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Search Results: 1 - 10 of 132924 matches for " Chris;Li "
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A Combination of Feature Selection and Co-occurrence Matrix Methods for Leukocyte Recognition System  [PDF]
Li Na, Arlends Chris, Bagus Mulyawan
Journal of Software Engineering and Applications (JSEA) , 2012, DOI: 10.4236/jsea.2012.512B020
Abstract: A leukocyte recognition system, as part of a differential blood counter system, is very important in hematology field. In this paper, the propose system aims to automatically classify the white blood cells (leukocytes) on a given microscopic image. The classifications of leukocytes are performed based on the combination of color and texture features of the blood cell images. The developed system classifies the leukocytes in one of the five categories (neutrophils, eosinophils, basophils, lymphocytes, and monocytes). In the preprocessing stage, the system starts with converting the microscopic images from Red Green Blue (RGB) color space to Hue Saturation Value (HSV) color space. Next, the system splits the Hue and Saturation features from the Value feature. For both Hue and Saturation features, the system processes their color information using the Feature Selection method and the Window Cropping method; while the Value feature is processed by its texture information using the Co-occurrence matrix method. The final recognition stage is performed using the Euclidean distance method. The combination of the Feature Selection and Co-occurrence Matrix methods gives the best overall recognition accuracies for classifying leukocyte images.
Chris Li,Kyuhyung Kim
Frontiers in Endocrinology , 2014, DOI: 10.3389/fendo.2014.00150
Abstract: Neuropeptides regulate all aspects of behavior in multicellular organisms. Because of their ability to act at long distances, neuropeptides can exert their effects beyond the conventional synaptic connections, thereby adding an intricate layer of complexity to the activity of neural networks. In the nematode Caenorhabditis elegans, a large number of neuropeptide genes that are expressed throughout the nervous system has been identified. The actions of these peptides supplement the synaptic connections of the 302 neurons, allowing for fine tuning of neural networks and increasing the ways in which behaviors can be regulated. In this review, we focus on a large family of genes encoding FMRFamide-related peptides. These genes, the flp genes, have been used as a starting point to identifying flp genes throughout Nematoda. Nematodes have the largest family of FMRFamide-related peptides described thus far. The challenges in the future are the elucidation of their functions and the identification of the receptors and signaling pathways through which they function.
Represent MOD function by low degree polynomial with unbounded one-sided error
Chris Beck,Yuan Li
Computer Science , 2013,
Abstract: In this paper, we prove tight lower bounds on the smallest degree of a nonzero polynomial in the ideal generated by $MOD_q$ or $\neg MOD_q$ in the polynomial ring $F_p[x_1, \ldots, x_n]/(x_1^2 = x_1, \ldots, x_n^2 = x_n)$, $p,q$ are coprime, which is called \emph{immunity} over $F_p$. The immunity of $MOD_q$ is lower bounded by $\lfloor (n+1)/2 \rfloor$, which is achievable when $n$ is a multiple of $2q$; the immunity of $\neg MOD_q$ is exactly $\lfloor (n+q-1)/q \rfloor$ for every $q$ and $n$. Our result improves the previous bound $\lfloor \frac{n}{2(q-1)} \rfloor$ by Green. We observe how immunity over $F_p$ is related to $\acc$ circuit lower bound. For example, if the immunity of $f$ over $F_p$ is lower bounded by $n/2 - o(\sqrt{n})$, and $|1_f| = \Omega(2^n)$, then $f$ requires $\acc$ circuit of exponential size to compute.
Persistence of Cytosine Methylation of DNA following Fertilisation in the Mouse
Yan Li, Chris O'Neill
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0030687
Abstract: Normal development of the mammalian embryo requires epigenetic reprogramming of the genome. The level of cytosine methylation of CpG-rich (5meC) regions of the genome is a major epigenetic regulator and active global demethylation of 5meC throughout the genome is reported to occur within the first cell-cycle following fertilization. An enzyme or mechanism capable of catalysing such rapid global demethylation has not been identified. The mouse is a widely used model for studying developmental epigenetics. We have reassessed the evidence for this phenomenon of genome-wide demethylation following fertilisation in the mouse. We found when using conventional methods of immunolocalization that 5meC showed a progressive acid-resistant antigenic masking during zygotic maturation which gave the appearance of demethylation. Changing the unmasking strategy by also performing tryptic digestion revealed a persistence of a methylated state. Analysis of methyl binding domain 1 protein (MBD1) binding confirmed that the genome remained methylated following fertilisation. The maintenance of this methylated state over the first several cell-cycles required the actions of DNA methyltransferase activity. The study shows that any 5meC remodelling that occurs during early development is not explained by a global active loss of 5meC staining during the cleavage stage of development and global loss of methylation following fertilization is not a major component of epigenetic reprogramming in the mouse zygote.
OLD SCHOOL LINGUISTICS MADE NEW— REVIEW OF Contemporary Linguistics: An Introduction. 5th ed. By William O’Grady, John Archibald, Mark Arnoff, and Janie Rees-Miller. New York: Bedford/St. Martin’s, 2005. Pp. xxvi + 684.
Chris Wen-chao Li
Taiwan Journal of Linguistics , 2008,
Abstract: Amidst the recent explosion of interest in linguistic science and the subsequent publication of large numbers of introductory works on the subject, O'Grady et al.'s Contemporary Linguistics (5th ed.) stands out as a solid general purpose primer directed at an academic audience. Written by some eighteen contributors specializing in each of the seventeen branches of linguistics covered, topics are judiciously chosen while drawing on current scholarship and integrating different theoretical persuasions, without losing sight of the book's target readership. The result is an up-to-date text balanced in its treatment of subject matter and perspectives--a work that lives up to its moniker of "Contemporary" Linguistics.
5′-methylcytosine and 5′-hydroxymethylcytosine Each Provide Epigenetic Information to the Mouse Zygote
Yan Li, Chris O’Neill
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0063689
Abstract: Covalent modification of cytosine nucleotides within the genome encode essential epigenetic information, with methylation (5meC) and hydroxymethylation (5hmC) having received most attention. It has been proposed that the formation of 5hmC is an intermediate in the active demethylation of 5meC. Some reports show that global loss of 5meC in the newly fertilised embryo is accompanied by increased 5hmC, but others have failed to confirm this finding. These analyses have relied on immuno-localization of these modifications. In this study we have established the conditions required for equilibrium binding of antibodies to 5meC and 5hmC in zygotes. Simultaneous detection of these antigens required denaturation of chromatin by acid treatment followed by antigen retrieval by tryptic digestion. Equilibrium binding then required incubation at 4°C for greater than 6 h. These are more demanding conditions than generally reported and resulted in the consistent detection of 5meC and 5hmC in both male and female pronuclei throughout zygotic maturation. No dynamic reciprocal change in the level of 5meC relative to 5hmC was observed. Both 5meC and 5hmC accumulated within the peri-nucleolar regions and this was more pronounced in the male pronucleus. Staining of 5meC was relatively more intense within the cortical and 5hmC in the central regions of pronuclei. The results are not consistent with a role for 5hmC in global demethylation in the zygote. The persistence of both modifications throughout zygotic maturation, and their differing patterns of localization and solvent exposure infer each modification provides its own epigenetic information to the early embryo.
Analysing the Security of Google's implementation of OpenID Connect
Wanpeng Li,Chris J Mitchell
Computer Science , 2015,
Abstract: Many millions of users routinely use their Google accounts to log in to relying party (RP) websites supporting the Google OpenID Connect service. OpenID Connect, a newly standardised single-sign-on protocol, builds an identity layer on top of the OAuth 2.0 protocol, which has itself been widely adopted to support identity management services. It adds identity management functionality to the OAuth 2.0 system and allows an RP to obtain assurances regarding the authenticity of an end user. A number of authors have analysed the security of the OAuth 2.0 protocol, but whether OpenID Connect is secure in practice remains an open question. We report on a large-scale practical study of Google's implementation of OpenID Connect, involving forensic examination of 103 RP websites which support its use for sign-in. Our study reveals serious vulnerabilities of a number of types, all of which allow an attacker to log in to an RP website as a victim user. Further examination suggests that these vulnerabilities are caused by a combination of Google's design of its OpenID Connect service and RP developers making design decisions which sacrifice security for simplicity of implementation. We also give practical recommendations for both RPs and OPs to help improve the security of real world OpenID Connect systems.
Electrospun nanofiber-based drug delivery systems  [PDF]
Deng-Guang Yu, Li-Min Zhu, Kenneth White, Chris Branford-White
Health (Health) , 2009, DOI: 10.4236/health.2009.12012
Abstract: Electrospinning is a very simple and versatile process by which polymer nanofibers with di-ameters ranging from a few nanometers to sev-eral micrometers can be produced using an electrostatically driven jet of polymer solution or polymer melt. Significant progress has been made in this process throughout the past few years and electrospinning has advanced its ap-plications in many fields, including pharmaceu-tics. Electrospun nanofibers show great prom-ise for developing many types of novel drug delivery systems (DDS) due to their special characteristics and the simple but useful and effective top-down fabricating process. The current state of electrospun nanofiber-based DDS is focused on drug-loaded nanofiber preparation from pharmaceutical and biode-gradable polymers and different types of DDS. However, there are more opportunities to be exploited from the electrospinning process and the corresponding drug-loaded nanofibers for drug delivery. Additionally, some other related challenges and the possible resolutions are outlined in this review.
Is there a role for workplaces in reducing employees' driving to work? Findings from a cross-sectional survey from inner-west Sydney, Australia
Li Wen, James Kite, Chris Rissel
BMC Public Health , 2010, DOI: 10.1186/1471-2458-10-50
Abstract: An analysis of a cross-sectional survey was conducted using data from parents/guardians whose children participated in the Central Sydney Walk to School Program in inner-west Sydney, Australia. A total of 888 parents/guardians who were employed and worked outside home were included in this analysis. The role of the workplace in regards to active travel was assessed by asking the respondents' level of agreement to eight statements including workplace encouragement of active travel, flexible working hours, public transport availability, convenient parking, shower and change rooms for employees and whether they lived or worked in a safe place. Self-reported main mode of journey to work and demographic data were collected through a self-administrated survey. Binary logistic regression modelling was used to ascertain independent predictors of driving to work.Sixty nine per cent of respondents travelled to work by car, and 19% agreed with the statement, "My workplace encourages its employees to go to and from work by public transport, cycling and/or walking (active travel)." The survey respondents with a workplace encouraging active travel to work were significantly less likely to drive to work (49%) than those without this encouragement (73%) with an adjusted odds ratio (AOR) of 0.41 (95% CI 0.23-0.73, P = 0.002). Having convenient public transport close to the workplace or home was also an important factor that could discourage employees from driving to work with AOR 0.17 (95% CI 0.09-0.31, P < 0.0001) and AOR 0.50 (95% CI 0.28-0.90, P = 0.02) respectively. In contrast, convenient parking near the workplace significantly increased the likelihood of respondents driving to work (AOR 4.6, 95% CI 2.8-7.4, P < 0.0001).There is a significant inverse association between the perception of workplace encouragement for active travel and driving to work. Increases in the number of workplaces that encourage their employees to commute to work via active travel could potentially lead
1,3-Di-4-pyridylpropane–4,4′-oxydibenzoic acid (1/1)
Guangzhe Li,Chris Salim,Hirofumi Hinode
Acta Crystallographica Section E , 2008, DOI: 10.1107/s160053680803331x
Abstract: The hydrothermal reaction of Cd(NO3)2·4H2O, 1,3-di-4-pyridylpropane (BPP) and 4,4′-oxydibenzoic acid (OBA) led to the formation of the title compound, C13H14N2·C14H10O5. The asymmetric unit consists of one molecule of OBA and one of BPP. In the OBA molecule, one COOH group is nearly planar with its attached benzene ring [dihedral angle = 0.9 (1)°], while the other COOH group is slightly twisted with a dihedral angle of 10.8 (3)°. The carboxyl groups form strong intermolecular O—H...N hydrogen bonds with N atoms of the pyridine rings in BPP, linking the molecules into zigzag chains.
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