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Search Results: 1 - 10 of 144 matches for " Chinnasamy Muthukumar "
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Antimicrobial activity of sesquiterpene lactones isolated from traditional medicinal plant, Costus speciosus (Koen ex.Retz.) Sm
Veeramuthu Duraipandiyan, Naif Abdullah Al-Harbi, Savarimuthu Ignacimuthu, Chinnasamy Muthukumar
BMC Complementary and Alternative Medicine , 2012, DOI: 10.1186/1472-6882-12-13
Abstract: Antibacterial and antifungal activities were tested using Disc diffusion method and Minimum Inhibitory Concentration (MIC). Column chromatography was used to isolate compounds from hexane extract. X-ray crystallography technique and GC-MS analysis were used to identify the compoundsAntibacterial and antifungal activities were observed in hexane, chloroform, ethyl acetate and methanol extracts. Hexane extract of C.speciosus showed good activity against tested fungi also. Two sesquiterpenoid compounds were isolated (costunolide and eremanthin) from the hexane extract. Both the compounds did not inhibit the growth of tested bacteria. But, both the compounds inhibited the tested fungi. The compound costunolide showed significant antifungal activity. The MIC values of costunolide were; 62.5 μg/ml against Trichophyton mentagrophytes, 62. μg/ml against T. simii, 31.25 μg/ml against T. rubrum 296, 62.5 μg/ml against T. rubrum 57, 125 μg/ml against Epidermophyton floccosum, 250 μg/ml against Scopulariopsis sp, 250 μg/ml against Aspergillus niger, 125 μg/ml against Curvulari lunata, 250 μg/ml against Magnaporthe grisea.Hexane extract showed promising antibacterial and antifungal activity. The isolated compound costunolide showed good antifungal activity.Infectious diseases caused by bacteria, fungi, viruses and parasites are still a major threat to public health, despite the tremendous progress in human medicine. Their impact is particularly large in developing countries due to the relative unavailability of medicines and the emergence of widespread drug resistance [1]. Medicinal plants have been a source of bioactive compounds to treat many diseases. Traditionally used medicinal plants produce a variety of compounds with known therapeutic properties [2].Costus speciosus (Koen ex.Retz.) Sm. (Costaceae, Family)is widely used in Ayurveda. The plant rhizome is bitter, useful in treating burning sensation, constipation, leprosy, worm infection, skin diseases, fever, asthma, bronc
Analytical expression of concentrations of adsorbed CO molecules, O atoms and oxide oxygen  [PDF]
Chinnasamy Thangapandi, Lakshmanan Rajendran
Natural Science (NS) , 2013, DOI: 10.4236/ns.2013.53045
Abstract:

A mathematical model of the oscillatory regimes of CO oxidation over plantinum-group metal catalysts are discussed. The model is based on nonstationary diffusion equation containing a nonlinear term related to Michaelis-Menten kinetics of the enzymatic reaction. This paper presents the analytical and numerical solution of the system of non-linear differential equations. Here the Homotopy perturbation method (HPM) is used to find out the analytical expressions of the concentration of CO molecules, O atom and oxide oxygen respectively. A comparison of the analytical approximation and numerical simulation is also presented. A good agreement between theoretical and numerical results is observed.

Social Media and On-Line Political Campaigning in Malaysia  [PDF]
Sara Chinnasamy, Izyan Roslan
Advances in Journalism and Communication (AJC) , 2015, DOI: 10.4236/ajc.2015.34014
Abstract: Since the controversies surrounding the 2008 and 2013 Malaysian general elections due to the rising Opposition, social media networks have played a vital role in conveying political messages and debates. In 2014 there were a few state by-elections and they were influenced by the Kuala Lumpur Court of Appeal that found Anwar Ibrahim guilty of sodomy and sentenced him to five years jail (Kajang) on 23 March. He was expected to win, opening the way for him to become the chief minister of Selangor state, the country’s main economic hub surrounding Kuala Lumpur. In another event, a well known Malaysian and opposition politician, Karpal Singh, \"the Tiger of Jelutong\" died tragically following a motor vehicle accident. This paper analyses the influence of Facebook in the Kajang by-election and to what extent the social media impacted on the victory by Dr. Wan Azizah Wan Ismail. Using compliance gaining theory, this paper presents strategies used by the two major political parties, Barisan Nasional (BN) and Pakatan Rakyat (PR) to achieve their electoral goals. Though online political campaigning is not new from a Western perspective it is for Malaysia. To understand how the compliance gaining approach works in practice, selected political parties’ Facebook advertisements were examined within two weeks after nomination day and election observers from diverse backgrounds were interviewed. It can be concluded that since 2008 political messages have been heavily debated through blogs. Independent Internet Media, Facebook and Twitter are very popular among Malaysian political candidates and voters.
Analytical expressions of the concentrations of substrate and product in enzyme inhibition process  [PDF]
Sankaranarayanan Muthukumar, Lakshmanan Rajendran
Natural Science (NS) , 2013, DOI: 10.4236/ns.2013.59129
Abstract: The initial and boundary value problem in enzyme reactions mechanism for inhabitation process is discussed. Approximate analytical expressions for the concentrations of substrate and product are presented. Approximate analytical solutions of non-linear reaction equations containing non-linear terms related to enzymatic reaction mechanism are solved using Homotopy perturbation method. The relevant analytical expression for the substrate and product concentration profiles is discussed in terms of dimensionless reaction diffusion parameters α, β, γE, and γS. Numerical solution is also obtained using Matlab program. Our analytical expression compared with numerical estimation and good agreement is noted.
Video Based Vehicle Detection and its Application in Intelligent Transportation Systems  [PDF]
Naveen Chintalacheruvu, Venkatesan Muthukumar
Journal of Transportation Technologies (JTTs) , 2012, DOI: 10.4236/jtts.2012.24033
Abstract: Video based vehicle detection technology is an integral part of Intelligent Transportation System (ITS), due to its non-intrusiveness and comprehensive vehicle behavior data collection capabilities. This paper proposes an efficient video based vehicle detection system based on Harris-Stephen corner detector algorithm. The algorithm was used to develop a stand alone vehicle detection and tracking system that determines vehicle counts and speeds at arterial roadways and freeways. The proposed video based vehicle detection system was developed to eliminate the need of complex calibration, robustness to contrasts variations, and better performance with low resolutions videos. The algorithm performance for accuracy in vehicle counts and speed was evaluated. The performance of the proposed system is equivalent or better compared to a commercial vehicle detection system. Using the developed vehicle detection and tracking system an advance warning intelligent transportation system was designed and implemented to alert commuters in advance of speed reductions and congestions at work zones and special events. The effectiveness of the advance warning system was evaluated and the impact discussed.
Indolin-2-Ones in Clinical Trials as Potential Kinase Inhibitors: A Review  [PDF]
Chinnasamy Rajaram Prakash, Sundararajan Raja, Panneerselvam Theivendren
Pharmacology & Pharmacy (PP) , 2012, DOI: 10.4236/pp.2012.31010
Abstract: The kinases have been intensely studied because of their involvement in regulating essential cellular activation of signaling cascades in response to extracellular and intracellular stimuli to control cell growth, proliferation, and survival. Recent cancer genomic sequencing studies have revealed that many more kinases contribute to tumor genesis and are potential targets for inhibitor drug development intervention. Herein we review recent results that have helped to unravel the indolin-2-ones underlying the confiicting roles of the kinase inhibition regulation. This review focuses on the potential of kinases as a chemotherapeutic target in cancer treatment and highlights important recent advances in the development of indolin-2-ones as kinase inhibitors.
Immunomodulatory effect of Hawthorn extract in an experimental stroke model
Chinnasamy Elango, Sivasithambaram Devaraj
Journal of Neuroinflammation , 2010, DOI: 10.1186/1742-2094-7-97
Abstract: After 15 days of treatment with Hawthorn extract [100 mg/kg, pretreatment (oral)], male Sprague Dawley rats underwent transient MCAO for 75 mins followed by reperfusion (either 3 or 24 hrs). We measured pro-inflammatory cytokines (IL-1β, TNF-α, IL-6), ICAM-1, IL-10 and pSTAT-3 expression in the brain by appropriate methods. We also looked at the cytotoxic T cell sub-population among leukocytes (FACS) and inflammatory cell activation and recruitment in brain (using a myeloperoxidase activity assay) after ischemia and reperfusion (I/R). Apoptosis (TUNEL), and Bcl-xL- and Foxp3- (Treg marker) positive cells in the ipsilateral hemisphere of the brain were analyzed separately using immunofluorescence.Our results indicate that occlusion followed by 3 hrs of reperfusion increased pro-inflammatory cytokine and ICAM-1 gene expressions in the ipsilateral hemisphere, and that Hawthorn pre-treatment significantly (p ≤ 0.01) lowered these levels. Furthermore, such pre-treatment was able to increase IL-10 levels and Foxp3-positive cells in brain after 24 hrs of reperfusion. The increase in cytotoxic T cell population in vehicle rats after 24 hrs of reperfusion was decreased by at least 40% with Hawthorn pretreatment. In addition, there was a decrease in inflammatory cell activation and infiltration in pretreated brain. Hawthorn pretreatment elevated pSTAT-3 levels in brain after I/R. We also observed an increase in Bcl-xL-positive cells, which in turn may have influenced the reduction in TUNEL-positive cells compared to vehicle-treated brain.In summary, Hawthorn extract helped alleviate pro-inflammatory immune responses associated with I/R-induced injury, boosted IL-10 levels, and increased Foxp3-positive Tregs in the brain, which may have aided in suppression of activated inflammatory cells. Such treatment also minimizes apoptotic cell death by influencing STAT-3 phosphorylation and Bcl-xL expression in the brain. Taken together, the immunomodulatory effect of Hawthorn extract m
Performance Enhancement Evaluation in Database Decompression Using HIRAC Algorithm
Muthukumar Murugesan
International Journal of Computer Science Issues , 2012,
Abstract: Storage space ability and computational authority increases, processing and analyzing large volumes of database systems acts as a significant role in several areas of scientific research. Database compression and decompression is a susceptible problem in the database framework. Disk storage systems can often be the most expensive components of a database solution, even a small reduction in the storage subsystem can result in substantial cost savings for the entire database solution. When you have large amounts of data, the cost of the storage subsystem can easily exceed the cost of your data server. In this paper we proposed a new algorithm for database compression and decompression called HIRAC algorithm. If we compress the database, there is chance of hurting the data in the compressed database systems. Projected algorithm will manipulates each row in compressed database inside the file to extract the original database without losing any data.
INFORMATION RETRIEVAL USING INDEXING SCHEME FOR TREE PATTERN FRAMEWORK
Muthukumar R
Journal of Global Research in Computer Science , 2012,
Abstract: Indexing an XML database in data warehouse is a complex problem. The major rationale for indexing XML database in data warehouse is owing to the heterogeneous and structural environment of XML data that can construct query pattern tedious. Existing techniques focused on clustering methods based on integrating the data warehouse with web data for Online Analytical Processing (OLAP) techniques. Through clustering process, fast retrieval of information is impossible because clustering technique exactly used for tree pattern building framework. Most XML indexing strategies split it into several sub-queries, and subsequently connect their results to present the response to the unique query. Join operations have been determined as the mainly time-consuming component in XML query processing for information retrieval. To enhance the search criteria in XML database present in the data warehouse, in this paper, an indexing scheme is used which separates the data based on the objective. An indexing technique XSeq is presented based on the tree structure pattern framework. XSeq constructs its indexing infrastructure framework on a much simpler and symbolize both XML data and XML queries as formation encoded sequences. Furthermore, the XSeq infrastructure unites both the content and the construction of XML documents, thus it attains a further presentation over indexing both just content and construction, or indexing them individually. A reliable performance improvement is achieved with the proposed IRIS (Information Retrieval using Indexing Scheme) in XML database to data warehouse, compared to an existing SDC technique for OLAP, in terms of search path length, search cost, Maintenance.
Remarks on the Formulation of Quantum Mechanics on Noncommutative Phase Spaces
B. Muthukumar
Physics , 2006, DOI: 10.1088/1126-6708/2007/01/073
Abstract: We consider the probabilistic description of nonrelativistic, spinless one-particle classical mechanics, and immerse the particle in a deformed noncommutative phase space in which position coordinates do not commute among themselves and also with canonically conjugate momenta. With a postulated normalized distribution function in the quantum domain, the square of the Dirac delta density distribution in the classical case is properly realised in noncommutative phase space and it serves as the quantum condition. With only these inputs, we pull out the entire formalisms of noncommutative quantum mechanics in phase space and in Hilbert space, and elegantly establish the link between classical and quantum formalisms and between Hilbert space and phase space formalisms of noncommutative quantum mechanics. Also, we show that the distribution function in this case possesses 'twisted' Galilean symmetry.
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