, Eugenia Pasceri, Jolanda Sabatino, Sabato Sorrentino, Salvatore Giampà, Mariella Micieli, Alberto Polimeni, Beverley J. Henning, Angelo Leone, Daniele Catalucci, Georgina M. Ellison, Gianluigi Condorelli, Ciro Indolfi
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0070158
Abstract: Downregulation of the muscle-specific microRNA-1 (miR-1) mediates the induction of pathologic cardiac hypertrophy. Dysfunction of the gap junction protein connexin 43 (Cx43), an established miR-1 target, during cardiac hypertrophy leads to ventricular tachyarrhythmias (VT). However, it is still unknown whether miR-1 and Cx43 are interconnected in the pro-arrhythmic context of hypertrophy. Thus, in this study we investigated whether a reduction in the extent of cardiac hypertrophy could limit the pathological electrical remodeling of Cx43 and the onset of VT by modulating miR-1 levels. Wistar male rats underwent mechanical constriction of the ascending aorta to induce pathologic left ventricular hypertrophy (LVH) and afterwards were randomly assigned to receive 10mg/kg valsartan, VAL (LVH+VAL) delivered in the drinking water or placebo (LVH) for 12 weeks. Sham surgery was performed for control groups. Programmed ventricular stimulation reproducibly induced VT in LVH compared to LVH+VAL group. When compared to sham controls, rats from LVH group showed a significant decrease of miR-1 and an increase of Cx43 expression and its ERK1/2-dependent phosphorylation, which displaces Cx43 from the gap junction. Interestingly, VAL administration to rats with aortic banding significantly reduced cardiac hypertrophy and prevented miR-1 down-regulation and Cx43 up-regulation and phosphorylation. Gain- and loss-of-function experiments in neonatal cardiomyocytes (NCMs) in vitro confirmed that Cx43 is a direct target of miR-1. Accordingly, in vitro angiotensin II stimulation reduced miR-1 levels and increased Cx43 expression and phosphorylation compared to un-stimulated NCMs. Finally, in vivo miR-1 cardiac overexpression by an adenoviral vector intra-myocardial injection reduced Cx43 expression and phosphorylation in mice with isoproterenol-induced LVH. In conclusion, miR-1 regulates Cx43 expression and activity in hypertrophic cardiomyocytes in vitro and in vivo. Treatment of pressure overload-induced myocyte hypertrophy reduces the risk of life-threatening VT by normalizing miR-1 expression levels with the consequent stabilization of Cx43 expression and activity within the gap junction.
Autoimmunity and Extrahepatic Manifestations in Treatment-Na?ve Children with Chronic Hepatitis C Virus Infection
Giuseppe Indolfi,Elisa Bartolini,Biagio Olivito,Chiara Azzari,Massimo Resti
Clinical and Developmental Immunology , 2012, DOI: 10.1155/2012/785627
Abstract: Hepatitis C virus (HCV) infection has been associated with autoimmunity and extrahepatic manifestations in adults. Few data are available on these topics in children. Nonorgan specific auto-antibodies development is part of the natural course of chronic hepatitis C in children. Smooth muscle autoantibody is the most common autoantibody found, while liver-kidney microsomal type-1 antibody positivity is the most peculiar autoimmune feature of children with HCV infection. The clinical significance of non-organ specific autoantibodies in the course of paediatric chronic hepatitis C is still debated. Autoantibody positivity can be considered neutral for most patients, while it can be associated with negative connotations for others, especially those positive for liver-kidney microsomal type-1 autoantibody. Subclinical hypothyroidism but not autoimmune thyroiditis has been demonstrated in HCV infection in children, while only few cases of HCV-associated membranoproliferative glomerulonephritis have been described. Single reports are available in the literature reporting the anecdotal association between chronic hepatitis C and other extrahepatic manifestations such as myopathy and opsoclonus-myoclonus syndrome. Despite the low incidence of extrahepatic manifestations of chronic hepatitis C in children, overall, available data suggest a careful monitoring.
Tubular Bridges for Bronchial Epithelial Cell Migration and Communication
Brett G. Zani,Laura Indolfi,Elazer R. Edelman
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0008930
Abstract: Biological processes from embryogenesis to tumorigenesis rely on the coordinated coalescence of cells and synchronized cell-to-cell communication. Intercellular signaling enables cell masses to communicate through endocrine pathways at a distance or by direct contact over shorter dimensions. Cellular bridges, the longest direct connections between cells, facilitate transfer of cellular signals and components over hundreds of microns in vitro and in vivo.
Chronic hepatitis C virus infection in children and adolescents: Epidemiology, natural history, and assessment of the safety and efficacy of combination therapy
Giuseppe Indolfi, Elisa Bartolini, Davide Casavola, et al
Adolescent Health, Medicine and Therapeutics , 2010, DOI: http://dx.doi.org/10.2147/AHMT.S6750
Abstract: onic hepatitis C virus infection in children and adolescents: Epidemiology, natural history, and assessment of the safety and efficacy of combination therapy Review (3949) Total Article Views Authors: Giuseppe Indolfi, Elisa Bartolini, Davide Casavola, et al Published Date October 2010 Volume 2010:1 Pages 115 - 128 DOI: http://dx.doi.org/10.2147/AHMT.S6750 Giuseppe Indolfi, Elisa Bartolini, Davide Casavola, Massimo Resti Department of Sciences for Women and Child’s Health, Liver and Pediatric Unit, Anna Meyer Children’s Hospital, University of Florence, Florence, Italy Abstract: Hepatitis C virus (HCV) is the most common cause of chronic liver disease of infectious etiology in children. Most of the children infected with HCV are asymptomatic, and only a few of them develop signs and symptoms of end-stage liver disease early in life. It is not possible to predict either in which patients HCV infection will have a bad outcome or the critical time in early adulthood when disease progression will accelerate. The experiences with therapy in children with chronic hepatitis C are based on earlier and continuing data from adult trials. The currently recommended treatment for chronic HCV infection in adults is the combination of peginterferon-a and ribavirin. The choice of this regimen is based on the results of randomized clinical trials that demonstrated the superiority of this combination treatment over standard interferon-a and ribavirin. Recently, results of pivotal, multicenter, interventional open-label studies on combined treatment with peginterferon-a and ribavirin in children have been published, and the US Food and Drug Administration and the European Medicines Agency have approved the combination therapy in those older than 3 years. The aim of this review is to evaluate critically the available data regarding the safety and efficacy of combination treatment with peginterferon-a and ribavirin in children.
Resistencia a la enfermedad de cría yesificada por colonias de Apis mellifera con eficiente comportamiento higiénico (Hymenoptera, Apidae)
Invernizzi, Ciro;
Iheringia. Série Zoologia , 2001, DOI: 10.1590/S0073-47212001000200016
Abstract: in an apiary composed of 14 hygienic and 7 non-hygienic colonies of apis mellifera linnaeus, 1758 the presence of visible and capped mummies was recorded, one hygienic and 4 non-hygienic colonies showed symptoms of chalkbrood. twenty-eight days after a massive contamination of the colonies with pollen patties containing ascosphaera apis olive & spiltoir, 1955, the situation was almost identical to that at the beginning: the same 4 non-hygienic colonies still were infected and one hygienic colony that was healthy became infected. the high proportion of hygienic colonies that eliminated the disease symptoms suggests that they could maintain themselves healthy in spite of the presence of colonies with chalkbrood in the apiary.
Book Review: Berenice Cavarra e Vallori Rasini (a cura di) Passaggi. Pianta, animale, uomo Mimesis, Milano 2012
Ciro Incoronato
S&F_scienzaefilosofia.it , 2012,
Abstract:
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