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Search Results: 1 - 10 of 411484 matches for " Christopher M. Barth "
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Systemic Inflammation in Non-Demented Elderly Human Subjects: Brain Microstructure and Cognition
Konstantinos Arfanakis, Debra A. Fleischman, Giorgia Grisot, Christopher M. Barth, Anna Varentsova, Martha C. Morris, Lisa L. Barnes, David A. Bennett
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0073107
Abstract: The purpose of this study was to test the hypothesis that higher levels of systemic inflammation in a community sample of non-demented subjects older than seventy years of age are associated with reduced diffusion anisotropy in brain white matter and lower cognition. Ninety-five older persons without dementia underwent detailed clinical and cognitive evaluation and magnetic resonance imaging, including diffusion tensor imaging. Systemic inflammation was assessed with a composite measure of commonly used circulating inflammatory markers (C-reactive protein and tumor necrosis factor-alpha). Tract-based spatial statistics analyses demonstrated that diffusion anisotropy in the body and isthmus of the corpus callosum was negatively correlated with the composite measure of systemic inflammation, controlling for demographic, clinical and radiologic factors. Visuospatial ability was negatively correlated with systemic inflammation, and diffusion anisotropy in the body and isthmus of the corpus callosum was shown to mediate this association. The findings of the present study suggest that higher levels of systemic inflammation may be associated with lower microstructural integrity in the corpus callosum of non-demented elderly individuals, and this may partially explain the finding of reduced higher-order visual cognition in aging.
Catálogo sistemático dos pólens das plantas arbóreas do Brasil meridional (Parte complementar: Coniferales)
Barth, Ortrud M.;
Memórias do Instituto Oswaldo Cruz , 1962, DOI: 10.1590/S0074-02761962000200005
Abstract: in ergaenzung des 1. teils des katalogs der baumpollen sued-brasiliens werden die drei einzigen hier vorkommenden gymnospermaearten beschrieben: araucaria angustifolia, podocarpus sellowii und p. lamberti. die erste besitzt runde, mit zwei ausbuchtungen versehene pollen und eine komplex gebaute exine. beide podocarpusarten aehneln einander sehr. bezueglich ihrer groesse koennen sie nicht voneinander geschieden werden. die beste art der unterscheidung besteht in der oberflaechenstruktur der pollenkoerper: p. sellowii hat eine feine, engmaschige, anaehernd netzartige oberflaeche (entsprechend dem "reticulate-ornate" = typ), waehrend p. lamberti grobe erhebungen (entsprechend dem "ornate" = typ) vorweist.
Catálogo sistemático dos pólens das plantas arbóreas do brasil meridional: V - Leguminosae: Papilionatae
Barth, Ortrud M.;
Memórias do Instituto Oswaldo Cruz , 1964, DOI: 10.1590/S0074-02761964000100010
Abstract: in this paper of the catalogue of south brazilian arboreal pollen grains, the autor deals with the papilionatae. the mimosoideae and caesalpinioideae are yet in preparation, so that a discussion of the three subfamilies (or families) is not possible. in relation with the systematical subdivision of the papilionatae, we found a large correspondence with the morphology of the present pollen grains. the group of phaseoleae contains the genera mucuna, erythrina and dioclea; the grains of the studied species are very different one from another; the first of the genera possesses very volumous grains, with three colpori and a reticulated superficies; the second has three-porated pollen grains with a large reticulated superficies, and the third, dioclea, is yet different; it possesses oblated grains, each three-colporated, with a thick sexine and a psilated superficies. so, we can say, that phaseoleae is a erypalynous group. dalbergieae, with the genera: andira, dalbergia, lonchocarpus, machaerium, platymiscium and pterocarpus (and dahlstedtia, the only exception), has very uniform pollen grains, and may be considered stenopalynous. it is not possible to include the genus dahlstedtia into this group. a little exception is represented by pterocarpus violaceus, because of the reticulated sexine of its grains, while the others, also three-colporated, possess a tectate-reticulated sexine. the genera myrocarpus and ormosia, from sophoreae, are very more similar to the dalbergieae as to any other genus of the phaseoleae.
Two-Phase Epistemology and Models for Dialogue Logic
E. M. Barth
Philosophica , 1985,
Abstract:
Comparison of a nurse initiated insulin infusion protocol for intensive insulin therapy between adult surgical trauma, medical and coronary care intensive care patients
Melissa M Barth, Lance J Oyen, Karen T Warfield, Jennifer L Elmer, Laura K Evenson, Ann N Tescher, Philip J Kuper, Michael P Bannon, Ognjen Gajic, J Christopher Farmer
BMC Emergency Medicine , 2007, DOI: 10.1186/1471-227x-7-14
Abstract: A descriptive, retrospective review of 366 patients having 28,192 blood glucose values in three intensive care units, Surgical Trauma Intensive Care Unit (STICU), Medical (MICU) and Coronary Care Unit (CCU) in a quaternary care hospital was conducted. Patients were > 15 years of age, admitted to STICU (n = 162), MICU (n = 110) or CCU (n = 94) over 8 months; October 2003-June 2004 and who had an initial blood glucose level > 150 mg/dL. We summarized the effectiveness and safety of a nurse initiated IIP, and compared these endpoints among STICU, MICU and CCU patients.The median blood glucose values (mg/dL) at initiation of insulin infusion protocol were lower in STICU (188; IQR, 162–217) than in MICU, (201; IQR, 170–268) and CCU (227; IQR, 178–313); p < 0.0001. Mean time to achieving a target glucose level (100–150 mg/dL) was similar between the three units: 4.6 hours in STICU, 4.7 hours in MICU and 4.9 hours in CCU (p = 0.27). Hypoglycemia (BG < 60 mg/dL) occurred in 7% of STICU, 5% of MICU, and 5% of CCU patients (p = 0.85). Protocol violations were uncommon in all three ICUs. Mean blood glucose 48 hours following IIP discontinuation was significantly different for each population: 142 mg/dL in STICU, 167 mg/dL in MICU, and 160 mg/dL in CCU (p < 0.0001).The safety and effectiveness of nurse initiated IIP was similar across different ICUs in our hospital. Marked variability in glucose control after the protocol discontinuation suggests the need for further research regarding glucose control in patients transitioning out of the ICU.Sustained hyperglycemia is a known risk factor for adverse outcomes in the critically ill patient, whether or not the patient has a history of diabetes mellitus [1-3]. There are many factors that affect glycemic control; metabolic derangement and counter-regulation, increased stress, decrease insulin (resistance or underproduction), increased glucose administration just to name a few [4,5]. Although short term glycemic increases related to
Evaluation of a new lightning-produced NOx parameterization for cloud resolving models and its associated uncertainties
C. Barthe,M. C. Barth
Atmospheric Chemistry and Physics (ACP) & Discussions (ACPD) , 2008,
Abstract: A new parameterization of the lightning-produced NOx has been developed for cloud-resolving models. This parameterization is based on the unique characteristics of identifying which convective cells are capable of producing lightning based on a vertical velocity threshold and estimating the lightning flash rate in each convective cell from the non-precipitation and precipitation ice mass flux product. Further, the source location is filamentary instead of volumetric as in most previous parameterizations. This parameterization has been tested on the 10 July 1996 Stratospheric-Tropospheric Experiment: Radiation, Aerosols and Ozone (STERAO) storm. Comparisons of the simulated flash rate and NO mixing ratio (control experiment) with observations at different locations and stages of the storm show good agreement. An individual flash produces on average 121±41 moles of NO (7.3±2.5×1025 molecules NO) for the simulated high cloud base, high shear storm that is dominated by intra-cloud flash activity. Sensitivity tests have been performed to study the impact of the flash rate, the cloud-to-ground flash ratio, the flash length, the spatial distribution of the NO molecules, and the production rate per flash on the NO concentration and distribution. Results show a strong impact from the flash rate, the spatial placement of the lightning-NOx source and the number of moles produced per flash. On the other hand, the simulations show almost no impact from the different cloud-to-ground (CG) ratios and the lightning-NOx production rates per CG flash used as input to the model.
Evaluation of a new lightning-produced NOx parameterization for cloud resolving models and its associated uncertainties
C. Barthe,M. C. Barth
Atmospheric Chemistry and Physics Discussions , 2008,
Abstract: A new parameterization of the lightning-produced NOx has been developed for cloud-resolving models. This parameterization is based on three unique characteristics. First, the cells that can produce lightning are identified using a vertical velocity threshold. Second, the flash rate in each cell is estimated from the non-precipitation and precipitation ice mass flux product. Third, the source location is filamentary instead of volumetric as in previous parameterizations. This parameterization has been tested on the 10 July 1996 Stratospheric-Tropospheric Experiment: Radiation, Aerosols and Ozone (STERAO) storm. Comparisons of the simulated flash rate and NO mixing ratio with observations at different locations and stages of the storm show a good agreement. An individual flash produces on average 121±41 moles of NO (7.3±2.5×1025 molecules NO) for the simulated high cloud base, high shear storm. Sensitivity tests have been performed to study the impact of the flash rate, the cloud-to-ground flash ratio, the flash length, the spatial distribution of the NO molecules, and the production rate per flash on the NO concentration and distribution. Results show a strong impact from the flash rate, the spatial placement of the lightning-NOx source and the number of moles produced per flash.
The correlation potential in density functional theory at the GW-level: spherical atoms
M. Hellgren,U. von Barth
Physics , 2007, DOI: 10.1103/PhysRevB.76.075107
Abstract: As part of a project to obtain better optical response functions for nano materials and other systems with strong excitonic effects we here calculate the exchange-correlation (XC) potential of density-functional theory (DFT) at a level of approximation which corresponds to the dynamically- screened-exchange or GW approximation. In this process we have designed a new numerical method based on cubic splines which appears to be superior to other techniques previously applied to the "inverse engineering problem" of DFT, i.e., the problem of finding an XC potential from a known particle density. The potentials we obtain do not suffer from unphysical ripple and have, to within a reasonable accuracy, the correct asymptotic tails outside localized systems. The XC potential is an important ingredient in finding the particle-conserving excitation energies in atoms and molecules and our potentials perform better in this regard as compared to the LDA potential, potentials from GGA:s, and a DFT potential based on MP2 theory.
Foxo3a induces motoneuron death through the Fas pathway in cooperation with JNK
Catherine Barthélémy, Christopher E Henderson, Brigitte Pettmann
BMC Neuroscience , 2004, DOI: 10.1186/1471-2202-5-48
Abstract: We show here that as a result of removal of neurotrophic factors and the consequent reduction in signalling through the PI3K/Akt pathway, Foxo3a translocates from the cytoplasm to the nucleus where it triggers cell death. Death is reduced in Fas and FasL mutant motoneurons and in the presence of JNK inhibitors indicating that a significant part of it requires activation of the Fas/FasL pathway through JNK.Therefore, in motoneurons as in other cell types, FOXO transcriptional regulators provide an important link between other signalling pathways and the cell death machinery.During development of higher vertebrates, motoneurons within the spinal cord are generated in excess, and about half the cells initially generated undergo programmed cell death (PCD) during the days following target muscle contact [1]. The most frequently proposed explanation for this death is that motoneurons compete for access to limiting quantities of neurotrophic factors produced by their target tissue, and that only those which are successful survive (reviewed in [2]). Primary motoneurons purified from embryonic spinal cords and cultured in the absence of neurotrophic support mimic this process; many of them undergo programmed cell death over a period of 2–3 days [3,4]. Cell death in these conditions results from lack of activation of the survival pathways which normally inhibit the PCD machinery (reviewed in [5]). Thus, it is essential to identify the precise mechanisms by which motoneurons die, and the ways in which removal of trophic factors leads to their activation.We have shown that a major driving force for the death of motoneurons deprived of neurotrophic factors in vitro is activation of the Fas/CD95 death receptor by its cognate ligand, FasL [6]. Fas and FasL are expressed by embryonic motoneurons at the stage at which naturally-occurring PCD is about to occur [6]. While levels of Fas are not affected by the presence or absence of neurotrophic factors, FasL expression is strongly up
Do unemployment and payor category impact length of stay and hospital charges of spine fusion patients?  [PDF]
Mohammad Sami Walid, Nadezhda Zaytseva, Aaron C. M. Barth, Joe Sam Robinson Jr.
Health (Health) , 2012, DOI: 10.4236/health.2012.43023
Abstract: Introduction: In this paper we investigate the possible connection between socioeconomic status as demarcated by employment and in-surance status and consumption of healthcare resources in spine surgery patients. Methods: The clinical records of 1599 spine surgery pa-tients counted from 2008-2009 were reviewed. The largest groups of patients belonged to MS-DRG 460 (N = 585) and to MS-DRG 473 (N = 700). These two MS-DRG patient groups were used as the study cohort representing patients who, by definition, did not have serious comor-bidities or complications. Results: Unemployed non-cervical patients tended to stay on average 1.8 days longer in hospital and had on average $5800 higher hospital charges. No major differ-ences were noted in length of stay and hospital cost between government and private insurance patients. However, self-pay non-cervical fusion patients had notable increases in length of stay and hospital cost, especially in the >39 and <60 age group with the difference in length of stay amounting to 5 days and in hospital charges to $10,000. Univariate analysis with DRG (460 or 473) as a covariate showed significant impact from employment status on length of stay (F = 4.259, P = 0.014) and less significant impact from payor category on hospital charges (F = 2.229, P = 0.064) in the economically-productive 40 -59 age group. Conclusions: In general, no increase in hospital resource consumption was noted except among self-pay patients, the same group seemingly least able to afford expensive healthcare.
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