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Search Results: 1 - 10 of 6476 matches for " Chin Leong Lim "
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Embolisation of Bleeding Renal Angiomyolipoma in Pregnancy  [PDF]
Chin Hong Lim, David Mulvin
Open Journal of Urology (OJU) , 2011, DOI: 10.4236/oju.2011.13007
Abstract: Bleeding from renal angiomyolipoma in pregnancy can be catastrophic to both mother and fetus. Selective arterial embolisation is considered more superior than conventional surgery in these patients. Our case report exemplifies how a bleeding angiomyolipoma was halted with embolisation in our pregnant patient.
Enzymatic Characterization of Insecticide Resistance Mechanisms in Field Populations of Malaysian Culex quinquefasciatus Say (Diptera: Culicidae)
Van Lun Low, Chee Dhang Chen, Han Lim Lee, Tiong Kai Tan, Chin Fong Chen, Cherng Shii Leong, Yvonne Ai Lian Lim, Phaik Eem Lim, Yusoff Norma-Rashid, Mohd Sofian-Azirun
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0079928
Abstract: Background There has been no comprehensive study on biochemical characterization of insecticide resistance mechanisms in field populations of Malaysian Culex quinquefasciatus. To fill this void in the literature, a nationwide investigation was performed to quantify the enzyme activities, thereby attempting to characterize the potential resistance mechanisms in Cx. quinquefasciatus in residential areas in Malaysia. Methodology/Principal Findings Culex quinquefasciatus from 14 residential areas across 13 states and one federal territory were subjected to esterases, mixed function oxidases, glutathione-S-transferase and insensitive acetylcholinesterase assays. Enzyme assays revealed that α-esterases and β-esterases were elevated in 13 populations and 12 populations, respectively. Nine populations demonstrated elevated levels of mixed function oxidases and glutathione-S-transferase. Acetylcholinesterase was insensitive to propoxur in all 14 populations. Activity of α-esterases associated with malathion resistance was found in the present study. In addition, an association between the activity of α-esterases and β-esterases was also demonstrated. Conclusions/Significance The present study has characterized the potential biochemical mechanisms in contributing towards insecticide resistance in Cx. quinquefasciatus field populations in Malaysia. Identification of mechanisms underlying the insecticide resistance will be beneficial in developing effective mosquito control programs in Malaysia.
Statistical Modeling Reveals the Effect of Absolute Humidity on Dengue in Singapore
Hai-Yan Xu,Xiuju Fu ,Lionel Kim Hock Lee,Stefan Ma,Kee Tai Goh,Jiancheng Wong,Mohamed Salahuddin Habibullah,Gary Kee Khoon Lee,Tian Kuay Lim,Paul Anantharajah Tambyah,Chin Leong Lim,Lee Ching Ng
PLOS Neglected Tropical Diseases , 2014, DOI: 10.1371/journal.pntd.0002805
Abstract: Weather factors are widely studied for their effects on indicating dengue incidence trends. However, these studies have been limited due to the complex epidemiology of dengue, which involves dynamic interplay of multiple factors such as herd immunity within a population, distinct serotypes of the virus, environmental factors and intervention programs. In this study, we investigate the impact of weather factors on dengue in Singapore, considering the disease epidemiology and profile of virus serotypes. A Poisson regression combined with Distributed Lag Non-linear Model (DLNM) was used to evaluate and compare the impact of weekly Absolute Humidity (AH) and other weather factors (mean temperature, minimum temperature, maximum temperature, rainfall, relative humidity and wind speed) on dengue incidence from 2001 to 2009. The same analysis was also performed on three sub-periods, defined by predominant circulating serotypes. The performance of DLNM regression models were then evaluated through the Akaike's Information Criterion. From the correlation and DLNM regression modeling analyses of the studied period, AH was found to be a better predictor for modeling dengue incidence than the other unique weather variables. Whilst mean temperature (MeanT) also showed significant correlation with dengue incidence, the relationship between AH or MeanT and dengue incidence, however, varied in the three sub-periods. Our results showed that AH had a more stable impact on dengue incidence than temperature when virological factors were taken into consideration. AH appeared to be the most consistent factor in modeling dengue incidence in Singapore. Considering the changes in dominant serotypes, the improvements in vector control programs and the inconsistent weather patterns observed in the sub-periods, the impact of weather on dengue is modulated by these other factors. Future studies on the impact of climate change on dengue need to take all the other contributing factors into consideration in order to make meaningful public policy recommendations.
Weather Impact on Heat-Related Illness in a Tropical City State, Singapore  [PDF]
Hai-Yan Xu, Xiuju Fu, Chin Leong Lim, Stefan Ma, Tian Kuay Lim, Paul Anantharajah Tambyah, Mohd Salahuddin Habibullah, Gary Kee Khoon Lee, Lee Ching Ng, Kee Tai Goh, Rick Siow Mong Goh, Lionel Kim Hock Lee
Atmospheric and Climate Sciences (ACS) , 2018, DOI: 10.4236/acs.2018.81007
Abstract: In this article we propose a novel hurdle negative binomial (HNB) regression combined with a distributed lag nonlinear model (DLNM) to model weather factors’ impact on heat related illness (HRI) in Singapore. AIC criterion is adopted to help select proper combination of weather variables and check their lagged effect as well as nonlinear effect. The process of model selection and validation is demonstrated. It is observed that the predicted occurrence rate is close to the observed one. The proposed combined model can be used to predict HRI cases for mitigating HRI occurrences and provide inputs for related public health policy considering climate change impact.
Enhancement of TiB Grain Refining Effect on A356 Gravity Die Casting with the Addition of Yttrium  [PDF]
Lim Ying Pio, Wang Chan Chin
Materials Sciences and Applications (MSA) , 2012, DOI: 10.4236/msa.2012.310104
Abstract: The present work investigates the effect yttrium on the grain refining efficiency of Al-5Ti-1B in gravity die cast A356 aluminum alloy. A series of casting experiments were carried out in which the Ti and B contents were maintained constantly at 0.1 and 0.02 wt% respectively. The inoculation level of yttrium was manipulated at the amount of 0, 0.1, 0.2, 0.3, 0.4 and 0.5 wt%. Microstructural characterization of the as-cast A356 alloy was investigated by means of optical microscope and its phases are detected by XRD. XRF is used to determine the contents of inoculating elements such as Ti, B and Y so that their actual optimal ratio in the casting can be approximated. The mechanical properties tested are tensile strength and hardness. The inoculation of yttrium was found to enhance the grain refinement effect of Al-5Ti-1B grain refiner and improve the mechanical properties. The optimal weight percentage of yttrium was discovered to be 0.3. The grain refining efficiency of combining yttrium and Al-5Ti-1B on A356 aluminum alloy was mainly attributed to the heterogeneous nucleation of TiB2 and TiAl3 particles which were dispersed more evenly in the presence of yttrium and also as a result of α-Al grain growth restriction by AlY3compound precipitated at grain boundaries during solidification.
Globalizing Asia: Towards a New Development Paradigm
Hyun-Chin Lim
Globality Studies Journal : Global History, Society, Civilization , 2007,
Abstract: Asia is a rising leader in the international political and economic system. Japan plus the Four Dragons, Five Tigers and two potential world economic powers — they all positively describe Asia. Yet Asia is also identified with “orientalism,” Asian values, and the Pacific way. The economic crisis in 1997 challenged the multiple Asias and its various cultural and religious traditions to conform to global standards through structural adjustment programs. The crisis functioned as a test bed of the market, state, and culture approach to Asian development. However, the negative impacts of top-down economic globalization have shown us that the structural adjustment programs end with social dissolution, political decay, and economic stagnation. Given this, this article suggests, tentatively, an alternative development paradigm for globalizing Asia: the “stakeholder model” of capitalism. This model highlights the critical role of NGOs in committing themselves to the organized interests of the people as public goods.
Blood-Based Biomarkers of Aggressive Prostate Cancer
Men Long Liong, Chun Ren Lim, Hengxuan Yang, Samuel Chao, Chin Wei Bong, Wing Seng Leong, Prashanta Kumar Das, Chit Sin Loh, Ban Eng Lau, Choon Geok Yu, Edie Jian Jiek Ooi, Robert K. Nam, Paul D. Allen, Graeme S. Steele, Karl Wassmann, Jerome P. Richie, Choong Chin Liew
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0045802
Abstract: Purpose Prostate cancer is a bimodal disease with aggressive and indolent forms. Current prostate-specific-antigen testing and digital rectal examination screening provide ambiguous results leading to both under-and over-treatment. Accurate, consistent diagnosis is crucial to risk-stratify patients and facilitate clinical decision making as to treatment versus active surveillance. Diagnosis is currently achieved by needle biopsy, a painful procedure. Thus, there is a clinical need for a minimally-invasive test to determine prostate cancer aggressiveness. A blood sample to predict Gleason score, which is known to reflect aggressiveness of the cancer, could serve as such a test. Materials and Methods Blood mRNA was isolated from North American and Malaysian prostate cancer patients/controls. Microarray analysis was conducted utilizing the Affymetrix U133 plus 2·0 platform. Expression profiles from 255 patients/controls generated 85 candidate biomarkers. Following quantitative real-time PCR (qRT-PCR) analysis, ten disease-associated biomarkers remained for paired statistical analysis and normalization. Results Microarray analysis was conducted to identify 85 genes differentially expressed between aggressive prostate cancer (Gleason score ≥8) and controls. Expression of these genes was qRT-PCR verified. Statistical analysis yielded a final seven-gene panel evaluated as six gene-ratio duplexes. This molecular signature predicted as aggressive (ie, Gleason score ≥8) 55% of G6 samples, 49% of G7(3+4), 79% of G7(4+3) and 83% of G8-10, while rejecting 98% of controls. Conclusion In this study, we have developed a novel, blood-based biomarker panel which can be used as the basis of a simple blood test to identify men with aggressive prostate cancer and thereby reduce the overdiagnosis and overtreatment that currently results from diagnosis using PSA alone. We discuss possible clinical uses of the panel to identify men more likely to benefit from biopsy and immediate therapy versus those more suited to an “active surveillance” strategy.
Role of the ubiquitin proteasome system in Parkinson's disease
Lim Kah-Leong,Tan Jeanne MM
BMC Biochemistry , 2007, DOI: 10.1186/1471-2091-8-s1-s13
Abstract: Parkinson's disease (PD) is the most common neurodegenerative movement disorder. Although a subject of intense research, the etiology of PD remains poorly understood. Recently, several lines of evidence have implicated an intimate link between aberrations in the ubiquitin proteasome system (UPS) and PD pathogenesis. Derangements of the UPS, which normally functions as a type of protein degradation machinery, lead to alterations in protein homeostasis that could conceivably promote the toxic accumulation of proteins detrimental to neuronal survival. Not surprisingly, various cellular and animal models of PD that are based on direct disruption of UPS function reproduce the most prominent features of PD. Although persuasive, new developments in the past few years have in fact raised serious questions about the link between the UPS and PD. Here I review current thoughts and controversies about their relationship and discuss whether strategies aimed at mitigating UPS dysfunction could represent rational ways to intervene in the disease. Publication history: Republished from Current BioData's Targeted Proteins database (TPdb; http://www.targetedproteinsdb.com).
Reconstruction of Vital Blade Signal from Unsteady Casing Vibration
Meng Hee Lim,M. S. Leong
Advances in Mechanical Engineering , 2014, DOI: 10.1155/2014/146983
Abstract: Some important information pertaining to blade fault is thought to be concealed in highly unsteady casing vibration. This paper explores suitable methods to best reconstruct blade related signals from raw casing vibration, which could be used for diagnosis of blade fault. The feasibility of translation invariant wavelet transform and cycle spinning (TIWT-CS) technique in reconstruction of these signals is investigated in this paper. Subsequently, a new parameter for blade fault diagnosis, namely, the energy profile of blade signal (EPBS), is formulated. Experimental results show that TIWT-CS method effectively retained blade related signals, while other unwanted signals such as system noises and aerodynamic induced vibration are reasonably suppressed. EPBS provides an indication of the condition of blade faults in rotor system, whereby the exact position and the quantity of faulty blades, as well as the root cause of blade fault, can be identified. In comparison, the energy profile plots using unfiltered casing vibration were found to be highly unstable and therefore provides inconsistent results for diagnosis of blade fault. 1. Introduction Blade fault is one of the most destructive and elusive problems in power generation and aerospace industries. The most common types of blade fault include blade rubbing, low and high cycle fatigue failures, blade creep, fouled blade, loose blade, and blade induced foreign object damage (FOD). Undetected blade fault could further deteriorate to trigger some serious consequences such as in the event of FOD that could potentially undermine the functionality and total integrity of the machine. Traditionally, detection of blade fault is often conducted via spectrum analysis of bearing vibration. This method monitors changes in the vibration spectrum and in particular the amplitude of blade pass frequency (BPF) and its sidebands components. Any abnormal changes in the amplitudes of these frequencies together with the presence of some peculiar vibration peaks in the vibration spectrum could indicate the occurrence of blade fault. This method has been studied by Kubiak et al. [1] and Simmons ([2, 3] and Parge et al. [4] and Parge [5]), amongst others. In more recent years, the application of advanced signal analysis techniques such as wavelet analysis and artificial intelligence methods to detect blade fault has been reported. Angelakis et al. [6] applied neural networks technique to classify healthy and faulty blade condition based on experimental study. Peng et al. [7] used the reassigned wavelet scalograms to improve the
Locally Advanced Anaplastic Thyroid Carcinoma with Long-Term Survival of More Than 7 Years after Combined Surgery Including Tracheal Resection and Radiotherapy: Case Report  [PDF]
Weizhong Ernest Fu, Ming Yann Lim, Khoon Leong Chuah, Li-Chung Mark Khoo
International Journal of Otolaryngology and Head & Neck Surgery (IJOHNS) , 2015, DOI: 10.4236/ijohns.2015.44053
Abstract: Background: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human malignancies with a mean survival time of 6 months regardless of treatment. Aim: To present a case of locally advanced anaplastic thyroid carcinoma with long-term survival. A 10-year literature review of locally advanced ATC with long-term survival (more than 2 years) is also presented. Case presentation: We present a case of locally advanced anaplastic thyroid carcinoma (ATC) with tracheal invasion in a 67-year-old elderly Chinese man who was treated with radical surgery encompassing total thyroidectomy, neck dissection and tracheal resection followed by adjuvant radiotherapy. Long-term disease-free survival is more than 7 years to date. Conclusion: The prognosis of ATC remains poor as it is characterized by aggressive and extensive disease at presentation, the inability in most patients to perform radical enough surgery in order to achieve clear margins, high morbidity of complete extirpation and limited response to radiotherapy or chemotherapy. However, if complete surgical resection is possible, patients should be treated aggressively with a combination of surgery and adjuvant radiotherapy.
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