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Search Results: 1 - 10 of 63477 matches for " Chih-Teng Yu "
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Erlotinib-associated Near-fatal Interstitial Pneumonitis in A Patient with Relapsed Lung Adenocarcinoma
Chun-Liang Chou,How-Wen Ko,Chih-Wei Wang,Chih-Teng Yu
Chang Gung Medical Journal , 2010,
Abstract: Erlotinib (Tarceva ) is a human epidermal growth factor receptor (EGFR) tyrosinekinase inhibitor used for treatment of locally advanced or metastatic non-small cell lung cancer(NSCLC) after failure of at least one prior chemotherapy regimen. Interstitial lung disease,associated with gefitinib (Iressa ) use, has been reported in approximately 1% ofpatients worldwide. However, the adverse pulmonary effects of erlotinib remain poorly documented.Reviewed English language publications in MEDLINE and PubMed suggest thatthis report is to be the first case report in English of a histologically-confirmed case of nearfatalinterstitial pneumonitis with acute lung injury, associated with erlotinib, in East Asianpatients. Physicians are hereby encouraged to promptly evaluate new or worsening pulmonarysymptoms so that they can detect early radiographic signs of pulmonary toxicity inpatients on erlotinib. If toxicity is confirmed, erlotinib should be discontinued and thepatient treated appropriately. The case presented suggests that the outcome of erlotinib-associatedpulmonary toxicity with acute respiratory failure may be favorable with adequateearly management.
The Effects of Ciprofloxacin on Chest Radiographic Regression in Patients with Drug Intolerance or Resistant Tuberculosis.
Horng-Chyuan Lin,Kang-Yun Lee,Shu-Min Lin,Chih-Teng Yu
Chang Gung Medical Journal , 2004,
Abstract: Background: The aim of this study was to identify the clinical efficacy of ciprofloxacin asa second-line anti-tuberculosis agent in pulmonary tuberculosis patients withdrug intolerance or resistance.Methods: There were 20 patients with drug related adverse effects or drug resistanceenrolled in the ciprofloxacin treatment group (CG). There were also 32patients enrolled in the non-ciprofloxacin treatment group (NCG) that maintainedconventional drug regimens or the addition of other drugs like streptomycin.The radiographic presentation was evaluated using score grading.The speed and outcome of regression in the chest radiographic presentationswere also evaluated.Results: Data showed the CG had significantly more rapid regression than the NCGin drug-resistant patients ( p < 0.01). For the adversely effected patients in theCG, the mean scores of pre- and post-treatment were 3.1
Good Response to Gefitinib for Lung Adenocarcinoma with Hyperamylasemia: A Case Report
How-Wen Ko,Ying-Huang Tsai,Chih-Teng Yu,Chun-Yao Huang
Chang Gung Medical Journal , 2008,
Abstract: Hyperamylasemia in patients with bronchogenic carcinoma has been reported rarely.Gefitinib, an oral tyrosine kinase inhibitor of epidermal growth factor receptor (EGFR) signaling,has shown activity for treating patients with refractory advanced non-small cell lungcancer (NSCLC). This report describes a case of lung adenocarcinoma coexisting withhyperamylasemia in a 67-year-old man. Abdominal computed tomograhy and ultrasonographydemonstrated a normal pancreas. A mutational analysis of the EGFR gene indicated anin-frame deletion at exon 19. He underwent treatment with gefitinib. Chest radiography follow-up showed a partial response and the amylase level also decreased to normal. We suggestthat treatment with gefitinib is an effective therapeutic option for this rare patient subset.
Complications of airway self-expandable metallic stent in benign airway diseases  [PDF]
Fu-Tsai Chung, Shu-Min Lin, Chun-Liang Chou, Hao-Cheng Chen, Chih-Hsi Kuo, Horng-Chyuan Lin, Chien-Ying Liu, Chun-Hua Wang, Han-Pin Kuo, Chih-Teng Yu
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.41A016

Objectives: To present the complications of Ultraflex Self-Expandable Metallic Stents (SEMSs) applied in patients with benign tracheobronchial diseases. Methods: Eighty patients received 124 SEMSs were retrospectively reviewed in a tertiary hospital. Results: The baseline characteristics of patients received SEMS implantation including age (mean + standard deviation: 62.5 + 14.8 years), gender (male, 60.5%), smoking (46.8%), forced expiratory volume in first one second (FEV1) (mean + standard deviation, 0.92 +0.41 L/s), follow-up days after SEMS implantation (median (interquartile range); 457 (131 - 897)) and covered SEMS (33.9%) were listed. Symptoms improved after SEMS implantation among 95 patients (76.6%). Time to complications developed was 236 (median; interquartile range, 59 - 672) days. The overall complication rate was 41.9% after SEMS implantation. The complications included SEMS migration (6.5%), granuloma (19.3%) and SEMS fracture (16.1%). Successful management rates of SEMS migration, granuloma and SEMS fracture were up to 100%, 83.3%, and 85% respectively. Conclusions: Patients received SEMS implantation due to benign conditions had poor lung function and were old. The complication rate in patients with benign conditions was high after longer follow-up period, however, successful management achieved in most patients with complications.

An outcome analysis of self-expandable metallic stents in central airway obstruction: a cohort study
Fu-Tsai Chung, Hao-Cheng Chen, Chun-Liang Chou, Chih-Teng Yu, Chih-Hsi Kuo, Han-Pin Kuo, Shu-Min Lin
Journal of Cardiothoracic Surgery , 2011, DOI: 10.1186/1749-8090-6-46
Abstract: Of 149 patients, 72 with benign and 77 with malignant tracheobronchial disease received 211 SEMSs (benign, 116; malignant, 95) and were retrospectively reviewed in a tertiary hospital.The baseline characteristics of patients who received SEMS implantation for benign conditions and those who underwent implantation for malignant conditions were significantly different. These characteristics included age (mean, 63.9 vs. 58; p < 0.01), gender (male, 62% vs. 90%; p < 0.0001), smoking (47% vs. 85%; p < 0.0001), forced expiratory volume in 1 second (mean, 0.9 vs. 1.47 L/s; p < 0.0001), follow-up days after SEMS implantation (median; 429 vs. 57; p < 0.0001), and use of covered SEMS (36.2% vs. 94.7%; p < 0.0001). Symptoms improved more after SEMS implantation in patients with benign conditions than in those with malignant conditions (76.7% vs. 51.6%; p < 0.0001). The overall complication rate after SEMS implantation in patients with benign conditions was higher than that in patients with malignancy (42.2% vs. 21.1%; p = 0.001). Successful management of SEMS migration, granulation tissue formation, and SEMS fracture occurred in 100%, 81.25%, and 85% of patients, respectively.Patients who received SEMS implantation owing to benign conditions had worse lung function and were older than those who received SEMS for malignancies. There was higher complication rate in patients with benign conditions after a longer follow-up period owing to the nature of the underlying diseases.Patients with symptomatic central airway lesions can be treated with surgery or endoscopic intervention [1-3]. Owing to advances in endobronchial stents and insertion techniques, interventional bronchoscopic procedures have been widely used in patients with benign and malignant lesions [4-7]. Rigid and flexible bronchoscopies are the most common methods of stent implantation in these patients. Some patients are not candidates for surgical intervention or rigid bronchoscopy with a general anaesthetic, however,
Endobronchial Mucosa Invasion Predicts Survival in Patients with Small Cell Lung Cancer
Pai-Chien Chou, Shu-Min Lin, Chun-Yu Lo, Hao-Cheng Chen, Chih-Wei Wang, Chun-Liang Chou, Chih-Teng Yu, Horng-Chyuan Lin, Chun-Hua Wang, Han-Pin Kuo
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0047613
Abstract: Background Current staging system for small cell lung cancer (SCLC) categorizes patients into limited- or extensive-stage disease groups according to anatomical localizations. Even so, a wide-range of survival times has been observed among patients in the same staging system. This study aimed to identify whether endobronchial mucosa invasion is an independent predictor for poor survival in patients with SCLC, and to compare the survival time between patients with and without endobronchial mucosa invasion. Methods We studied 432 consecutive patients with SCLC based on histological examination of biopsy specimens or on fine-needle aspiration cytology, and received computed tomography and bone scan for staging. All the enrolled patients were assessed for endobronchial mucosa invasion by bronchoscopic and histological examination. Survival days were compared between patients with or without endobronchial mucosa invasion and the predictors of decreased survival days were investigated. Results 84% (364/432) of SCLC patients had endobronchial mucosal invasion by cancer cells at initial diagnosis. Endobronchial mucosal involvement (Hazard ratio [HR], 2.01; 95% Confidence Interval [CI], 1.30–3.10), age (HR, 1.04; 95% CI, 1.03–1.06), and extensive stage (HR, 1.39; 95% CI, 1.06–1.84) were independent contributing factors for shorter survival time, while received chemotherapy (HR, 0.32; 95% CI, 0.25–0.42) was an independent contributing factor better outcome. The survival days of SCLC patients with endobronchial involvement were markedly decreased compared with patients without (median 145 vs. 290, p<0.0001). Among SCLC patients of either limited (median 180 vs. 460, p<0.0001) or extensive (median 125 vs. 207, p<0.0001) stages, the median survival duration for patients with endobronchial mucosal invasion was shorter than those with intact endobronchial mucosa, respectively. Conclusion Endobronchial mucosal involvement is an independent prognostic factor for SCLC patients and associated with decreased survival days.
Extravascular Lung Water Correlates Multiorgan Dysfunction Syndrome and Mortality in Sepsis
Fu-Tsai Chung,Horng-Chyuan Lin,Chih-Hsi Kuo,Chih-Teng Yu,Chun-Liang Chou,Kang-Yun Lee,Han-Pin Kuo,Shu-Min Lin
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0015265
Abstract: This study was designated to investigate whether increased extravascular lung water index (EVLWI) may correlate multiple organ dysfunction syndrome (MODS) and mortality in sepsis.
The Potential Regimen of Target-Controlled Infusion of Propofol in Flexible Bronchoscopy Sedation: A Randomized Controlled Trial
Ting-Yu Lin, Yu-Lun Lo, Chung-Hsing Hsieh, Yung-Lun Ni, Tsai-Yu Wang, Horng-Chyuan Lin, Chun-Hua Wang, Chih-Teng Yu, Han-Pin Kuo
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0062744
Abstract: Objectives Target-controlled infusion (TCI) provides precise pharmacokinetic control of propofol concentration in the effect-site (Ce), eg. brain. This pilot study aims to evaluate the feasibility and optimal TCI regimen for flexible bronchoscopy (FB) sedation. Methods After alfentanil bolus, initial induction Ce of propofol was targeted at 2 μg/ml. Patients were randomized into three titration groups (i.e., by 0.5, 0.2 and 0.1 μg/ml, respectively) to maintain stable sedation levels and vital signs. Adverse events, frequency of adjustments, drug doses, and induction and recovery times were recorded. Results The study was closed early due to significantly severe hypoxemia events (oxyhemoglobin saturation <70%) in the group titrated at 0.5 μg/ml. Forty-nine, 49 and 46 patients were enrolled into the 3 respective groups before study closure. The proportion of patients with hypoxemia events differed significantly between groups (67.3 vs. 46.9 vs. 41.3%, p = 0.027). Hypotension events, induction and recovery time and propofol doses were not different. The Ce of induction differed significantly between groups (2.4±0.5 vs. 2.1±0.4 vs. 2.1±0.3 μg/ml, p = 0.005) and the Ce of procedures was higher at 0.5 μg/ml titration (2.4±0.5 vs. 2.1±0.4 vs. 2.2±0.3 μg/ml, p = 0.006). The adjustment frequency tended to be higher for titration at 0.1 μg/ml but was not statistically significant (2 (0~6) vs. 3 (0~6) vs. 3 (0~11)). Subgroup analysis revealed 14% of all patients required no further adjustment during the whole sedation. Comparing patients requiring at least one adjustment with those who did not, they were observed to have a shorter induction time (87.6±34.9 vs. 226.9±147.9 sec, p<0.001), a smaller induction dose and Ce (32.5±4.1 vs. 56.8±22.7 mg, p<0.001; 1.76±0.17 vs. 2.28 ±0.41, p<0.001, respectively), and less hypoxemia and hypotension (15.8 vs.56.9%, p = 0.001; 0 vs. 24.1%, p = 0.008, respectively). Conclusion Titration at 0.5 μg/ml is risky for FB sedation. A subgroup of patients required no more TCI adjustment with fewer complications. Further studies are warranted to determine the optimal regimen of TCI for FB sedation. Trial Registration ClinicalTrials.gov NCT01101477
Strategic Analysis and Model Construction on Conflict Resolution with Motion Game Theory
Chih-Yao Lo,Yu-Teng Chang
Journal of Information and Organizational Sciences , 2010,
Abstract: This research uses the “Participating Observation Method” to observe the interaction between manufacturer and distributor negotiation strategies, determine the preference and expectation of participants, and establish a framework for this type of research. Then it sets up the “analysis framework of negotiation strategies” between the manufacturer and the distributor based on an analysis of the respective conditions, advantages, and disadvantages of the manufacturer and distributor. Thirdly, this study sets up a reward matrix of the strategy action game between the manufacturer and the distributor. Then establishes a set of feasible “negotiation models” based on the reward matrix of the strategy game between the both parties to observe how the manufacturer and the distributor make their own bargaining decisions in the situation of information asymmetry or exterior opportunity/threat. Finally, this study establishes a “multi-agent strategy game protocol system model” to solve the conflict resulting from the self-strategizing of both parties for their own interests, and to achieve the utmost efficiency in the negotiation.
An Effective Marketing Strategy for Revenue Maximization with a Quantity Constraint
Ya-Wen Teng,Chih-Hua Tai,Philip S. Yu,Ming-Syan Chen
Computer Science , 2015,
Abstract: Recently the influence maximization problem has received much attention for its applications on viral marketing and product promotions. However, such influence maximization problems have not taken into account the monetary effect on the purchasing decision of individuals. To fulfill this gap, in this paper, we aim for maximizing the revenue by considering the quantity constraint on the promoted commodity. For this problem, we not only identify a proper small group of individuals as seeds for promotion but also determine the pricing of the commodity. To tackle the revenue maximization problem, we first introduce a strategic searching algorithm, referred to as Algorithm PRUB, which is able to derive the optimal solutions. After that, we further modify PRUB to propose a heuristic, Algorithm PRUB+IF, for obtaining feasible solutions more effciently on larger instances. Experiments on real social networks with different valuation distributions demonstrate the effectiveness of PRUB and PRUB+IF.
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