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Search Results: 1 - 10 of 23944 matches for " Chunxia Hui "
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The Characteristics of Breast Cancer Mortality in Inner Mongolia between 2008 and 2010  [PDF]
Yueling Hu, Yun Li, Wenrui Wang, Yonggang Qian, Chunxia Hui, Kepeng Xin, Shiqi Wang, Juan Sun
Open Journal of Epidemiology (OJEpi) , 2014, DOI: 10.4236/ojepi.2014.43019

Background: The aim of this study was to explore the characteristics of breast cancer mortality in Inner Mongolia, and to provide evidence for the prevention of female breast cancer. Methods: Using data from the Death Registry System from 2008 to 2010. We classified female cancer deaths according to the International Classification of Disease-10th Revision. The mortality of different age groups and the potential years of life lost were calculated for female breast cancer in Inner Mongolia. Results: Breast cancer mortality for Inner Mongolian women was higher in older age groups. The potential years of life lost were also much higher in younger groups than in older groups. Marital status, education level and occupation may contribute to this increase in breast cancer mortality in younger groups. Conclusion: Preventive policies should be implemented to de- velop strategies aimed at reducing the breast cancer mortality, especially with regard to younger age groups in Inner Mongolia.

Comparative Analysis of Eight Undergraduate Universities Based on InCites Database  [PDF]
Chunxia Guo
Open Journal of Social Sciences (JSS) , 2019, DOI: 10.4236/jss.2019.74022
Abstract: This paper selects the papers collected by Web of Science from 8 local universities in Shandong Province from 2008 to 2018 in the InCites database as a research sample for chemistry, mathematics, engineering, biology and biochemistry, environment and ecology, physics, computer science, and analyzes the amount of documents and the frequency of citations. At the same time, the secondary disciplines with more than 15 papers published in 7 university departments also carried out statistical analysis on the number of publications, citation frequency, and frequency. Using these 7 disciplines, the eight universities will be compared horizontally, and the scientific research gaps between different universities will be located to reveal the research status of the undergraduate universities in Shandong Province of China.
State Reconstruction for Complex Dynamical Networks with Noises  [PDF]
Chunxia Fan, Guoping Jiang
International Journal of Modern Nonlinear Theory and Application (IJMNTA) , 2012, DOI: 10.4236/ijmnta.2012.11001
Abstract: The state reconstruction problem is addressed for complex dynamical networks coupled with states and outputs respectively, in a noisy transmission channel. By using Lyapunov stability theory and H performance, two schemes of state reconstruction are proposed for the complex dynamical networks with the nodes coupled by states and outputs respectively, and the estimation errors are convergent to zeros with H performance index. A numerical simulation demonstrates the effectiveness of the proposed observers.
Improving Personal Product Recommendation via Friendships’ Expansion  [PDF]
Chunxia Yin, Tao Chu
Journal of Computer and Communications (JCC) , 2013, DOI: 10.4236/jcc.2013.15001

The trust as a social relationship captures similarity of tastes or interests in perspective. However, the existent trust information is usually very sparse, which may suppress the accuracy of our personal product recommendation algorithm via a listening and trust preference network. Based on this thinking, we experiment the typical trust inference methods to find out the most excellent friend-recommending index which is used to expand the current trust network. Experimental results demonstrate the expanded friendships via superposed random walk can indeed improve the accuracy of our personal product recommendation.

Impact of Mutations on K-Ras-p120GAP Interaction  [PDF]
Chunxia Gao, Leif A. Eriksson
Computational Molecular Bioscience (CMB) , 2013, DOI: 10.4236/cmb.2013.32002

The K-Ras protein plays a key role in the signal transduction cascade. Certain mutations in K-Ras lead to a permanent “on” state which results in tumorigenesis due to failed interaction with the GTPase activating protein (GAP). In this study, we examined the mutations E31N, D33N and D38N of K-Ras coupled and decoupled to wildtype GAP-334 and mutation K935N of GAP-334 coupled and decoupled to wildtype K-Ras, to illustrate the potential mechanism by which these mutants affect the interaction between the two proteins. We identify Tyr32 in the Ras Switch I region as a critical residue that acts as a gate to the GTP binding site and which needs to be “open” during Ras coupling with GAP to allow for insertion of GAP residue Arg789. This residue plays a vital role in stabilizing the transition state during GTP hydrolysis. The different mutations studied herein caused a reduced binding affinity, and the fluctuation of the Tyr32 side chain might hinder the insertion of Arg789. This may in turn be the cause of decreased GTP hydrolysis, and permanent on state of K-Ras, observed for these mutants.


Yang Jiudong,Tian Hui,Zhou Chunxia,

大地测量与地球动力学 , 2010,
Abstract: According to the principles of D-InSAR,by using Doris and ENVISAT SAR data,two-pass method of D-InSAR is utilized to acquire coseismic surface deformation images caused by L'Aquila(Italy)earthquake.Preliminary quantitative cognition was completed based on the D-InSAR interferogram.The results show that the main driving force of the earthquake is the southwest wards and up back-arc spreading of the area and the earthquake makes the area uplift 25.2 cm in the sight line direction of SAR.
An In Vitro and In Vivo Evaluation of a Reporter Gene/Probe System hERL/18F-FES
Chunxia Qin, Xiaoli Lan, Jiang He, Xiaotian Xia, Yueli Tian, Zhijun Pei, Hui Yuan, Yongxue Zhang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0061911
Abstract: Purpose To evaluate the feasibility of a reporter gene/probe system, namely the human estrogen receptor ligand binding domain (hERL)/16α-[18F] fluoro-17β-estradiol (18F-FES), for monitoring gene and cell therapy. Methods The recombinant adenovirus vector Ad5-hERL-IRES-VEGF (Ad-EIV), carrying a reporter gene (hERL) and a therapeutic gene (vascular endothelial growth factor, VEGF165) through an internal ribosome entry site (IRES), was constructed. After transfection of Ad-EIV into bone marrow mesenchymal stem cells (Ad-EIV-MSCs), hERL and VEGF165 mRNA and protein expressions were identified using Real-Time qRT-PCR and immunofluorescence. The uptake of 18F-FES was measured in both Ad-EIV-MSCs and nontransfected MSCs after different incubation time. Micro-PET/CT images were obtained at 1 day after injection of Ad-EIV-MSCs into the left foreleg of the rat. The right foreleg was injected with nontransfected MSCs, which served as self-control. Results After transfection with Ad-EIV, the mRNA and protein expression of hERL and VEGF165 were successfully detected in MSCs, and correlated well with each other (R2 = 0.9840, P<0.05). This indicated the reporter gene could reflect the therapeutic gene indirectly. Ad-EIV-MSCs uptake of 18F-FES increased with incubation time with a peak value of 9.13%±0.33% at 150 min, which was significantly higher than that of the control group. A far higher level of radioactivity could be seen in the left foreleg on the micro-PET/CT image than in the opposite foreleg. Conclusion These preliminary in vitro and in vivo studies confirmed that hERL/18F-FES might be used as a novel reporter gene/probe system for monitoring gene and cell therapy. This imaging platform may have broad applications for basic research and clinical studies.
Multimodality Molecular Imaging to Monitor Transplanted Stem Cells for the Treatment of Ischemic Heart Disease
Zhijun Pei, Xiaoli Lan, Zhen Cheng, Chunxia Qin, Xiaotian Xia, Hui Yuan, Zhiling Ding, Yongxue Zhang
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0090543
Abstract: Purpose Non-invasive techniques to monitor the survival and migration of transplanted stem cells in real-time is crucial for the success of stem cell therapy. The aim of this study was to explore multimodality molecular imaging to monitor transplanted stem cells with a triple-fused reporter gene [TGF; herpes simplex virus type 1 thymidine kinase (HSV1-tk), enhanced green fluorescence protein (eGFP), and firefly luciferase (FLuc)] in acute myocardial infarction rat models. Methods Rat myocardial infarction was established by ligating the left anterior descending coronary artery. A recombinant adenovirus carrying TGF (Ad5-TGF) was constructed. After transfection with Ad5-TGF, 5×106 bone marrow mesenchymal stem cells (BMSCs) were transplanted into the anterior wall of the left ventricle (n = 14). Untransfected BMSCs were as controls (n = 8). MicroPET/CT, fluorescence and bioluminescence imaging were performed. Continuous images were obtained at day 2, 3 and 7 after transplantation with all three imaging modalities and additional images were performed with bioluminescence imaging until day 15 after transplantation. Results High signals in the heart area were observed using microPET/CT, fluorescence and bioluminescence imaging of infarcted rats injected with Ad5-TGF-transfected BMSCs, whereas no signals were observed in controls. Semi-quantitative analysis showed the gradual decrease of signals in all three imaging modalities with time. Immunohistochemistry assays confirmed the location of the TGF protein expression was the same as the site of stem cell-specific marker expression, suggesting that TGF tracked the stem cells in situ. Conclusions We demonstrated that TGF could be used as a reporter gene to monitor stem cells in a myocardial infarction model by multimodality molecular imaging.
Feature Optimization of Speech Emotion Recognition  [PDF]
Chunxia Yu, Ling Xie, Weiping Hu
Journal of Biomedical Science and Engineering (JBiSE) , 2016, DOI: 10.4236/jbise.2016.910B005
Speech emotion is divided into four categories, Fear, Happy, Neutral and Surprise in this paper. Traditional features and their statistics are generally applied to recognize speech emotion. In order to quantify each feature’s contribution to emotion recogni-tion, a method based on the Back Propagation (BP) neural network is adopted. Then we can obtain the optimal subset of the features. What’s more, two new characteristics of speech emotion, MFCC feature extracted from the fundamental frequency curve (MFCCF0) and amplitude perturbation parameters extracted from the short- time av-erage magnitude curve (APSAM), are added to the selected features. With the Gaus-sian Mixture Model (GMM), we get the highest average recognition rate of the four emotions 82.25%, and the recognition rate of Neutral 90%.
Exponential Admissibility and Dynamic Output Feedback Control of Switched Singular Systems with Interval Time-Varying Delay
Jinxing Lin,Chunxia Fan
Mathematical Problems in Engineering , 2010, DOI: 10.1155/2010/680382
Abstract: This paper is concerned with the problems of exponential admissibility and dynamic output feedback (DOF) control for a class of continuous-time switched singular systems with interval time-varying delay. A full-order, dynamic, synchronously switched DOF controller is considered. First, by using the average dwell time approach, a delay-range-dependent exponential admissibility criterion for the unforced switched singular time-delay system is established in terms of linear matrix inequalities (LMIs). Then, based on this criterion, a sufficient condition on the existence of a desired DOF controller, which guarantees that the closed-loop system is regular, impulse free and exponentially stable, is proposed by employing the LMI technique. Finally, some illustrative examples are given to show the effectiveness of the proposed approach. 1. Introduction The past decades have witnessed an enormous interest in switched systems, due to their powerful ability in modeling of event-driven systems, logic-based systems, parameter- or structure-varying systems, and so forth; for details, see [1–4] and the references therein. Switched systems are a class of hybrid systems, which consist of a collection of continuous- or discrete-time subsystems and a switching rule specifying the switching between them. When focusing on the classification problems in switched systems, it is commonly recognized that there exist three basic problems [1]: (i) finding conditions for stability under arbitrary switching; (ii) identifing the limited but useful class of stabilizing switching signals, and (iii) construct a stabilizing switching signal. Many effective methods have been presented to tackle these three basic problems such as the multiple Lyapunov function approach [5], the piecewise Lyapunov function approach [6], the switched Lyapunov function approach [7], the convex combination technique [8], and the dwell time or average dwell time scheme [9–12]. On the other hand, time-delay is very common in engineering systems and is frequently a source of instability and poor performance [13]. Therefore, control of switched time-delay systems has received more and more attention in the past few years; see [14–23] and the references therein. As far as we know, singular systems (known also as descriptor, implicit or differential algebraic systems) also provide a natural framework for modeling of dynamic systems and describe a larger class of systems than the regular system models [24]. Switched singular systems have strong engineering background such as electrical networks [25], economic
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