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Search Results: 1 - 10 of 6766 matches for " Christine Gross "
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Recent Advances in Molecular Diagnostics and Treatment of Heart Muscle Diseases  [PDF]
Dirk Lassner, Christine S. Siegismund, Jenny Stehr, Maria Rohde, Felicitas Escher, Carsten Tsch?pe, Ulrich Michael Gross, Uwe Kühl, Heinz-Peter Schultheiss
Journal of Analytical Sciences, Methods and Instrumentation (JASMI) , 2013, DOI: 10.4236/jasmi.2013.32012
Abstract:

Cardiomyopathies are acute or chronic disorders of myocardium. Diagnostic characterization of disease entities demands endomyocardial biopsy analyses with histological, immunohistochemical and molecular biological tissue evaluations to establish a final diagnosis. Only such biopsy-based information allows so far a specific treatment of distinct cardiomyopathy subgroups. In order to reduce sampling error, tissue specimens have to be obtained and analyzed to get clinically relevant data for specific treatment options. Specific gene expression and microRNA (miRNAs) profiles as well as genetic markers add additional valuable information which not only reduce the sampling error but also improve patient management. Advantages of such biomarkers result from their general expression within the entire altered myocardium. Thus, obtained information does not depend on small tissue areas reached by biopsy. This very fact allows prediction of a myocardial infection even in virus-negative areas adjoining positive biopsy specimen. The combination of multiple deregulated miRNAs or genes into one disease specific diagnostic profile demands the integration of new profiling technologies in the routine workflows of cardiological laboratories. In future, multiplex approaches allowing rapid and absolutely reliable identification of inflammatory or virally-induced myocardial diseases will replace singleplex methods such as direct detection of viral genomes in one single biopsy. miRNAs are stable biomarkers which are not only detectable in tissue samples but also in body fluids. Consequently, the determination of distinct miRNA patterns in e.g. peripheral blood samples will provide a systemic diagnostic approach for the characterization of distinct cardiomyopathies by means of non-invasive methods. This will reduce the number of undiagnosed patients who have to undergo endomyocardial biopsy for final confirmation of their myocardial complaints. The resulting molecular diagnostics will pave the way from biopsy focused interpretation to systemic analysis of cardiomyopathies. To reach this goal, the set-up of modern diagnostics harks back to the broad

Myocarditis—Personalized Medicine by Expanded Endomyocardial Biopsy Diagnostics  [PDF]
Dirk Lassner, Maria Rohde, Christine Sabine Siegismund, Uwe Kühl, Ulrich Michael Gross, Felicitas Escher, Carsten Tsch?pe, Heinz-Peter Schultheiss
World Journal of Cardiovascular Diseases (WJCD) , 2014, DOI: 10.4236/wjcd.2014.46042
Abstract: Myocarditis and dilated cardiomyopathy (DCM) are acute or chronic disorders of myocardium. The gold standard for final confirmation of causative reasons of these heart muscle diseases is the endomyocardial biopsy (EMB) analysis. Due to focal pathology, diagnostics are failing if the EMB does not contain the area of interest. Personalized medicine comprises the genetic information together with the phenotypic and environmental factors to yield a tailored healthcare for each individual and removes the limitations of the “one-size-fits-all” therapy approach. This provides the opportunity to translate therapies from bench to bedside, to diagnose and predict disease, and to improve patient-tailored treatments based on the unique signatures of a patient’s disease. Furthermore, novel treatment schedules can be identified which have eventually the chance to enhance long-term survivals. Global biomarkers such as specific gene expression signatures or miRNA profiles not only have the potential to reduce this problem but also add valuable information for individualized therapy decisions. In future, multiplex approaches allowing rapid and absolutely reliable identification of inflammatory or virally-induced myocardial diseases will replace singleplex methods such as direct detection of viral genomes in one single biopsy. Gene or miRNA profiles are upcoming diagnostic biomarkers for cardiomyopathies which are not only detectable in tissue samples but in body fluids as well. Consequently, a systemic diagnostic approach by determination of distinct expression pattern in e.g., peripheral blood samples will support the characterization of distinct cardiomyopathies by means of non-invasive methods.
PLoS Biology at 5: The Future Is Open Access
Theodora Bloom,Christine Ferguson,Liza Gross,Catriona J. MacCallum,Jami Milton,Robert Shields,Stephanie Wai,Janelle Weaver,Liz Williams
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.0060267
Abstract:
Please Welcome Our First Academic Editor-in-Chief
Theodora Bloom,Jami Dantzker,Christine Ferguson,Liza Gross,Catriona MacCallum,Mark Patterson,Robert Shields,Janelle Weaver,Elizabeth Whiteman
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.0060049
Abstract:
Avian Ultraviolet/Violet Cones Identified as Probable Magnetoreceptors
Christine Nie?ner,Susanne Denzau,Julia Christina Gross,Leo Peichl,Hans-Joachim Bischof,Gerta Fleissner,Wolfgang Wiltschko,Roswitha Wiltschko
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0020091
Abstract: The Radical-Pair-Model postulates that the reception of magnetic compass directions in birds is based on spin-chemical reactions in specialized photopigments in the eye, with cryptochromes discussed as candidate molecules. But so far, the exact subcellular characterization of these molecules in the retina remained unknown.
Genomic island excisions in Bordetella petrii
Melanie Lechner, Karin Schmitt, Susanne Bauer, David Hot, Christine Hubans, Erwan Levillain, Camille Locht, Yves Lemoine, Roy Gross
BMC Microbiology , 2009, DOI: 10.1186/1471-2180-9-141
Abstract: During in vitro culture of Bordetella petrii colony variants appear frequently. We show that this variability can be attributed to the presence of a large number of metastable mobile genetic elements on its chromosome. In fact, the genome sequence of B. petrii revealed the presence of at least seven large genomic islands mostly encoding accessory metabolic functions involved in the degradation of aromatic compounds and detoxification of heavy metals. Four of these islands (termed GI1 to GI3 and GI6) are highly related to ICEclc of Pseudomonas knackmussii sp. strain B13. Here we present first data about the molecular characterization of these islands. We defined the exact borders of each island and we show that during standard culture of the bacteria these islands get excised from the chromosome. For all but one of these islands (GI5) we could detect circular intermediates. For the clc-like elements GI1 to GI3 of B. petrii we provide evidence that tandem insertion of these islands which all encode highly related integrases and attachment sites may also lead to incorporation of genomic DNA which originally was not part of the island and to the formation of huge composite islands. By integration of a tetracycline resistance cassette into GI3 we found this island to be rather unstable and to be lost from the bacterial population within about 100 consecutive generations. Furthermore, we show that GI3 is self transmissible and by conjugation can be transferred to B. bronchiseptica thus proving it to be an active integrative and conjugative elementThe results show that phenotypic variation of B. petrii is correlated with the presence of genomic islands. Tandem integration of related islands may contribute to island evolution by the acquisition of genes originally belonging to the bacterial core genome. In conclusion, B. petrii appears to be the first member of the genus in which horizontal gene transfer events have massively shaped its genome structure.The enormous impact
Please Welcome Our First Academic Editor-in-Chief
Theodora Bloom,Jami Dantzker,Christine Ferguson,Liza Gross,Catriona MacCallum,Mark Patterson ,Robert Shields,Janelle Weaver,Elizabeth Whiteman
PLOS Biology , 2008, DOI: 10.1371/journal.pbio.0060049
Abstract:
PLoS Biology at 5: The Future Is Open Access
Theodora Bloom,Christine Ferguson,Liza Gross,Catriona J MacCallum ,Jami Milton,Robert Shields,Stephanie Wai,Janelle Weaver,Liz Williams
PLOS Biology , 2008, DOI: 10.1371/journal.pbio.0060267
Abstract:
Reducing Land Degradation on the Highlands of Kilimanjaro Region: A Biogeographical Perspective  [PDF]
Christine Noe
Open Journal of Soil Science (OJSS) , 2014, DOI: 10.4236/ojss.2014.413043
Abstract:

In 2012, governments across the world adopted “The Future We Want” outcome document in Rio De Janeiro as a commitment to achieve a land-degradation-neutral world. This document reasserts the importance of sustainable land management in the top of the debates on sustainable development. This paper provides an overview of Tanzania’s preparedness towards achieving these global objectives. The paper is based on a keynote address which was presented in the conference on reducing land degradation on the highlands of Kilimanjaro Region in Tanzania. Using a biogeographical perspective, the paper assesses challenges of adopting programmatic approach to sustainable land management in Tanzania. It also presents some opportunities that exist through Global Mechanism of the United Nations Convention to Combat Desertification, which promote actions leading to coordination, mobilization and channeling of financial resources to assist member countries to coordinate and sustain sustainable land management projects.

Compressors for Hyper-Sonic Engines —A Theoretical Study of Future Compressors for Hyper Sonic Engines  [PDF]
Christine Cherian
Advances in Aerospace Science and Technology (AAST) , 2018, DOI: 10.4236/aast.2018.34007
Abstract:
This paper is an eye opening to the new horizon of the design of operational Compressors in our jet engines. That are compressors usually perform an operation called isentropic process and which levitate the pressure and temperature to the optimum level which require for effective ignition. Basically, our compressors have several sets of blades to perform this function, more precisely saying Rotor and stator blades. Where rotor blade provides air molecule to push at very high velocity to the Stationary blade and when the air Enders to the Stator, the stator races its pressure to move on to the next stage. And we call this set of Stator and rotor as a stage ref [1]. However, in this work, I consider the geometry of the incoming air molecule and how it transforms its physical quantities such as Pressure and temperature ref [2]. For that I tie the concept of Thermodynamic and mechanics on the platform of Tensor analysis ref [3]. That is, I consider the quantities like Pressure, Temperature and rate of flow are their corresponding vector spaces and energy related quintets like heat, work as the scaling elements on the above vector space. And quantities such as entropy enthalpy and specific heat capacity are corresponding physics of it. Considering the advantages, one of the important advantages of this approach is the applicability of results of this work to the formulation of blade less compression Example: Ram and Scram jet engine. Again, the relevant upgrading which is essential for future hypersonic air crafts can achieve from this study and this will be a mile stone for bright air and space travel. To conclude, this approach will be a great transformation on the conventional idea for realization of compression for operational Scram and Ram jet engines ref [4] [5].
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