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Search Results: 1 - 10 of 4176 matches for " Christophe Vinsonneau "
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Too early initiation of renal replacement therapy may be harmful
Christophe Vinsonneau, Mehran Monchi
Critical Care , 2011, DOI: 10.1186/cc9405
Abstract: In an observational study published in the previous issue of Critical Care, Elseviers and colleagues [1] report that the mortality of critically ill patients treated with renal replacement therapy (RRT) for acute kidney injury (AKI) is much higher than that of those treated by a conservative strategy (that is, without RRT). RRT remains an independent factor associated with a higher mortality after adjustments for acute disease severity (risk ratio [RR] 1.73, 95% confidence interval [CI] 1.4 to 2.2) based on the Stuivenberg Hospital Acute Renal Failure (SHARF) score as well as other corrections for usually well-established prognostic factors (age, sex, Sequential Organ Failure Assessment [SOFA] score, type of AKI, delayed admission, and clinical conditions). This observation might have two alternative explanations: first, RRT per se could worsen the prognosis of acutely ill patients experiencing AKI; second, AKI of patients treated by RRT was more severe and this greater severity is not fully reflected by the severity scores and adjustment factors used in the multivariable models of the study. In fact, the role of AKI, as an independent factor for mortality, is currently well documented, regardless of the severity of AKI [2,3]. The subpopulation requiring RRT in the intensive care unit represents the more severe population, and the need for RRT appears to be an independent risk factor for death [4]. However, the need for renal supportive care is nonetheless a marker of severity. The specific role of RRT was first proposed by Guerin and colleagues [5] in their French epidemiological study. Indeed, they reported, in a multiple logistic regression analysis, that the absence of hemodialysis in their severe AKI population (serum creatinine [sCr] of greater than 300 μmol/L, urine output of less than 500 mL/24 hours, or the need for hemodialysis) was a significant predictor of survival (odds ratio 1.78, 95% CI 1.05 to 3.04; P 0.032). This finding is of paramount importance
Des guides touristiques pour le peuple et par le peuple
Ninon Vinsonneau
Transatlantica : Revue d'études Américaines , 2006,
Abstract: Le Federal Writers’ Project (FWP) constitua l’un des quatre programmes culturels lancés par l’administration du New Deal en 1935 en vue de résorber le problème du ch mage parmi les professions dites en col blanc . Il employa de 1935 à 1943, entre quatre et six mille ch meurs par an, tous membres des professions de l’écrit — les écrivains , au sens large que l’administration fédérale donnait à ce terme : romanciers, poètes, dramaturges, mais aussi journalistes, enseignants, cherc...
How to Value GDP-Linked Collar Bonds? An Introductory Perspective  [PDF]
Christophe Schinckus
Theoretical Economics Letters (TEL) , 2013, DOI: 10.4236/tel.2013.33024
Abstract:

This short paper proposed a pricing method for GDP-linked collar bonds based on the classical discounted pricing model and the assumption that the GDP can be described with a geometric Brownian motion. The estimation of parameters was not discussed because it is not central in our numerical exercise.

Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury
Kianoush Kashani, Ali Al-Khafaji, Thomas Ardiles, Antonio Artigas, Sean M Bagshaw, Max Bell, Azra Bihorac, Robert Birkhahn, Cynthia M Cely, Lakhmir S Chawla, Danielle L Davison, Thorsten Feldkamp, Lui G Forni, Michelle Gong, Kyle J Gunnerson, Michael Haase, James Hackett, Patrick M Honore, Eric AJ Hoste, Olivier Joannes-Boyau, Michael Joannidis, Patrick Kim, Jay L Koyner, Daniel T Laskowitz, Matthew E Lissauer, Gernot Marx, Peter A McCullough, Scott Mullaney, Marlies Ostermann, Thomas Rimmelé, Nathan I Shapiro, Andrew D Shaw, Jing Shi, Amy M Sprague, Jean-Louis Vincent, Christophe Vinsonneau
Critical Care , 2013, DOI: 10.1186/cc12503
Abstract: We performed two multicenter observational studies in critically ill patients at risk for AKI - discovery and validation. The top two markers from discovery were validated in a second study (Sapphire) and compared to a number of previously described biomarkers. In the discovery phase, we enrolled 522 adults in three distinct cohorts including patients with sepsis, shock, major surgery, and trauma and examined over 300 markers. In the Sapphire validation study, we enrolled 744 adult subjects with critical illness and without evidence of AKI at enrollment; the final analysis cohort was a heterogeneous sample of 728 critically ill patients. The primary endpoint was moderate to severe AKI (KDIGO stage 2 to 3) within 12 hours of sample collection.Moderate to severe AKI occurred in 14% of Sapphire subjects. The two top biomarkers from discovery were validated. Urine insulin-like growth factor-binding protein 7 (IGFBP7) and tissue inhibitor of metalloproteinases-2 (TIMP-2), both inducers of G1 cell cycle arrest, a key mechanism implicated in AKI, together demonstrated an AUC of 0.80 (0.76 and 0.79 alone). Urine [TIMP-2].[IGFBP7] was significantly superior to all previously described markers of AKI (P <0.002), none of which achieved an AUC >0.72. Furthermore, [TIMP-2].[IGFBP7] significantly improved risk stratification when added to a nine-variable clinical model when analyzed using Cox proportional hazards model, generalized estimating equation, integrated discrimination improvement or net reclassification improvement. Finally, in sensitivity analyses [TIMP-2].[IGFBP7] remained significant and superior to all other markers regardless of changes in reference creatinine method.Two novel markers for AKI have been identified and validated in independent multicenter cohorts. Both markers are superior to existing markers, provide additional information over clinical variables and add mechanistic insight into AKI. Trial registration: ClinicalTrials.gov number NCT01209169.
Automated Colorization of Grayscale Images Using Texture Descriptors and a Modified Fuzzy C-Means Clustering  [PDF]
Christophe Gauge, Sreela Sasi
Journal of Intelligent Learning Systems and Applications (JILSA) , 2012, DOI: 10.4236/jilsa.2012.42013
Abstract: A novel example-based process for Automated Colorization of grayscale images using Texture Descriptors (ACTD) without any human intervention is proposed. By analyzing a set of sample color images, coherent regions of homogeneous textures are extracted. A multi-channel filtering technique is used for texture-based image segmentation, combined with a modified Fuzzy C-means (FCM) clustering algorithm. This modified FCM clustering algorithm includes both the local spatial information from neighboring pixels, and the spatial Euclidian distance to the cluster’s center of gravity. For each area of interest, state-of-the-art texture descriptors are then computed and stored, along with corresponding color information. These texture descriptors and the color information are used for colorization of a grayscale image with similar textures. Given a grayscale image to be colorized, the segmentation and feature extraction processes are repeated. The texture descriptors are used to perform Content-Based Image Retrieval (CBIR). The colorization process is performed by Chroma replacement. This research finds numerous applications, ranging from classic film restoration and enhancement, to adding valuable information into medical and satellite imaging. Also, this can be used to enhance the detection of objects from x-ray images at the airports.
Novel Epistemic and Predictive Heuristic for Semantic and Dynamic Social Networks Analysis  [PDF]
Christophe Thovex, Francky Trichet
Social Networking (SN) , 2014, DOI: 10.4236/sn.2014.33021
Abstract:

Using Kripke semantics, we have identified and reduced an epistemic incompleteness in the metaphor commonly employed in Social Networks Analysis (SNA), which basically compares information flows with current flows in advanced centrality measures. Our theoretical approach defines a new paradigm for the semantic and dynamic analysis of social networks including shared content. Based on our theoretical findings, we define a semantic and predictive model of dynamic SNA for Enterprises Social Networks (ESN), and experiment it on a real dataset.

La question locale comme nouvelle frontière socio-spatiale
Christophe Gibout,Christophe Mauny
SociologieS , 2009,
Abstract: Partant de l’objet football socialement reconnu et de deux formes de pratique préalablement identifiées – pratiques fédérale et de pied d’immeuble – notre travail interroge l’influence et l’importance de la localisation dans la définition formelle des pratiques et la compréhension de leurs logiques identitaires. Parce que les pratiquants déploient des arts de faire singuliers sur un territoire jouant le r le de lien et de liant, notre enquête montre que la dichotomie rural/urbain ne semble plus aujourd’hui heuristiquement pertinente pour comprendre le construit de la pratique sportive. Dès lors émerge la question locale – celle du chez soi – comme élément central de la construction sociale de la pratique sportive ; en témoigne la réalité d’une autre forme de football, non exclusive des deux autres : le football sauvage . The local question as a new socio-spatial frontierBeyond opposition between urban and rural soccer: the “at home” oneOn the basis of socially recognized football and of two beforehand identified forms of practice – official soccer and football played at the foot of one's building – our work questions the influence and the importance of the localization in the definition of the practices and in the comprehension of their identity logics. Because of the players use second hand habits on a territory playing the part of bond and binder, our investigation shows that the rural/urban dichotomy doesn’t seem any more relevant today to understand the construction of sport’s practice. Consequently emerges the local question – the one of at home – as central element of the social construction of the sport’s practice as testified to the reality of another form of football, nonexclusive of both others: wild football. Lo local como nueva frontera socio-espacialMas allá de la oposición entre el futbol urbano y el futbol rural: “nuestro” futbolA partir del futbol, en tanto que objeto social objetivado, y de dos maneras de jugar, la practica institucionalizada por los clubes por una parte y por otro lado la practica callejera, el artículo se plantea la influencia y la importancia de la localización espacial en la definición puramente formal de la practica futbolística y la comprensión de las lógicas identitaria respectivas. Los jugadores desplegan diferentes formas singulares de jugar dentro de un espacio, y asumen implícitamente el doble papel de lazo y de aglutinante social. El artículo demuestra que la división entre lo rural y lo urbano no es hoy día eficaz desde el punto de vista heurística para explicar lo que hay de pert
Pauvreté et droits humains (Poverty and Human Rights)
Christophe Gironde,Christophe Golay
Ceriscope , 2012,
Abstract: Depuis les années 1980, les questions de droits humains, notamment économiques, sociaux et culturels, se sont progressivement imposées dans l'étude des causes de la pauvreté et des mesures qui permettraient de la réduire. Pourtant, force est de constater que les cas de non-respect, dénis et violations des droits humains n'ont pas sensiblement diminué. Les abus entra nés par le phénomène des acquisitions massives de terres agricoles dans les pays les plus pauvres de la planète en fournissent une bonne illustration. Dans ce contexte, les limites des principes volontaires sautent aux yeux, mais la revendication et la protection d'un droit contraignant, tel le droit à l'alimentation, offre des opportunités plus intéressantes pour les communautés locales et les acteurs qui les soutiennent.(Human rights, particularly economic, social and cultural rights, have, since the 1980s, assumed an important part in the study of the causes of poverty and methods used to reduce it. Nevertheless, there has not been a noticeable decline in human rights abuses. One example is the massive agricultural land grabs in the poorest nations of the world. It is clear that voluntary principles are insufficient. However, imposition of a right to food offers an opportunity for local communities and their supporters).
The Production of CNT Flower-Like Structures with 3-Fold and 4-Fold Symmetries on a Pt/Si Substrate  [PDF]
Madjid Arab, Marjorie David, Jean-Christophe Valmalette, Christophe Ramseyer
Advances in Chemical Engineering and Science (ACES) , 2013, DOI: 10.4236/aces.2013.31009
Abstract:

Carbon nanotubes flower (CNTs-F) films were prepared by catalytic chemical vapor deposition (CVD) on a platinum (Pt) thin layer, supported on a silicon wafer. The products were synthesized from an aerosol composed of ferrocene and toluene, as catalyst and carbon precursor respectively, at 820\"\". The high synthesis temperature induces a modification of a Pt thin layer to a nano-structured island giving rise to the formation of CNTs-F during the following films growth step by CVD process. The suggested mechanism involves the selective diffusion of the catalyst and carbon atoms through the Pt grain boundaries. This results in the appearance of flower-like structures with 3-and 4-fold symmetries.

Cosmic Strings and Their Induced Non-Gaussianities in the Cosmic Microwave Background
Christophe Ringeval
Advances in Astronomy , 2010, DOI: 10.1155/2010/380507
Abstract: Motivated by the fact that cosmological perturbations of inflationary quantum origin were born Gaussian, the search for non-Gaussianities in the cosmic microwave background (CMB) anisotropies is considered as the privileged probe of nonlinear physics in the early universe. Cosmic strings are active sources of gravitational perturbations and incessantly produce non-Gaussian distortions in the CMB. Even if, on the currently observed angular scales, they can only contribute a small fraction of the CMB angular power spectrum, cosmic strings could actually be the main source of its non-Gaussianities. In this paper, after having reviewed the basic cosmological properties of a string network, we present the signatures Nambu-Goto cosmic strings would induce in various observables ranging from the one-point function of the temperature anisotropies to the bispectrum and trispectrum. It is shown that string imprints are significantly different than those expected from the primordial type of non-Gaussianity and could therefore be easily distinguished.
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