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Search Results: 1 - 10 of 37 matches for " Chutima Roomruangwong "
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Genome-Wide Association Study in Thai Tsunami Survivors Identified Risk Alleles for Posttraumatic Stress Disorder  [PDF]
Nuntika Thavichachart, Taisei Mushiroda, Thongchai Thavichachart, Ongart Charoensook, Anchalee Prasansuklab, Prathan Rutchatajumroon, Sookjaroen Tangwongchai, Puangsoi Worakul, Buranee Kanchanatawan, Siriluck Suppapitiporn, Atapol Sughondhabirom, Chutima Roomruangwong, Wasun Chantratita, Atsushi Takahashi, Michiaki Kubo, Naoyuki Kamatani, Yusuke Nakamura
Open Journal of Genetics (OJGen) , 2015, DOI: 10.4236/ojgen.2015.52004
Abstract: Posttraumatic stress disorder (PTSD) is a psychiatric disorder found in individuals afflicted by a traumatic event. Multiple environmental and genetic factors can contribute to PTSD susceptibility. Since it is rare to find members of the same family afflicted by the same catastrophic event, it is not practical to determine PTSD susceptibility genes by a gene linkage analysis. A natural disaster, such as the 2004 Tsunami, provided us with a rare chance for a genetic analysis of PTSD. To identify SNPs associated with PTSD susceptibility, we conducted a genome-association study (GWAS) in Thai-Tsunami survivors. Initial phase of the study with 396 chronic PTSD patients and 457 controls, we identified top ninety SNPs (P < 1 × 10-4), which were further assessed in the second phase with 395 chronic PTSD patients and 798 controls. Two SNPs (rs267950 and rs954406), were identified in the second phase, and subjected to fine mapping using a data set from both phases. SNP rs267943 showed the strongest association with PTSD susceptibility and was in complete linkage disequilibrium with SNP rs267950 with P = 6.15 × 10-8, OR = 1.46 and 95% CI = 1.19 - 1.79, reaching genome-wide significance. SNP rs267943 is located on chromosome 5 in the intron of the death-associated protein 1 (DAP1) gene and, when linked to a synthetic promoter, could regulate transcription. To our knowledge, this is the first GWAS for PTSD susceptibility in an Asian population which could provide an important insight into the genetic contribution of PTSD and may lead to new treatment strategies for PTSD.
Mixed-Model U-Shaped Assembly Line Balancing Problems with Coincidence Memetic Algorithm  [PDF]
Parames Chutima, Panuwat Olanviwatchai
Journal of Software Engineering and Applications (JSEA) , 2010, DOI: 10.4236/jsea.2010.34040
Abstract: Mixed-model U-shaped assembly line balancing problems (MMUALBP) is known to be NP-hard resulting in it being nearly impossible to obtain an optimal solution for practical problems with deterministic algorithms. This paper pre-sents a new evolutionary method called combinatorial optimisation with coincidence algorithm (COIN) being applied to Type I problems of MMUALBP in a just-in-time production system. Three objectives are simultaneously considered; minimum number workstations, minimum work relatedness, and minimum workload smoothness. The variances of COIN are also proposed, i.e. CNSGA II, and COIN-MA. COIN and its variances are tested against a well-known algo-rithm namely non-dominated sorting genetic algorithm II (NSGA II) and MNSGA II (a memetic version of NSGA II). Experimental results showed that COIN outperformed NSGA II. In addition, although COIN-MA uses a marginal CPU time than CNSGA II, its other performances are dominated.
Estimating the Demand for a Preventive HIV Vaccine: Why We Need to Do Better
Robert Hecht ,Chutima Suraratdecha
PLOS Medicine , 2006, DOI: 10.1371/journal.pmed.0030398
Network Design for Quality of Services in Wireless Local Area Networks: a Cross-layer Approach for Optimal Access Point Placement and Frequency Channel Assignment
Chutima Prommak,Boriboon Deeka
Lecture Notes in Engineering and Computer Science , 2007,
Simultaneous HPLC method for determination of sodium trimethoprim phenylpropanol disulphonate and sodium sulfaquinoxaline in veterinary drugs
Puangkaew Lakkanatinaporn,Chutima Matayatsuk
Songklanakarin Journal of Science and Technology , 2004,
Abstract: A simple HPLC method has been developed for the separation and determination of sodium trimethoprim phenylpropanol disulphonate and sodium sulfaquinoxaline in veterinary preparations. Both drugs were separated well on a Kromasil C18 column (5 μm, 150 × 4.6 mm) using a mixture of acetonitrile and 0.5% triethylamine in 1% acetic acid, pH 3 (18:82, v/v) as the mobile phase at the flow rate of 1.5 ml/ min. The presence of both substances was monitored by UV absorption detection at 271 nm. The retention times of sodium trimethoprim phenylpropanol disulphonate and sodium sulfaquinoxaline were 3.2 and 16.0 min, respectively. The performance of the developed method was tested. Linear responses of both drugs were achieved between 48-145% of labeled amount over the concentration ranges of 35-101 μg/ml and 102-306 μg/ ml for sodium trimethoprim phenylpropanol disulphonate and sodium sulfaquinoxaline with correlation coefficients (R2) of 0.9980 and 0.9998, respectively. Accuracy expressed in term of recoveries were 101.4± 1.21% (n=6) for sodium trimethoprim phenylpropanol disulphonate and 99.7±0.92% (n=6) for sodium sulfaquinoxaline. Precision of the method in terms of the relative standard deviation is not more than 2% in all cases. These figures of merit indicated the validity of the developed method.
Network reliability analysis for 3G cellular topology design
Chutima Prommak,Ekkaluk Eksook
Songklanakarin Journal of Science and Technology , 2010,
Abstract: Network reliability is an important issue in the topological design of the 3G cellular networks in order to guaranteeconsistent services. This paper aims to present network reliability analysis of various network topologies, including spanning tree, single ring, multiring, and two versions of hybrid ring-and-tree. We derived reliability analysis models for the hybrid ring-and-tree topologies in terms of the operational probability of the network links. The preliminary results show that the network reliability of the hybrid multiring-and-tree topologies is 116.78% and 13.78% higher than that of the spanning tree and the single ring topology, respectively, while it is only about 37.3% less than that of the pure multiring topologies.
Cross-layer Network Design for Quality of Services in Wireless Local Area Networks: Optimal Access Point Placement and Frequency Channel Assign
Chutima Prommak,Boriboon Deeka
IAENG International Journal of Computer Science , 2008,
The Impact of Walking Time on U-Shaped Assembly Line Worker Allocation Problems
Ronnachai Sirovetnukul,Parames Chutima
Engineering Journal , 2010, DOI: 10.4186/ej.2010.14.2.53
Abstract: The one-piece flow manufacturing line of single and customized products is usually organized as a U-shaped assembly layout. In this study, the characteristics of a single U-line are described and modeled. The worker allocation problem is hierarchically concerned with the task assignment into a U-line and allocate task to workers in sequence. Several products are assembled in 7-task to 297-task problems, and each problem is performed with a given cycle time. The primary purpose is to identify the impact of walking time on both symmetrical and rectangular U-shaped assembly layouts. The minor purpose is to compare the number of workers between two fixed layouts. Coincidence algorithm demonstrates clarifying solutions. To respond to two previous aims, the primary objective function of a number of workers is used. Finally, with the Pareto-optimal frontier between the deviation of operation times of workers and the walking time, its computational study is exemplified to identify good task assignment and walking path.
The Involvement of Microglial Cells in Japanese Encephalitis Infections
Thananya Thongtan,Chutima Thepparit,Duncan R. Smith
Clinical and Developmental Immunology , 2012, DOI: 10.1155/2012/890586
Abstract: Despite the availability of effective vaccines, Japanese encephalitis virus (JEV) infections remain a leading cause of encephalitis in many Asian countries. The virus is transmitted to humans by Culex mosquitoes, and, while the majority of human infections are asymptomatic, up to 30% of JE cases admitted to hospital die and 50% of the survivors suffer from neurological sequelae. Microglia are brain-resident macrophages that play key roles in both the innate and adaptive immune responses in the CNS and are thus of importance in determining the pathology of encephalitis as a result of JEV infection.
A behavior study of automotive drum brake under various braking conditions
Chutima, S.,Kamnerdtong, T.,Atjanakul, W.
Songklanakarin Journal of Science and Technology , 2007,
Abstract: During vehicle deceleration due to friction between the lining and the brake drum, kinetic energy of the vehicle is turned into thermal energy that raises temperature of the drum brake components. This causesthermal elastic instability that affects braking performance and the brake drum lining failure. This work aimed to study the dynamic behaviors of the drum brake under various braking conditions. Three cases ofsevere braking are considered i.e., high wheel speed without carrying load, medium wheel speed without carrying load and medium wheel speed with full load. Moreover, a case of normal braking, having high wheelspeed without carrying load is also included for comparison purpose. Two dimensional finite element technique was adopted to simulate the dynamic interaction between temperature distribution, brake shoe movementand the declined of wheel speed. The coupled thermo-mechanical results reveal that severe braking is an important factor that causes high non-uniform temperature distributions and high-risk thermal elastic instability; whereas wheel speed and vehicle load have less effect on the braking behaviors.
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