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Search Results: 1 - 10 of 188284 matches for " Cintia Mara Costa de;Castilho "
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Hepatite cr?nica B oculta: prevalência e aspectos clínicos em popula??o de elevada endemicidade de infec??o pelo vírus da hepatite B na Amaz?nia Ocidental Brasileira
Barros Júnior, Gildo Maia;Braga, Wornei Silva Miranda;Oliveira, Cintia Mara Costa de;Castilho, Márcia da Costa;Araújo, José de Ribamar;
Revista da Sociedade Brasileira de Medicina Tropical , 2008, DOI: 10.1590/S0037-86822008000600010
Abstract: a persistent form of the hepatitis b virus called occult chronic hepatitis b has recently been described. its prevalence and physiopathology are unknown. the aim of this study was to evaluate the occurrence of this clinical entity among patients in the brazilian amazon region. out of 51 anti-hbc total-positive patients who were tested using the polymerase chain reaction, 17% were positive. we did not find any associations with classical risk factors for hepatitis b virus infection or with biochemical tests, hematological tests or histological patterns. however, the jaundiced and hiv-positive patients showed a statistical association with the presence of hepatitis b virus-dna. the results demonstrated that occult hepatitis b occurred among our patients, but at prevalence rates lower than expected for this region. we believe that despite the small sample size, the occurrence might have been found to be greater if we had used primers for the s, c and x regions of the hepatitis b virus genome, thereby increasing the sensitivity of the test.
Serological evidence of hantavirus infection in rural and urban regions in the state of Amazonas, Brazil
Gimaque, Jo?o Bosco Lima;Bastos, Michele de Souza;Braga, Wornei Silva Miranda;Oliveira, Cintia Mara Costa de;Castilho, Márcia da Costa;Figueiredo, Regina Maria Pinto de;Galusso, Elizabeth dos Santos;Itapirema, Evaulino Ferreira;Figueiredo, Luiz Tadeu Moraes de;Mour?o, Maria Paula Gomes;
Memórias do Instituto Oswaldo Cruz , 2012, DOI: 10.1590/S0074-02762012000100019
Abstract: hantavirus disease is caused by the hantavirus, which is an rna virus belonging to the family bunyaviridae. hantavirus disease is an anthropozoonotic infection transmitted through the inhalation of aerosols from the excreta of hantavirus-infected rodents. in the county of itacoatiara in the state of amazonas (am), brazil, the first human cases of hantavirus pulmonary and cardiovascular syndrome were described in july 2004. these first cases were followed by two fatal cases, one in the municipality of maués in 2005 and another in itacoatiara in 2007. in this study, we investigated the antibody levels to hantavirus in a population of 1,731 individuals from four different counties of am. sera were tested by igg/igm- enzyme-linked immune-sorbent assay using a recombinant nucleocapsid protein of the araraquara hantavirus as an antigen. ten sera were igg positive to hantavirus (0.6%). among the positive sera, 0.8% (1/122), 0.4% (1/256), 0.2% (1/556) and 0.9% (7/797) were from atalaia do norte, careiro castanho, itacoatiara and lábrea, respectively. none of the sera in this survey were igm-positive. because these counties are distributed in different areas of am, we can assume that infected individuals are found throughout the entire state, which suggests that hantavirus disease could be a local emerging health problem.
Molecular characterization of the hepatitis B virus in autochthonous and endogenous populations in the Western Brazilian Amazon
Dias, ádila Liliane Barros;Oliveira, Cintia Mara da Costa;Castilho, Márcia da Costa;Silva, Maria do Socorro Pontes da;Braga, Wornei Silva Miranda;
Revista da Sociedade Brasileira de Medicina Tropical , 2012, DOI: 10.1590/S0037-86822012000100003
Abstract: introduction: hepatitis b virus (hbv) infection is a serious public health issue worldwide. hepatitis b virus is classified into eight genotypes, varying from a to h, with distinct geographical distributions. in brazil, the most frequent genotypes are a, d, and f. methods: this study aimed to characterize the hbv genotypes in cases of hepatitis b virus and hepatitis d virus (hdv) co-infections in an endemic area in the western brazilian amazon. we analyzed 86 serum samples reactive for hbsag from indigenous and non-indigenous populations obtained from previous serological surveys. results: of the 86 reactive serum samples, 39 were found to be hbv-dna-positive by semi-nested pcr. the genotypes were established by sequencing the amplified s gene region. we obtained 20 sequences classified into three genotypes: a, d, and f. genotype a was the most frequent (60%), followed by d (35%) and f (5%). conclusions: the distribution of the hbv genotypes reflected the pattern of historical occupation of the region.
Contribui o da ausculta cervical para a avalia o clínica das disfagia orofaríngeas Contribution of the cervical auscultation in clinical assessment of the oropharyngeal dysphagia
Geovana de Paula Bolzan,Mara Keli Christmann,Luana Cristina Berwig,Cintia Concei??o Costa
Revista CEFAC , 2013,
Abstract: Para auxiliar na avalia o funcional da degluti o, a maior parte dos fonoaudiólogos utiliza recursos instrumentais como a ausculta cervical. Em vista disso, o objetivo deste estudo foi verificar na literatura a contribui o da ausculta cervical para a avalia o clínica das disfagias. Para tanto, foram revisados periódicos nacionais e internacionais, indexados nas bases de dados Springer, Lilacs, Bireme, Medline e Scielo, entre os anos de 1992 e 2011. A partir da análise dos estudos foi possível verificar que a ausculta cervical vem se modernizando com a evolu o tecnológica, possibilitando a realiza o de estudos quantitativos dos sons da degluti o; que ainda há evidências pouco claras das correspondências entre os componentes sonoros da degluti o e os eventos fisiológicos da fase faríngea; que n o foram evidenciadas diferen as nos sons da degluti o entre crian as e adultos; e que alguns estudos apresentaram concordancia entre a ausculta cervical e a avalia o videofluoroscópica da degluti o, e outros ainda apresentaram correla o positiva entre estas duas avalia es. Assim, considerando-se que a videofluoroscopia da degluti o em nosso país ainda é um exame de difícil acesso, com custo relativamente alto, acredita-se que a ausculta cervical constitui um importante recurso para o diagnóstico e acompanhamento clínico em casos de disfagia orofaríngea. In order to assist on the functional assessment of swallowing, most speech therapists make use of instrumental resources such as cervical auscultation. Thus, the objective of this study was to search the literature in order to find the contribution of cervical auscultation for assessing dysphagias. To this end, international and national journals were reviewed. These journals were indexed in Springer, Lilacs, Bireme, Medline and Scielo databases, comprising the period between 1992 and 2011. From the analysis of the studies, it was possible to verify that: cervical auscultation has been modernized with the technologic evolution, enabling the realization of quantitative studies of the swallowing sounds; there are still few clear evidence of the connections between the sound components of swallowing and the physiological events of the pharyngeal phase; no differences were observed between the swallowing sounds in children and adults; in some studies, cervical auscultation was positively correlated with the videofluoroscopic assessment of swallowing, and others presented positive correlation between these two assessment procedures. Hence, considering that the swallowing videofluoroscopy examination is still
Characterization of HBeAg-negative chronic hepatitis B in western Brazilian Amazonia
Victoria, Flamir da Silva;Oliveira, Cintia Mara Costa de;Victoria, Marilu Barbieri;Victoria, Cristian Barbieri;Ferreira, Luis Carlos Lima;
Brazilian Journal of Infectious Diseases , 2008, DOI: 10.1590/S1413-86702008000100008
Abstract: the present study was conducted with 55 patients native from western brazilian amazonia, who were hbv-dna positive after seroconversion of hbeag. it is a descriptive case study, with the patients separated into two groups: with hepatitis and without hepatitis on histological examination. the aim of the present study was to describe the clinical and molecular characteristics of patients who are chronic carriers of hbsag. the prevalence of hepatitis was 63.64%, with a predominance of males (41.82%) and a mean age of 42.5 years, occurring mostly in natives of the southeast sub-region (32.73%). time was a variable proportional to the course of the disease and the most frequent symptoms were: dyspepsia, asthenia and loss of libido with the majority of the patients having history of prior contact with hbv or positive family history. splenomegalia was the most frequent sign (40%). among the tests, platelet count, serum albumin and prothrombin activity were significant in the diagnosis of hepatitis. alpha-fetoprotein was greater in patients with hepatitis, and hepatocellular carcinoma was detected in 3.63% of the patients with hepatic cirrhosis. three types of hbv genotypes were diagnosed: a, d and f in the samples amplified for gene s. genotype a (aa) was observed in 54.54% of the cases with hepatitis, in contrast to other studies showing the predominance of genotype f in this region. we observed mutations in 36.36%, with a predominance of the mutations in the core promoter region (31.81%), due to the greater prevalence of genotype a in this study.
HIV-associated tuberculous lymphadenitis: the importance of polymerase chain reaction (PCR) as a complementary tool for the diagnosis of tuberculosis - a study of 104 patients
Cortez, Marcio Valle;Oliveira, Cintia Mara Costa de;Monte, Rossicléia Lins;Araújo, José Ribamar de;Braga, Bruna Backsmann;Reis, Débora Zotteli dos;Ferreira, Luis Carlos de Lima;Moraes, Milton Ozório;Talhari, Sinésio;
Anais Brasileiros de Dermatologia , 2011, DOI: 10.1590/S0365-05962011000500010
Abstract: background: lymphadenitis is common in hiv-positive patients. diagnosis of the infections associated with this condition is complex, particularly in the case of tuberculosis. rapid and specific detection of mycobacterium tuberculosis (m. tuberculosis) is fundamental in ensuring adequate treatment. in addition, frequent causes of lymphadenitis such as those associated with lymphoma and histoplasmosis, among others, must be eliminated as possible causes. objectives: to evaluate the accuracy of polymerase chain reaction as a tool for the diagnosis of lymphadenitis resulting from m. tuberculosis. methods: in this study, a protocol was developed using the following procedures: direct microscopy using ziehl-neelsen staining, culture in lowenstein-jensen medium, histology and polymerase chain reaction. results: a total of 104 patients were included in the study. according to histopathology, 38 patients (36%) were found to have nonspecific chronic lymphadenitis, 27 (26%) had tuberculous lymphadenitis, 11 patients (10.5%) had lymphoma and 9 (8.7%) had histoplasmosis. when lowenstein-jensen culture was performed, positive tests for tuberculous lymphadenitis increased by 30%. with polymerase chain reaction, m. tuberculosis dna was detected in 6 out of 38 samples of non-specific chronic lymphadenitis. three of these patients were followed up, developed symptoms of tuberculosis and were cured following specific treatment. conclusion: the data obtained in this study suggest that all cases of lymphadenopathies should be submitted to histopathology, lowenstein-jensen or ogawa culture and polymerase chain reaction. polymerase chain reaction may prove to be useful in providing an early and accurate detection of cases of extrapulmonary tuberculosis in hiv-positive patients with lymphadenopathies, avoiding empirical treatment and the possible development of resistant strains.
Cytogenetic biomonitoring of Brazilian dentists occupationally exposed to low doses of X-radiation
Miyaji, Cintia Kaori;Cólus, Ilce Mara de Syllos;
Pesquisa Odontológica Brasileira , 2002, DOI: 10.1590/S1517-74912002000300003
Abstract: exposure to x-rays (ionizing radiation) may cause chromosomal aberrations (ca) in somatic or germinative cells in exposed individuals, and may lead to manifestations of diseases such as cancer. this study was carried out to assess the ca frequency in lymphocytes obtained by means of temporary culture of peripheral blood from dentists in londrina, paraná, brazil, who have worked for more than ten years with x-rays. the results obtained from the experimental group were compared with a matched negative control group, which had never been exposed to x-rays. all individuals, dentists and controls, answered a personal questionnaire, from which a profile of each group was obtained. slides, prepared after the cultures, were stained with giemsa, and 100 to 200 metaphase cells were analyzed per individual. ca frequencies and types were registered and statistical tests were not necessary to evaluate the obtained data. the analysis of mitotic index (mi) did not indicate significant differences (p < 0.05) between the group of individuals exposed to x-rays and the control group. the analyzed confounding factors did not influence the results of mi and ca frequencies.
Cytogenetic biomonitoring of Brazilian dentists occupationally exposed to low doses of X-radiation
Miyaji Cintia Kaori,Cólus Ilce Mara de Syllos
Pesquisa Odontológica Brasileira , 2002,
Abstract: Exposure to X-rays (ionizing radiation) may cause chromosomal aberrations (CA) in somatic or germinative cells in exposed individuals, and may lead to manifestations of diseases such as cancer. This study was carried out to assess the CA frequency in lymphocytes obtained by means of temporary culture of peripheral blood from dentists in Londrina, Paraná, Brazil, who have worked for more than ten years with X-rays. The results obtained from the experimental group were compared with a matched negative control group, which had never been exposed to X-rays. All individuals, dentists and controls, answered a personal questionnaire, from which a profile of each group was obtained. Slides, prepared after the cultures, were stained with Giemsa, and 100 to 200 metaphase cells were analyzed per individual. CA frequencies and types were registered and statistical tests were not necessary to evaluate the obtained data. The analysis of mitotic index (MI) did not indicate significant differences (p < 0.05) between the group of individuals exposed to X-rays and the control group. The analyzed confounding factors did not influence the results of MI and CA frequencies.
Combining diagnostic procedures for the management of leishmaniasis in areas with high prevalence of Leishmania guyanensis
Benicio, Ednelza de Almeida;Nunes Gadelha, Ellen Pricilla;Talhari, Anette;Silva Jr, Roberto Moreira da;Ferreira, Luis Carlos;Santos, Mayara Cristina Cordeiro dos;Mira, Marcelo Távora;Oliveira, Cintia Mara Costa de;Talhari, Carolina;Talhari, Sinésio;Machado, Paulo Roberto;Schriefer, Albert;
Anais Brasileiros de Dermatologia , 2011, DOI: 10.1590/S0365-05962011000600012
Abstract: background: the amazon region corresponds to approximately 40% of the cases of leishmaniasis in brazil. we report a prospective study with 180 patients conducted in a health care unit that diagnoses 10% of the cases of leishmaniasis in the brazilian amazon. the study addresses how a combination of procedures improves diagnosis in areas with high prevalence of leishmania guyanensis. objectives: to evaluate diagnostic methods in areas with high prevalence of leishmania guyanensis. methods: all subjects were amastigote-positive by direct microscopic examination of lesion scarifications. we conducted skin biopsy and histopathology, polymerase chain reaction and parasite cultivation. results: polymerase chain reaction detected almost ninety percent of infections when two amplification protocols were used (mini-exon and hsp-70). hsp-70 specific polymerase chain reaction matched the sensitivity of parasite cultivation plus histopathology. conclusion: the best combination was polymerase chain reaction plus histopathology, which increased diagnostic sensitivity to 94%. species discrimination by polymerase chain reaction disclosed prevalence of human infections with leishmania guyanensis of 94% and with leishmania braziliensis of 6% for this region
Concep??es de surdez: a vis?o do surdo que se comunica em língua de sinais
Lopes, Mara Aparecida de Castilho;Leite, Lúcia Pereira;
Revista Brasileira de Educa??o Especial , 2011, DOI: 10.1590/S1413-65382011000200009
Abstract: at this time, diverse views on deafness are present in society. such views, in general, are characterized by theoretical disputes between communicative possibilities - either oral or gestural - based on the importance of having appropriated oneself of a language code for the development of language, which is essential in the constitution of subjectivity of human beings. thus, this study aimed to identify the conceptions of deaf people had about their condition. to collect the data we used semi-structured interviews, applied to ten participants who were deaf adult users of the brazilian sign language - libras. the interviews were taped, transcribed and subjected to content analysis. the results indicate that the conceptions of deafness constitute a multifaceted view on this condition, influenced by social relations throughout each person’s life trajectories. the researchers perceived that learning libras enabled deaf persons to constitute their own assertiveness as someone who is different, with different needs.
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