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Search Results: 1 - 10 of 139629 matches for " Chun-Yu Chen "
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Gut Microbiota: Physiology and Relationship with Inflammatory Bowel Disease  [PDF]
Chun-Yu Lin, Yeong-Jang Lin, Hung-An Chen
Open Journal of Endocrine and Metabolic Diseases (OJEMD) , 2013, DOI: 10.4236/ojemd.2013.37039

The intestinal microbiota, which evolved over tens of thousands of years along with their human hosts, constitutes a complex and diverse ecosystem whose composition differs from person to person. Accumulating evidence indicates that commensal bacteria exert numerous beneficial physiological effects for humans, including nutrition, protection, metabolism, organ development and immunomodulation. However, mucosal immune responses to intestinal microflora require precise control to allow appropriate defense against potential pathogens but restrict the immune response to beneficial resident bacteria. The task of intestinal homeostasis is accomplished by epithelium and specialized immune system in the gastrointestinal tract. Alternation in the composition of the bacterial community, consisting of increased representation of harmful species or under presence of protective species, or dysbiosis has been linked to various chronic and inflammatory disorders, such as inflammatory bowel disease. An improved understanding of the underlying molecular mechanisms of host-microorganism interactions could bring new insights into onset and pathogenesis of several autoimmune diseases. This review will discuss physiologic properties of commensal microbiota and how dysregulated immune responses to them contribute to chronic mucosal inflammation.

Usefulness of Transesophageal Echocardiography for Transcatheter Closure of Ostium Secundum Atrial Septum Defect with the Amplatzer Septal Occluder
Chun-Yu Chen,Chun-Hui Lee,Min-Wen Yang,Hung-Tao Chung
Chang Gung Medical Journal , 2005,
Abstract: Background: Transcatheter closure of ostium secundum atrial septum defect (ASDII)using the new self-centering occluder, Amplatzer Septal Occluder (ASO),has been well developed in recent years. We describe the importance and roleof transesophageal echocardiography (TEE) in the selection and closure ofsuch defects.Methods: Thirty patients referred for transcatheter closure of ASDII by ASO wereenrolled in this study. During catheterization, two-dimensional TEE was performedon all patients during and after transcatheter closure. ASD size andmorphology were assessed by TEE before catheterization. The ASDstretched diameter was also measured by TEE and fluoroscopy.Results: With the aid of TEE, transcatheter closure of an ASD was successfully, safelyand effectively performed on 29 patients. The mean ASD diameter determinedby TEE was 17.4 4.8 mm. The mean stretched diameters measuredby TEE and fluoroscopy were 18.7 5.6 mm and 17.9 5.5 mm, respectively.The mean device diameter was 19 5.6 mm. Immediate completeclosure was documented by color Doppler TEE in 29 patients. Complicationswere encountered in one patient, with the device becoming dislodged into themain pulmonary artery. The device was retrieved by surgery and the defectwas repaired in the operating room.Conclusions: Transcatheter closure of ASDs using an Amplatzer device is feasible, safeand effective. Two-dimensional TEE can provide useful information before,during and after transcatheter closure of ASDs.
Folding a protein with equal probability of being helix or hairpin
Chun-Yu Lin,Nan-Yow Chen,Chung-Yu Mou
Physics , 2011, DOI: 10.1016/j.bpj.2012.05.029
Abstract: We explore the possibility for the native state of a protein being inherently a multi-conformation state in an ab initio coarse-grained model. Based on the Wang-Landau algorithm, the complete free energy landscape for the designed sequence 2D4X: INYWLAHAKAGYIVHWTA is constructed. It is shown that 2DX4 possesses two nearly degenerate native states: one has a helix structure, while the other has a hairpin structure and their energy difference is less than 2% of that of local minimums. Two degenerate native states are stabilized by an energy barrier of the order 10kcal/mol. Furthermore, the hydrogen-bond and dipole-dipole interactions are found to be two major competing interactions in transforming one conformation into the other. Our results indicate that degenerate native states are stabilized by subtle balance between different interactions in proteins; furthermore, for small proteins, degeneracy only happens for proteins of sizes being around 18 amino acids or 40 amino acids. These results provide important clues to the study of native structures of proteins.
Blockade of phospholipid scramblase 1 with its N-terminal domain antibody reduces tumorigenesis of colorectal carcinomas in vitro and in vivo
Fan Chung-Wei,Chen Chun-Yu,Chen Kuei-Tien,Shen Chia-Rui
Journal of Translational Medicine , 2012, DOI: 10.1186/1479-5876-10-254
Abstract: Background Membrane-bound phospholipid scramblase 1 (PLSCR1) is involved in both lipid trafficking and cell signaling. Previously, we showed that PLSCR1 is overexpressed in many colorectal carcinomas (CRCs). In the present study, we investigated the tumorigenic role of PLSCR1 in CRC and suggest that it is a potential therapeutic target. Methods To identify PLSCR1 as a therapeutic target, we studied the tumorigenic properties of CRC cell lines treated with a monoclonal antibody (NP1) against the N-terminus of PLSCR1 in vitro and in vivo. We also investigated cell cycle status and epidermal growth factor receptor–related pathways and downstream effectors of PLSCR1 after blocking its function with NP1. Results Treating CRC cells with NP1 in vitro and in vivo decreased cell proliferation, anchorage-independent growth, migration, and invasion. Adding NP1 to the CRC cell line HT29 caused arrest at G1/S. Treating HT29 cells with NP1 significantly decreased the expression of cyclin D1 and phosphorylation levels of Src, the adaptor protein Shc, and Erks. The reduced level of cyclin D1 led to an increase in the activated form of the tumor suppressor retinoblastoma protein via dephosphorylation. These actions led to attenuation of tumorigenesis. Conclusions Therefore, PLSCR1 may serve as a potential therapeutic target for CRC.
A performance comparison of SVMs based on Fourier kernel and RBF kernel

LIN Mao-liu,CHEN Chun-yu,

重庆邮电大学学报(自然科学版) , 2005,
Abstract: 支持向量机(SVMs)是由Vapnik提出的一种建立在统计学习理论上的新方法。这种方法被深入地研究并广泛应用在诸如分类和回归问题上。由于其基于结构风险最小化的机理,因此相对于其他的经典方法有着更好的泛化特性,其中核函数的选择对支持向量机的性能有着很大的影响。深入地研究了基于傅立叶核函数的支持向量机的特性,得出在某些特殊的情况下,基于傅立叶核函数的支持向量机的性能要好于基于RBF核的支持向量机。最后的仿真对其进行了比较验证。 
Could $Z_{c}(3900)$ be a $I^{G}J^{P}=1^{+}1^{+}$ $D^{*}\bar{D}$ molecular state?
Cui, Chun-Yu;Liu, Yong-Lu;Chen, Wen-Bo;Huang, Ming-Qiu
High Energy Physics - Phenomenology , 2013,
Abstract: The recently observed narrow resonance $Z_{c}(3900)$ is examined with the assumptions as a $D^{*}\bar{D}$ molecular state with quantum numbers $I^{G}J^{P}=1^{+}1^{+}$. Using QCD sum rules (QCDSR), we consider contributions up to dimension six in the operator product expansion (OPE) at the leading order in $\alpha_{s}$. The mass is obtained as $(3.91 \pm 0.19) {GeV}$ which coincide with the $Z_{c}(3900)$.
Jugular venous reflux and plasma endothelin-1 are associated with cough syncope: a case control pilot study
Chung Chih-Ping,Cheng Chun-Yu,Zivadinov Robert,Chen Wei-Chih
BMC Neurology , 2013, DOI: 10.1186/1471-2377-13-9
Abstract: Background Jugular venous reflux (JVR) has been reported to cause cough syncope via retrograde-transmitted venous hypertension and consequently decreased cerebral blood flow (CBF). Unmatched frequencies of JVR and cough syncope led us to postulate that there should be additional factors combined with JVR to exaggerate CBF decrement during cough, leading to syncope. The present pilot study tested the hypothesis that JVR, in addition to an increased level of plasma endothelin-1 (ET-1), a potent vasoconstrictor, is involved in the pathophysiology of cough syncope. Methods Seventeen patients with cough syncope or pre-syncope (Mean[SD] = 74.63(12.37) years; 15 males) and 51 age/gender-matched controls received color-coded duplex ultrasonography for JVR determination and plasma ET-1 level measurements. Results Multivariate logistic analysis showed that the presence of both-side JVR (odds ratio [OR] = 10.77, 95% confident interval [CI] = 2.40-48.35, p = 0.0019) and plasma ET-1 > 3.43 pg/ml (OR = 14.57, 95% CI = 2.95-71.59, p = 0.001) were independently associated with the presence of cough syncope/ pre-syncope respectively. There was less incidence of cough syncope/ pre-syncope in subjects with the absence of both-side JVR and a plasma ET-1 ≦3.43 pg/ml. Presence of both side JVR and plasma ET-1 level of > 3.43 pg/ml, increased risk for cough syncope/pre-syncope (p < 0.001). Conclusions JVR and higher plasma levels of ET-1 are associated with cough syncope/ pre-syncope. Although sample size of this study was small, we showed a synergistic effect between JVR and plasma ET-1 levels on the occurrence of cough syncope/pre-syncope. Future studies should confirm our pilot findings.
Use of the Arndt Wire-Guided Endobronchial Blocker to Facilitate One-Lung Ventilation for Pediatric Empyema during Video-Assisted Thoracoscopy.
Angie CY Ho,Chun-Yu Chen,Min-Wen Yang,Hung-Pin Liu
Chang Gung Medical Journal , 2005,
Abstract: Background: Video-assisted thoracoscopic surgery (VATS) has emerged as an innovativeand popular procedure for the management of postpneumonic empyema inchildren refractory to a medical response. One-lung ventilation is requiredduring VATS. In this study, we evaluated the efficacy of intraoperative wireguidedendobronchial blockade (WEB) for achieving 1-lung ventilation duringa thoracoscopic procedure for pediatric empyema.Methods: Eighteen patients undergoing a VATS approach for evacuation of an empyemacavity were studied. We used a new device, a bronchial blocker tube, toestablish 1-lung ventilation. Intraoperative oxygenation, ventilation, andhemodynamics, as well as the duration of the operation during 1-lung ventilationwere recorded. The number of unsuccessful placement attempts, numberof malpositionings of the device, and the number of secondary dislodgementsof the device after turning the patient into the lateral position werealso counted. The quality of lung deflation and inflation was rated by the surgeonunder direct visualization as either excellent, fair, or poor.Results: The mean operative time was 80 ± 10.8 (range, 50~120) min. The mean peakinspiratory pressure under 1-lung ventilation was 28.7 3.6 cmH2O, and nodesaturation was noted. A number of unsuccessful placement attempts wererequired in 1 patient (1/18) for left-sided VATS. No malpositioning or secondarydislodgement of the device was noted. The quality of lung deflationwas judged as being excellent in all patients.Conclusions: VATS can safely and effectively be performed in children with a proper anesthetictechnique. With the development and clinical use of this new device,the bronchial blocker tube proved to be effective and easy to use for establishing1-lung ventilation in a pediatric population.
Discovery of Dihydrochalcone as Potential Lead for Alzheimer’s Disease: In Silico and In Vitro Study
Man Hoang Viet, Chun-Yu Chen, Chin-Kun Hu, Yun-Ru Chen, Mai Suan Li
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0079151
Abstract: By the virtual screening method we have screened out Dihydrochalcone as a top-lead for the Alzheimer’s disease using the database of about 32364 natural compounds. The binding affinity of this ligand to amyloid beta (A) fibril has been thoroughly studied by computer simulation and experiment. Using the Thioflavin T (ThT) assay we have obtained the inhibition constant IC50 M. This result is in good agreement with the estimation of the binding free energy obtained by the molecular mechanic-Poisson Boltzmann surface area method and all-atom simulation with the force field CHARMM 27 and water model TIP3P. Cell viability assays indicated that Dihydrochalcone could effectively reduce the cytotoxicity induced by A. Thus, both in silico and in vitro studies show that Dihydrochalcone is a potential drug for the Alzheimers disease.
Biomonitoring of bisphenol A concentrations in maternal and umbilical cord blood in regard to birth outcomes and adipokine expression: a birth cohort study in Taiwan
Wei-Chun Chou, Jyh-Larng Chen, Chung-Fen Lin, Yi-Chun Chen, Feng-Cheng Shih, Chun-Yu Chuang
Environmental Health , 2011, DOI: 10.1186/1476-069x-10-94
Abstract: We measured the BPA levels of maternal blood (n = 97) and umbilical cord blood (n = 97) with a high-performance liquid chromatography/UV detector. The protein secretion of leptin and adiponectin were separately determined using enzyme-linked immunosorbent assay. A logistic regression was performed to estimate the effects of maternal exposure to BPA on LBW, SGA, and adverse action of adipokines in newborns.The geometric means of BPA concentration in maternal blood and fetal cord blood were 2.5 ng/ml and 0.5 ng/ml, respectively. Elevated risks of LBW (OR 2.42, 95% confidence interval (CI) 1.72-3.36), SGA (OR 2.01, 95% CI 1.39-3.01), and adverse action of leptin (OR 1.67, 95% CI 1.12-2.25) and adiponectin (OR 1.25, 95% CI 1.52-3.97) were observed in male neonates in the highest quartile of maternal BPA exposure.Elevated prenatal BPA exposure increased the risk of LBW, SGA, and adverse actions of adipokines in neonates, especially in male infants. These results provide further evidence that maternal exposure is correlated with adverse birth outcomes.Bisphenol A (2, 2-bis (4-hydroxyphenol) propane; BPA), a chemical compound found in plastic products, is being used increasingly in industrial manufacturing materials. Numerous reports state that BPA production was 2, 214, 000 metric tons worldwide per year in 2003 [1], and 3, 200, 000 tons in 2005 [2]. Because BPA is used to manufacture polycarbonate plastic, epoxy resins and certain dental sealants [3], humans are frequently exposed to BPA released from plastics and food cans in daily life [4]. Therefore, through these daily exposures BPA potentially affects human health.Previous studies through analyses of BPA in the serum of pregnant women and in cord blood collected at birth have indicated that BPA accumulates early in fetuses [5,6]. Schonfelder et al. [7] stated that BPA levels vary: from 0.3 to 18.9 ng/ml (median 3.1 ng/ml) in maternal plasma, from 0.2 to 9.2 ng/ml (median 2.3 ng/ml) in fetal plasma, and from 1.0 to 1
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