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Search Results: 1 - 10 of 30108 matches for " Chien-Hung Lee "
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Prevalence and Clinical Relevance of Serum Autoantibodies in Patients with Chronic Hepatitis C
Chih-Hung Chen,Chuan-Mo Lee,Chien-Hung Chen,Tsung-Hui Hu
Chang Gung Medical Journal , 2010,
Abstract: Background: Chronic hepatitis C (CHC) is frequently associated with the presence ofserum autoantibodies. The prevalence and clinical relevance of serumautoantibodies in CHC patients and their influence on antiviral treatmenthave not been well established.Methods: From February 1999 to July 2004, 460 consecutive adult patients with CHCwere studied. Antinuclear antibody (ANA) and smooth muscle antibody(SMA) were determined by indirect immunofluorescence. The presence ofthese antibodies was related to patient characteristics and to the outcome of24 weeks of therapy with interferon (IFN) alfa-2b (n = 376) or pegylated-IFN alfa-2b (n = 84) plus ribavirin.Results: The prevalence of ANA and SMA was 7.4% and 19.3%, respectively.Seropositivity for ANA and/or SMA was associated with old age and highaspartate aminotransferase (AST) levels. The rates of sustained virologicalresponse and early withdrawal of therapy were comparable between autoantibody-positive and -negative patients. None of the autoantibody-positivepatients experienced a flare-up of transaminase during treatment, or developedsevere systemic autoimmune disease.Conclusion: Serum ANA and/or SMA-positive HCV-infected patients are older, and havehigher disease activity and severity than their negative counterparts.However, the presence of ANA or SMA did not influence the response tocombination antiviral therapy, which is safe and effective in autoantibody -positive CHC patients.
Thinking of the Textbook in the ESL/EFL Classroom
Wang Wen-Cheng,Lin Chien-Hung,Lee Chung-Chieh
English Language Teaching , 2011, DOI: 10.5539/elt.v4n2p91
Abstract: Textbooks provide novice teachers with guidance in course and activity design; it assures a measure of structure, consistency, and logical progression in a class; It meets a learner’s needs or expectations of having something concrete to work from and take home for further study; It may provide multiple resources: tapes, CDs, videos, self-study workbooks etc. While the quality of ESL reading textbooks has improved dramatically in recent years, the process of selecting an appropriate text has not become any easier for most teachers and administrators. Thus, the paper discusses for evaluating reading textbooks for use in ESL/EFL classrooms. Classroom teachers spend much time using textbooks in class, so choosing an appropriate one is important. And the paper describes the role of the textbook. Using this will make the textbook selection process more efficient and more reliable.
A 20-31 GHz High Image Rejection Ratio Subharmonic Mixer
Yi-Chang Lee;Chien-Hung Liu;Shih-Han Hung;Chun-Chi Su;Yeong-Her Wang
PIER C , 2012, DOI: 10.2528/PIERC12011115
Abstract: A broadband monolithic image rejection subharmonic mixer using a standard 0.18 μm CMOS technology is proposed. This circuit is composed of a band-pass filter with an intermediate frequency (IF) extraction function that can simplify the block diagram of the image rejection mixer. The entire passive circuit is constructed using a broadside coupling structure to achieve a high level of integration. Based on measured results, the proposed mixer exhibits conversion loss of 15.5-18.5 dB at a local oscillator (LO) power of 13 dBm, whereas the 3 dB bandwidth ranges from 20 to 31 GHz (43.1%) with a miniature chip dimension of 0.77×0.81 mm. The LO-to-radio frequency (RF), 2LO-to-RF, and RF-to-IF isolation levels are higher than 22.5, 42.9, and 34.5 dB, respectively. The best image rejection ratio of 29 dBc with 20° phase compensation at 24.5 GHz can be achieved.
Second-hand smoke exposure and the factors associated with avoidance behavior among the mothers of pre-school children: a school-based cross-sectional study
Pi-Li Lin, Hsiao-Ling Huang, Kuei-Yun Lu, Ted Chen, Wei-Ting Lin, Chien-Hung Lee, Hsiang-Ming Hsu
BMC Public Health , 2010, DOI: 10.1186/1471-2458-10-606
Abstract: A cross-sectional study was used to obtain a sample of the mothers of pre-school children (n = 1,020) in 30 registered kindergartens in eastern Taiwan. Overall, 919 (a response rate of 90%) completed the questionnaires. Regression models were used to identify factors with respect to the avoidance behavior of SHS.The prevalence of exposure to SHS was 70% and 50% for the mothers and their children, respectively. After adjusting for other variables, mothers who were current smokers (β = -0.260, p < 0.001), had spouses who smoked (β = -0.060, p < 0.05), SHS exposure (β = -0.138, p < 0.001), and/or children with exposure to SHS (β = -0.084, p < 0.05) were found to be less likely to avoid SHS, whereas mothers with a high knowledge score about SHS (β = 0.082, p < 0.01), positive attitudes (β = 0.274, p < 0.001) and a high self-efficacy level in regard to the avoidance of SHS (β = 0.397, p < 0.001) were observed to be more likely to avoid SHS. Regression analyses confirmed that the significantly factors associated with the avoidance behavior of SHS were self-efficacy, being a current smoker, and the attitude toward the avoidance of SHS to be that of 55.5% of the total variance explained (p < 0.001).The high prevalence rate of exposure to SHS for mothers and their children suggests that a well-designed future intervention program should be implemented in regard to pre-school children's mothers in order to prevent these mothers and their children from SHS exposure hazards, more particularly, to strengthen the knowledge base, to enhance self-efficacy and to foster a more positive attitude toward the avoidance of SHS in the mothers.Exposure to Second-hand Smoke (SHS), also called Environmental Tobacco Smoke, is a serious health hazard for children and causes substantial morbidity [1], including bronchitis, acute respiratory illness [2], and numerous chronic respiratory diseases [3]. Previous studies have shown that exposure to SHS could result in a stronger risk of incident whe
Intra-articular injections of sodium hyaluronate (Hyalgan?) in osteoarthritis of the knee. a randomized, controlled, double-blind, multicenter trial in the asian population
Teng-Le Huang, Chi-Ching Chang, Chian-Her Lee, Shih-Ching Chen, Chien-Hung Lai, Ching-Lin Tsai
BMC Musculoskeletal Disorders , 2011, DOI: 10.1186/1471-2474-12-221
Abstract: Two hundred patients with mild to moderate OA of the knee were randomized to receive five weekly intra-articular injections of sodium hyaluronate or placebo. The primary efficacy outcome was the change from baseline to Week 25 in patients' evaluation of pain using a 100-mm visual analog scale (VAS) during the 50-foot walking test. Additional outcomes included Western Ontario and McMaster Universities (WOMAC) scores, time on the 50-foot walking test, patient's and investigator's subjective assessment of effectiveness, acetaminophen consumption, and the amounts of synovial fluid.The Hyalgan? treatment group showed a significantly greater improvement from baseline to Week 25 in VAS pain on the 50-foot walking test than the placebo group (p = 0.0020). The Hyalgan? group revealed significant improvements from baseline to week 25 in WOMAC pain and function score than the placebo group (p = 0.005 and 0.0038, respectively) Other outcomes, such as time on the 50-foot walking test and subjective assessment of effectiveness, did not show any significant difference between groups. Both groups were safe and well tolerated.The present study suggests that five weekly intra-articular injections of sodium hyaluronate are well tolerated, can provide sustained relief of pain, and can improve function in Asian patients with osteoarthritis of the knee.Therapeutic study, Level I-1a (randomized controlled trial with a significant difference).ClinicalTrials.gov Identifier: NCT01319461Osteoarthritis (OA) of the knee is a common arthropathy and a leading cause of disability in elderly adults. The disease is characterized by a reduction in the lubricating and viscoelastic properties of the synovial fluid, accompanied by progressive destruction of the cartilage surface [1,2]. When simple analgesics, such as acetaminophen, prove ineffective for reducing the pain of OA, the most common therapy for treating the signs and symptoms of OA is nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs have
Computer-Aided Diagnosis of Skin Lesions Using Conventional Digital Photography: A Reliability and Feasibility Study
Wen-Yu Chang, Adam Huang, Chung-Yi Yang, Chien-Hung Lee, Yin-Chun Chen, Tian-Yau Wu, Gwo-Shing Chen
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0076212
Abstract: Background Computer-aided diagnosis (CADx) software that provides a second opinion has been widely used to assist physicians with various tasks. In dermatology, however, CADx has been mostly limited to melanoma or melanocytic skin cancer diagnosis. The frequency of non-melanocytic skin cancers and the accessibility of regular digital macrographs have raised interest in developing CADx for broader applications. Objectives To investigate the feasibility of using CADx to diagnose both melanocytic and non-melanocytic skin lesions based on conventional digital photographic images. Methods This study was approved by an institutional review board, and the requirement to obtain informed consent was waived. In total, 769 conventional photographs of melanocytic and non-melanocytic skin lesions were retrospectively reviewed and used to develop a CADx system. Conventional and new color-related image features were developed to classify the lesions as benign or malignant using support vector machines (SVMs). The performance of CADx was compared with that of dermatologists. Results The clinicians' overall sensitivity, specificity, and accuracy were 83.33%, 85.88%, and 85.31%, respectively. New color correlation and principal component analysis (PCA) features improved the classification ability of the baseline CADx (p = 0.001). The estimated area under the receiver operating characteristic (ROC) curve (Az) of the proposed CADx system was 0.949, with a sensitivity and specificity of 85.63% and 87.65%, respectively, and a maximum accuracy of 90.64%. Conclusions We have developed an effective CADx system to classify both melanocytic and non-melanocytic skin lesions using conventional digital macrographs. The system's performance was similar to that of dermatologists at our institute. Through improved feature extraction and SVM analysis, we found that conventional digital macrographs were feasible for providing useful information for CADx applications. The new color-related features significantly improved CADx applications for skin cancer.
How Big Data Ecosystem Changes Cloud Services: A Design Science Perspective  [PDF]
Chien-Hung Liu, Sheng-Chi Chen, Pei-Hung Hsieh
Open Journal of Social Sciences (JSS) , 2015, DOI: 10.4236/jss.2015.37013

With the trend of digital economy, cloud services and its ecosystem have developed and matured. Another fast-growing trend, data Economy and big data, changes the way how cloud services create value. This research aims to explain the evolution of cloud service development during the big data era in the design science perspective. An ecosystem model with three roles is proposed to show the big data ecosystem and the relationships with the development of cloud services. Currently, we use a cloud service case to explain the proposed model and believe that the proposed model can inspire further research on cloud and big data ecosystem.

Successful High-Dosage Dexamethasone Treatment of H1N1 Influenza A Pneumonia Complicated with Acute Necrotizing Encephalitis in an HIV-Infected Adult  [PDF]
Kuan-Chih Chen, Chien-Hung Gow, Chia-Jui Yang, Hou-Tai Chang
Case Reports in Clinical Medicine (CRCM) , 2015, DOI: 10.4236/crcm.2015.47048
Neurological manifestations in H1N1 influenza A infection are very rare, especially in adults, and its mechanism of action is still uncertain. Here, we reported the case of a 53-year-old woman with human immunodeficiency virus infection (HIV) who had H1N1 influenza A pneumonia complicated with very rare acute necrotizing encephalitis, although the HIV was under control. With prompt identification and administration of high dosage of dexamethasone, her mental status improved from stupor to clear, with minimal right hemiparesis. Further, brain magnetic resonance image revealed great resolution of mass effect. This dramatic improvement in response to the treatment may improve our understanding of the pathophysiology between H1N1 influenza A infection and acute necrotizing encephalitis.
Generalizations and limitations of string-net models
Chien-Hung Lin,Michael Levin
Physics , 2014, DOI: 10.1103/PhysRevB.89.195130
Abstract: We ask which topological phases can and cannot be realized by exactly soluble string-net models. We answer this question for the simplest class of topological phases, namely those with abelian braiding statistics. Specifically, we find that an abelian topological phase can be realized by a string-net model if and only if (i) it has a vanishing thermal Hall conductance and (ii) it has at least one Lagrangian subgroup --- a subset of quasiparticles with particular topological properties. Equivalently, we find that an abelian topological phase is realizable if and only if it supports a gapped edge. We conjecture that the latter criterion generalizes to the non-abelian case. We establish these results by systematically constructing all possible abelian string-net models and analyzing the quasiparticle braiding statistics in each model. We show that the low energy effective field theories for these models are multicomponent U(1) Chern-Simons theories, and we derive the K-matrix description of each model. An additional feature of this work is that the models we construct are more general than the original string-net models, due to several new ingredients. First, we introduce two new objects $\gamma, \alpha$ into the construction which are related to $\mathbb{Z}_2$ and $\mathbb{Z}_3$ Frobenius-Schur indicators. Second, we do not assume parity invariance. As a result, we can realize topological phases that were not accessible to the original construction, including phases that break time-reversal and parity symmetry.
Loop braiding statistics in exactly soluble 3D lattice models
Chien-Hung Lin,Michael Levin
Physics , 2015, DOI: 10.1103/PhysRevB.92.035115
Abstract: We construct two exactly soluble lattice spin models that demonstrate the importance of three-loop braiding statistics for the classification of 3D gapped quantum phases. The two models are superficially similar: both are gapped and both support particle-like and loop-like excitations similar to that of charges and vortex lines in a $\mathbb{Z}_2 \times \mathbb{Z}_2$ gauge theory. Furthermore, in both models the particle excitations are bosons, and in both models the particle and loop excitations have the same mutual braiding statistics. The difference between the two models is only apparent when one considers the recently proposed three-loop braiding process in which one loop is braided around another while both are linked to a third loop. We find that the statistical phase associated with this process is different in the two models, thus proving that they belong to two distinct phases. An important feature of this work is that we derive our results using a concrete approach: we construct string and membrane operators that create and move the particle and loop excitations and then we extract the braiding statistics from the commutation algebra of these operators.
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