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Search Results: 1 - 10 of 346 matches for " Chromobacterium violaceum CV026 "
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Piericidins, Novel Quorum-Sensing Inhibitors against Chromobacterium violaceum CV026, from Streptomyces sp. TOHO-Y209 and TOHO-O348  [PDF]
Kazuhiro Ooka, Atsushi Fukumoto, Tomoe Yamanaka, Kanako Shimada, Ryo Ishihara, Yojiro Anzai, Fumio Kato
Open Journal of Medicinal Chemistry (OJMC) , 2013, DOI: 10.4236/ojmc.2013.34012
Abstract: Piericidin A1, 3’-rhamnopiericidin A1, and a novel compound piericidin E, a new quorum-sensing (QS) inhibitor
against Chromobacterium violaceum CV026, were isolated from the culture broth of Streptomyces sp. QS is well
known as a microbial signaling system and controls certain types of gene expression resulting in bioluminescence,
biofilm formation, swarming motility, antibiotic biosynthesis, and virulence factor production. C. violaceum CV026 is
commonly used to determine qualitative and quantitative QS activity. The structures of piericidin derivatives were characterized,
and their QS activities were determined.
Isolation and Identification of Marine Actinomycetes with Quorum Sensing Inhibitory Activity
具有群体感应抑制活性海洋放线菌的分离和鉴定

WANG Wei-Shan,ZOU Shan-Shan,YIN Shou-Liang,GONG Qian-Hong,YU Wen-Gong,
王为善
,邹姗姗,尹守亮,宫倩红,于文功

微生物学通报 , 2009,
Abstract: Quorum sensing systems of pathogens are central regulators for the expression of virulence factors. Increasing evidence implies that targeting the quorum sensing system of many pathogenic bacteria is a promising therapeutic approach to control infections. In this work, we isolated 47 strains of actinomycetes from the mud sample of Jiaozhou Bay. Quorum sensing inhibitory activity was monitored by Chromobacterium violaceum CV026. As a result, the culture broth extract of actinomycetes WA-7 was found to have significant quorum sensing inhibitory activity. This strain was assigned to the genus Streptomyces based on its 16S rDNA sequence. Further investigation revealed that the extract could inhibit the quorum sensing-controlled violacein and proteases production of C. violaceum in a concentration-dependent manner.
Screening and identification of marine fungi against bacterial quorum sensing
具有细菌群体感应抑制活性海洋来源真菌的筛选鉴定

Shouliang Yin,Yajing Chang,Suping Deng,Qingchi Wang,Wengong Yu,Qianhong Gong,
尹守亮
,常亚婧,邓苏萍,王清池,于文功,宫倩红

生物工程学报 , 2011,
Abstract: The discovery of quorum sensing (QS) system and its critical role in bacterial virulence have revealed a new way to attack pathogenic bacterium. The pathogenecity of QS deletion mutants decreases significantly. Targeting bacterial QS system is a promising therapeutic approach to control infections and anti-microbial resistance. To obtain natural QS inhibitors from marine organisms, marine fungi (69 strains) were isolated from marine mollusca, and their extracts were screened using improved QSIS2 (Quorum Sensing Inhibitor Selector 2) assay and Chromobacterium violaceum CV026. To improve the efficiency of QSIS2 screening, 2,3,5-triphenyltetrazolium chloride (TTC) staining method was used. Extract from strain QY013 was found to have QS inhibitory activity. Further experiment indicated that pyocyanin in Pseudomonas aeruginosa PAOI and violacein in C. violaceum CV026 were reduced by QY013 extract, without affecting bacterial growth. Morphological and 18S rDNA sequence analysis revealed that strain QY013 was most closely related to Penicillium species. The above results suggest that active constituents from QY013 may be used as novel antimicrobial agents against bacterial infection.
Caffeine as a Potential Quorum Sensing Inhibitor
Siti Nur Maisarah Norizan,Wai-Fong Yin,Kok-Gan Chan
Sensors , 2013, DOI: 10.3390/s130405117
Abstract: Quorum sensing enables bacteria to control the gene expression in response to the cell density. It regulates a variety of bacterial physiological functions such as biofilm formation, bioluminescence, virulence factors and swarming which has been shown contribute to bacterial pathogenesis. The use of quorum sensing inhibitor would be of particular interest in treating bacterial pathogenicity and infections. In this work, we have tested caffeine as quorum sensing inhibitor by using Chromobacterium violaceum CV026 as a biosensor. We verified that caffeine did not degrade the N-acyl homoserine lactones tested. In this work, it is shown that caffeine could inhibit N-acyl homoserine lactone production and swarming of a human opportunistic pathogen, namely Pseudomonas aeruginosa PA01. To the best of our knowledge, this is the first documentation providing evidence on the presence of anti-quorum sensing activity in caffeine. Our work will allow caffeine to be explored as anti-infective drugs.
Chromobacterium Violaceum Septicaemia-A Case Report
Rekha Rai*, Vimal Kumar Karnaker, Veena Shetty and Krishnaprasad MS
Al Ameen Journal of Medical Sciences , 2011,
Abstract: Chromobacterium violaceum is a rare human pathogen with a high rate of mortality. Since the first case from Malaysia in 1927, about 150 cases have been reported till 2004 in the world literature [1]. We report a case of septicaemia with bronchopneumonia in a young healthy male
Solution NMR Structure of Hypothetical Protein CV_2116 Encoded by a Viral Prophage Element in Chromobacterium violaceum
Yunhuang Yang,Theresa A. Ramelot,John R. Cort,Maite Garcia,Adelinda Yee,Cheryl H. Arrowsmith,Michael A. Kennedy
International Journal of Molecular Sciences , 2012, DOI: 10.3390/ijms13067354
Abstract: CV_2116 is a small hypothetical protein of 82 amino acids from the Gram-negative coccobacillus Chromobacterium violaceum. A PSI-BLAST search using the CV_2116 sequence as a query identified only one hit (E = 2e ?07) corresponding to a hypothetical protein OR16_04617 from Cupriavidus basilensis OR16, which failed to provide insight into the function of CV_2116. The CV_2116 gene was cloned into the p15TvLic expression plasmid, transformed into E. coli, and 13C- and 15N-labeled NMR samples of CV_2116 were overexpressed in E. coli and purified for structure determination using NMR spectroscopy. The resulting high-quality solution NMR structure of CV_2116 revealed a novel α + β fold containing two anti-parallel β -sheets in the N-terminal two-thirds of the protein and one α-helix in the C-terminal third of the protein. CV_2116 does not belong to any known protein sequence family and a Dali search indicated that no similar structures exist in the protein data bank. Although no function of CV_2116 could be derived from either sequence or structural similarity searches, the neighboring genes of CV_2116 encode various proteins annotated as similar to bacteriophage tail assembly proteins. Interestingly, C. violaceum exhibits an extensive network of bacteriophage tail-like structures that likely result from lateral gene transfer by incorporation of viral DNA into its genome (prophages) due to bacteriophage infection. Indeed, C. violaceum has been shown to contain four prophage elements and CV_2116 resides in the fourth of these elements. Analysis of the putative operon in which CV_2116 resides indicates that CV_2116 might be a component of the bacteriophage tail-like assembly that occurs in C. violaceum.
Sepsis by Chromobacterium violaceum: first case report from Colombia
Díaz Pérez, Julio Alexander;García, Jorge;Rodriguez Villamizar, Laura Andrea;
Brazilian Journal of Infectious Diseases , 2007, DOI: 10.1590/S1413-86702007000400016
Abstract: chromobacterium violaceum is found in tropical and subtropical regions; it is the only chromobacterium species pathogenic for humans. due to its rare presentation, physicians often ignore the importance of this pathogen. we report a fulminant fatal case of bacteremia in a 38-year-old colombian man. the clinical manifestations were fever, thoracic pain, respiratory failure and death. his condition, from the beginning of clinical diagnosis, went into continuous deterioration, till his death, within a few days after the symptoms began. two hemocultures isolated c. violaceum. we conclude that doctors should consider this differential diagnosis in patients with systemic inflammatory response syndrome, with continuous deterioration.
Fatal septicemia caused by Chromobacterium violaceum in a child from Colombia
Martinez, Pedro;Mattar, Salim;
Revista do Instituto de Medicina Tropical de S?o Paulo , 2007, DOI: 10.1590/S0036-46652007000600011
Abstract: a 4-year old child living in colombia presented with a history of fever and severe abdominal pain for four days. the patient developed pneumonia, septic shock, multiple organ failure and died on the fifth day of hospitalization. chromobacterium violaceum was isolated from admission blood cultures and was resistant to ampicillin, cephalosporins, carbapenems and aminoglycosides.
Chromobacterium violaceum infection in Brazil. A case report
MARTINEZ, Roberto;VELLUDO, Maria Angeles Sanches L.;SANTOS, Vanda Roseli dos;DINAMARCO, Paula Vanessa;
Revista do Instituto de Medicina Tropical de S?o Paulo , 2000, DOI: 10.1590/S0036-46652000000200008
Abstract: we report the second case of infection with chromobacterium violaceum that occurred in brazil. a farm worker living in the state of s?o paulo presented fever and severe abdominal pain for four days. at hospitalization the patient was in a toxemic state and had a distended and painful abdomen. chest x-ray and abdominal ultrasound revealed bilateral pneumonia and hypoechoic areas in the liver. the patient developed failure of multiple organs and died a few hours later. blood culture led to isolation of c. violaceum resistant to ampicillin and cephalosporins and sensitive to chloramphenicol, tetracyclin, aminoglicosydes, and ciprofloxacin. autopsy revealed pulmonary microabscesses and multiple abscesses in the liver. the major features of this case are generally observed in infections by c. violaceum: rapid clinical course, multiple visceral abscesses, and high mortality. because of the antimicrobial resistance profile of this gram-negative bacillus, for appropriate empirical antibiotic therapy it is important to consider chromobacteriosis in the differential diagnosis of severe community infections in brazil.
Chromobacterium violaceum infection in Brazil. A case report
MARTINEZ Roberto,VELLUDO Maria Angeles Sanches L.,SANTOS Vanda Roseli dos,DINAMARCO Paula Vanessa
Revista do Instituto de Medicina Tropical de S?o Paulo , 2000,
Abstract: We report the second case of infection with Chromobacterium violaceum that occurred in Brazil. A farm worker living in the State of S o Paulo presented fever and severe abdominal pain for four days. At hospitalization the patient was in a toxemic state and had a distended and painful abdomen. Chest X-ray and abdominal ultrasound revealed bilateral pneumonia and hypoechoic areas in the liver. The patient developed failure of multiple organs and died a few hours later. Blood culture led to isolation of C. violaceum resistant to ampicillin and cephalosporins and sensitive to chloramphenicol, tetracyclin, aminoglicosydes, and ciprofloxacin. Autopsy revealed pulmonary microabscesses and multiple abscesses in the liver. The major features of this case are generally observed in infections by C. violaceum: rapid clinical course, multiple visceral abscesses, and high mortality. Because of the antimicrobial resistance profile of this Gram-negative bacillus, for appropriate empirical antibiotic therapy it is important to consider chromobacteriosis in the differential diagnosis of severe community infections in Brazil.
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