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Search Results: 1 - 10 of 29881 matches for " Chuei-Wen Kuo "
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Risk of new acute myocardial infarction hospitalization associated with use of oral and parenteral non-steroidal anti-inflammation drugs (NSAIDs): a case-crossover study of Taiwan's National Health Insurance claims database and review of current evidence
Wen-Yi Shau, Hsi-Chieh Chen, Shu-Ting Chen, Hsu-Wen Chou, Chia-Hsuin Chang, Chuei-Wen Kuo, Mei-Shu Lai
BMC Cardiovascular Disorders , 2012, DOI: 10.1186/1471-2261-12-4
Abstract: We conducted a case-crossover study using the Taiwan's National Health Insurance claim database, identifying patients with new AMI hospitalized in 2006. The 1-30 days and 91-120 days prior to the admission were defined as case and matched control period for each patient, respectively. Uses of NSAIDs during the respective periods were compared using conditional logistic regression and adjusted for use of co-medications.8354 new AMI hospitalization patients fulfilled the study criteria. 14 oral and 3 parenteral NSAIDs were selected based on drug utilization profile among 13.7 million NSAID users. The adjusted odds ratio, aOR (95% confidence interval), for risk of AMI and use of oral and parenteral non-selective NSAIDs were 1.42 (1.29, 1.56) and 3.35 (2.50, 4.47), respectively, and significantly greater for parenteral than oral drugs (p for interaction < 0.01). Ketorolac was associated with the highest AMI risk among both of oral and parenteral NSAIDs studied, the aORs were 2.02 (1.00, 4.09) and 4.27 (2.90, 6.29) respectively. Use of oral flurbiprofen, ibuprofen, sulindac, diclofenac, and parenteral ketoprofen were also significantly associated with increased AMI risk. The results of the present study were consistent with the majority of evidence from previous studies.The collective evidence revealed the tendency of increased AMI risk with current use of some NSAIDs. A higher AMI risk associated with use of parenteral NSAIDs was observed in the present study. Ketorolac had the highest associated risk in both oral and parenteral NSAIDs studied. Though further investigation to confirm the association is warranted, prescribing physicians and the general public should be cautious about the potential risk of AMI when using NSAIDs.Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used medications for reducing inflammation and relief pain. Due to large population exposed to NSAIDs, the risk of serious adverse cardiovascular effect for patient taking NSAIDs is an are
Cancer Risk Associated with Insulin Glargine among Adult Type 2 Diabetes Patients – A Nationwide Cohort Study
Chia-Hsuin Chang, Sengwee Toh, Jou-Wei Lin, Shu-Ting Chen, Chuei-Wen Kuo, Lee-Ming Chuang, Mei-Shu Lai
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0021368
Abstract: Background Preclinical and observational studies raise the concern about the safety of insulin glargine in terms of cancer initiation and promotion. This study is designed to examine cancer incidence associated with use of insulin glargine vs. intermediate/long-acting human insulin (HI). Methodology A retrospective cohort study using the Taiwan National Health Insurance claims database was conducted to identify adult patients with type 2 diabetes mellitus and without a history of cancer who initiated insulin glargine (n = 10,190) or intermediate/long-acting HI (n = 49,253) during 2004–2007. Exclusive users were followed from the date of insulin initiation to the earliest of cancer diagnosis, death, disenrollment, or December 31 2007. We estimated adjusted hazard ratios and 95% confidence intervals (CIs) with Cox proportional hazards models adjusting for baseline propensity score. Findings The incidence rate of all cancer per 1,000 person-years was 13.8 for insulin glargine initiators (179 cases) and 16.0 for intermediate/long-acting HI initiators (1,445 cases) during an average follow-up of 2 years. No significant difference in overall cancer risk between insulin glargine initiators and HI initiators was found. For men, however, the adjusted hazard ratio of insulin glargine use as compared with intermediate/long-acting HI was 2.15 (95% CI 1.01–4.59) for pancreatic cancer, and 2.42 (95% CI 1.50–8.40) for prostate cancer. The increased risk was not observed among women. Conclusions Insulin glargine use did not increase the risk of overall cancer incidence as compared with HI. The positive associations with pancreatic and prostate cancer need further evaluation and validation.
Equilibrating effect of Maxwell-type boundary condition in highly rarefied gas
Hung-Wen Kuo
Mathematics , 2015, DOI: 10.1007/s10955-015-1355-1
Abstract: We study the equilibrating effects of the boundary and intermolecular collision in the kinetic theory for rarefied gases. We consider the Maxwell-type boundary condition, which has weaker equilibrating effect than the commonly studied diffuse reflection boundary condition. The gas region is the spherical domain in $\mathbb{R}^d$, $d=1,2$. First, without the equilibrating effect of collision, we obtain the algebraic convergence rates to the steady state of free molecular flow with variable boundary temperature. The convergence behavior has intricate dependence on the accommodation coefficient of the Maxwell-type boundary condition. Then we couple the boundary effect with the intermolecular collision and study their interaction. We are able to construct the steady state solutions of the full Boltzmann equation for large Knudsen numbers and small boundary temperature variation. We also establish the nonlinear stability with exponential rate of the stationary Boltzmann solutions. Our analysis is based on the explicit formulations of the boundary condition for symmetric domains.
A Novel Exo-Glucanase Explored from a Meyerozyma sp. Fungal Strain  [PDF]
Hsion-Wen Kuo, Jia-Kun Zeng, Pi-Han Wang, Wen-Chin Chen
Advances in Enzyme Research (AER) , 2015, DOI: 10.4236/aer.2015.33006
Abstract: Isolating cellulase-secreting microbes followed-by screening their cellulolytic activities has been an essential approach to discover novel and potential cellulases for cellulolytic industrial applications. This study was aimed to explore competitive exoglucanases by screening avicelase activities for 92 fungal strains isolated from environmental airborne-fungal-spore samples. Results showed that an isolated fungal strain numbered 58 exhibited the best avicelase activity of 0.209 U/mL when cultured for six days at pH 5.0 - 5.3 and 25℃ - 27℃, and was lately identified as a yeast strain of Meyerozyma sp. (96% ITS fragment similar with Meyerozyma caribbica, HG970748). Based on amino acid sequences revealed from LC/MS/MS, the target exoglucanase was identical to 1,4-beta-D-glucan cellobiohydrolases and was named Mc-CBHI which had optimal avicelase reaction conditions of pH 5 and 70℃ and could remain fairly stable after 4hr incubation at acid conditions (pH 3 - 5) or wide temperature ranges (30℃ - 80℃). Additionally, the Mc-CBHI (~70 kDa and ~3.6% of crude enzyme) had specific FPase and avicelase activities of 0.179 U/mg and 0.126 U/mg, respectively (which were about 40% - 50% activities of a commercial cellulase Accellerase-1000). These results demonstrated that the newly-found Mc-CBHI could become one of potential exoglucanase resources for related cellulolytic industrial applications.
An Expanded Optimal Control Policy for a Coupled Tanks System with Random Disturbance  [PDF]
Sie Long Kek, Sy Yi Sim, Chuei Yee Chen
Advances in Pure Mathematics (APM) , 2019, DOI: 10.4236/apm.2019.94014
Abstract: In this paper, an expanded optimal control policy is proposed to study the coupled tanks system, where the random disturbance is added into the system. Since the dynamics of the coupled tanks system can be formulated as a nonlinear system, determination of the optimal water level in the tanks is useful for the operation decision. On this point of view, the coupled tanks system dynamics is usually linearized to give the steady state operating height. In our approach, a model-based optimal control problem, which is adding with adjusted parameters, is considered to obtain the true operating height of the real coupled tanks system. During the computation procedure, the differences between the real plant and the model used are measured repeatedly, where the optimal solution of the model used is updated. On this basis, system optimization and parameter estimation are integrated. At the end of the iteration, the iterative solution approximates to the correct optimal solution of the original optimal control problem, in spite of model-reality differences. In conclusion, the efficiency of the approach proposed is shown.
Birefringence Caused by the Presence of Permanent Dipoles and Its Possible Threat on the Accuracy of Traditional Surface Plasmon  [PDF]
Po-Yu Tsai, Chien-Jung Liao, Wen-Kai Kuo, Chungpin Liao
World Journal of Condensed Matter Physics (WJCMP) , 2011, DOI: 10.4236/wjcmp.2011.11002
Abstract: In arriving at the more intuitive “scattering form” of the Fresnel equations, microscopic physical electric and magnetic dipoles were rigorously employed as the source of electromagnetic waves by Doyle et al. Motivated by such an ap-proach, the authors started to speculate how the incorporation of permanent dipoles might affect Brewster angle of a specific optical material. It is found that in the presence of permanent dipoles, not only is the Brewster angle dependent on the incident light power as well as the dipole orientation, but also that two conjugate incident light paths result in distinctively different refractions. Experiments on dipole-engineered polyvinylidene fluoride films show that by way of adding/reducing permanent dipole density and varying orientations, the aforementioned theoretical predictions can be evidenced unambiguously in the visible light range. Further, effective polarization density can be quantified from the above experiments subjected to different dipole engineering processes. As a result, the traditionally elliptic contour of a slanted two dimensional section of the refractive index ellipsoid now manifests symmetric open splittings at near the traditional incident angle. It implies that severe challenge to the accuracy of traditional surface plasmon resonance measurements may arise in the presence of permanent dipoles of various morphologies, such as in the forms of na-no-particles or membrane double layers.
Does Salary Discrimination by Nationality Exist? The Case of Nippon Professional Baseball League  [PDF]
Wen-Jhan Jane, Sheng-Tung Chen, Min-Hua Kuo
Modern Economy (ME) , 2013, DOI: 10.4236/me.2013.42012

This article focuses on the issue of nationality as related to salary discrimination in the Nippon Professional Baseball (NPB) league. Salary data for 663 players during the period from 2000 to 2008 was collected, and Quantile Regression (QR) was employed to investigate the nationality discrimination in salary. The main finding indicates that, on average, international players were paid 54.7% - 57.3% more than domestic players ceteris paribus. QR results show that the positive effect of nationality on salary is larger for players with relatively higher salaries. The finding indicates that an international player’s salary premium increases with salary.

The Influence of Notch Depth on the Response of Local Sharp-Notched Circular Tubes under Cyclic Bending  [PDF]
Kuo-Long Lee, Ching-Hsun Meng, Wen-Fung Pan
Journal of Applied Mathematics and Physics (JAMP) , 2014, DOI: 10.4236/jamp.2014.26040

In this paper, the mechanical behavior and buckling failure of SUS304 stainless steel tubes with different local sharp-notched depths subjected to cyclic bending were experimentally investigated. It can be seen that the experimental moment-curvature relationship exhibits cyclic hardening and becomes a steady loop after a few cycles. However, the experimental ovalization-curvature relationship exhibits an increasing and ratcheting manner with the number of the bending cycles. In addition, higher notch depth of a tube leads to a more severe unsymmetrical trend of the ovalization-curvature relationship. It has been observed that the notch depth has almost no influence on the moment-curvature relationship. But, it has a strong influence on the ovalization-curvature relationship. Finally, the theoretical model proposed by Kyriakides and Shaw [1] was used in this study for simulating the controlled curvature-number of cycles to produce buckling relationship. Through comparison with the experimental data, the theoretical model can properly simulate the experimental findings

Simulating the Gene Flow of Genetically Modified Maize in Taiwan  [PDF]
Bo-Jein Kuo, Shuo-Cheng Nieh, Guang-Jauh Shieh, Wen-Shin Lin
Agricultural Sciences (AS) , 2014, DOI: 10.4236/as.2014.55045

A field experiment was conducted in Taiwan to measure the cross-pollination (CP) rate of maize pollen recipients from pollen sources using phenotypic marker and to determine the isolation dis- tance between the 2 maize varieties. A waxy variety (Black Pearl) with purple kernels simulated the genetically modified (GM) pollen donor, and another waxy variety (White Pearl) with white kernels simulated the non-GM recipient. For the first crop, the total area was approximately1.5 hawith a pollen source and recipient acreage ratio of approximately 1:32. For the second crop, the total area was approximately1.83 hawith a ratio of approximately 1:17.3. The source fields were surrounded by the recipient fields for 2 crop seasons. The results showed that the rate of CP was <0.05% beyond15 mupwind and84.8 mdownwind in all crop seasons. The CP rate was below 5% at a distance of10min the downwind direction. A sample with 0.24% CP was recorded at107.3 mdownwind; however, the CP rate was 0% at68 mupwind. Three empirical models were used, that is, exponential, log/log and log/log, and a simplified Gaussian Plume model, to examine the relationship between the CP rates and the source-field distances. All of the models were appropriate for predicting CP rates, and the Gaussian Plume model performed better compared to the empirical models. The results show that it is possible to control CP from foreign pollen by using an appropriate isolation distance.

Comparison of Primary Gas Tamponade and a Vitrectomy for Repair of Macular Holes with Retinal Detachment in Highly Myopic Eyes
Chien-Neng Kuo,Hsi-Kung Kuo,Chian-Jue Kuo,Hsueh-Wen Chang
Chang Gung Medical Journal , 2003,
Abstract: Background: A preference for the primary use of standard gas tamponade or a vitrectomycombined with other adjuvant measures to treat myopic eyes with macularholes (MHs) and retinal detachment (RD) has not been established. This articleevaluates postoperative outcomes of both surgeries, and recommends asurgical method based on the findings.Methods: We reviewed the records of 61 patients (62 eyes) with high myopia (> -6.0diopter, > 26 mm of axial length, or visible posterior staphyloma) and MHswith secondary RD (no peripheral retinal break) who were treated betweenApril 1986 and September 2002 in southern Taiwan. Descriptive statistics ofbaseline examinations and results of the operations were retrospectively analyzed.Results: Baseline clinical data of the primary gas tamponade and vitrectomy groupsdid not significantly differ, except for the mean preoperative log (minimumangle of resolution) visual acuity (VA) ( p = 0.016) and extent of RD( p = 0.001, located in the posterior staphyloma only). None of the results(including success rate, cause of failure, number of operations until stabilitywas achieved, and mean duration of postoperative follow-up) of the operationsin the 2 groups significantly differed, except for the improved VA at thefinal status ( p = 0.03).Conclusion: Among highly myopic eyes with MHs, we suggest a vitrectomy for those withpoorer VA and a greater extent of RD. However, gas tamponade is stronglyrecommended for those with RD with posterior staphyloma (PS) only becausethis procedure is safer and requires no sophisticated instruments.
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