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Search Results: 1 - 10 of 19912 matches for " Chun Soo Lim "
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Study of Timing Characteristics of NOT Gate Transistor Level Circuit Implemented Using Nano-MOSFET by Analyzing Sub-Band Potential Energy Profile and Current-Voltage Characteristic of Quasi-Ballistic Transport  [PDF]
Chek Yee Ooi, Soo King Lim
World Journal of Nano Science and Engineering (WJNSE) , 2016, DOI: 10.4236/wjnse.2016.64016
Abstract: This paper presents the quasi-ballistic electron transport of a symmetric double-gate (DG) nano-MOSFET with 10 nm gate length and implementation of logical NOT transistor circuit using this nano-MOSFET. Theoretical calculation and simulation using NanoMOS have been done to obtain parameters such as ballistic efficiency, backscattering mean free path, backscattering coefficient, critical length, thermal velocity, capacitances, resistance and drain current. NanoMOS is an on-line device simulator. Theoretical and simulated drain current per micro of width is closely matched. Transistor loaded NOT gate is simulated using WinSpice. Theoretical and simulated value of rise time, fall time, propagation delay and maximum signal frequency of logical NOT transistor level circuit is closely matched. Quasi-ballistic transport has been investigated in this paper since modern MOSFET devices operate between the drift-diffusion and ballistic regimes. This paper aims to enable modern semiconductor device engineers to become familiar with both approaches.
Serum Bilirubin Affects Graft Outcomes through UDP-Glucuronosyltransferase Sequence Variation in Kidney Transplantation
Jung Pyo Lee, Do Hyoung Kim, Seung Hee Yang, Jin Ho Hwang, Jung Nam An, Sang Il Min, Jongwon Ha, Yun Kyu Oh, Yon Su Kim, Chun Soo Lim
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0093633
Abstract: Background Oxidative stress is a major mediator of adverse outcome after kidney transplantation. Bilirubin is produced by heme oxygenase-1 (HO-1), catalyzed by UDP-glucuronosyltransferase (UGT1A1), and has potential as an antioxidant. In this study, we investigated the effects of HO-1 and UGT1A1 sequence variations on kidney allograft outcomes. Methods Clinical data were collected from 429 Korean recipients who underwent kidney transplantation from 1990–2008. Genotyping for UGT1A1*28 and HO-1 (A?413T) was performed. Acute rejection and graft survival were monitored as end-points. Results Serum levels of total bilirubin were significantly increased after transplantation (0.41±0.19 mg/dL to 0.80±0.33 mg/dL, P<0.001). Post-transplant 1-year bilirubin level was higher in 6/7 or 7/7 carriers compared with 6/6 homozygotes in terms of the UGT1A1*28 polymorphism (6/6 vs. 6/7 vs. 7/7: 0.71±0.27 vs. 1.06±0.36 vs. 1.10±0.45 mg/dL, P<0.001). According to an additive model of genotype analysis, the 7-allele genotype had a protective effect on the development of acute rejection compared with the 6-allele (odds ratio 0.43, 95% CI 0.25–0.73, P for trend = 0.006). Multivariate Cox regression analysis revealed that individuals carrying the 7-allele had a decreased risk of graft loss, by a factor of 0.36 (95% CI 0.15–0.85, P = 0.019). The HO-1 (A?413T) polymorphism had no effect on serum bilirubin levels or graft outcomes. Conclusions The UGT1A1*28 polymorphism is associated with changes in serum bilirubin and with graft outcome after kidney transplantation.
Andreev Bound States in the Kondo Quantum Dots Coupled to Superconducting Leads
Jong Soo Lim,Mahn-Soo Choi
Physics , 2006, DOI: 10.1088/0953-8984/20/41/415225
Abstract: We have studied the Kondo quantum dot coupled to two superconducting leads and investigated the subgap Andreev states using the NRG method. Contrary to the recent NCA results [Clerk and Ambegaokar, Phys. Rev. B 61, 9109 (2000); Sellier et al., Phys. Rev. B 72, 174502 (2005)], we observe Andreev states both below and above the Fermi level.
PEMFC Application in a Gliding Arc Plasam-Catalysis Reforming System using Biogas  [PDF]
Mun Sup Lim, Young Nam Chun
Energy and Power Engineering (EPE) , 2011, DOI: 10.4236/epe.2011.32020
Abstract: In this study, bio-waste gas is converted to sustainable hydrogen energy in good quality and low pollution. In addition, generated highly concentrated hydrogen is applied to fuel cell (PEMFC) to resolve environmental and energy crisis issue via gliding arc plasma system. Parameters that can affect the reforming performance of bio-gas in gliding arc plasma system were studied. Especially, the optimal operating condition in water gas shift reactor and preferential oxidation reactor for CO removal was proposed. For the parametric re-searches, change in steam feed amount and temperature change in catalyst bed in water gas shift reactor were studied. For the preferential oxidation reactor, air input flow rate change and temperature variation in catalyst bed were evaluated. The optimal operating conditions for gliding arc plasma reforming system are proposed as 6:4 of biogas component ratio (i.e., CHR4R:CO), 3 of steam/carbon ratio, 16 L/min of total gas flow rate, and 2.4 kW of input electric power. Where, the concentration of biogas that passed each reactor shows 57.5% of HR2R, 7 ppm of CO, 9.2% of COR2R, and 3.4% of CHR4R. Therefore, less than 10 ppm of CO is achieved, and this system can be applicable for PEMFC.
Three Cases of Neoplastic Meningitis Initially Diagnosed with Infectious Meningitis in Emergency Department
Shin Ahn,Kyung Soo Lim
Case Reports in Emergency Medicine , 2013, DOI: 10.1155/2013/561475
Abstract: Neoplastic meningitis (NM) is diagnosed by the presence of malignant cells in the cerebrospinal fluid (CSF). We report 3 patients with NM, who were misdiagnosed with infectious meningitis in emergency department (ED). Case 1. A 68-year-old man visited our ED with a 3-month history of headache. With MRI and CSF study, he was diagnosed with tuberculous meningitis. After 20 days, repeated CSF cytology showed malignant cells. His diagnosis was lung cancer with NM. Case 2. A 57-year-old man visited regional hospital ED with a 3-week history of headache and diplopia. Brain MRI was not contributory. With CSF examination, his diagnosis was aseptic meningitis. With worsening headache, he was referred to our ED. Repeated CSF showed malignant cells. His diagnosis was stomach cancer with NM. Case 3. A 75-year-old man visited a regional hospital with headache lasting for 4 months. His diagnosis was sinusitis. Persistent symptom brought him back, and he developed recurrent generalized seizures. Brain MRI showed diffuse leptomeningeal enhancement suggesting meningitis, and he was transferred to our ED. CSF exam showed malignant cells. His diagnosis was NM with unknown primary focus. When evaluating the patients with headache in ED, NM should be kept in mind as a differential diagnosis of meningitis. 1. Introduction Leptomeningeal carcinomatosis, so-called neoplastic meningitis (NM), is one of the complications of advanced cancer, occurring in 3–8% of all cancers with major neurological disability and high mortality [1]. Diagnosis of NM is made by clinical manifestations with appropriate findings on neuroimaging study or by examination of the cerebrospinal fluid (CSF) for the presence of malignant cells. However, the sensitivity of the initial CSF is approximately 50–60% and that of the enhanced magnetic resonance imaging (MRI) of brain is about 70% in diagnosing NM [2]. In this paper, we report 3 patients without previous history of malignancy, whose initial presentation was NM, but were misdiagnosed with meningitis of infectious origin in emergency department (ED) (Table 1). Table 1: Summary of 3 cases of neoplastic meningitis. 2. Case 1 A 68-year-old man presented to our ED with a 3-month history of headache, which was managed at a private clinic but showed no improvements. His past medical history included hypertension for 10 years and pulmonary tuberculosis which was diagnosed 20 years ago but did not receive any treatment. His headache was continuous with dull ache in the frontal area, associated with nausea and low-grade fever. On initial examination, he
TRIP Database 2.0: A Manually Curated Information Hub for Accessing TRP Channel Interaction Network
Young-Cheul Shin, Soo-Yong Shin, Jung Nyeo Chun, Hyeon Sung Cho, Jin Muk Lim, Hong-Gee Kim, Insuk So, Dongseop Kwon, Ju-Hong Jeon
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0047165
Abstract: Transient receptor potential (TRP) channels are a family of Ca2+-permeable cation channels that play a crucial role in biological and disease processes. To advance TRP channel research, we previously created the TRIP (TRansient receptor potential channel-Interacting Protein) Database, a manually curated database that compiles scattered information on TRP channel protein-protein interactions (PPIs). However, the database needs to be improved for information accessibility and data utilization. Here, we present the TRIP Database 2.0 (http://www.trpchannel.org) in which many helpful, user-friendly web interfaces have been developed to facilitate knowledge acquisition and inspire new approaches to studying TRP channel functions: 1) the PPI information found in the supplementary data of referred articles was curated; 2) the PPI summary matrix enables users to intuitively grasp overall PPI information; 3) the search capability has been expanded to retrieve information from ‘PubMed’ and ‘PIE the search’ (a specialized search engine for PPI-related articles); and 4) the PPI data are available as sif files for network visualization and analysis using ‘Cytoscape’. Therefore, our TRIP Database 2.0 is an information hub that works toward advancing data-driven TRP channel research.
Soluble Epoxide Hydrolase Activity Determines the Severity of Ischemia-Reperfusion Injury in Kidney
Jung Pyo Lee, Seung Hee Yang, Hee-Yoon Lee, Bora Kim, Joo-Youn Cho, Jin Ho Paik, Yun Jung Oh, Dong Ki Kim, Chun Soo Lim, Yon Su Kim
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0037075
Abstract: Soluble epoxide hydrolase (sEH) in endothelial cells determines the plasma concentrations of epoxyeicosatrienoic acids (EETs), which may act as vasoactive agents to control vascular tone. We hypothesized that the regulation of sEH activity may have a therapeutic value in preventing acute kidney injury by controlling the concentration of EETs. In this study, we therefore induced ischemia-reperfusion injury (IRI) in C57BL/6 mice and controlled sEH activity by intraperitoneal administration of the sEH inhibitor 12-(3-adamantan-1-ylureido)-dodecanoic acid (AUDA). The deterioration of kidney function induced by IRI was partially moderated and prevented by AUDA treatment. In addition, AUDA treatment significantly attenuated tubular necrosis induced by IRI. Ischemic injury induced the down-regulation of sEH, and AUDA administration had no effect on the expression pattern of sEH induced by IRI. In vivo sEH activity was assessed by measuring the substrate epoxyoctadecenoic acid (EpOME) and its metabolite dihydroxyoctadec-12-enoic acid (DHOME). Ischemic injury had no effects on the plasma concentrations of EpOME and DHOME, but inhibition of sEH by AUDA significantly increased plasma EpOME and the EpOME/DHOME ratio. The protective effect of the sEH inhibitor was achieved by suppression of proinflammatory cytokines and up-regulation of regulatory cytokines. AUDA treatment prevented the intrarenal infiltration of inflammatory cells, but promoted endothelial cell migration and neovascularization. The results of this study suggest that treatment with sEH inhibitors can reduce acute kidney injury.
The association of moderate renal dysfunction with impaired preference-based health-related quality of life: 3rd Korean national health and nutritional examination survey
Hajeong Lee, Yun Jung Oh, Myounghee Kim, Ho Kim, Jung Pyo Lee, Sejoong Kim, Kook-Hwan Oh, Ho Jun Chin, Kwon Wook Joo, Chun Soo Lim, Suhnggwon Kim, Yon Su Kim, Dong Ki Kim
BMC Nephrology , 2012, DOI: 10.1186/1471-2369-13-19
Abstract: We analyzed data for 5,555 adults from the 3rd Korean National Health and Nutritional Examination Survey 2005. The EuroQol-5D (EQ-5D) utility score was used to evaluate HRQOL. The study subjects were stratified into three groups based on their estimated glomerular filtration rates (eGFRs): ≥ 90.0, 60.0-89.9 and 30.0-59.9 mL/min/1.73 m2. Individuals with advanced renal dysfunction were excluded from the analysis.The proportions of participants who reported problems in each of the five EQ-5D dimensions increased significantly with decreasing eGFR. However, a significant decrease in the EQ-5D utility score was observed among participants with an eGFR of 30.0-59.9 mL/min/1.73 m2. Participants with an eGFR of 30.0-59.9 mL/min/1.73 m2 had an almost 1.5-fold higher risk of impaired health utility (the lowest quartile of EQ-5D utility score) compared with those participants with eGFRs ≥ 90.0 mL/min/1.73 m2, after adjustment for age, gender, health-related behaviors, socioeconomic and psychological variables, and other comorbidities. Among the five dimensions of the EQ-5D, an eGFR of 30.0-59.9 mL/min/1.73 m2 was an independent determinant of self-reported problems in the mobility and pain/discomfort dimensions.Although age affects the association between renal dysfunction and the EQ-5D, moderate renal dysfunction seems to be an important determinant of impaired health utility in a general population and may affect the mobility and pain/discomfort dimensions of health utility.
Non-Linear Relationship between Serum 25-Hydroxyvitamin D and Hemoglobin in Korean Females: The Korean National Health and Nutrition Examination Survey 2010–2011
Seung Seok Han, Myounghee Kim, Ho Kim, Su Mi Lee, Yun Jung Oh, Jung Pyo Lee, Sejoong Kim, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0072605
Abstract: Background Anemia and vitamin D deficiency are both important health issues; however, the nature of the association between vitamin D and either hemoglobin or anemia remains unresolved in the general population. Methods Data on 11,206 adults were obtained from the fifth Korean National Health and Nutritional Examination Survey. A generalized additive model was used to examine the threshold level for relationship between serum 25-hydroxyvitamin D [25(OH)D] and hemoglobin levels. A multivariate logistic regression for anemia was conducted according to 25(OH)D quintiles. All analyses were stratified according to sex and menstrual status. Results The generalized additive model confirmed a threshold 25(OH)D level of 26.4 ng/mL (male, 27.4 ng/mL; premenopausal females, 11.8 ng/mL; postmenopausal females, 13.4 ng/mL). The threshold level affected the pattern of association between 25(OH)D and anemia risk: the odds ratio of the 1st quintile but not the 2nd, 3rd, and 4th quintiles were significantly different from the 5th quintile in both premenopausal and postmenopausal females, however there was no obvious trend in males. Conclusions This population-based study demonstrated a non-linear relationship with a threshold effect between serum 25(OH)D and hemoglobin levels in females. Further interventional studies are warranted to determine whether the appropriate level of hemoglobin can be achieved by the correction of vitamin D deficiency.
Quantum Dissipative Dynamics of Entanglement in the Spin-Boson Model
Jong Soo Lim,Mahn-Soo Choi,M. Y. Choi
Physics , 2006,
Abstract: We study quantum dissipative dynamics of entanglement in the spin-boson model, described by the generalized master equation. We consider the two opposite limits of pure-dephasing and relaxation models, measuring the degree of entanglement with the concurrence. When the Markovian approximation is employed, entanglement is shown to decay exponentially in both cases. On the other hand, non-Markovian contributions alter the analytic structure of the master equation, resulting in logarithmic decay in the pure dephasing model.
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