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Search Results: 1 - 10 of 1430 matches for " Christos Coutifaris "
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DNA methylation differences at growth related genes correlate with birth weight: a molecular signature linked to developmental origins of adult disease?
Nahid Turan, Mohamed F Ghalwash, Sunita Katari, Christos Coutifaris, Zoran Obradovic, Carmen Sapienza
BMC Medical Genomics , 2012, DOI: 10.1186/1755-8794-5-10
Abstract: We performed DNA methylation and transcript profiling on cord blood and placenta from newborns. We then used novel computational approaches to identify genes correlated with birth weight.We identified 23 genes whose methylation levels explain 70-87% of the variance in birth weight. Six of these (ANGPT4, APOE, CDK2, GRB10, OSBPL5 and REG1B) are associated with growth phenotypes in human or mouse models. Gene expression profiling explained a much smaller fraction of variance in birth weight than did DNA methylation. We further show that two genes, the transcriptional repressor MSX1 and the growth factor receptor adaptor protein GRB10, are correlated with transcriptional control of at least seven genes reported to be involved in fetal or placental growth, suggesting that we have identified important networks in growth control. GRB10 methylation is also correlated with genes involved in reactive oxygen species signaling, stress signaling and oxygen sensing and more recent data implicate GRB10 in insulin signaling.Single time point measurements of gene expression may reflect many factors unrelated to birth weight, while inter-individual differences in DNA methylation may represent a "molecular fossil record" of differences in birth weight-related gene expression. Finding these "unexpected" pathways may tell us something about the long-term association between low birth weight and adult disease, as well as which genes may be susceptible to environmental effects. These findings increase our understanding of the molecular mechanisms involved in human development and disease progression.One common non-disease phenotype that puts children at increased risk for multiple adverse outcomes is "low birth weight". Low birth weight is simply the transformation of the quantitative phenotype of birth weight into a discrete trait by truncation at the lowest decile of infant birth weights; i.e., a birth weight of less than 2,500 g. Low birth weight increases the risk of neonatal death b
Inter- and Intra-Individual Variation in Allele-Specific DNA Methylation and Gene Expression in Children Conceived using Assisted Reproductive Technology
Nahid Turan,Sunita Katari,Leigh F. Gerson,Raffi Chalian,Michael W. Foster,John P. Gaughan,Christos Coutifaris,Carmen Sapienza
PLOS Genetics , 2010, DOI: 10.1371/journal.pgen.1001033
Abstract: Epidemiological studies have reported a higher incidence of rare disorders involving imprinted genes among children conceived using assisted reproductive technology (ART), suggesting that ART procedures may be disruptive to imprinted gene methylation patterns. We examined intra- and inter-individual variation in DNA methylation at the differentially methylated regions (DMRs) of the IGF2/H19 and IGF2R loci in a population of children conceived in vitro or in vivo. We found substantial variation in allele-specific methylation at both loci in both groups. Aberrant methylation of the maternal IGF2/H19 DMR was more common in the in vitro group, and the overall variance was also significantly greater in the in vitro group. We estimated the number of trophoblast stem cells in each group based on approximation of the variance of the binomial distribution of IGF2/H19 methylation ratios, as well as the distribution of X chromosome inactivation scores in placenta. Both of these independent measures indicated that placentas of the in vitro group were derived from fewer stem cells than the in vivo conceived group. Both IGF2 and H19 mRNAs were significantly lower in placenta from the in vitro group. Although average birth weight was lower in the in vitro group, we found no correlation between birth weight and IGF2 or IGF2R transcript levels or the ratio of IGF2/IGF2R transcript levels. Our results show that in vitro conception is associated with aberrant methylation patterns at the IGF2/H19 locus. However, very little of the inter- or intra-individual variation in H19 or IGF2 mRNA levels can be explained by differences in maternal DMR DNA methylation, in contrast to the expectations of current transcriptional imprinting models. Extraembryonic tissues of embryos cultured in vitro appear to be derived from fewer trophoblast stem cells. It is possible that this developmental difference has an effect on placental and fetal growth.
Tobacco Networks in the Aegean Islands  [PDF]
Christos Bakalis
Advances in Historical Studies (AHS) , 2016, DOI: 10.4236/ahs.2016.52007
Abstract: The Aegean Archipelagos could be seen as a networked cultural space covered by multilevel web frameworks. The lines (flows or trajectories) are routes of people, goods, ideas and the nodes are the islands and their communities. At the same time islands are also fields of production that makes them matrixes of social and cultural creation. This paper deals with the cultivation and marketing of tobacco in the Aegean islands from the second half of the 19th century to the end of the 20th century. The presence of tobacco was combined with the transition to modernity for island communities when the capitalistic economy was spread and became dominant in the eastern Mediterranean. Following the division of labor, the tobacco processing reinforced the dependency of island economies from regional and global financial systems; also the establishment of an industrial working class within island societies. The tobacco left its mark in social and spatial formation in the Aegean islands both in urban and rural environments.
Deviation Measures on Banach Spaces and Applications  [PDF]
Christos E. Kountzakis
Journal of Financial Risk Management (JFRM) , 2013, DOI: 10.4236/jfrm.2013.21003

In this article we generalize the notion of the deviation measure, which were initially defined on spaces of squarely integrable random variables, as an extension of the notion of standard deviation. We extend them both under a frame which requires some elements from the theory of partially ordered linear spaces and also under a frame which refers to some closed subspace, whose elements are supposed to have zero deviation. This subspace denotes in general a set of risk-less assets, since in finance deviation measures may replace standard deviation as a measure of risk. In the last sections of the article we treat the minimization of deviation measures over a set of financial positions as a zero-sum game between the investor and the nature and we determine the solution of such a minimization problem via min-max theorems.

7BThe 2-Dimensional Lattice-Subspaces in Finite-State Finance  [PDF]
Christos E. Kountzakis
Journal of Mathematical Finance (JMF) , 2014, DOI: 10.4236/jmf.2014.44022
The main result of this paper is the construction of a strictly positive extension of any no-arbitrage price system defined on an incomplete market of any dimension and for any (finite) number of states of the world. This is proved by using the component functionals of the positive basis of the 2-dimensional lattice-subspace, which is spanned by the riskless asset and any of the state-discriminating payoffs, which are generically existent in the span of the primitive, non-redundant assets of the incomplete market, whose time-period 1 payoffs are x1, x2,···, xn, respectively. This result is also valid in the case where the market is complete. Both of these results lead to a new statement of both of the Fundamental Theorems of Asset Pricing in the finite-state case.
Severe Thyrotoxicosis Does Not Accelerate 1a-Hydroxylation of 25-Hydroxyvitamin D3 in Dogs. Experimental Study  [PDF]
Christos Georgiou Velentzas
International Journal of Clinical Medicine (IJCM) , 2013, DOI: 10.4236/ijcm.2013.412093

Two healthy dogs weighing 18 kg and 13 kg each received an intravenous injection of 7 μg/kg 25-hydroxyvitamin D3 (25OHD3). Subsequently, they were blood-sampled in order to determine the plasma levels of 25(OH)D3 over 4-hourly time intervals and for a time period of 24 hours. After a period of 18 days since the last blood sampling, the animals were brought to a hyperthyroid state and the intravenous injection of 7 μg/kg 25OHD3 was repeated. Blood sampling was performed every 4 hours and over a time period of 24 hours in order to determine the levels of 25OHD3. The graphic plotting of plasma levels of 25OHD3 in the euthyroid state did not differ from that in the hyperthyroid state. This finding in dog animal experimentation is indicative that the increased levels of thyroid hormones did not affect the activity of CYP27B1 and CYP24A1 enzymes that are related to the catabolism of 25OHD3 over a minimum of 24 hours period.

On the Order Form of the Fundamental Theorems of Asset Pricing  [PDF]
Christos E. Kountzakis
Journal of Mathematical Finance (JMF) , 2014, DOI: 10.4236/jmf.2014.44019
In this article, we provide an order-form of the First and the Second Fundamental Theorem of Asset Pricing both in the one-period market model for a finite and infinite state-space and in the case of multi-period model for a finite state-space and a finite time-horizon. The space of the financial positions is supposed to be a Banach lattice. We also prove relevant results in the case where the space of the financial positions is not ordered by a lattice cone.
Pelvic Floor Function in the Female  [PDF]
Christos E. Constantinou
Open Journal of Obstetrics and Gynecology (OJOG) , 2014, DOI: 10.4236/ojog.2014.414115
Abstract: Pelvic Floor (PF) disorders, such as urinary incontinence and prolapse accounted for over 400,000 operations in the USA in 1987 [1], and nearly a third of these were re-operations. It is estimated that 30% - 50% of women in Europe and the USA are affected by Urinary incontinence [2]. Stress Urinary Incontinence (SUI), the involuntary leakage of urine on coughing, sneezing, exertion or effort, is the most common form of urinary incontinence in women. The scientific understanding of normal PF function is limited and consequently treatment of these prevalent, disabling conditions is, at best, inefficient.
Reflections on Neoliberal Policy: A Critical Insight into Recent Development Practices in Egypt and Morocco  [PDF]
Alex Afouxenidis, Christos Kourtelis
Open Journal of Political Science (OJPS) , 2017, DOI: 10.4236/ojps.2017.72024
Abstract: For a number of years, western states and international institutions provided financial assistance to the developing countries and promoted solutions to political inequality based on two main principles. The first was related to the notion of economic liberalization, which would unfold the potentials of the market and minimize the role of the state in the economic sphere. The second was that western support to the embryonic civil societies of the developing world would give voice to the populations of these countries and would change the nature of authoritative political regimes. These ideas continue to inform the debate about the development of north African countries. This paper presents and analyzes two nations in north Africa, Egypt and Morocco, in terms of how they exploited the global economic situation and whether they benefited from the openness of the markets. Reference is made to the fact that some political freedoms were initiated in those countries, but they were not democratized. Therefore, the paper critically examines and distinguishes the notion of economic liberalization from the idea of democratization by exploring the ways regimes handled fundamental notions of political equality.
Valuation of Derivatives on the Cost Variables of the Shipping Market  [PDF]
Christos E. Kountzakis
Journal of Mathematical Finance (JMF) , 2017, DOI: 10.4236/jmf.2017.72027
Abstract: In this paper, we present stochastic differential equations related to the cost variables of the shipping market. These SDEs arise under the addition of stochastic terms on the deterministic differential equations concerning the same variables. The financial interest arises from the fact that these SDEs may be used for the valuation of derivatives on these variables, such as futures, options, and others.
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