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Search Results: 1 - 10 of 302366 matches for " Chris J. J. Mulder "
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Classifying visuomotor workload in a driving simulator using subject specific spatial brain patterns
Chris Dijksterhuis,Dick de Waard,Ben L. J. M. Mulder
Frontiers in Neuroscience , 2013, DOI: 10.3389/fnins.2013.00149
Abstract: A passive Brain Computer Interface (BCI) is a system that responds to the spontaneously produced brain activity of its user and could be used to develop interactive task support. A human-machine system that could benefit from brain-based task support is the driver-car interaction system. To investigate the feasibility of such a system to detect changes in visuomotor workload, 34 drivers were exposed to several levels of driving demand in a driving simulator. Driving demand was manipulated by varying driving speed and by asking the drivers to comply to individually set lane keeping performance targets. Differences in the individual driver's workload levels were classified by applying the Common Spatial Pattern (CSP) and Fisher's linear discriminant analysis to frequency filtered electroencephalogram (EEG) data during an off line classification study. Several frequency ranges, EEG cap configurations, and condition pairs were explored. It was found that classifications were most accurate when based on high frequencies, larger electrode sets, and the frontal electrodes. Depending on these factors, classification accuracies across participants reached about 95% on average. The association between high accuracies and high frequencies suggests that part of the underlying information did not originate directly from neuronal activity. Nonetheless, average classification accuracies up to 75–80% were obtained from the lower EEG ranges that are likely to reflect neuronal activity. For a system designer, this implies that a passive BCI system may use several frequency ranges for workload classifications.
Small Intestinal Imaging
Marcela Kopá?ová,Andre Van Gossum,Chris J. J. Mulder,Antonín Vavre?ka,Jan Bure?
Gastroenterology Research and Practice , 2013, DOI: 10.1155/2013/623091
Nonalcoholic fatty liver disease: An overview of current insights in pathogenesis, diagnosis, treatment
Tim CMA Schreuder, Bart J Verwer, Carin MJ van Nieuwkerk, Chris JJ Mulder
World Journal of Gastroenterology , 2008,
Abstract: Estimates of people suffering from overweight (one billion) and obesity (300 million) are increasing. The accumulation of triglycerides in the liver, in the absence of excess alcohol intake, has been described in the early sixties. It was not until 1980, however, that Ludwig et al named this condition nonalcoholic steatohepatitis (NASH). Subsequently, nonalcoholic fatty liver disease (NAFLD) has been used as a general name for conditions ranging from simple steatosis through steatohepatitis to end-stage liver disease (cirrhosis). Many studies have demonstrated the significant correlation with obesity and insulin resistance. Other studies have revealed a significant correlation between hepatic steatosis, cardiovascular disease and increased intima-media thickness. WHO estimated that at least two million patients will develop cirrhosis due to hepatic steatosis in the years to come. Longitudinal cohort studies have demonstrated that those patients with cirrhosis have a similar risk to develop hepatocellular carcinoma as those with other causes of cirrhosis. Taken all together, NAFLD has become the third most important indication for liver transplantation. Therefore, training programmes in internal medicine, gastroenterology and hepatology should stress the importance of diagnosing this entity and treat properly those at risk for developing complications of portal hypertension and concomittant cardiovascular disease. This review will focus on the clinical characteristics, pathophysiology, imaging techniques and the readily available therapeutic options.
Vitamin and Mineral Deficiencies Are Highly Prevalent in Newly Diagnosed Celiac Disease Patients
Nicolette J. Wierdsma,Marian A. E. van Bokhorst-de van der Schueren,Marijke Berkenpas,Chris J. J. Mulder,Ad A. van Bodegraven
Nutrients , 2013, DOI: 10.3390/nu5103975
Abstract: Malabsorption, weight loss and vitamin/mineral-deficiencies characterize classical celiac disease (CD). This study aimed to assess the nutritional and vitamin/mineral status of current “early diagnosed” untreated adult CD-patients in the Netherlands. Newly diagnosed adult CD-patients were included ( n = 80, 42.8 ± 15.1 years) and a comparable sample of 24 healthy Dutch subjects was added to compare vitamin concentrations. Nutritional status and serum concentrations of folic acid, vitamin A, B 6, B 12, and (25-hydroxy) D, zinc, haemoglobin (Hb) and ferritin were determined (before prescribing gluten free diet). Almost all CD-patients (87%) had at least one value below the lower limit of reference. Specifically, for vitamin A, 7.5% of patients showed deficient levels, for vitamin B 6 14.5%, folic acid 20%, and vitamin B 12 19%. Likewise, zinc deficiency was observed in 67% of the CD-patients, 46% had decreased iron storage, and 32% had anaemia. Overall, 17% were malnourished (>10% undesired weight loss), 22% of the women were underweight (Body Mass Index (BMI) < 18.5), and 29% of the patients were overweight (BMI > 25). Vitamin deficiencies were barely seen in healthy controls, with the exception of vitamin B 12. Vitamin/mineral deficiencies were counter-intuitively not associated with a (higher) grade of histological intestinal damage or (impaired) nutritional status. In conclusion, vitamin/mineral deficiencies are still common in newly “early diagnosed” CD-patients, even though the prevalence of obesity at initial diagnosis is rising. Extensive nutritional assessments seem warranted to guide nutritional advices and follow-up in CD treatment.
Retrospective analysis of old-age colitis in the Dutch inflammatory bowel disease population
Muhammed Hadithi, Marcel Cazemier, Gerrit A Meijer, Elisabeth Bloemena, Richel J Felt-Bersma, Chris J Mulder, Stephan GM Meuwissen, Amado Salvador Pe?a, Adriaan A van Bodegraven
World Journal of Gastroenterology , 2008,
Abstract: AIM: To describe the characteristics of Dutch patients with chronic inflammatory bowel disease (IBD) first diagnosed above 60 years of age-a disease also known as old-age colitis (OAC) and to highlight a condition that has a similar appearance to IBD, namely segmental colitis associated with diverticular disease (SCAD).METHODS: A retrospective longitudinal survey of patient demographic and clinical characteristics, disease characteristics, diagnostic methods, management and course of disease was performed. The median follow-up period was 10 years.RESULTS: Of a total of 1100 IBD patients attending the Department of Gastroenterology, 59 (5%) [median age 82 years (range 64-101); 25 male (42%)] were identified. These patients were diagnosed with ulcerative colitis (n = 37, 61%), Crohn’s disease (n = 14, 24%), and indeterminate colitis (n = 8, 15%). Remission was induced in 40 (68%) patients within a median interval of 6 mo (range 1-21) and immunosuppressive therapy was well tolerated. Histological evaluation based on many biopsy samples and the course of the disease led to other diagnosis, namely SCAD instead of IBD in five (8%) patients.CONCLUSION: OAC is not an infrequent problem for the gastroenterologist, and should be considered in the evaluation of older patients with clinical features suggestive of IBD. Extra awareness and extensive biopsy sampling are required in order to avoid an erroneous diagnosis purely based on histological mimicry of changes seen in SCAD, when diagnosing IBD in the presence of diverticulosis coli.
Evaluation of Cladribine treatment in refractory celiac disease type II
Greetje J Tack, Wieke HM Verbeek, Abdul Al-Toma, Dirk J Kuik, Marco WJ Schreurs, Otto Visser, Chris JJ Mulder
World Journal of Gastroenterology , 2011,
Abstract: AIM: To evaluate cladribine [2-chlorodeoxyadenosine (2-CdA)] therapy in refractory celiac disease (RCD) II.METHODS: An open-label cohort-study of RCD II patients treated with 2-CdA was performed between 2000 and 2010. Survival rate, enteropathy associated T-cell lymphoma (EATL) occurrence, clinical course, and histological and immunological response rates were evaluated.RESULTS: Overall, 32 patients were included with a median follow-up of 31 mo. Eighteen patients responded well to 2-CdA. Patients responsive to 2-CdA had a statistically significant increased survival compared to those who were unresponsive. The overall 3- and 5-year survival was 83% in the responder and 63% and 22% in the non-responder group, respectively. The overall 2-year clinical, histological and immunological response rates were 81%, 47% and 41%, respectively. Progression into EATL was reported in 16%, all of these patients died.CONCLUSION: Treatment of RCD II with 2-CdA holds promise, showing excellent clinical and histological response rates, and probably less frequent transition into EATL.
Die aandeel van die lewensopvattelike in die proses van opleiding van die opvoederonderwyser
J. J. Mulder
Koers : Bulletin for Christian Scholarship , 1960, DOI: 10.4102/koers.v28i3.1543
Abstract: Inougurele Rede gehou by die aanvaarding van ’n ere-professoraat in Opvoedkunde aan die P.U. vir C.H.O., op 26 Aug. 1960, deur prof. J. J. Mulder.
Safety and efficacy of the immunosuppressive agent 6-tioguanine in murine model of acute and chronic colitis
Miloslav Kverka, Pavel Rossmann, Helena Tlaskalova-Hogenova, Klara Klimesova, Bindia Jharap, Nanne K de Boer, Rene M Vos, Adriaan A van Bodegraven, Milan Lukas, Chris J Mulder
BMC Gastroenterology , 2011, DOI: 10.1186/1471-230x-11-47
Abstract: We induced acute or chronic colitis in BALB/c mice by one or four cycles of 3% dextran sulphate sodium (DSS), respectively. Mice were treated by daily gavages of various dosages of 6-tioguanine, azathioprine, or by phosphate buffered saline (PBS) starting the first day of DSS or after two cycles of DSS, respectively. We monitored the efficacy and toxicity by measuring the weight change and serum alanine aminotransferase (ALT) activity and by disease severity and histology, at the end of the experiment. Moreover, we measured cytokine production after colon fragment cultivation by enzyme-linked immunoabsorbent assay and numbers of apoptotic cells in the spleen by flow cytometry.6-TG is effective in the treatment of acute DSS-induced colitis in a dose-dependent manner and 40 μg of 6-TG is significantly more effective in the treatment of acute colitis than both AZA and PBS. This effect is accompanied by decrease of IL-6 and IFN-γ production in colon. We did not observe histological abnormalities in liver samples from control (PBS) or 6-TG treated mice. However, liver samples from most mice treated with AZA showed mild, yet distinct signs of hepatotoxicity. In chronic colitis, all thiopurine derivatives improved colitis, 20 μg of 6-TG per dose was superior. High doses of 6-TG led to significant weight loss at the end of the therapy, but none of the thiopurine derivatives increased levels of serum ALT. Both thiopurine derivatives reduced the proportion of apoptotic T helper cells, but a high production of both IL-6 and TGF-β was observed only in colon of AZA-treated mice.Use of 6-TG in the treatment of experimental colitis in mice appears superior to AZA administration and placebo. In contrast to 6-TG, the use of AZA resulted in histological liver abnormalities.The immune-modulating thiopurines, 6-mercaptopurine (6-MP), and its pro-drug azathioprine (AZA), are widely used in inflammatory bowel diseases (IBD) treatment [1-3]. Both AZA and 6-MP require extensive metabolisat
Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease
Muhammed Hadithi, Chris JJ Mulder, Frank Stam, Joshan Azizi, J Bart A Crusius, Amado Salvador Pe?a, Coen DA Stehouwer, Yvo M Smulders
World Journal of Gastroenterology , 2009,
Abstract: AIM: To investigate the effect of vitamin supplements on homocysteine levels in patients with celiac disease.METHODS: Vitamin B6, folate, vitamin B12, and fasting plasma homocysteine levels were measured in 51 consecutive adults with celiac disease [median (range) age 56 (18-63) years; 40% men, 26 (51%) had villous atrophy, and 25 (49%) used B-vitamin supplements] and 50 healthy control individuals matched for age and sex. Finally, the C677T polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) was evaluated in 46 patients with celiac disease and all control individuals.RESULTS: Patients with celiac disease and using vitamin supplements had higher serum vitamin B6 (P = 0.003), folate (P < 0.001), and vitamin B12 (P = 0.012) levels than patients who did not or healthy controls (P = 0.035, P < 0.001, P = 0.007, for vitamin B6, folate, and vitamin B12, respectively). Lower plasma homocysteine levels were found in patients using vitamin supplements than in patients who did not (P = 0.001) or healthy controls (P = 0.003). However, vitamin B6 and folate, not vitamin B12, were significantly and independently associated with homocysteine levels. Twenty-four (48%) of 50 controls and 23 (50%) of 46 patients with celiac disease carried the MTHFR thermolabile variant T-allele (P = 0.89).CONCLUSION: Homocysteine levels are dependent on Marsh classification and the regular use of B-vitamin supplements is effective in reduction of homocysteine levels in patients with celiac disease and should be considered in disease management.
Perception of the Psychosocial Aspects of Subfertility by Parents Following Successful Medically Assisted Conception: A Qualitative Study  [PDF]
J. Catja Warmelink, Janiek M. Meijer, Nienke Mulder, Sybren Mulder, Mirjam T. van Lohuizen
Open Journal of Obstetrics and Gynecology (OJOG) , 2016, DOI: 10.4236/ojog.2016.613101
Abstract: Nearly 5% of new-borns in the Netherlands are now born following Medically Assisted Conception (MAC), a steadily increasing number. Our qualitative study explored the subjective impact of subfertility and fertility treatment for parents who successfully achieve pregnancy following MAC and make health professionals more aware of the psychological needs of those clients. The study was based on the constructive/interpretative paradigm using a constant comparison/grounded theory design. Two men and nine women in the Netherlands who conceived as a result of MAC were interviewed in 2011. Our findings show that MAC-parents were exposed to a range of emotions such as disappointment, hope and uncertainty during the subfertile period, and these feelings were even felt after successful fertility treatment. The relationship and social support from friends and others in the same position were very important. Regarding the relationship with the partner during the subfertile period, the main thing the couple have to do is to keep talking with one another. Although they did not always agree on all issues, it was found that maintaining the communication strengthened the links between them by the end of the process. We concluded that the feelings and emotions during fertility treatment play a big role during the subfertile period and remain important during pregnancy and even after childbirth. Subfertile clients want maternity care providers to ask those who successfully achieve pregnancy following MAC about their experiences during fertility treatment, check that they still are receiving adequate social support, and involve the partner in prenatal checks.
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