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Search Results: 1 - 10 of 172596 matches for " Christine E Mathews "
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Prevalence of antibody to Trypanosoma cruzi in Hispanic-surnamed patients seen at Parkland Health & Hospital System, Dallas, Texas
Roberto Arena, Christine E Mathews, Anne Y Kim, Tim E Lenz, Paul M Southern
BMC Research Notes , 2011, DOI: 10.1186/1756-0500-4-132
Abstract: Five hundred serum specimens from Hispanic-surnamed patients were tested by a preliminary ELISA method. On a subset of 50 sera confirmatory testing was also performed using an alternative ELISA, indirect immunofluorescence, and TESA immunoblot. For 274 of 500 Hispanic-surnamed patients, we were able to ascertain immigration status upon medical chart review. Of the 274 sera analyzed, one sample tested as positive for anti-T. cruzi antibody by the preliminary ELISA, and by the three confirmatory methods.The goal of this study is to increase the awareness of T. cruzi infection and Chagas disease in areas where the Latin American immigrant communities are growing. Our study highlights the importance of testing for Chagas disease in the populations most at risk, and the need for current data on the actual seroprevalence in areas where such immigrant populations are conspicuous. Larger-scale epidemiologic surveys on Chagas disease in the immigrant communities from Latin America are warranted.Chagas disease, also known as American trypanosomiasis, is an infection caused by the parasite Trypanosoma cruzi. This parasite is usually transmitted to humans by Triatominae insects as vectors. Transmission of the infection also occurs transplacentally, via blood transfusion, organ transplantation, laboratory incident, and ingestion of triatomine-contaminated food or drink [1-12]. Chagas disease has an acute stage, typically asymptomatic or with mild symptoms (e.g., fever, malaise, swelling at the site of inoculation, and lymphadenopathy) during the first 6 to 8 weeks after infection. This acute stage is often undetected and thus not treated. If not treated, Chagas disease becomes a chronic, lifelong condition which can go undetected for several decades in any given patient. The majority of infected persons remain asymptomatic in the chronic indeterminate phase (i.e., a prolonged period of clinically silent infection that follows acute primary infection). However, an estimated ~30%
MRI Findings in Post-Operative Bilateral Posterior Ischemic Optic Neuropathy  [PDF]
Nirali P. Bhatt, Robert E. Morales, Michaela K. Mathews
Open Journal of Ophthalmology (OJOph) , 2013, DOI: 10.4236/ojoph.2013.33013

A 62-year-old female complained of vision loss following multiple abdominal surgeries for mesenteric ischemia. The patients visual acuity was no light perception (NLP) in the right eye and hand motion (HM) at 1 in the left eye. Both pupils were unreactive and no relative afferent pupillary defect was noted. Anterior segment and fundus examination were unremarkable. T1 and T2 weighted MRI imaging of the brain was normal but diffusion weighted imaging (DWI) revealed areas of bright signal within both intraorbital optic nerves, confirming the diagnosis of posterior ischemic optic neuropathy.

The (often ignored) role of vicariance in evolutionary diversification on oceanic islands
Christine E. Parent
Frontiers of Biogeography , 2012,
Corpo, self e identidade sexual: reflex es baseadas nas evidências atuais
Christine E. Gudorf
REVER : Revista de Estudos da Religi?o , 2005,
Abstract: This article integrates a wide variety of research and experience, including aging, chronic illness/disability, race, and sexuality, into a discussion of the ways in which body should and should not be identified with self. Concluding that self both is and transcends the body, Gudorf argues for revising understandings of self identity in the direction of greater constructionism, at the same time she develops some reservations about propositions for a discontinuous self.
El contexto político de la educación multicultural en los Estados Unidos
Christine E. Sleeter
Cuadernos Interculturales , 2004,
Abstract: En esta presentación sostendré que la educación multicultural en los Estados Unidos puede ser entendida como un terreno de diálogo y acción dirigida hacia cómo los educadores pueden acortar diferencias colectivas que están vinculadas a relaciones de poder en toda la sociedad. Esta concepción conecta la historia de la aparición del campo, los contextos políticos en los cuales cualquier escuela dada existe y las contribuciones teóricas y prácticas de la ense anza de educación multicultural. De cualquier modo, la educación multicultural es muy a menudo conceptualizada en términos mucho más limitados, lo que implica hacer ciertas adiciones al programa de una escuela (tales como agregar contenido al currículo sobre los grupos de minorías étnicas, o las mujeres), o como un modelo particular o fórmula para acortar las diferencias. Como ejemplo de interacciones que tuve en Sudáfrica unos cuantos a os atrás, mostraré cómo estas concepciones más limitadas de la educación multicultural se pueden agarrar con el objeto de alcanzar sus preocupaciones centrales. Luego daré una muy breve historia de la educación multicultural en los EEUU, para discutir cómo y por qué ha evolucionado hacia la inclusión de género, clases sociales, discapacidad y lengua, junto con raza y etnicidad. La inclusión de esta amplitud de formas de diferencia y opresión pueden ser útiles de muchas maneras, tales como proveer puntos de entrada para los educadores blancos y el desarrollo de conexiones entre dimensiones relacionadas de opresión (tales como raza y clase o raza y género).
Circular versus linear versus hand-sewn gastrojejunostomy in Roux-en-Y-Gastric Bypass influence on weight loss and amelioration of comorbidities: Data analysis from a quality assurance study of the surgical treatment of obesity in Germany
Christine E. Stroh
Frontiers in Surgery , 2014, DOI: 10.3389/fsurg.2014.00023
Abstract: Background: Since January 1 2005, the outcomes of bariatric surgeries have been recorded in Germany. All data are registered prospectively in cooperation with the Institute of Quality Assurance in Surgery at Otto-von-Guericke University Magdeburg. Methods: Data are collected in an online data bank. Data collection began in 2005 for the results of Roux-en-Y Gastric Bypass (RYGB). In addition to primary bariatric operations, data regarding the complications and the amelioration of comorbidities have been analyzed. Participation in the quality assurance study is required for all certified centers in Germany. Results: Roux-en-Y Gastric Bypass is the most popular bariatric operation in Germany. There were 5115 operations performed from 2005 to 2010. A circular anastomosis was performed in 1587 patients, and a linear anastomosis was performed in 2734 patients. In 783 patients the hand-sewn technique was used. The leakage rate for the linear technique is 1.6%, and the leakage rate is 1.2% for circular anastomosis and 1.4% for hand-sewn technique. Conclusion: RYGB is a popular procedure in Germany. The complication rate has decreased since 2005. The amelioration of comorbidities is not influenced by the anastomosis technique. Additional data are necessary to evaluate the long-term effect of linear versus hand-sewn and versus circular stapled gastrojejunal anastomosis regarding pouch dilatation, small bowel dilatation and consecutive weight loss.
A Facile Method for the Synthesis of Oxoketene-N,S- and -N,N-acetals from Reactions of Amino Compounds
Annie Mathews,E. R. Anabha,C. G. Sholly
Organic Chemistry International , 2010, DOI: 10.1155/2010/396020
Abstract: 2-Aroyl-3,3-bis(alkylsulfanyl)acrylaldehydes reacted with various primary amines, namely, o-phenylenediamine, ethylenediamine, and anilines to produce functionalized oxoketene-N,S-acetals and N,N-acetals in good yields. Imidazolo derivatives synthesized with o-phenylenediamine and ethylenediamine containing a formyl group could act as valuable starting materials for a variety of substituted heterocyclic compounds. 1. Introduction Oxoketene-N,S- and -N,N-acetals are highly versatile synthons for heterocyclic synthesis [1–3]. They are quite stable and can be stored indefinitely without any decomposition. They exhibit the nucleophilic displacement reactions by various binucleophiles followed by intramolecular cyclisation leading to the formation of cyclic compounds, and such reactions are characteristics of enamines [1–3]. Junjappa and coworkers prepared a series of functionalized heterocycles by treating them with binucleophiles like hydrazines, hydroxylamines, guanidines, cyanoacetamides, and so forth, [4–6]. They have also prepared functionalized quinolines from α-oxoketene-N,S-acetals employing Vilsmeier-Haack reaction [7]. A similar strategy was reported for the synthesis of quinoxalines from nitroketene-N,S-acetals, important benzoheterocycles displaying a broad spectrum of biological activities [8]. Our research group has also made attempts to explore the synthetic utility of oxoketene-N,S-acetals derived from thioamides [9]. We have shown that their reactions with α-halo ketones or ethyl bromoacetates afford amino thiophenes [10]. The α-oxoketene-N,S-acetals are generally prepared by the direct amination reactions of oxoketene-S,S-acetals by appropriate amines which resulted in a mixture of oxoketene-N,S-acetals and -N,N-acetals in most of the cases. They have also been synthesized directly from active methylene ketones by treating them with phenyl isothiocyanate followed by alkylation. We envisioned that the 2-aroyl-3,3-bis(alkylsulfanyl)acrylaldehydes 2 which we had reported recently could be transformed into aroyl formyl ketene-N,S-acetals or aroyl formyl ketene-N,N-acetals by direct amination reaction. The literature survey shows that such formyl ketene-N,S-acetals and formyl ketene-N,N-acetals have not been reported so far, and such compounds will be established in near future as valuable pivot for a variety of amino substituted heterocyclic compounds. Therefore, it appeared worthwhile to utilize 2-aroyl-3,3-bis(alkylsulfanyl)acrylaldehydes for the synthesis of those synthons. In this paper, we report the reactions of 2-aroyl-3,
Role of the Mitochondria in Immune-Mediated Apoptotic Death of the Human Pancreatic β Cell Line βLox5
Yaíma L. Lightfoot, Jing Chen, Clayton E. Mathews
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0020617
Abstract: Mitochondria are indispensable in the life and death of many types of eukaryotic cells. In pancreatic beta cells, mitochondria play an essential role in the secretion of insulin, a hormone that regulates blood glucose levels. Unregulated blood glucose is a hallmark symptom of diabetes. The onset of Type 1 diabetes is preceded by autoimmune-mediated destruction of beta cells. However, the exact role of mitochondria has not been assessed in beta cell death. In this study, we examine the role of mitochondria in both Fas- and proinflammatory cytokine-mediated destruction of the human beta cell line, βLox5. IFNγ primed βLox5 cells for apoptosis by elevating cell surface Fas. Consequently, βLox5 cells were killed by caspase-dependent apoptosis by agonistic activation of Fas, but only after priming with IFNγ. This beta cell line undergoes both apoptotic and necrotic cell death after incubation with the combination of the proinflammatory cytokines IFNγ and TNFα. Additionally, both caspase-dependent and -independent mechanisms that require proper mitochondrial function are involved. Mitochondrial contributions to βLox5 cell death were analyzed using mitochondrial DNA (mtDNA) depleted βLox5 cells, or βLox5 ρ0 cells. βLox5 ρ0 cells are not sensitive to IFNγ and TNFα killing, indicating a direct role for the mitochondria in cytokine-induced cell death of the parental cell line. However, βLox5 ρ0 cells are susceptible to Fas killing, implicating caspase-dependent extrinsic apoptotic death is the mechanism by which these human beta cells die after Fas ligation. These data support the hypothesis that immune mediators kill βLox5 cells by both mitochondrial-dependent intrinsic and caspase-dependent extrinsic pathways.
From desk to bed: Computational simulations provide indication for rheumatoid arthritis clinical trials
Jennifer E Dent, Christine Nardini
BMC Systems Biology , 2013, DOI: 10.1186/1752-0509-7-10
Abstract: Analysis of the CRKL network -available at http://www.picb.ac.cn/ClinicalGenomicNTW/software.html- allows for investigation of the potential effect of perturbing genes of interest. Within the group of genes that are significantly affected by simulated perturbation of CRKL, we are lead to further investigate the importance of PXN. Our results allow us to (1) refine the hypothesis on CRKL as a novel drug target (2) indicate potential causes of side effects in on-going trials and (3) importantly, provide recommendations with impact on on-going clinical studies.Based on a virtual network that collects and connects a large number of the molecules known to be involved in a disease, one can simulate the effects of controlling molecules, allowing for the observation of how this affects the rest of the network. This is important to mimic the effect of a drug, but also to be aware of -and possibly control- its side effects. Using this approach in RA research we have been able to contribute to the field by suggesting molecules to be targeted in new therapies and more importantly, to warrant efficacy, to hypothesise novel recommendations on existing drugs currently under test.
Metastases: the glycan connection
Christine Couldrey, Jeffrey E Green
Breast Cancer Research , 2000, DOI: 10.1186/bcr75
Abstract: The progression of breast cancer to a metastatic, hormone-refractory stage heralds a poor prognosis, with less than 5% of patients having a long-term, complete response to treatment [1]. The cancer cell has to overcome many levels of regulation that maintain normal cellular growth for breast cancer to evolve to this advanced state. Multiple genetic alterations that enable the cancer cell to become self-sufficient (reviewed in [2]) in the production of growth signals have accumulated, such as the overexpression of myc (for a review, see [3]) and her2/neu [4], as well as losing the inhibitory effects of tumor suppressor genes such as p53 and Rb (reviewed in [5]). It is also clear that the normal protective apoptotic response to genomic damage is suppressed through the expression of survival factors, allowing such cells to accumulate and undergo further genetic aberration. The reactivation of telomerase also ensures that tumor cells have limitless replicative potential [6]. However, it is the ability of cancer cells to spread to remote locations and grow without restraint that kills the patient. The metastatic spread of breast cancer involves the ability of the cancer cells to escape their normal tissue boundaries through invasion, engraftment and their ability to recruit a vascular supply (for a review, see [7]). Tissue invasion and metastasis are highly dependent on alterations in the extra-cellular matrix [8] and cell-cell interactions that, in part, involve structural changes in cell surface components, including glycosylation (for a review, see [9]). In the work of Granovsky et al, the importance of specific glycosylation events in mammary cancer metastases has been clearly demonstrated in vivo using genetically altered mice [10].The N-linked glycoproteins have been shown to have important roles in cell-cell interactions including fertilization, inflammation, development and differentiation. These molecules are composed of a polypeptide backbone glycosylated in th
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