oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

2020 ( 3 )

2019 ( 51 )

2018 ( 295 )

2017 ( 296 )

Custom range...

Search Results: 1 - 10 of 27786 matches for " Chung Min Hyun "
All listed articles are free for downloading (OA Articles)
Page 1 /27786
Display every page Item
Three-Dimensional Thermo-Elastic-Plastic Finite Element Method Modeling for Predicting Weld-Induced Residual Stresses and Distortions in Steel Stiffened-Plate Structures  [PDF]
Myung Su Yi, Chung Min Hyun, Jeom Kee Paik
World Journal of Engineering and Technology (WJET) , 2018, DOI: 10.4236/wjet.2018.61010
Abstract: The objective of the present paper is to develop nonlinear finite element method models for predicting the weld-induced initial deflection and residual stress of plating in steel stiffened-plate structures. For this purpose, three-dimensional thermo-elastic-plastic finite element method computations are performed with varying plate thickness and weld bead length (leg length) in welded plate panels, the latter being associated with weld heat input. The finite element models are verified by a comparison with experimental database which was obtained by the authors in separate studies with full scale measurements. It is concluded that the nonlinear finite element method models developed in the present paper are very accurate in terms of predicting the weld-induced initial imperfections of steel stiffened plate structures. Details of the numerical computations together with test database are documented.
Ontology Design for Creating Adaptive Learning Path in e-Learning Environment
Hyun-Sook Chung,Jung-Min Kim
Lecture Notes in Engineering and Computer Science , 2012,
Abstract:
Genome-wide genetic aberrations of thymoma using cDNA microarray based comparative genomic hybridization
Gui Lee, Woo Yang, Hei Jeung, Sang Kim, Min Seo, Chan Park, Hyun Chung, Sun Rha
BMC Genomics , 2007, DOI: 10.1186/1471-2164-8-305
Abstract: We investigated the molecular characteristics of genetic changes variation of thymoma using cDNA microarray based-comparative genomic hybridization (CGH) with a 17 K cDNA microarray in an indirect, sex-matched design. Genomic DNA from the paraffin embedded 39 thymoma tissues (A 6, AB 11, B1 7, B2 7, B3 8) labeled with Cy-3 was co-hybridized with the reference placenta gDNA labeled with Cy-5. Using the CAMVS software, we investigated the deletions on chromosomes 1, 2, 3, 4, 5, 6, 8, 12, 13 and 18 throughout the thymoma. Then, we evaluated the genetic variations of thymoma based on the subgroups and the clinical behavior. First, the 36 significant genes differentiating five subgroups were selected by Significance Analysis of Microarray. Based on these genes, type AB was suggested to be heterogeneous at the molecular level as well as histologically. Next, we observed that the thymoma was divided into A, B (1, 2) and B3 subgroups with 33 significant genes. In addition, we selected 70 genes differentiating types A and B3, which differ largely in clinical behaviors. Finally, the 11 heterogeneous AB subtypes were able to correctly assign into A and B (1, 2) types based on their genetic characteristics.In our study, we observed the genome-wide chromosomal aberrations of thymoma and identified significant gene sets with genetic variations related to thymoma subgroups, which might provide useful information for thymoma pathobiology.Thymoma is a thymic epithelial cell tumor having organotypic features and no overt cytologic atypia. Although controversy still remains, the classical histological classifications of thymoma based on the proportion of reactive lymphocytes and tumor epithelial cells have been replaced by a histogenetic classification that basically subdivides thymoma into medullary, cortical, and mixed types, according to cytological features of epithelial cells [1-5]. Several studies supported the validity of the histogenetic classification and the World Health Org
Guest Editorial
Min Young Chung,Jae-Hyun Kim,Masato Oguchi,Jeng-Shyang Pan
Journal of Networks , 2010, DOI: 10.4304/jnw.5.3.265-266
Abstract: This special issue comprises of 10 selected papers from the 3rd International Conference on Ubiquitous Information Management and Communication (ICUIMC 2009). From 358 papers submitted in the conference, 106 papers were selected for presentation. Among them, ten qualified papers have been selected as the papers for this special issue, which deal with state-of-the-art communication technology. Sensor network is vulnerable to hostile environments. Thus, 3 papers focus on security issues in wireless sensor network. Also, energy consumption is an important problem in sensor network, which is considered in this issue: "Environment-based selection method for en-route filtering scheme using fuzzy logic" by Sang Jin Lee, Hae Young Lee, Tae Ho Cho, adopts the fuzzy logic to determine the threshold to filter false reports in wireless sensor networks. "Light weight key renewals for clustered sensor networks" by Gicheol Wang, Seunghae Kim, Daewook Kang, Deokjai Choi and Gihwan Cho, proposed a lightweight key renewal scheme, which removes the compromised nodes by reforming clusters. In a cluster, each member uses a pair-wise key to communicate with its cluster head. "An isolation intrusion detection system for hierarchical wireless sensor networks" by Rung-Ching Chen, Chia-Fen Hsieh and Yu
Mouse Homologue of the Schizophrenia Susceptibility Gene ZNF804A as a Target of Hoxc8
Hyun Joo Chung,Ji-Yeon Lee,Custer C. Deocaris,Hyehyun Min,Sang Hoon Kim,Myoung Hee Kim
Journal of Biomedicine and Biotechnology , 2010, DOI: 10.1155/2010/231708
Abstract: Using a ChIP-cloning technique, we identified a Zinc finger protein 804a (Zfp804a) as one of the putative Hoxc8 downstream target genes. We confirmed binding of Hoxc8 to an intronic region of Zfp804a by ChIP-PCR in F9 cells as well as in mouse embryos. Hoxc8 upregulated Zfp804a mRNA levels and augmented minimal promoter activity in vitro. In E11.5 mouse embryos, Zfp804a and Hoxc8 were coexpressed. Recent genome-wide studies identified Zfp804a (or ZNF804A in humans) as a plausible marker for schizophrenia, leading us to hypothesize that this embryogenic regulatory control might also exert influence in development of complex traits such as psychosis.
Anti-malarial activity of 6-(8'Z-pentadecenyl)-salicylic acid from Viola websteri in mice
Ill-Min Chung, Su-Hyun Seo, Eun-Young Kang, Won-Hwan Park, Hyung-In Moon
Malaria Journal , 2009, DOI: 10.1186/1475-2875-8-151
Abstract: The schizontocidal activity of 6-SA on early Plasmodium berghei infections was evaluated in a four-day test. The possible 'repository' activity of 6-SA was assessed using the method described by Peters. The median lethal dose (LD50) of 6-SA, when given intraperitoneally, was also determined using uninfected ICR mice and the method of Lorke.In the present study, 6-SA was found to have anti-malarial activity in vivo, when tested against P. berghei in mice. 6-SA at 5, 10 and 25 mg/kg·day exhibited a significant blood schizontocidal activity in four-day early infections, repository evaluations and established infections with a significant mean survival time comparable to that of the standard drug, chloroquine (5 mg/kg·day).6-SA possesses a moderate anti-malarial activity that could be exploited for malaria therapy.Malaria is a major tropical disease caused by parasites and is responsible for significant morbidity and mortality worldwide [1]. There is currently a dramatic resurgence of the disease because of the increasing resistance of the vectors to insecticides and the progressive resistance of the causative parasites, particularly Plasmodium falciparum, to anti-malarial drugs [2]. Therefore, there is an urgent need to discover and develop new, effective and safe drugs for the treatment of this disease [3]. Malarial parasites and plant plastids have several common pathways and functions that are fundamentally different from the analogous pathways and functions in humans and may therefore make good targets for anti-malarial drugs [4]. In traditional medicine, Viola is used for the treatment of insect infections, cancer, virus infection, and skin diseases [5]. A previous study [6] revealed that the petroleum ether extracts from dried whole parts of the 15 Viola genera screened, Viola websteri had inhibition values of 31.7 as percentage of parasite inhibition at 25 μg/ml. Petroleum ether extracts from Viola websteri were found to have anti-plasmodial activity against P.
Interleukin-10 Promoter Gene Polymorphisms and Susceptibility to Asthma: A Meta-Analysis
Myung-Han Hyun, Chung-Ho Lee, Min-Hyung Kang, Bong-Kyung Park, Young Ho Lee
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0053758
Abstract: Objective The aim of this study was to explore whether the interleukin (IL)-10 polymorphisms and their haplotypes contribute to asthma susceptibility. Methods MEDLINE, EMBASE and the COCHRANE library databases were utilized to identify available articles. A meta-analysis was conducted on IL-10 -1082 G/A, -819 C/T, -592 C/A polymorphisms, and their haplotypes and asthma. Results Eleven studies involving 2,215 asthma patients and 2,170 controls were considered in the meta-analysis. The meta-analysis revealed no association between asthma and the IL-10 -1082 G allele [Odds ratio (OR) = 0.87, 95% Confidence interval (CI) = 0.68–1.12, p = 0.28]. However, meta-analysis of the five studies in Hardy-Weinburg equilibrium produced the relationship between the IL-10 -1082 G allele and asthma (OR = 0.71, 95% CI = 0.60–0.83, p<0.0001). Stratification by ethnicity indicated an association between the IL-10 -1082 G allele and asthma in East Asians (OR = 0.74, 95% CI = 0.57–0.96, p = 0.02), but not in West Asians. Furthermore, stratification by age indicated an association between the IL-10 -1082 G allele and asthma in adults and mixed groups (OR = 0.77, 95% CI = 0.62–0.96, p = 0.02; OR = 0.67, 95% CI = 0.49–0.92, p = 0.01). No association was found between asthma and IL-10 -819 C/T and IL-10 -592 C/A polymorphisms and their haplotypes. Conclusion The IL-10 -1082 G/A polymorphism confers susceptibility to asthma in East Asians and in adults. However, the IL-10 -819 C/T, -592 C/A polymorphisms and their haplotypes are not associated with asthma.
Molecular Study of Dietary Heptadecane for the Anti-Inflammatory Modulation of NF-kB in the Aged Kidney
Dae Hyun Kim, Min Hi Park, Yeon Ja Choi, Ki Wung Chung, Chan Hum Park, Eun Ji Jang, Hye Jin An, Byung Pal Yu, Hae Young Chung
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0059316
Abstract: Heptadecane is a volatile component of Spirulina platensis, and blocks the de novo synthesis of fatty acids and ameliorates several oxidative stress-related diseases. In a redox state disrupted by oxidative stress, pro-inflammatory genes are upregulated by the activation of NF-kB via diverse kinases. Thus, the search and characterization of new substances that modulate NF-kB are lively research topics. In the present study, heptadecane was examined in terms of its ability to suppress inflammatory NF-kB activation via redox-related NIK/IKK and MAPKs pathway in aged rats. In the first part of the study, Fischer 344 rats, aged 9 and 20 months, were administered on average approximately 20 or 40 mg/Kg body weight over 10 days. The potency of heptadecane was investigated by examining its ability to suppress the gene expressions of COX-2 and iNOS (both NF-κB-related genes) and reactive species (RS) production in aged kidney tissue. In the second part of the study, YPEN-1 cells (an endothelial cell line) were used to explore the molecular mechanism underlying the anti-inflammatory effect of heptadecane by examining its modulation of NF-kB and NF-kB signal pathway. Results showed that heptadecane exhibited a potent anti-oxidative effect by protecting YPEN-1 cells from tert-butylhydroperoxide induced oxidative stress. Further molecular investigations revealed that heptadecane attenuated RS-induced NF-kB via the NIK/IKK and MAPKs pathways in YPEN-1 cells and aged kidney tissues. Based on these results, we conclude that heptadecane suppresses age-related increases in pro-inflammatory gene expressions by reducing NF-kB activity by upregulating the NIK/IKK and MAPKs pathways induced by RS. These findings provide molecular insight of the mechanisms by which heptadecane exerts its antiinflammatory effect in aged kidney tissues. We conclude that heptadecane suppresses age-related increases in pro-inflammatory gene expressions then travel upstream set by step by reducing NF-kB activity by downregulating the NIK/IKK and MAPKs pathways induced by RS.
Neural Stem Cells Achieve and Maintain Pluripotency without Feeder Cells
Hyun Woo Choi, Jong Soo Kim, Sol Choi, Hyo Jin Jang, Min Jung Kim, Youngsok Choi, Hans R. Sch?ler, Hyung Min Chung, Jeong Tae Do
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0021367
Abstract: Background Differentiated cells can be reprogrammed into pluripotency by transduction of four defined transcription factors. Induced pluripotent stem cells (iPS cells) are expected to be useful for regenerative medicine as well as basic research. Recently, the report showed that mouse embryonic fibroblasts (MEF) cells are not essential for reprogramming. However, in using fibroblasts as donor cells for reprogramming, individual fibroblasts that had failed to reprogram could function as feeder cells. Methodology/Principal Finding Here, we show that adult mouse neural stem cells (NSCs), which are not functional feeder cells, can be reprogrammed into iPS cells using defined four factors (Oct4, Sox2, Klf4, and c-Myc) under feeder-free conditions. The iPS cells, generated from NSCs expressing the Oct4-GFP reporter gene, could proliferate for more than two months (passage 20). Generated and maintained without feeder cells, these iPS cells expressed pluripotency markers (Oct4 and Nanog), the promoter regions of Oct4 and Nanog were hypomethylated, could differentiated into to all three germ layers in vitro, and formed a germline chimera. These data indicate that NSCs can achieve and maintain pluripotency under feeder-free conditions. Conclusion/Significance This study suggested that factors secreted by feeder cells are not essential in the initial/early stages of reprogramming and for pluripotency maintenance. This technology might be useful for a human system, as a feeder-free reprogramming system may help generate iPS cells of a clinical grade for tissue or organ regeneration.
Narrating the “Back Story” Through E-learning Resources in Libraries
Hyun-Duck Chung
In the Library with the Lead Pipe , 2009,
Abstract: We at In the Library with the Lead Pipe are happy to welcome two guest authors to our blog! Hyun-Duck Chung and Kim Duckett are two of our creative and inspiring colleagues at the North Carolina State University Libraries. Read on to learn more… Lately we’ve been thinking a lot about the creation and re-use [...]
Page 1 /27786
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.