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Search Results: 1 - 10 of 401718 matches for " Cindy M. Bukach "
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Early Electrophysiological Basis of Experience-Associated Holistic Processing of Chinese Characters
Hui Chen, Cindy M. Bukach, Alan C.-N. Wong
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0061221
Abstract: Recent studies have found holistic processing to be a marker of expertise for perception of words in alphabetic (e.g., English) and non-alphabetic (e.g., Chinese) writing systems, consistent with what has been found for faces and other objects of face-like expertise. It is unknown, however, whether holistic processing of words occurs in an early, perceptual stage as it does for faces. We examined how early holistic processing of Chinese characters emerges by recording the event-related potentials (ERPs) in an adaptation paradigm. Participants judged if the top parts of two sequentially presented characters were the same or different while ignoring the bottom part. An early potential (P1) at the posterior channels was smaller when the attended top parts were the same compared with when they are different, indicating an adaptation effect. Critically, for trials with identical top parts, P1 was larger when the irrelevant bottom parts were different, indicating a release of adaptation. This effect was present only when the two character parts were aligned but not misaligned, and only for characters but not for pseudocharacters. The finding of early sensitivity to all parts of a Chinese character suggests that Chinese characters are represented holistically at a perceptual level.
Holistic Processing of Words Modulated by Reading Experience
Alan C.-N. Wong,Cindy M. Bukach,Crystal Yuen,Lizhuang Yang,Shirley Leung,Emma Greenspon
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0020753
Abstract: Perceptual expertise has been studied intensively with faces and object categories involving detailed individuation. A common finding is that experience in fulfilling the task demand of fine, subordinate-level discrimination between highly similar instances is associated with the development of holistic processing. This study examines whether holistic processing is also engaged by expert word recognition, which is thought to involve coarser, basic-level processing that is more part-based. We adopted a paradigm widely used for faces – the composite task, and found clear evidence of holistic processing for English words. A second experiment further showed that holistic processing for words was sensitive to the amount of experience with the language concerned (native vs. second-language readers) and with the specific stimuli (words vs. pseudowords). The adoption of a paradigm from the face perception literature to the study of expert word perception is important for further comparison between perceptual expertise with words and face-like expertise.
An Evidence-Based Approach to the Use of Predictive Biomarkers in the Treatment of Non- Small Cell Lung Cancer (NSCLC)
Cindy Quinton,Peter M. Ellis
Cancers , 2011, DOI: 10.3390/cancers3033506
Abstract: Recent advances in the treatment of non-small cell lung cancer (NSCLC) have led to improvements in patient survival and quality of life. It is unclear whether molecular abnormalities associated with NSCLC cell survival, growth and proliferation are useful in predicting treatment benefit. We conducted a systematic review to establish which biomarkers contribute meaningfully to the management of NSCLC. A team of researchers searched PubMed and conference proceedings (ASCO, ESMO, IASLC, USCAP) using MESH terms for NSCLC and randomized trials (RCT), plus keywords for variables of interest. Evidence from multiple RCTs confirmed that histologic subtype is prognostic for survival and predictive of treatment efficacy and/or toxicity in NSCLC. Likewise, activating mutations of the epidermal growth factor receptor ( EGFR) are associated with benefit from EGFR tyrosine kinase inhibitors in patients with advanced non-squamous NSCLC and should be assessed routinely. No biomarkers to date reliably predict response to anti-Vascular Endothelial Growth Factor (VEGF) therapies. There are inconsistent data on the role of ERCC1, BRCA, Beta tubulin III, RRM1, K-RAS, or TP-53 in treatment decisions. These tests should not be routinely used in selecting treatment at this time, whereas EML4/ALK translocations predict responses to specific targeted agents, the optimal assessment of this molecular abnormality has yet to be established. Personalized care of patients with NSCLC based on biomarkers is increasingly important to both clinical practice and research.
Scalar Equivalence in Self-Rated Depressive Symptomatology as Measured by the Beck Depression Inventory-II: Do Racial and Gender Differences in College Students Exist?  [PDF]
Lisa M. Hooper, Lixin Qu, Cindy A. Crusto, Lauren E. Huffman
Psychology (PSYCH) , 2012, DOI: 10.4236/psych.2012.329116
Abstract: Using item response theory and confirmatory factor analysis, the current investigation examined the equivalence in responses derived from the widely used 21-item Beck Depression Inventory-II (BDI-II; Beck, Steer, & Brown, 1996) among 1229 college students (mean = 21.15, SD = 6.19) in the United States. Results from differential item functioning analyses indicated that the items endorsed by Black American and White American college students were slightly different. However, items endorsed by female and male college students were almost invariant. The results of the study found partial support for using the BDI-II in college student populations. Directions for future culturally tailored assessment and research are proffered.
Adhesion of monocytes to type I collagen stimulates an APP-dependent proinflammatory signaling response and release of Aβ1-40
Cindy M Sondag, Colin K Combs
Journal of Neuroinflammation , 2010, DOI: 10.1186/1742-2094-7-22
Abstract: In an effort to determine the function of APP on monocytic lineage cells, in particular, the human monocyte cell line, THP-1, was used to assess the role of APP during adhesion to the extracelluar matrix component type I collagen.Pull-down assays demonstrated that THP-1 adhesion to collagen stimulated a tyrosine kinase-associated signaling response which included subsequent phosphorylation of p38 MAP kinase and increased association of APP with α2β1 integrin, specifically. In addition, cell adhesion was dependent upon APP expression since APP siRNA knockdown attenuated THP-1 adhesion to collagen compared to mock transfected controls. One consequence of the tyrosine kinase-dependent signaling response was increased secretion of interleukin-1β (IL-1β) and Aβ1-40 but not the Aβ1-42 fragment of APP. Increased secretion of IL-1β was dependent upon p38 MAP kinase activity while Aβ1-40 secretion required Src family kinase activity since the specific p38 inhibitor, SB202190, and the Src family kinase inhibitor, PP2, attenuated IL-1β and Aβ1-40 secretion, respectively.These data demonstrate that APP is involved in classic integrin-dependent tyrosine kinase-associated adhesion and activation of peripheral monocytic cells. Moreover, divergent APP-dependent signaling is required for increased secretion of both IL-1β and Aβ1-40 as a component of the adhesion-dependent change in phenotype. This suggests that APP may have a broad role in not only mediating cell-matrix adhesion but also in the function of peripheral immune cells.The progressive accumulation of extracellular beta amyloid-containing plaques is a cardinal feature of Alzheimer's disease (AD) pathology. The beta amyloid (Aβ) peptide is generated through sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretase. Altered proteolysis of APP due to missense mutations in the APP gene results in increased production of Aβ and increased accumulation of plaques [1-3]. APP is a ubiquitously expressed integ
Carga inmediata en implantes dentales Implantología
Liendo M,Cindy; Herschdorfer F,Tania;
Acta Odontológica Venezolana , 2009,
Abstract: the technological advance with scientific support of last forty years, has located the implantodonthics whitin dentistry, not only as a working philosophy, but rather as a scientific verified truth. the validity of the osseous integration proposed in the decade of the eighties has forced further research in the bone histology of the interface of dental implants as a base of permanent scientific support.
Carga inmediata en implantes dentales Implantología
Cindy Liendo M,Tania Herschdorfer F
Acta Odontológica Venezolana , 2009,
Abstract: El avance tecnológico con respaldo científico de los últimos cuarenta a os ha ubicado a la Implantodoncia dentro de la Odontología, no sólo como una filosofía de trabajo sino más bien como una verdad científica comprobada. La vigencia de la Osteointegraciòn propuesta en la década de los ochenta ha obligado a seguir investigando en la histología de la interfaz ósea de los implantes dentales como una base de sustentación científica permanente. The technological advance with scientific support of last forty years, has located the Implantodonthics whitin dentistry, not only as a working philosophy, but rather as a scientific verified truth. The validity of the osseous integration proposed in the decade of the eighties has forced further research in the bone histology of the interface of dental implants as a base of permanent scientific support.
Assessment of the 2006-2012 Climatological Fields and Mesoscale Features from Regional Downscaling of CESM Data by WRF-Chem over Southeast Alaska  [PDF]
Nicole M?lders, Cindy L. Bruyère, Scott Gende, Michael A. Pirhalla
Atmospheric and Climate Sciences (ACS) , 2014, DOI: 10.4236/acs.2014.44053
Abstract: This case study examined how well downscaling of Community Earth System Model (CESM) data can reproduce climatological conditions relevant for summer (JJA) air quality in Glacier Bay National Park. Climatology was determined from the meteorological results obtained by the Weather Research and Forecasting model inline coupled with chemistry (WRF-chem) when driven with CESM data of 2006-2012. The climatology of this experiment (EXP) was evaluated by climatology from gridded blended sea-wind speeds, CRU data, and 42 surface meteorology sites. The quality relative to known performance was assessed by comparison to climatology determined from WRF-chem control simulations driven with FNL analysis data (CON) in forecast mode. Compared to observations, the thermodynamic and dynamic performances of EXP showed similar shortcomings (dampened diurnal temperature range, overestimation of wind speed over land) as CON. Over water EXP wind-speed climatology JJA bias (simulated minus observed) was -0.7 m/s. With respect to the CRU data EXP biases in JJA 2m temperature, diurnal temperature range, relative humidity and accumulated precipitation were -1.1 K, -4.9 K, 13%, and 110 mm, respectively. The slightly warmer atmosphere in EXP compensated for deficiencies in the cloud schemes leading to better results for the number of wet days and accumulated precipitation than in CON. Downscaling captured known mesoscale responses important for regional climate in a similar way as CON. When using CESM forcing, lateral boundary effects expanded spatially farther into the domain than known for forcing by analysis data. Overall, climatologies obtained from downscaling for Southeast Alaska had similar skill than those derived from forecasts driven by analysis data.
心理学报 , 2009,
Abstract: ?两种记忆状况组来自于参与加拿大维多利亚纵向研究(vls)的老年人原样本。一种是未受损伤的控制组(nic),另一种是轻度记忆损伤组(mmd)。在基线水平和纵向水平上(即5次追踪或12年)比较了他们在日常生活中对记忆补偿技术的使用。我们使用多水平模型(以年龄和教育水平为协变量)来检验基线水平的差异和长期的变化模式。基线的结果表明mmd组被试报告了近期在日常生活中使用记忆补偿策略方面有更大的增长。纵向的结果表明记忆补偿的使用在12年中具有明显的稳定性,但是与努力相关的补偿机制存在显著组间差异。教育水平这一协变量(可认为是潜在的认知储备指标)和三种记忆补偿策略随时间的不同变化相关。
How Do Commercial Children’s Foods Influence Their Growth and Development? A Map of Commercially Available Children’s Foods in Honduras  [PDF]
Adriana Santana Hernández, Sofía Raquel Mejía Moti?o, Adriana Beatriz Di Iorio, Cindy Mérida
Food and Nutrition Sciences (FNS) , 2019, DOI: 10.4236/fns.2019.102013
Abstract: Background: The premature consumption of processed foods with high sugar and sodium content over the course of life has been associated with an increased risk of suffering from chronic diseases starting in adolescence or early adulthood. Methods: There was an examination of the nutritional labelling of processed products for young children (n = 140) available in the Honduran market to evaluate their nutritional quality with regard to sodium and sugar content, pursuant to various international recommendations. Results: 54% of the products evaluated derive more than 20% of their calories from sugar. The categories that to a large degree exceed the recommended sugar content range are fruit drinks (80%) and dessert purees (65%). The average price per product serving is lower than one US dollar ($0.81). 46% and 6% of the products place sugar and salt, respectively, among the first five positions in their ingredient lists. Conclusions: Processed foods for infants and young children generally exceed the recommended sugar content, but due to their low cost and easy access, they are displacing traditional food consumption, contributing to increasing childhood obesity and chronic disease in the early stages of life.
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