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Search Results: 1 - 10 of 4242 matches for " Christophe Cellier "
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Validation of a French Version of the Quality of Life “Celiac Disease Questionnaire”
Jacques Pouchot, Carole Despujol, Georgia Malamut, Emmanuel Ecosse, Jo?l Coste, Christophe Cellier
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0096346
Abstract: Background and Objective Celiac disease (CD) is a common chronic autoimmune disorder. Both the manifestations of the disease and the burden of the compulsory life-long gluten-free diet (GFD) have been shown to be associated with impairment of health-related quality of life. The objectives of this study were to provide a cross-cultural adaptation of the specific quality of life “Celiac Disease Questionnaire” (CDQ) and to analyze its psychometric properties. Materials and Methods A cross-cultural French adaptation of the CDQ (F-CDQ) was obtained according to the revised international guidelines. The questionnaire was administered at baseline to 211 patients with biopsy proven CD followed-up in a single tertiary referral centre. The questionnaire was also administered after 7 days and 6 months. Reliability (intraclass correlation coefficients (ICC), Cronbach's alpha and Bland and Altman graphical analysis), validity (factorial structure and Rasch analysis, convergent validity), and responsiveness (effect size) of the F-CDQ were studied. Results The reliability of the F-CDQ was excellent with ICC and Cronbach's alpha coefficients being between 0.79 and 0.94 for the four subscales and the total score. The factorial structure and the Rasch analysis showed that the four dimensions of the original instrument were retained. Correlations with external measures (a generic measure of quality of life, an anxiety and depression instrument, a self-assessed disease severity, and clinical manifestations) were all in the expected direction confirming the validity of the instrument. Responsiveness was studied and effect sizes ≥0.20 were demonstrated for most of the subscales for patients who reported improvement or deterioration after 6 months. Conclusion The F-CDQ retains the psychometric properties of the original instrument and should be useful in cross-national surveys and to assess outcome in clinical trials involving patients with CD.
Cell-Type Specific Determinants of NRAMP1 Expression in Professional Phagocytes
Mathieu F. M. Cellier
Biology , 2013, DOI: 10.3390/biology2010233
Abstract: The Natural resistance-associated macrophage protein 1 (Nramp1 or Solute carrier 11 member 1, Slc11a1) transports divalent metals across the membrane of late endosomes and lysosomes in professional phagocytes. Nramp1 represents an ancient eukaryotic cell-autonomous defense whereas the gene duplication that yielded Nramp1 and Nramp 2 predated the origin of Sarcopterygians (lobe-finned fishes and tetrapods). SLC11A1 genetic polymorphisms associated with human resistance to tuberculosis consist of potential regulatory variants. Herein, current knowledge of the regulation of SLC11A1 gene expression is reviewed and comprehensive analysis of ENCODE data available for hematopoietic cell-types suggests a hypothesis for the regulation of SLC11A1 expression during myeloid development and phagocyte functional polarization. SLC11A1 is part of a 34.6 kb CTCF-insulated locus scattered with predicted regulatory elements: a 3' enhancer, a large 5' enhancer domain and four elements spread around the transcription start site (TSS), including several C/EBP and PU.1 sites. SLC11A1 locus ends appear mobilized by ETS-related factors early during myelopoiesis; activation of both 5' and 3' enhancers in myelo-monocytic cells correlate with transcription factor binding at the TSS. Characterizing the corresponding cis/ trans determinants functionally will establish the mechanisms involved and possibly reveal genetic variation that impacts susceptibility to infectious or immune diseases.
Evolution and Perspectives of Simulation Languages Following the CSSL Standard
Magnus Rimvall,Francois Cellier
Modeling, Identification and Control , 1985, DOI: 10.4173/mic.1985.4.1
Abstract: Since its publication in 1967 the CSSL specification has served as a successful standard for continuous simulation languages. However, recent advantages in modeling techniques, simulation methodologies and computer languages has motivated the simulation community to spur several standardization committees. In this paper the 1967 standard as well as several modern CSSL languages are reviewed, some current trends and developments are discussed and the status of present standardization efforts is presented. An outlook on some of the facilities we can expect to find in future simulation packages (with or without standardization) is given.
PROgnosticating COeliac patieNts SUrvivaL: The PROCONSUL Score
Federico Biagi, Annalisa Schiepatti, Georgia Malamut, Alessandra Marchese, Christophe Cellier, Sjoerd F. Bakker, Chris J. J. Mulder, Umberto Volta, Fabiana Zingone, Carolina Ciacci, Anna D’Odorico, Alida Andrealli, Marco Astegiano, Catherine Klersy, Gino R. Corazza
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0084163
Abstract: Introduction It has been shown that mortality rates of coeliac patients correlate with age at diagnosis of coeliac disease, diagnostic delay for coeliac disease, pattern of clinical presentation and HLA typing. Our aim was to create a tool that identifies coeliac patients at higher risk of developing complications. Methods To identify predictors of complications in patients with coeliac disease, we organised an observational multicenter case-control study based on a retrospective collection of clinical data. Clinical data from 116 cases (patients with complicated coeliac disease) and 181 controls (coeliac patients without any complications) were collected from seven European centres. For each case, one or two controls, matched to cases according to the year of assessment, gender and age, were selected. Diagnostic delay, pattern of clinical presentation, HLA typing and age at diagnosis were used as predictors. Results Differences between cases and controls were detected for diagnostic delay and classical presentation. Conditional logistic models based on these statistically different predictors allowed the development of a score system. Tertiles analysis showed a relationship between score and risk of developing complications. Discussion A score that shows the risk of a newly diagnosed coeliac patient developing complications was devised for the first time. This will make it possible to set up the follow-up of coeliac patients with great benefits not only for their health but also for management of economic resources. Conclusions We think that our results are very encouraging and represent the first attempt to build a prognostic score for coeliac patients.
How to Value GDP-Linked Collar Bonds? An Introductory Perspective  [PDF]
Christophe Schinckus
Theoretical Economics Letters (TEL) , 2013, DOI: 10.4236/tel.2013.33024

This short paper proposed a pricing method for GDP-linked collar bonds based on the classical discounted pricing model and the assumption that the GDP can be described with a geometric Brownian motion. The estimation of parameters was not discussed because it is not central in our numerical exercise.

Toward a Unifying Perspective on Economic Complexity: The Contribution of Chinese Econophysics Community  [PDF]
Christophe Schinckus
Theoretical Economics Letters (TEL) , 2018, DOI: 10.4236/tel.2018.83042
Abstract: Recent years have witnessed a series of economic problems and financial crises, the recent subprime debacle being one of the worst. All these events called traditional economics into question and new perspectives have been developed to take into account the complexity of economic systems. This essay aims at contributing to a better understanding of a new trend labeled econophysics through two points: 1) a discussion on the conceptual links between statistical econophysics and agent-based econophysics; and 2) an overview of works dealing with these links that interestingly, emphasize the importance of econophysics in China.
Incidence of Sarcoma Histotypes and Molecular Subtypes in a Prospective Epidemiological Study with Central Pathology Review and Molecular Testing
Fran?oise Ducimetière, Antoine Lurkin, Dominique Ranchère-Vince, Anne-Valérie Decouvelaere, Michel Péoc'h, Luc Istier, Philippe Chalabreysse, Christine Muller, Laurent Alberti, Pierre-Paul Bringuier, Jean-Yves Scoazec, Anne-Marie Schott, Christophe Bergeron, Dominic Cellier, Jean-Yves Blay, Isabelle Ray-Coquard
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0020294
Abstract: Background The exact overall incidence of sarcoma and sarcoma subtypes is not known. The objective of the present population-based study was to determine this incidence in a European region (Rhone-Alpes) of six million inhabitants, based on a central pathological review of the cases. Methodology/Principal Findings From March 2005 to February 2007, pathology reports and tumor blocks were prospectively collected from the 158 pathologists of the Rhone-Alpes region. All diagnosed or suspected cases of sarcoma were collected, reviewed centrally, examined for molecular alterations and classified according to the 2002 World Health Organization classification. Of the 1287 patients screened during the study period, 748 met the criteria for inclusion in the study. The overall crude and world age-standardized incidence rates were respectively 6.2 and 4.8 per 100,000/year. Incidence rates for soft tissue, visceral and bone sarcomas were respectively 3.6, 2.0 and 0.6 per 100,000. The most frequent histological subtypes were gastrointestinal stromal tumor (18%; 1.1/100,000), unclassified sarcoma (16%; 1/100,000), liposarcoma (15%; 0.9/100,000) and leiomyosarcoma (11%; 0.7/100,000). Conclusions/Significance The observed incidence of sarcomas was higher than expected. This study is the first detailed investigation of the crude incidence of histological and molecular subtypes of sarcomas.
Factors Associated with Adenoma Detection Rate and Diagnosis of Polyps and Colorectal Cancer during Colonoscopy in France: Results of a Prospective, Nationwide Survey
Maximilien Barret, Christian Boustiere, Jean-Marc Canard, Jean-Pierre Arpurt, David Bernardini, Philippe Bulois, Stanislas Chaussade, Denis Heresbach, Isabelle Joly, Jean Lapuelle, René Laugier, Gilles Lesur, Patrice Pienkowski, Thierry Ponchon, Bertrand Pujol, Bruno Richard-Molard, Michel Robaszkiewicz, Rémi Systchenko, Fatima Abbas, Anne-Marie Schott-Pethelaz, Christophe Cellier, for the Société Fran?aise d'Endoscopie Digestive
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0068947
Abstract: Introduction Colonoscopy can prevent deaths due to colorectal cancer (CRC) through early diagnosis or resection of colonic adenomas. We conducted a prospective, nationwide study on colonoscopy practice in France. Methods An online questionnaire was administered to 2,600 French gastroenterologists. Data from all consecutive colonoscopies performed during one week were collected. A statistical extrapolation of the results to a whole year was performed, and factors potentially associated with the adenoma detection rate (ADR) or the diagnosis of polyps or cancer were assessed. Results A total of 342 gastroenterologists, representative of the overall population of French gastroenterologists, provided data on 3,266 colonoscopies, corresponding to 1,200,529 (95% CI: 1,125,936-1,275,122) procedures for the year 2011. The indication for colonoscopy was CRC screening and digestive symptoms in 49.6% and 38.9% of cases, respectively. Polypectomy was performed in 35.5% of cases. The ADR and prevalence of CRC were 17.7% and 2.9%, respectively. The main factors associated with a high ADR were male gender (p=0.0001), age over 50 (p=0.0001), personal or family history of CRC or colorectal polyps (p<0.0001 and p<0.0001, respectively), and positive fecal occult blood test (p=0.0005). The prevalence of CRC was three times higher in patients with their first colonoscopy (4.2% vs. 1.4%; p<0.0001). Conclusions For the first time in France, we report nationwide prospective data on colonoscopy practice, including histological results. We found an average ADR of 17.7%, and observed reduced CRC incidence in patients with previous colonoscopy.
Automated Colorization of Grayscale Images Using Texture Descriptors and a Modified Fuzzy C-Means Clustering  [PDF]
Christophe Gauge, Sreela Sasi
Journal of Intelligent Learning Systems and Applications (JILSA) , 2012, DOI: 10.4236/jilsa.2012.42013
Abstract: A novel example-based process for Automated Colorization of grayscale images using Texture Descriptors (ACTD) without any human intervention is proposed. By analyzing a set of sample color images, coherent regions of homogeneous textures are extracted. A multi-channel filtering technique is used for texture-based image segmentation, combined with a modified Fuzzy C-means (FCM) clustering algorithm. This modified FCM clustering algorithm includes both the local spatial information from neighboring pixels, and the spatial Euclidian distance to the cluster’s center of gravity. For each area of interest, state-of-the-art texture descriptors are then computed and stored, along with corresponding color information. These texture descriptors and the color information are used for colorization of a grayscale image with similar textures. Given a grayscale image to be colorized, the segmentation and feature extraction processes are repeated. The texture descriptors are used to perform Content-Based Image Retrieval (CBIR). The colorization process is performed by Chroma replacement. This research finds numerous applications, ranging from classic film restoration and enhancement, to adding valuable information into medical and satellite imaging. Also, this can be used to enhance the detection of objects from x-ray images at the airports.
Novel Epistemic and Predictive Heuristic for Semantic and Dynamic Social Networks Analysis  [PDF]
Christophe Thovex, Francky Trichet
Social Networking (SN) , 2014, DOI: 10.4236/sn.2014.33021

Using Kripke semantics, we have identified and reduced an epistemic incompleteness in the metaphor commonly employed in Social Networks Analysis (SNA), which basically compares information flows with current flows in advanced centrality measures. Our theoretical approach defines a new paradigm for the semantic and dynamic analysis of social networks including shared content. Based on our theoretical findings, we define a semantic and predictive model of dynamic SNA for Enterprises Social Networks (ESN), and experiment it on a real dataset.

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