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Search Results: 1 - 10 of 12484 matches for " Christopher Duma "
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Proof of Concept in a Case Study of Glioblastoma Multiforme Successfully Treated with IV Quercetin in Combination with Leading Edge Gamma Knife and Standard Treatments  [PDF]
M. A. Nezami, Christopher Duma
Journal of Cancer Therapy (JCT) , 2018, DOI: 10.4236/jct.2018.96043
Abstract: The Stupp protocol has become standard of care for the treatment of glioblastoma (GBM) (since its publication in 2005) and has led to some limited survival improvements. This protocol, consists of radiotherapy and concomitant chemotherapy with temozolomide, an alkylating agent. Temozolomide + radiation, compared to radiation alone had added in average 3 months additional life span, 16 percent improved survival at 2 years. That said since 2005, the standard of care has not changed in regards to the treatment of early diagnosed aggressive or multifocal GBM, and unfortunately the expected survival is still poor with 75 percent of patients dying in less than 2 years and average survival of 15 months. In patients with multifocal tumors (such as the case below) the average survival is even worse with less than 4 months at her age [1]. Here we present a case study of a patient with advanced multifocal, and rapidly progressing Glioblastoma Multiforme treated with STUPP protocol in combination with IV Quercetin. The patient experienced improved quality of life and response, compared to historical data. It is our recommendation to investigate such combinational approach in patients with Glioblastoma, as in our case it proved to be safe and effective with improved quality of life and performance as well as clinical response and survival.
A Novel Combined Approach for Metastatic Breast Cancer with Dural and Leptomeningeal Disease with an Impressive Clinical Outcome: A Case Study  [PDF]
Julie Taguchi, Christopher Duma, M. A. Nezami
Journal of Cancer Therapy (JCT) , 2018, DOI: 10.4236/jct.2018.93025
Abstract: Concurrent dural and leptomeningeal metastatic carcinomatosis are very rare and have a poor prognosis. Here we present a woman with advanced estrogen receptor (ER) positive and progesterone receptor (PR) positive breast cancer who presented with leptomeningeal disease. Patient underwent multi targeted epigenetic therapies applied in a protocol called MTET. She continued to respond to the interval treatment, which consisted only of the nutraceutical agents. Here we discuss her case in detail and we believe that such an example might be applied to other patients in this situation resulting clinical improvement and less toxicity.
The Impact of Mining Activity upon the Aquatic Environment in the Southern Apuseni Mountains
SIGISMUND DUMA
Romanian Review of Regional Studies , 2009,
Abstract: In the Southern Apuseni Mountains, mining activities have taken place since Antiquity, leaving their marks upon the natural environment, the aquatic one inclusively. If the traditional technologies had a low impact upon the aquatic environment, the ones in the modern period have affected it up to the “dead water” level. It is about the disorganization of the hydrographical basins and especially about aggressive pollution of surface waters with some of the most toxic chemical substances such as cyanides, as well as by an increase in the contents of metallic ions, chlorides, sulphides, sulphates, suspensions and fixed residuum. The decrease in pH, and implicitly the acidification of waters, is also remarkable. It must be mentioned that no systematic studies of the impact of mining activities upon the aquatic environment have been conducted in the area in the last years. In these conditions, the data about water quality have been taken over from the studies conducted by author between 1996 and 1998. The cause of the lack of concern in the field is no other but the cease in ore valorization activities in the majority of the mining objectives in the area. As none of the tailings settling ponds has guard canals, the direct pluvial waters and the ones drained from the slopes transport tailings with noxes which they subsequently discharge in the local pluvial network. In these conditions, both the quality of the mine waters which run freely into the emissary and of the ones that flow from the waste dumps remain mainly in the qualitative parameters analyzed and presented in the study.
Impact of Mining Activity upon Environment in Ro ia Montan
SIGISMUND DUMA
Romanian Review of Regional Studies , 2008,
Abstract: Ro ia Montan is the greatest gold ore in Romania and one of the greatest in Europe, and its exploitation has been carried out since Antiquity up to nowadays. If the traditional extraction and processing technologies had a minimal impact upon environment, the ones adopted in modern times have affected all the components of the natural environment. In the perspective of capitalizing the gold ore through the programme elaborated by the Canadian company, Gold Corporation, the zonal geographical space will be degraded up to the level of industrial dessert over an area of 100 km2 and in case of damage, the affected area can extend enormously. The environmental problems are related both to the specific nature of such an industrial activity and, especially, to the use of enormous quantities of sodium cyanide directly on the preparation flux from the industrial plant. Few such cases are known worldwide, in several economically less developed countries. Usually, cyanides are used for treating the gold concentrations, operation done in conditions of maximum security, in closed spaces, situated in isolated zones and the neutralization (detoxification) of cyanides is done in situ. The treatment of cyanides in open spaces has always generated environmental problems. Moreover, none of the cyanide treatment technologies eliminates entirely their toxic effect (less toxic chemical products are obtained). In order to avoid the production of an environmental disaster and to preserve the local patrimony values (in this place there lies the richest mining archeological site in Europe), we elaborated several recommendations we consider feasible as they allow both the capitalization of ore, which is a socio-economic necessity of the area, and the ecological reconstruction of the affected geographical space.
AGRICULTURAL POLICIES AND COMPETITION IN WORLD AGRICULTURE
Raluca Duma
Societate ?i Politic? , 2011,
Abstract: Agricultural policies have had a guiding role inagriculture development and implicitly in their marketing. Usually they belongto each state and government and are issued in accordance with their specificclimate, social-economic and cultural background which includes food andgastronomic traditions. Agricultural policies have in view home and foreignmarket demand, as well as the socio-demographic, political and military contextat a certain point in the socio-economic development
FAUNISTICAL DATA REGARDING SPIDERS (ARACHNIDA: ARANEAE) FROM SOUTH-EASTERN ROMANIA WITH MENTION OF SOME RARE SPECIES
I. DUMA
Annals of West University of Timi?oara : Series of Biology , 2005,
Abstract: In this paper we present the results of the faunistical study made in the south-eastern Romania in the summers of 2004 and 2006. We found 118 species of araneae belonging to 21 families. Among them there were some rare species: Argiope lobata (Pallas, 1772) mentioned for the third time in Romania, Hariaeus melloteei (Simon, 1886) mentioned for the second time in our country and Latrodectus tredecimguttatus (Rossi, 1890).
SMALL MAMMAL FAUNA (INSECTIVORA AND RODENTIA) FROM THE FLOOD PLAIN OF TIMI RIVER
I. DUMA
Annals of West University of Timi?oara : Series of Biology , 2005,
Abstract: Faunistical data regarding small mammal fauna from the south-western part of Romania are very poor and not to date. The only serious studies were made between 1966 and 1971 along the Danube River by the researchers: A. Popescu, Pr. Barbu, M. Hamar, M. utova. In our collection campaign we captured 6 species of Insectivora: Erinaceus concolor, Talpa europaea, Sorex araneus, Neomys fodiens, Neomys anomalus and Crocidura leucodon. Also we caught 9 species of rodents (Rodentia): Muscardinius avellanarius, Mus musculus, Mus spicilegus, Micromys minutus, Pitymis subterraneus, Apodemus flavicollis, Apodemus sylvaticus, Apodemus agrarius, and Microtus arvalis. Our study brings new faunistical data regarding distribution of some small species of mammals in this part of Romania. Also we confirm the presence of Apodemus agrarius kahmanni in the Banat.
COBWEB WEAVERS (ARANEAE: THERIDIIDAE) FROM THE SOUTH-WESTERN ROMANIA. A FAUNISTICAL APPROACH
IOAN DUMA
Annals of West University of Timi?oara : Series of Biology , 2006,
Abstract:
NOTES ON SPIDER (ARACHNIDA: ARANEAE) FAUNA FROM THE LOWER MURE RIVER VALLEY, WITH A NEW MENTION FOR ROMANIA
IOAN DUMA
Annals of West University of Timi?oara : Series of Biology , 2006,
Abstract:
ZELOTES TENUIS (L. KOCH, 1866) (ARANEAE: GNAPHOSIDAE) FIRST MENTION FOR THE ROMANIAN FAUNA
I. DUMA
Annals of West University of Timi?oara : Series of Biology , 2007,
Abstract: This paper presents new faunistical data on the gnaphosid spiders from Romania. The first distribution of the Zelotes tenuis (L. Kock, 1866) in Romania is given. The presence of Z. tenuis, a Mediterranean species in the fauna of Dobrogea region proves once again that the Black Sea coast of Romania is home to rare spiders of southern origin and that we should try to preserve at least some of the original habitats found here.
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