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Search Results: 1 - 10 of 25298 matches for " Christopher Eric "
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A Survey of 10-Micron Silicate Emission from Dust around Young Sun-Like Stars
Eric Gaidos,Christopher Koresko
Physics , 2003, DOI: 10.1016/j.newast.2003.07.002
Abstract: We obtained low resolution (R = 100) mid-infrared (8-13 micron wavelengths) spectra of 8 nearby young main sequence stars with the Keck 1 telescope and Long-Wavelength Spectrometer (LWS) to search for 10 micron silicate (Si-O stretch) emission from circumstellar dust. No stars exhibited readily apparent emission: Spectra were then analyzed by least-squares fitting of a template based on a spectrum of Comet Hale-Bopp. Using this technique, we were able to constrain the level of silicate emission to a threshold ten times below what was previously possible from space. We found one star, HD 17925, with a spectrum statistically different from its calibrator and consistent with a silicate emission peak of 7% of the photosphere at a wavelength of 10 microns. Excess emission at 60 microns from this star has already been reported.
Parathyroid Adenoma Presenting as a Giant Cystic Neck Mass  [PDF]
Thomas Muelleman, Eric Rosenberger, Clinton Humphrey, Christopher G. Larsen
International Journal of Otolaryngology and Head & Neck Surgery (IJOHNS) , 2016, DOI: 10.4236/ijohns.2016.51004
Abstract: We present a case report of a parathyroid adenoma, which presented as a giant cystic neck mass while providing thorough reviews of the pathophysiology of parathyroid adenomas and the differential diagnosis for large, cystic neck masses in adults. A 72 year old female presented to a tertiary academic medical center with a complicated past medical history and was found to have an asymptomatic central neck mass which measured 10.5 × 7.7 × 4.1 cm on ultrasound and extended from the retropharyngeal space with mass effect on the hypopharynx, esophagus, trachea, and right carotid space structures as well as the superior mediastinum. She had elevated calcium and parathyroid hormone (PTH) levels. She underwent surgical excision of this mass and had an uneventful postoperative period. Large cystic neck masses generate a wide differential diagnosis. In adults, it is important to consider the rare possibility of parathyroid adenoma, especially in patients who may not be able to communicate vague symptoms of hypercalcemia. This particular parathyroid adenoma is several orders of magnitude larger than an average parathyroid adenoma and its massive size served as a distraction for the proper diagnosis as large, cystic neck masses in adults are to be considered cancer until proven otherwise.
Mold Hysteria: Origin of the Hoax
Christopher Chang,M. Eric Gershwin
Clinical and Developmental Immunology , 2005, DOI: 10.1080/17402520500131409
Abstract: The topic of building related illness came into the public's eye as a major health issue in the mid 1970s, when several cases of pneumonia were found to be associated with an infectious agent in Philadelphia. This agent was subsequently found to be a gram-positive bacterium known as Legionella pneumoniae. During the ensuing 30 years, a myriad of symptom constellations, disorders, clinical syndromes and illnesses have been attributed to indoor living or working environments. Over time, there appeared to be no limit to claims of building related illness, and it was “reported” that almost any kind of clinical symptom, real or imaginary, could be blamed on indoor environments. As society became more and more litigious, many of these disorders were erroneously played out in courtrooms rather than medical offices, creating a circus atmosphere surrounding this class of disorders. With the advent of the internet, as well as other advances in telecommunications, these issues eventually became part of a media frenzy, and all truths could be thrown out the window as issues became more and more decided upon by emotions and unfounded beliefs, rather than scientific data and logical thinking.
From antiangiogenesis to hypoxia: current research and future directions
Christopher Rice, L Eric Huang
Cancer Management and Research , 2011, DOI: http://dx.doi.org/10.2147/CMAR.S14812
Abstract: om antiangiogenesis to hypoxia: current research and future directions Review (4109) Total Article Views Authors: Christopher Rice, L Eric Huang Published Date December 2010 Volume 2011:3 Pages 9 - 16 DOI: http://dx.doi.org/10.2147/CMAR.S14812 Christopher Rice1, L Eric Huang1,2 1Department of Neurosurgery, 2Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA Abstract: Angiogenesis has long been recognized as an essential element in tumor growth. Since the conception of antiangiogenesis for cancer therapeutics, great strides have been made in understanding the molecular biology underlying angiogenesis, both in cancer and in physiology. By capitalizing on these advancements through bench-to-bedside research, potent antiangiogenic agents have been developed and tested. To date, the clinical results of most of these antiangiogenic agents have not met expectations. Even with the most successful agents, such as bevacizumab, used either as single agents or in combination with chemotherapy, gains in overall survival of cancer patients have been modest in most cases. In this article, the authors present the evolving views of antiangiogenic therapy, review recent experimental and clinical studies on antiangiogenesis, and address the fundamental role of hypoxia in tumor progression, which may be key to improving the efficacy of antiangiogenic therapy.
Psychological interventions and coronary heart disease
Christopher Peterson,Eric S. Kim
International Journal of Clinical and Health Psychology , 2011,
Abstract: Los estudios epidemiológicos han demostrado que el malestar psicológico es un fuerte e independiente factor de riesgo para el desarrollo y el empeoramiento del pronóstico de la enfermedad coronaria del corazón. Los ensayos de las intervenciones psicológicas han pretendido disminuir el malestar psicológico para mejorar los resultados cardiovasculares. Los resultados de esos estudios, sin embargo, son mixtos. Evidencia de los estudios epidemiológicos recientes sugiere que los recursos de salud psicológica (también conocidos como factores psicológicos positivos) promueven independientemente la salud cardiovascular. A pesar de estos hallazgos prometedores, los estudios de intervención deben todavía examinar cómo la mejora de estos recursos de salud psicológica puede contribuir al aumento del bienestar cardiovascular. Por ello, abogamos por una mayor atención en los recursos de salud psicológica en la conceptualización de la relación entre el funcionamiento psicológico y la salud cardiovascular. Examinamos esta mayor focalización revisando los ensayos de intervenciones psicológicas (cuyos objetivos han sido reducir el malestar psicológico), los estudios epidemiológicos prospectivos recientes relacionan los recursos de salud psicológica con la salud cardiovascular y las intervenciones con recursos de salud psicológica. Mayor exploración de esta laguna en el conocimiento es importante, ya que finalmente puede llevar a innovar los modos de prevención e intervención.
From antiangiogenesis to hypoxia: current research and future directions
Christopher Rice,L Eric Huang
Cancer Management and Research , 2010,
Abstract: Christopher Rice1, L Eric Huang1,21Department of Neurosurgery, 2Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USAAbstract: Angiogenesis has long been recognized as an essential element in tumor growth. Since the conception of antiangiogenesis for cancer therapeutics, great strides have been made in understanding the molecular biology underlying angiogenesis, both in cancer and in physiology. By capitalizing on these advancements through bench-to-bedside research, potent antiangiogenic agents have been developed and tested. To date, the clinical results of most of these antiangiogenic agents have not met expectations. Even with the most successful agents, such as bevacizumab, used either as single agents or in combination with chemotherapy, gains in overall survival of cancer patients have been modest in most cases. In this article, the authors present the evolving views of antiangiogenic therapy, review recent experimental and clinical studies on antiangiogenesis, and address the fundamental role of hypoxia in tumor progression, which may be key to improving the efficacy of antiangiogenic therapy.Keywords: antiangiogenesis, genetic alteration, hypoxia, tumor progression
An Unusual Case of Acute Foot Drop Caused by a Pseudoaneurysm
Christopher J. Wong,Eric E. Kraus
Case Reports in Medicine , 2011, DOI: 10.1155/2011/515078
Abstract: Lower extremity neurologic symptoms are a common presenting problem. Here we report the case of a 73-year-old man who developed acute right foot pain and foot drop. History, physical examination, and electrodiagnostic studies were consistent with a lumbosacral plexopathy. Imaging studies revealed an internal iliac artery pseudoaneurysm, a rare cause of acute foot drop.
Task-Selective Memory Effects for Successfully Implemented Encoding Strategies
Eric D. Leshikar, Audrey Duarte, Christopher Hertzog
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0038160
Abstract: Previous behavioral evidence suggests that instructed strategy use benefits associative memory formation in paired associate tasks. Two such effective encoding strategies–visual imagery and sentence generation–facilitate memory through the production of different types of mediators (e.g., mental images and sentences). Neuroimaging evidence suggests that regions of the brain support memory reflecting the mental operations engaged at the time of study. That work, however, has not taken into account self-reported encoding task success (i.e., whether participants successfully generated a mediator). It is unknown, therefore, whether task-selective memory effects specific to each strategy might be found when encoding strategies are successfully implemented. In this experiment, participants studied pairs of abstract nouns under either visual imagery or sentence generation encoding instructions. At the time of study, participants reported their success at generating a mediator. Outside of the scanner, participants further reported the quality of the generated mediator (e.g., images, sentences) for each word pair. We observed task-selective memory effects for visual imagery in the left middle occipital gyrus, the left precuneus, and the lingual gyrus. No such task-selective effects were observed for sentence generation. Intriguingly, activity at the time of study in the left precuneus was modulated by the self-reported quality (vividness) of the generated mental images with greater activity for trials given higher ratings of quality. These data suggest that regions of the brain support memory in accord with the encoding operations engaged at the time of study.
The Advantages of a Tapered Whisker
Christopher M. Williams,Eric M. Kramer
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0008806
Abstract: The role of facial vibrissae (whiskers) in the behavior of terrestrial mammals is principally as a supplement or substitute for short-distance vision. Each whisker in the array functions as a mechanical transducer, conveying forces applied along the shaft to mechanoreceptors in the follicle at the whisker base. Subsequent processing of mechanoreceptor output in the trigeminal nucleus and somatosensory cortex allows high accuracy discriminations of object distance, direction, and surface texture. The whiskers of terrestrial mammals are tapered and approximately circular in cross section. We characterize the taper of whiskers in nine mammal species, measure the mechanical deflection of isolated felid whiskers, and discuss the mechanics of a single whisker under static and oscillatory deflections. We argue that a tapered whisker provides some advantages for tactile perception (as compared to a hypothetical untapered whisker), and that this may explain why the taper has been preserved during the evolution of terrestrial mammals.
Shh Signaling from the Nucleus Pulposus Is Required for the Postnatal Growth and Differentiation of the Mouse Intervertebral Disc
Chitra Lekha Dahia, Eric Mahoney, Christopher Wylie
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0035944
Abstract: Intervertebral discs (IVD) are essential components of the vertebral column. They maintain separation, and provide shock absorbing buffers, between adjacent vertebrae, while also allowing movements between them. Each IVD consists of a central semi-liquid nucleus pulposus (NP) surrounded by a multi-layered fibrocartilagenous annulus fibrosus (AF). Although the IVDs grow and differentiate after birth along with the vertebral column, little is known about the mechanism of this. Understanding the signals that control normal IVD growth and differentiation would also provide potential therapies for degenerative disc disease, which is the major cause of lower back pain and affects a large proportion of the population. In this work, we show that during postnatal growth of the mouse, Sonic hedgehog (Shh) signaling from the NP cells controls many aspects of growth and differentiation of both the NP cells themselves and of the surrounding AF, and that it acts, at least partly, by regulating other signaling pathways in the NP and AF. Recent studies have shown that the NP cells arise from the embryonic notochord, which acts as a major signaling center in the embryo. This work shows that this notochord-derived tissue continues to carry out a major signaling function in the postnatal body and that the IVDs are signaling centers, in addition to their already known functions in the mechanics of vertebral column function.
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